Christian Doutremepuich

Summary

Country: France

Publications

  1. pmc Paradoxical effect of aspirin
    Christian Doutremepuich
    Laboratoire d Hematologie, Université Bordeaux Segalen, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Thrombosis 2012:676237. 2012
  2. pmc Thrombotic events associated to aspirin therapy
    Christian Doutremepuich
    Laboratoire d Hematologie, Universite Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Thrombosis 2012:247363. 2012
  3. pmc Beneficial effect of ultra-low-dose aspirin in platelet activity alterations and haemorrhage observed in experimental portal hypertension
    F X Eizayaga
    Laboratoire d Hematologie, UFR des Sciences Pharmaceutiques, Universite de Bordeaux 2, Victor Segalen, 33076 Bordeaux Cedex, France
    Thrombosis 2012:430460. 2012
  4. ncbi request reprint Aspirin discontinuation syndromes: clinical implications of basic research studies
    Christian Doutremepuich
    Laboratoire d Hematologie, Université Bordeaux Segalen, 146 rue Leo Saignat, 33076, Bordeaux Cedex, France
    Am J Cardiovasc Drugs 13:377-84. 2013
  5. ncbi request reprint Paradoxical thrombotic effects of aspirin: experimental study on 1000 animals
    Christian Doutremepuich
    Laboratoire d Hematologie, Universite Victor Segalen, Bordeaux 2, Bordeaux, France
    Cardiovasc Hematol Disord Drug Targets 10:103-10. 2010
  6. doi request reprint Reverse effect of aspirin: is the prothrombotic effect after aspirin discontinuation mediated by cyclooxygenase 2 inhibition?
    Christian Doutremepuich
    Laboratoire d Hematologie, UFR des Sciences Pharmaceutiques, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Pathophysiol Haemost Thromb 36:40-4. 2007
  7. doi request reprint Aspirin therapy: an attempt to explain the events of prothrombotic complications after treatment discontinuation
    Christian Doutremepuich
    Laboratoire d Hematologie, Universite Victor Segalen, Bordeaux 2, 146 rue Leo Saignat, 33 076 Bordeaux Cedex, France
    Thromb Haemost 103:171-80. 2010
  8. doi request reprint Prothrombotic and hemorrhagic effects of aspirin
    Omar Aguejouf
    Laboratoire d Hématologie Université Victor Segalen Bordeaux 2, Bordeaux, France
    Clin Appl Thromb Hemost 15:523-8. 2009
  9. ncbi request reprint Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension
    Francisco X Eizayaga
    Universidad Maimónides, Buenos Aires, Argentina
    World J Gastroenterol 13:5065-70. 2007
  10. ncbi request reprint Modifications produced by indomethacin and L-NAME in the effect of ultralow-dose aspirin on platelet activity in portal hypertension
    Francisco X Eizayaga
    Facultad de Medicina, Universidad Maimónides, Buenos Aires, Argentina
    Pathophysiol Haemost Thromb 35:357-63. 2006

Collaborators

  • Francisco X Eizayaga
  • Omar Aguejouf
  • Philippe Belon
  • Vanessa Desplat
  • F X Eizayaga
  • V Desplat
  • O Aguejouf
  • Francisco Eizayaga

Detail Information

Publications12

  1. pmc Paradoxical effect of aspirin
    Christian Doutremepuich
    Laboratoire d Hematologie, Université Bordeaux Segalen, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Thrombosis 2012:676237. 2012
    ..The absence of COX 2 induced a hemorrhagic effect that needs further research, probably originated in compensatory phenomena...
  2. pmc Thrombotic events associated to aspirin therapy
    Christian Doutremepuich
    Laboratoire d Hematologie, Universite Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Thrombosis 2012:247363. 2012
    ..This review is the first report in which the effects of a wide range of ASA concentration on a microvessel model of laser-induced thrombus formation and Induced Hemorrhagic Time in animals were largely studied...
  3. pmc Beneficial effect of ultra-low-dose aspirin in platelet activity alterations and haemorrhage observed in experimental portal hypertension
    F X Eizayaga
    Laboratoire d Hematologie, UFR des Sciences Pharmaceutiques, Universite de Bordeaux 2, Victor Segalen, 33076 Bordeaux Cedex, France
    Thrombosis 2012:430460. 2012
    ..The possible beneficial role of these doses of aspirin and mechanism of COX 2 inhibition are discussed...
  4. ncbi request reprint Aspirin discontinuation syndromes: clinical implications of basic research studies
    Christian Doutremepuich
    Laboratoire d Hematologie, Université Bordeaux Segalen, 146 rue Leo Saignat, 33076, Bordeaux Cedex, France
    Am J Cardiovasc Drugs 13:377-84. 2013
    ..This effect in the rat may be reproduced 1 hour after a single injection of ultra-low-dose aspirin. Caution is therefore required regarding the possibility of drug discontinuation effects within the framework of drug safety evaluation. ..
  5. ncbi request reprint Paradoxical thrombotic effects of aspirin: experimental study on 1000 animals
    Christian Doutremepuich
    Laboratoire d Hematologie, Universite Victor Segalen, Bordeaux 2, Bordeaux, France
    Cardiovasc Hematol Disord Drug Targets 10:103-10. 2010
    ..Previous studies reported that high dilutions of aspirin might cause a pro-thrombotic effect. This paper studies the effect of the lower end of the aspirin dose-response curve, its possible mechanism and clinical implications...
  6. doi request reprint Reverse effect of aspirin: is the prothrombotic effect after aspirin discontinuation mediated by cyclooxygenase 2 inhibition?
    Christian Doutremepuich
    Laboratoire d Hematologie, UFR des Sciences Pharmaceutiques, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Pathophysiol Haemost Thromb 36:40-4. 2007
    ..While aspirin is the drug most often used to prevent cardiovascular complications, its discontinuation induces an increased risk of acute coronary syndrome and ischemic stroke in some patients...
  7. doi request reprint Aspirin therapy: an attempt to explain the events of prothrombotic complications after treatment discontinuation
    Christian Doutremepuich
    Laboratoire d Hematologie, Universite Victor Segalen, Bordeaux 2, 146 rue Leo Saignat, 33 076 Bordeaux Cedex, France
    Thromb Haemost 103:171-80. 2010
    ..COX 2 inhibition produced by residual ASA is the probable cause of ischaemic accidents and drug-eluting stents thrombosis a few days after ASA withdrawal...
  8. doi request reprint Prothrombotic and hemorrhagic effects of aspirin
    Omar Aguejouf
    Laboratoire d Hématologie Université Victor Segalen Bordeaux 2, Bordeaux, France
    Clin Appl Thromb Hemost 15:523-8. 2009
    ..In conclusion, the prothrombotic effects described in recent observational studies are likely produced by a direct effect of aspirin, whose putative mechanism involving COX 2 inhibition remains poorly understood...
  9. ncbi request reprint Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension
    Francisco X Eizayaga
    Universidad Maimónides, Buenos Aires, Argentina
    World J Gastroenterol 13:5065-70. 2007
    ....
  10. ncbi request reprint Modifications produced by indomethacin and L-NAME in the effect of ultralow-dose aspirin on platelet activity in portal hypertension
    Francisco X Eizayaga
    Facultad de Medicina, Universidad Maimónides, Buenos Aires, Argentina
    Pathophysiol Haemost Thromb 35:357-63. 2006
    ..The simultaneous administration of indomethacin and ULDA could inhibit its beneficial effect on bleeding in rats with PHT...
  11. ncbi request reprint Platelet aggregation in portal hypertension and its modification by ultra-low doses of aspirin
    Francisco X Eizayaga
    Catedra de Fisiopatologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina
    Pathophysiol Haemost Thromb 34:29-34. 2005
    ..These changes were reverted by one injection of ASA at ULD. This observation could be of importance for primary prevention or the treatment of recurrence in upper digestive tract hemorrhage in portal hypertensive patients...