D Dormont

Summary

Country: France

Publications

  1. ncbi request reprint A novel generation of heparan sulfate mimetics for the treatment of prion diseases
    Karim Tarik Adjou
    CEA, DSV DRM, 18 route du Panorama, BP6, 92265 Fontenay aux Roses Cedex, France
    J Gen Virol 84:2595-603. 2003
  2. ncbi request reprint Prion diseases: pathogenesis and public health concerns
    Dominique Dormont
    CEA, Service de Neurovirologie, CRSSA, EPHE, P O Box 6, Fontenay aux Roses, France
    FEBS Lett 529:17-21. 2002
  3. ncbi request reprint Strain specific and common pathogenic events in murine models of scrapie and bovine spongiform encephalopathy
    C I Lasmezas
    Service de Neurovirologie, DSV DRM CRSSA, Commissariat a l Energie Atomique, Fontenay aux Roses, France
    J Gen Virol 77:1601-9. 1996
  4. ncbi request reprint Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein
    C I Lasmezas
    Commissariat a l Energie Atomique, Service de Neurovirologie, DSV DRM SSA, B P 6, 60 68 avenue du General Leclerc, 92265 Fontenay aux Roses Cedex, France
    Science 275:402-5. 1997
  5. pmc Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt-- Jakob disease: implications for human health
    C I Lasmezas
    Commissariat a l Energie Atomique, Service de Neurovirologie, Direction des Sciences du Vivant Dèpartement de Recherche Médicale, Centre de Recherches du Service de Santé des Armées 60 68, Fontenay aux Roses, France
    Proc Natl Acad Sci U S A 98:4142-7. 2001
  6. ncbi request reprint Astrocyte gene expression in experimental mouse scrapie
    F Lazarini
    Laboratoire de Neuropathologie Expérimentale et Neurovirologie, CRSSA, Commissariat a l Energie Atomique, DPTE DSV, Fontenay aux Roses, France
    J Comp Pathol 111:87-98. 1994
  7. ncbi request reprint Probing the dynamics of prion diseases with amphotericin B
    K T Adjou
    Service de Neurovirologie, CEA CRSSA, DSV DRM, Fontenay aux Roses, France
    Trends Microbiol 5:27-31. 1997
  8. ncbi request reprint Regulation of the glial fibrillary acidic protein, beta actin and prion protein mRNAs during brain development in mouse
    F Lazarini
    Laboratoire de Neuropathologie Expérimentale et Neurovirologie, CRSSA, Commissariat a l Energie Atomique, DPTE DSV, Fontenay aux Roses, France
    Brain Res Mol Brain Res 10:343-6. 1991
  9. ncbi request reprint Longitudinal analysis of CD8(+) T-cell phenotype and IL-7, IL-15 and IL-16 mRNA expression in different tissues during primary simian immunodeficiency virus infection
    P Caufour
    CEA, Service de Neurovirologie, DSV/DRM, CRSSA, Institut Paris-Sud sur les Cytokines, Fontenay-aux-Roses, France
    Microbes Infect 3:181-91. 2001
  10. pmc Opposite effects of dextran sulfate 500, the polyene antibiotic MS-8209, and Congo red on accumulation of the protease-resistant isoform of PrP in the spleens of mice inoculated intraperitoneally with the scrapie agent
    V Beringue
    CEA, Service de Neurovirologie, DRM DSV, CRSSA, Fontenay aux Roses, France
    J Virol 74:5432-40. 2000

Collaborators

Detail Information

Publications51

  1. ncbi request reprint A novel generation of heparan sulfate mimetics for the treatment of prion diseases
    Karim Tarik Adjou
    CEA, DSV DRM, 18 route du Panorama, BP6, 92265 Fontenay aux Roses Cedex, France
    J Gen Virol 84:2595-603. 2003
    ..Since these molecules are particularly amenable to drug design, their anti-prion potential could be developed further and optimized for the treatment of prion diseases...
  2. ncbi request reprint Prion diseases: pathogenesis and public health concerns
    Dominique Dormont
    CEA, Service de Neurovirologie, CRSSA, EPHE, P O Box 6, Fontenay aux Roses, France
    FEBS Lett 529:17-21. 2002
    ..Transmissibility has been proven in natural situations such as the outbreak of CJD among patients treated with pituitary-derived hormones and the appearance of BSE that affected UK cattle in the mid-1980s...
  3. ncbi request reprint Strain specific and common pathogenic events in murine models of scrapie and bovine spongiform encephalopathy
    C I Lasmezas
    Service de Neurovirologie, DSV DRM CRSSA, Commissariat a l Energie Atomique, Fontenay aux Roses, France
    J Gen Virol 77:1601-9. 1996
    ..The possible involvement of a regulatory molecule accounting for these specificities has to be considered...
  4. ncbi request reprint Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein
    C I Lasmezas
    Commissariat a l Energie Atomique, Service de Neurovirologie, DSV DRM SSA, B P 6, 60 68 avenue du General Leclerc, 92265 Fontenay aux Roses Cedex, France
    Science 275:402-5. 1997
    ..During serial passage, PrPres appeared after the agent became adapted to the new host. Thus, PrPres may be involved in species adaptation, but a further unidentified agent may actually transmit BSE...
  5. pmc Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt-- Jakob disease: implications for human health
    C I Lasmezas
    Commissariat a l Energie Atomique, Service de Neurovirologie, Direction des Sciences du Vivant Dèpartement de Recherche Médicale, Centre de Recherches du Service de Santé des Armées 60 68, Fontenay aux Roses, France
    Proc Natl Acad Sci U S A 98:4142-7. 2001
    ..These data will be key in identifying the origin of human cases of prion disease, including accidental vCJD transmission, and could provide bases for vCJD risk assessment...
  6. ncbi request reprint Astrocyte gene expression in experimental mouse scrapie
    F Lazarini
    Laboratoire de Neuropathologie Expérimentale et Neurovirologie, CRSSA, Commissariat a l Energie Atomique, DPTE DSV, Fontenay aux Roses, France
    J Comp Pathol 111:87-98. 1994
    ..To conclude, these results show that GFAP and GS mRNAs are differently upregulated in brain in the scrapie mouse model...
  7. ncbi request reprint Probing the dynamics of prion diseases with amphotericin B
    K T Adjou
    Service de Neurovirologie, CEA CRSSA, DSV DRM, Fontenay aux Roses, France
    Trends Microbiol 5:27-31. 1997
    ..Therefore, AmB could be used as a pharmacological tool to contribute to our understanding of the pathogenic mechanisms involved in these neurodegenerative disorders...
  8. ncbi request reprint Regulation of the glial fibrillary acidic protein, beta actin and prion protein mRNAs during brain development in mouse
    F Lazarini
    Laboratoire de Neuropathologie Expérimentale et Neurovirologie, CRSSA, Commissariat a l Energie Atomique, DPTE DSV, Fontenay aux Roses, France
    Brain Res Mol Brain Res 10:343-6. 1991
    ..Nevertheless, slight but significant increases in the mRNA levels of both GFAP and PrP were observed at older stages (360 days). These results are analysed in the light of the implications of PrP and GFAP in scrapie infection models...
  9. ncbi request reprint Longitudinal analysis of CD8(+) T-cell phenotype and IL-7, IL-15 and IL-16 mRNA expression in different tissues during primary simian immunodeficiency virus infection
    P Caufour
    CEA, Service de Neurovirologie, DSV/DRM, CRSSA, Institut Paris-Sud sur les Cytokines, Fontenay-aux-Roses, France
    Microbes Infect 3:181-91. 2001
    ..Given the immunomodulatory properties of IL-15 and IL-7 and the potential antiviral ability of IL-16, these perturbations could have important implications in early viral dissemination and HIV immunopathogenesis...
  10. pmc Opposite effects of dextran sulfate 500, the polyene antibiotic MS-8209, and Congo red on accumulation of the protease-resistant isoform of PrP in the spleens of mice inoculated intraperitoneally with the scrapie agent
    V Beringue
    CEA, Service de Neurovirologie, DRM DSV, CRSSA, Fontenay aux Roses, France
    J Virol 74:5432-40. 2000
    ..We showed in vitro that this effect was related to a direct enhancement of the protease resistance of PrPres by the drug...
  11. ncbi request reprint Sodium valproate does not augment Prpsc in murine neuroblastoma cells
    C Legendre
    Service de Neurovirologie, CEA, CRSSA, Universite Paris XI, EPHE, IPSC, Fontenay aux Roses, France
    Neurotox Res 12:205-8. 2007
    ..8, 12, 18 or 24 microM VPA. Higher VPA concentrations (240 and 600 microM) also failed to augment PrPsc expression. In conclusion, in our experimental conditions, no deleterious effect was induced by VPA on prions replication...
  12. pmc Late treatment with polyene antibiotics can prolong the survival time of scrapie-infected animals
    R Demaimay
    Commissariat a l Energie Atomique, Departement de Recherche Medicale, service de santé des armées, Fontenay aux Roses, France
    J Virol 71:9685-9. 1997
    ..Our results indicate that polyene antibiotics may interfere, throughout the course of the experimental disease, with the propagation of the scrapie agent...
  13. pmc Macrophage activation switching: an asset for the resolution of inflammation
    F Porcheray
    Laboratoire de Neuro Immuno Virologie, Service de Neurovirologie UMR E1, Universite Paris Sud, Centre de Recherches du Service de Sante des Armees, IPSC, Fontenay aux Roses, France
    Clin Exp Immunol 142:481-9. 2005
    ..These findings may provide new insight into the inflammatory process as well as new fields of investigation for immunotherapy in the fields of chronic inflammatory diseases and cancer...
  14. ncbi request reprint [Anti-HIV therapeutic approaches in animal models]
    D Dormont
    Service de Neurovirologie, Commissariat a l Energie Atomique, Fontenay aux Roses, France
    Rev Med Interne 23:532s-534s. 2002
  15. ncbi request reprint [Astrocytes and lentivirus infection in an experimental models of macaque infected with SIVmac251]
    G Guillemin
    Service de Neurovirologie, Commissariat a l Energie Atomique, DSV DRM, Fontenay aux Roses
    C R Seances Soc Biol Fil 192:179-86. 1998
    ....
  16. ncbi request reprint Nervous and nonnervous cell transduction by recombinant adenoviruses that inducibly express the human PrP
    S Arrabal
    CEA, Service de Neurovirologie, BP 6 92265 Fontenay-aux-Roses Cedex, France
    Biochem Biophys Res Commun 285:623-32. 2001
    ..AdTRVal and AdTRMet will allow future studies on the human PrP and on the role of the codon 129 polyphormism in human TSE...
  17. ncbi request reprint Preclinical metabolic changes in mouse prion diseases detected by 1H-nuclear magnetic resonance spectroscopy
    Catherine Vidal
    CEA Atomic Energy Commission, Laboratory of Neurovirology, Fontenay aux Roses, France
    Neuroreport 17:89-93. 2006
    ..These results show that magnetic resonance spectroscopy is a valuable tool for detecting subtle metabolic changes associated to gliosis and neuronal dysfunction in prion diseases...
  18. ncbi request reprint Cationic phosphorus-containing dendrimers reduce prion replication both in cell culture and in mice infected with scrapie
    Jerome Solassol
    Institut de génétique humaine du CNRS, 141 rue de la Cardonille, 34396 Montpellier, France
    J Gen Virol 85:1791-9. 2004
    ..These molecules have a high bio-availability and therefore exhibit relevant potential for prion therapeutics for at least post-exposure prophylaxis...
  19. ncbi request reprint Expression of excitatory amino acid transporter-1 in brain macrophages and microglia of HIV-infected patients. A neuroprotective role for activated microglia?
    Anne Valérie Vallat-Decouvelaere
    Service d Anatomie et Cytologie Pathologiques, Hopital Calmette, Lille, France
    J Neuropathol Exp Neurol 62:475-85. 2003
    ..This is in keeping with the early microglial activation seen in pre-AIDS cases, and the late occurrence of neuronal loss. It may also explain the reversible cognitive disorders following treatment in some cases...
  20. ncbi request reprint Regulated expression of sodium-dependent glutamate transporters and synthetase: a neuroprotective role for activated microglia and macrophages in HIV infection?
    Gabriel Gras
    CEA, Service de Neurovirologie, DSV DRM, Centre de Recherches du Service de Sante des Armees, EPHE, IPSC, 92265 Fontenay aux Roses Cedex, France
    Brain Pathol 13:211-22. 2003
    ....
  21. ncbi request reprint Differences in the activation of the GFAP gene promoter by prion and viral infections
    Matthias Titeux
    Biologie Moleculaire de la Differenciation, Universite Paris 7, Case Postale 7136, 2 place Jussieu, 75005 Paris, France
    Brain Res Mol Brain Res 109:119-27. 2002
    ..The first 2 kb upstream from the start codon of the GFAP gene seems to provide enough activation domains to produce efficient activation of the reporter gene in prion-infected mice...
  22. ncbi request reprint [Neurotoxicity and neuroprotection, two aspects of microglial activation in human immunodeficiency virus (HIV) infection]
    Anne Valérie Vallat-Decouvelaere
    Service d Anatomie Pathologique, pôle biologie pathologie, Parc Eurosanté, 59037 Lille
    Ann Pathol 24:31-44. 2004
    ..It could also explain the regression of the cognitive disorders in some patients who received highly active antiretroviral treatment...
  23. ncbi request reprint Expression of excitatory amino acid transporter-1 (EAAT-1) in brain macrophages and microglia of patients with prion diseases
    Fabrice Chretien
    INSERM EMI0011 and Département de Pathologie, Hopital Henri Mondor, Assistance Publique Hôpital de Paris, Creteil, France
    J Neuropathol Exp Neurol 63:1058-71. 2004
    ..Whether this neuroprotective function of microglia is the cause or the effect of longer survival needs to be clarified...
  24. ncbi request reprint The expression of P-glycoprotein and cellular kinases is modulated at the transcriptional level by infection and highly active antiretroviral therapy in a primate model of AIDS
    Sylvie Jorajuria
    CEA, Service de Neurovirologie, DRM DSV, CRSSA, EPHE, IPSC, 92265 Fontenay aux Roses, France
    AIDS Res Hum Retroviruses 19:307-11. 2003
    ..In conclusion, retroviral infection and HAART modulate in vivo at the transcriptional level the expression of host cell factors that may affect the efficacy of HAART...
  25. ncbi request reprint BSE infection of the small short-lived primate Microcebus murinus
    Noëlle Bons
    Laboratoire de Neuromorphologie Fonctionnelle, EPHE, Universite Montpellier II, 34095 Montpellier, France
    C R Biol 325:67-74. 2002
    ....
  26. pmc Involvement of macrophages in the pathogenesis of transmissible spongiform encephalopathies
    Vincent Beringue
    CEA, Service de Neurovirologie, DRM DSV, CRSSA, Fontenay aux Roses, France
    Dev Immunol 9:19-27. 2002
    ....
  27. ncbi request reprint Prions, BSE and food
    Dominique Dormont
    CEA, Service de Neurovirologie, Centre de Recherches du Service de Sante des Armees, Ecole Pratique des Hautes Etudes, Fontenay aux Roses, France
    Int J Food Microbiol 78:181-9. 2002
    ..The consequences of the emergence of the new cCJD and the lack of information on the infectivity of cCJD at the clinical stage of the disease in relation to the need to reconsider the biological concepts currently used in microbiology...
  28. ncbi request reprint BSE and variant Creutzfeldt-Jakob disease: never say never
    Herbert Budka
    Acta Neuropathol 103:627-8. 2002
  29. pmc High incidence of scrapie induced by repeated injections of subinfectious prion doses
    Catherine Jacquemot
    Neurovirologie et Régénération du Système Nerveux, Dpt Neurosciences, Institut Pasteur, Paris, France
    J Virol 79:8904-8. 2005
    ..Repeated injections of low prion doses thus constitute a risk for development of prion disease even if the same total dose inoculated in a single challenge does not induce the disease...
  30. ncbi request reprint Structure-activity relationships in platelet-activating factor. 12. Synthesis and biological evaluation of platelet-activating factor antagonists with anti-HIV-1 activity
    Nawal Serradji
    Unité de Recherche Pharmacochimie Moléculaire et Systèmes Membranaires, Laboratoire de Pharmacochimie Moleculaire, Universite Paris 7 Denis Diderot, 2 place Jussieu, 75251 Paris Cedex 05, France
    J Med Chem 47:6410-9. 2004
    ..The transport parameter measured (K(in)) proves that 1a is able to cross this biological barrier, but a pharmacokinetic study reveals its weak bioavailability in rats...
  31. ncbi request reprint Involvement of IL-6 in the anti-human immunodeficiency virus activity of IFN-tau in human macrophages
    Christine Rogez-Kreuz
    Service de Neurovirologie, Commissariat a l Energie Atomique, Universite Paris Sud, CRSSA, EPHE, IPSC, Fontenay aux Roses, France
    Int Immunol 17:1047-57. 2005
    ..By focusing on the very early steps of the biological cycle of HIV, we showed that IL-6 co-operated with IFN-tau to decrease intracellular HIV RNA levels 2 h after infection...
  32. pmc Bovine prion is endocytosed by human enterocytes via the 37 kDa/67 kDa laminin receptor
    Etienne Morel
    UMR505 INSERM UPMC, 15 rue de l Ecole de Medecine, 75006 Paris, France
    Am J Pathol 167:1033-42. 2005
    ..Altogether, our results underscore a potential role of enterocytes in the absorption of bovine prions during oral infection through specific LRP/LR-dependent endocytosis...
  33. ncbi request reprint ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages
    Sylvie Jorajuria
    CEA, Service de Neurovirologie, Universite Paris XI, CRSSA, EPHE, IPSC, Fontenay aux Roses, France
    Antivir Ther 9:519-28. 2004
    ....
  34. ncbi request reprint Characterization of human monocyte-derived microglia-like cells
    Cathie Leone
    Laboratoire de Neuro Immuno Virologie, Service de Neurovirologie UMR E 01 CEA and Université Paris Sud XI, CRSSA, IFR13 Institut Paris Sud Cytokines, Fontenay aux Roses, France
    Glia 54:183-92. 2006
    ..This model of human microglia may be an interesting alternative to primary microglia for large scale in vitro HIV studies and may help to better understand HIV-associated microgliosis and chronic inflammation in the brain...
  35. ncbi request reprint Using budding yeast to screen for anti-prion drugs
    Déborah Tribouillard
    CNRS UMR7150, Amyloids and Cell Division Cycle Laboratory, Station Biologique, Roscoff, Bretagne, France
    Biotechnol J 1:58-67. 2006
    ..Finally, it would be very interesting to test active drugs isolated using the yeast-based assay in models for other diseases (neurodegenerative or not) involving amyloid fibers like Huntington's, Parkinson's or Alzheimer's diseases...
  36. ncbi request reprint Comparative effects of two type I interferons, human IFN-alpha and ovine IFN-tau on indoleamine-2,3-dioxygenase in primary cultures of human macrophages
    Benjamin Maneglier
    Departement de Biologie, Centre Hospitalier de Versailles, 78150 Le Chesnay, France
    Fundam Clin Pharmacol 21:29-34. 2007
    ..However, IDO activation was slightly and significantly lower with ovine IFN-tau than human IFN-alpha, suggesting that ovine IFN-tau might have a lower impact on serotoninergic pathway compared with human IFN-alpha...
  37. doi request reprint Increase of monoamine oxidase-B activity in the brain of scrapie-infected hamsters
    Karim Tarik Adjou
    Laboratoire de Pathologie du Bétail et des Animaux de Basse cour, Ecole Nationale Veterinaire d Alfort, Maisons Alfort Cedex, France
    Neurochem Int 52:1416-21. 2008
    ....
  38. ncbi request reprint Hydrolysis of the amyloid prion protein and nonpathogenic meat and bone meal by anaerobic thermophilic prokaryotes and streptomyces subspecies
    Kirill Tsiroulnikov
    Laboratoire d Etude des Interactions des Molécules Alimentaires LEIMA, Institut National de la Recherche Agronomique, B P 71627, 44316 Nantes Cedex 3, France
    J Agric Food Chem 52:6353-60. 2004
    ..The proteases from Thermoanaerobacter subsp. S290 and Streptomyces subsp. S6 are the best candidates for neutralization/elimination of amyloids in meat and bone meal and other protein-containing substances and materials...
  39. ncbi request reprint Impact of bone marrow hematopoiesis failure on T-cell generation during pathogenic simian immunodeficiency virus infection in macaques
    Hugues Thiebot
    CEA, Laboratoire d Immuno Pathologie Expérimentale, Service de Neurovirologie, Centre de Recherches du Service de Sante des Armees, Ecole Pratique des Hautes Etudes, Institut Paris Sud sur les Cytokines, Universite Paris XI, France
    Blood 105:2403-9. 2005
    ..This is the first demonstration that failure of BM hematopoiesis results in impaired T-cell production, which may contribute to the disruption of T-lymphocyte homeostasis characteristic of pathogenic lentiviral infections in primates...
  40. ncbi request reprint Brain and buffy coat transmission of bovine spongiform encephalopathy to the primate Microcebus murinus
    Noëlle Bons
    Laboratory of Functional Neuropathology, School of Advanced Studies, University of Montpellier II, Montpellier, France
    Transfusion 42:513-6. 2002
    ....
  41. ncbi request reprint HIV type 1 diversity in France, 1999-2001: molecular characterization of non-B HIV type 1 subtypes and potential impact on susceptibility to antiretroviral drugs
    Herve Fleury
    Laboratoire de Virologie, Hopital Pellegrin, CHU de Bordeaux, France
    AIDS Res Hum Retroviruses 19:41-7. 2003
    ..There is an extensive polymorphism of protease and RT genes compared with B consensus sequences; we have so far no data indicating that these non-B isolates may have reduced sensitivity to ARV drugs...
  42. ncbi request reprint Different isoforms of the non-integrin laminin receptor are present in mouse brain and bind PrP
    Steve Simoneau
    CEA, Departement de Recherche Medicale, DSV, B P 6, F 92 265 Fontenay aux Roses Cedex, France
    Biol Chem 384:243-6. 2003
    ..Our data strongly support a physiological role of the laminin receptor/PrP interaction in the brain and highlight its relevance for transmissible spongiform encephalopathies...
  43. ncbi request reprint Quinolinic acid upregulates chemokine production and chemokine receptor expression in astrocytes
    Gilles J Guillemin
    Centre for Immunology, St Vincent s Hospital, Sydney, Australia
    Glia 41:371-81. 2003
    ..These results suggest that QUIN may be critical in the amplification of brain inflammation, particularly in ADC...
  44. ncbi request reprint Isolation of drugs active against mammalian prions using a yeast-based screening assay
    Stephane Bach
    C N R S, Station Biologique, Cell Cycle Laboratory, Place Georges Teissier, 29680 Roscoff, Bretagne, France
    Nat Biotechnol 21:1075-81. 2003
    ....
  45. ncbi request reprint Approaches to prophylaxis and therapy
    Dominique Dormont
    Service de Neurovirologie, CEA, CRSSA, EPHE, Univeristé Paris XI, Fontenay aux Roses, France
    Br Med Bull 66:281-92. 2003
    ..Any rational therapeutic strategy needs to be based on pathogenesis data and/or knowledge on the nature of the causative agent. Therefore, progress in therapy is tightly linked to a better understanding of the basic science of TSE...
  46. pmc Anti-human immunodeficiency virus activity of tau interferon in human macrophages: involvement of cellular factors and beta-chemokines
    Christine Rogez
    Service de Neurovirologie SPI BIO, c o Service de Neurovirologie, CEA, CRSSA, Universite Paris Sud, EPHE, IPSC, Fontenay aux Roses, France
    J Virol 77:12914-20. 2003
    ..Our results suggest that IFN-tau induces the same antiviral pathways in macrophages as other type I IFNs but without associated toxicity...
  47. ncbi request reprint Up-regulation of glutamate concentration in the putamen and in the prefrontal cortex of asymptomatic SIVmac251-infected macaques without major brain involvement
    Christophe Bossuet
    Service de Neurovirologie, UMR E1 CEA, Universite Paris Sud, Centre de Recherches du Service de Sante des Armees, Ecole Pratique des Hautes Etudes, Institut Paris Sud Cytokines, Fontenay aux Roses, France
    J Neurochem 88:928-38. 2004
    ..Thus, there are probably compensatory mechanisms that may limit glutamate increase and/or counterbalance its effects...
  48. ncbi request reprint Synthesis and biological evaluation in human monocyte-derived macrophages of N-(N-acetyl-L-cysteinyl)-S-acetylcysteamine analogues with potent antioxidant and anti-HIV activities
    Joël Oiry
    Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR CNRS UM II 5625, Universite Montpellier II Sciences et Techniques du Languedoc, Place Eugene Bataillon, 34095 Montpellier, France
    J Med Chem 47:1789-95. 2004
    ....
  49. pmc Differential expression levels of MRP1, MRP4, and MRP5 in response to human immunodeficiency virus infection in human macrophages
    Sylvie Jorajuria
    CEA, Service de Neurovirologie, Universite Paris XI, CRSSA, EPHE, IPS, Fontenay aux Roses, France
    Antimicrob Agents Chemother 48:1889-91. 2004
    ..We show here that MRP1, MRP4, and MRP5 are expressed at the mRNA level in human monocyte-derived macrophages. HIV infection caused increased transcription of these MRPs; however, temporal differences in stimulation are reported...
  50. ncbi request reprint Aluminum hydroxide adjuvant induces macrophage differentiation towards a specialized antigen-presenting cell type
    Anne Cécile Rimaniol
    SPI Bio, c o Service de Neurovirologie, 92265 Fontenay aux Roses Cedex, France
    Vaccine 22:3127-35. 2004
    ....
  51. ncbi request reprint Effects of the polyene antibiotic derivative MS-8209 on the astrocyte lysosomal system of scrapie-infected hamsters
    Vladimir B Grigoriev
    CEA, Service de Neurovirologie, DSV DRM CRSSA EPHE, Fontenay aux Roses, France
    J Mol Neurosci 18:271-81. 2002
    ..The lysosomal system of these astrocytes could constitute a privileged target for MS-8209...