Research Topics
| D DormontSummaryCountry: France Publications
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Publications
A novel generation of heparan sulfate mimetics for the treatment of prion diseasesKarim Tarik Adjou
CEA, DSV/DRM, 18 route du Panorama, BP6, 92265 Fontenay aux Roses Cedex, France
J Gen Virol 84:2595-603. 2003..Since these molecules are particularly amenable to drug design, their anti-prion potential could be developed further and optimized for the treatment of prion diseases...- Prion diseases: pathogenesis and public health concernsDominique Dormont
CEA, Service de Neurovirologie, CRSSA, EPHE, P O Box 6, Fontenay aux Roses, France
FEBS Lett 529:17-21. 2002..Transmissibility has been proven in natural situations such as the outbreak of CJD among patients treated with pituitary-derived hormones and the appearance of BSE that affected UK cattle in the mid-1980s... - Strain specific and common pathogenic events in murine models of scrapie and bovine spongiform encephalopathyC I Lasmezas
Service de Neurovirologie, DSV DRM CRSSA, Commissariat a l Energie Atomique, Fontenay aux Roses, France
J Gen Virol 77:1601-9. 1996..The possible involvement of a regulatory molecule accounting for these specificities has to be considered... - Transmission of the BSE agent to mice in the absence of detectable abnormal prion proteinC I Lasmezas
Commissariat a l Energie Atomique, Service de Neurovirologie, DSV DRM SSA, B P 6, 60 68 avenue du General Leclerc, 92265 Fontenay aux Roses Cedex, France
Science 275:402-5. 1997..During serial passage, PrPres appeared after the agent became adapted to the new host. Thus, PrPres may be involved in species adaptation, but a further unidentified agent may actually transmit BSE... 
Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt-- Jakob disease: implications for human healthC I Lasmezas
Commissariat a l Energie Atomique, Service de Neurovirologie, Direction des Sciences du Vivant Dèpartement de Recherche Médicale, Centre de Recherches du Service de Santé des Armées 60 68, Fontenay aux Roses, France
Proc Natl Acad Sci U S A 98:4142-7. 2001..These data will be key in identifying the origin of human cases of prion disease, including accidental vCJD transmission, and could provide bases for vCJD risk assessment...- Astrocyte gene expression in experimental mouse scrapieF Lazarini
Laboratoire de Neuropathologie Expérimentale et Neurovirologie, CRSSA, Commissariat a l Energie Atomique, DPTE DSV, Fontenay aux Roses, France
J Comp Pathol 111:87-98. 1994..To conclude, these results show that GFAP and GS mRNAs are differently upregulated in brain in the scrapie mouse model... - Probing the dynamics of prion diseases with amphotericin BK T Adjou
Service de Neurovirologie, CEA CRSSA, DSV DRM, Fontenay aux Roses, France
Trends Microbiol 5:27-31. 1997..Therefore, AmB could be used as a pharmacological tool to contribute to our understanding of the pathogenic mechanisms involved in these neurodegenerative disorders... - Regulation of the glial fibrillary acidic protein, beta actin and prion protein mRNAs during brain development in mouseF Lazarini
Laboratoire de Neuropathologie Expérimentale et Neurovirologie, CRSSA, Commissariat a l Energie Atomique, DPTE DSV, Fontenay aux Roses, France
Brain Res Mol Brain Res 10:343-6. 1991..Nevertheless, slight but significant increases in the mRNA levels of both GFAP and PrP were observed at older stages (360 days). These results are analysed in the light of the implications of PrP and GFAP in scrapie infection models... - Longitudinal analysis of CD8(+) T-cell phenotype and IL-7, IL-15 and IL-16 mRNA expression in different tissues during primary simian immunodeficiency virus infectionP Caufour
CEA, Service de Neurovirologie, DSV/DRM, CRSSA, Institut Paris-Sud sur les Cytokines, Fontenay-aux-Roses, France
Microbes Infect 3:181-91. 2001..Given the immunomodulatory properties of IL-15 and IL-7 and the potential antiviral ability of IL-16, these perturbations could have important implications in early viral dissemination and HIV immunopathogenesis... - Opposite effects of dextran sulfate 500, the polyene antibiotic MS-8209, and Congo red on accumulation of the protease-resistant isoform of PrP in the spleens of mice inoculated intraperitoneally with the scrapie agentV Beringue
CEA, Service de Neurovirologie, DRM DSV, CRSSA, Fontenay aux Roses, France
J Virol 74:5432-40. 2000..We showed in vitro that this effect was related to a direct enhancement of the protease resistance of PrPres by the drug... - Sodium valproate does not augment Prpsc in murine neuroblastoma cellsC Legendre
Service de Neurovirologie, CEA, CRSSA, Universite Paris XI, EPHE, IPSC, Fontenay aux Roses, France
Neurotox Res 12:205-8. 2007..8, 12, 18 or 24 microM VPA. Higher VPA concentrations (240 and 600 microM) also failed to augment PrPsc expression. In conclusion, in our experimental conditions, no deleterious effect was induced by VPA on prions replication... - Late treatment with polyene antibiotics can prolong the survival time of scrapie-infected animalsR Demaimay
Commissariat a l Energie Atomique, Departement de Recherche Medicale, service de santé des armées, Fontenay aux Roses, France
J Virol 71:9685-9. 1997..Our results indicate that polyene antibiotics may interfere, throughout the course of the experimental disease, with the propagation of the scrapie agent... - Macrophage activation switching: an asset for the resolution of inflammationF Porcheray
Laboratoire de Neuro-Immuno-Virologie, Service de Neurovirologie UMR-E1, , , IPSC, Fontenay aux Roses, France
Clin Exp Immunol 142:481-9. 2005..These findings may provide new insight into the inflammatory process as well as new fields of investigation for immunotherapy in the fields of chronic inflammatory diseases and cancer... - [Anti-HIV therapeutic approaches in animal models]D Dormont
Service de Neurovirologie, , Fontenay-aux-Roses, France
Rev Med Interne 23:532s-534s. 2002 - [Astrocytes and lentivirus infection in an experimental models of macaque infected with SIVmac251]G Guillemin
Service de Neurovirologie, Commissariat a l Energie Atomique, DSV DRM, Fontenay aux Roses
C R Seances Soc Biol Fil 192:179-86. 1998.... - Nervous and nonnervous cell transduction by recombinant adenoviruses that inducibly express the human PrPS Arrabal
CEA, Service de Neurovirologie, BP 6 92265 Fontenay-aux-Roses Cedex, France
Biochem Biophys Res Commun 285:623-32. 2001..AdTRVal and AdTRMet will allow future studies on the human PrP and on the role of the codon 129 polyphormism in human TSE... - Preclinical metabolic changes in mouse prion diseases detected by 1H-nuclear magnetic resonance spectroscopyCatherine Vidal
CEA Atomic Energy Commission, Laboratory of Neurovirology, Fontenay aux Roses, France
Neuroreport 17:89-93. 2006..These results show that magnetic resonance spectroscopy is a valuable tool for detecting subtle metabolic changes associated to gliosis and neuronal dysfunction in prion diseases... - Cationic phosphorus-containing dendrimers reduce prion replication both in cell culture and in mice infected with scrapieJerome Solassol
Institut de génétique humaine du CNRS, 141 rue de la Cardonille, 34396 Montpellier, France
J Gen Virol 85:1791-9. 2004..These molecules have a high bio-availability and therefore exhibit relevant potential for prion therapeutics for at least post-exposure prophylaxis... - Expression of excitatory amino acid transporter-1 in brain macrophages and microglia of HIV-infected patients. A neuroprotective role for activated microglia?Anne Valérie Vallat-Decouvelaere
Service d Anatomie et Cytologie Pathologiques, Hopital Calmette, Lille, France
J Neuropathol Exp Neurol 62:475-85. 2003..This is in keeping with the early microglial activation seen in pre-AIDS cases, and the late occurrence of neuronal loss. It may also explain the reversible cognitive disorders following treatment in some cases... - Regulated expression of sodium-dependent glutamate transporters and synthetase: a neuroprotective role for activated microglia and macrophages in HIV infection?Gabriel Gras
CEA, Service de Neurovirologie, DSV DRM, Centre de Recherches du Service de Sante des Armees, EPHE, IPSC, 92265 Fontenay aux Roses Cedex, France
Brain Pathol 13:211-22. 2003.... - Differences in the activation of the GFAP gene promoter by prion and viral infectionsMatthias Titeux
Biologie Moleculaire de la Differenciation, Universite Paris 7, Case Postale 7136, 2 place Jussieu, 75005 Paris, France
Brain Res Mol Brain Res 109:119-27. 2002..The first 2 kb upstream from the start codon of the GFAP gene seems to provide enough activation domains to produce efficient activation of the reporter gene in prion-infected mice... - [Neurotoxicity and neuroprotection, two aspects of microglial activation in human immunodeficiency virus (HIV) infection]Anne Valérie Vallat-Decouvelaere
Service d Anatomie Pathologique, pôle biologie pathologie, Parc Eurosanté, 59037 Lille
Ann Pathol 24:31-44. 2004..It could also explain the regression of the cognitive disorders in some patients who received highly active antiretroviral treatment... - Expression of excitatory amino acid transporter-1 (EAAT-1) in brain macrophages and microglia of patients with prion diseasesFabrice Chretien
INSERM EMI0011 and Département de Pathologie, Hopital Henri Mondor, Assistance Publique Hôpital de Paris, Creteil, France
J Neuropathol Exp Neurol 63:1058-71. 2004..Whether this neuroprotective function of microglia is the cause or the effect of longer survival needs to be clarified... - The expression of P-glycoprotein and cellular kinases is modulated at the transcriptional level by infection and highly active antiretroviral therapy in a primate model of AIDSSylvie Jorajuria
CEA, Service de Neurovirologie, DRM/DSV, CRSSA, EPHE, IPSC, 92265 Fontenay-aux-Roses, France
AIDS Res Hum Retroviruses 19:307-11. 2003..In conclusion, retroviral infection and HAART modulate in vivo at the transcriptional level the expression of host cell factors that may affect the efficacy of HAART... - BSE infection of the small short-lived primate Microcebus murinusNoëlle Bons
Laboratoire de Neuromorphologie Fonctionnelle, EPHE, Universite Montpellier II, 34095 Montpellier, France
C R Biol 325:67-74. 2002.... - Involvement of macrophages in the pathogenesis of transmissible spongiform encephalopathiesVincent Beringue
CEA, Service de Neurovirologie, DRM DSV, CRSSA, Fontenay aux Roses, France
Dev Immunol 9:19-27. 2002.... - Prions, BSE and foodDominique Dormont
CEA, Service de Neurovirologie, , Ecole Pratique des Hautes Etudes, Fontenay aux Roses, France
Int J Food Microbiol 78:181-9. 2002..The consequences of the emergence of the new cCJD and the lack of information on the infectivity of cCJD at the clinical stage of the disease in relation to the need to reconsider the biological concepts currently used in microbiology... - BSE and variant Creutzfeldt-Jakob disease: never say neverHerbert Budka
Acta Neuropathol 103:627-8. 2002 - High incidence of scrapie induced by repeated injections of subinfectious prion dosesCatherine Jacquemot
, Dpt Neurosciences, Institut Pasteur, Paris, France
J Virol 79:8904-8. 2005..Repeated injections of low prion doses thus constitute a risk for development of prion disease even if the same total dose inoculated in a single challenge does not induce the disease... - Structure-activity relationships in platelet-activating factor. 12. Synthesis and biological evaluation of platelet-activating factor antagonists with anti-HIV-1 activityNawal Serradji
, , , 2 place Jussieu, 75251 Paris Cedex 05, France
J Med Chem 47:6410-9. 2004..The transport parameter measured (K(in)) proves that 1a is able to cross this biological barrier, but a pharmacokinetic study reveals its weak bioavailability in rats... - Involvement of IL-6 in the anti-human immunodeficiency virus activity of IFN-tau in human macrophagesChristine Rogez-Kreuz
Service de Neurovirologie, , , CRSSA, EPHE, IPSC, Fontenay-aux-Roses, France
Int Immunol 17:1047-57. 2005..By focusing on the very early steps of the biological cycle of HIV, we showed that IL-6 co-operated with IFN-tau to decrease intracellular HIV RNA levels 2 h after infection... - Bovine prion is endocytosed by human enterocytes via the 37 kDa/67 kDa laminin receptorEtienne Morel
UMR505 INSERM/UPMC, , 75006 Paris, France
Am J Pathol 167:1033-42. 2005..Altogether, our results underscore a potential role of enterocytes in the absorption of bovine prions during oral infection through specific LRP/LR-dependent endocytosis... - ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophagesSylvie Jorajuria
CEA, Service de Neurovirologie, , CRSSA, EPHE, IPSC, Fontenay-aux-Roses, France
Antivir Ther 9:519-28. 2004..The cellular efflux of AZT probably involves MRP4 or MRP5. In contrast, increases in indinavir anti-HIV activity require the inhibition of both P-gp and MRP1... - Characterization of human monocyte-derived microglia-like cellsCathie Leone
Laboratoire de Neuro-Immuno-Virologie, , CRSSA, IFR13 Institut Paris Sud Cytokines, Fontenay-aux Roses, France
Glia 54:183-92. 2006..This model of human microglia may be an interesting alternative to primary microglia for large scale in vitro HIV studies and may help to better understand HIV-associated microgliosis and chronic inflammation in the brain... - Using budding yeast to screen for anti-prion drugsDéborah Tribouillard
CNRS UMR7150, Amyloids and Cell Division Cycle Laboratory, Station Biologique, Roscoff, Bretagne, France
Biotechnol J 1:58-67. 2006..Finally, it would be very interesting to test active drugs isolated using the yeast-based assay in models for other diseases (neurodegenerative or not) involving amyloid fibers like Huntington's, Parkinson's or Alzheimer's diseases... - Comparative effects of two type I interferons, human IFN-alpha and ovine IFN-tau on indoleamine-2,3-dioxygenase in primary cultures of human macrophagesBenjamin Maneglier
Departement de Biologie, Centre Hospitalier de Versailles, 78150 Le Chesnay, France
Fundam Clin Pharmacol 21:29-34. 2007..However, IDO activation was slightly and significantly lower with ovine IFN-tau than human IFN-alpha, suggesting that ovine IFN-tau might have a lower impact on serotoninergic pathway compared with human IFN-alpha... 
Increase of monoamine oxidase-B activity in the brain of scrapie-infected hamstersKarim Tarik Adjou
Laboratoire de Pathologie du Bétail et des Animaux de Basse cour, Ecole Nationale Veterinaire d Alfort, Maisons Alfort Cedex, France
Neurochem Int 52:1416-21. 2008....- Hydrolysis of the amyloid prion protein and nonpathogenic meat and bone meal by anaerobic thermophilic prokaryotes and streptomyces subspeciesKirill Tsiroulnikov
, Institut National de la Recherche Agronomique, B.P. 71627, 44316 Nantes Cedex 3, France
J Agric Food Chem 52:6353-60. 2004..The proteases from Thermoanaerobacter subsp. S290 and Streptomyces subsp. S6 are the best candidates for neutralization/elimination of amyloids in meat and bone meal and other protein-containing substances and materials... - Impact of bone marrow hematopoiesis failure on T-cell generation during pathogenic simian immunodeficiency virus infection in macaquesHugues Thiebot
CEA, , Service de Neurovirologie, , Ecole Pratique des Hautes Etudes, Institut Paris-Sud sur les Cytokines, , France
Blood 105:2403-9. 2005..This is the first demonstration that failure of BM hematopoiesis results in impaired T-cell production, which may contribute to the disruption of T-lymphocyte homeostasis characteristic of pathogenic lentiviral infections in primates... - Brain and buffy coat transmission of bovine spongiform encephalopathy to the primate Microcebus murinusNoëlle Bons
Laboratory of Functional Neuropathology, School of Advanced Studies, University of Montpellier II, Montpellier, France
Transfusion 42:513-6. 2002.... - HIV type 1 diversity in France, 1999-2001: molecular characterization of non-B HIV type 1 subtypes and potential impact on susceptibility to antiretroviral drugsHerve Fleury
Laboratoire de Virologie, Hopital Pellegrin, CHU de Bordeaux, France
AIDS Res Hum Retroviruses 19:41-7. 2003..There is an extensive polymorphism of protease and RT genes compared with B consensus sequences; we have so far no data indicating that these non-B isolates may have reduced sensitivity to ARV drugs... - Different isoforms of the non-integrin laminin receptor are present in mouse brain and bind PrPSteve Simoneau
CEA, , DSV, B.P. 6, F-92 265 Fontenay-aux-Roses Cedex, France
Biol Chem 384:243-6. 2003..Our data strongly support a physiological role of the laminin receptor/PrP interaction in the brain and highlight its relevance for transmissible spongiform encephalopathies... - Quinolinic acid upregulates chemokine production and chemokine receptor expression in astrocytesGilles J Guillemin
Centre for Immunology, St Vincent s Hospital, Sydney, Australia
Glia 41:371-81. 2003..These results suggest that QUIN may be critical in the amplification of brain inflammation, particularly in ADC... - Isolation of drugs active against mammalian prions using a yeast-based screening assayStephane Bach
C N R S, Station Biologique, Cell Cycle Laboratory, Place Georges Teissier, 29680 Roscoff, Bretagne, France
Nat Biotechnol 21:1075-81. 2003.... - Approaches to prophylaxis and therapyDominique Dormont
Service de Neurovirologie, CEA, CRSSA, EPHE, , Fontenay-aux-Roses, France
Br Med Bull 66:281-92. 2003..Any rational therapeutic strategy needs to be based on pathogenesis data and/or knowledge on the nature of the causative agent. Therefore, progress in therapy is tightly linked to a better understanding of the basic science of TSE... - Anti-human immunodeficiency virus activity of tau interferon in human macrophages: involvement of cellular factors and beta-chemokinesChristine Rogez
Service de Neurovirologie. SPI-BIO, c/o Service de Neurovirologie, CEA, CRSSA, , EPHE, IPSC, Fontenay-aux-Roses, France
J Virol 77:12914-20. 2003..Our results suggest that IFN-tau induces the same antiviral pathways in macrophages as other type I IFNs but without associated toxicity... - Up-regulation of glutamate concentration in the putamen and in the prefrontal cortex of asymptomatic SIVmac251-infected macaques without major brain involvementChristophe Bossuet
Service de Neurovirologie, UMR-E1 CEA, , , Ecole Pratique des Hautes Etudes, Institut Paris-Sud Cytokines, Fontenay-aux-Roses, France
J Neurochem 88:928-38. 2004..Thus, there are probably compensatory mechanisms that may limit glutamate increase and/or counterbalance its effects... - Synthesis and biological evaluation in human monocyte-derived macrophages of N-(N-acetyl-L-cysteinyl)-S-acetylcysteamine analogues with potent antioxidant and anti-HIV activitiesJoël Oiry
Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR CNRS UM II 5625, Universite Montpellier II Sciences et Techniques du Languedoc, Place Eugene Bataillon, 34095 Montpellier, France
J Med Chem 47:1789-95. 2004.... - Differential expression levels of MRP1, MRP4, and MRP5 in response to human immunodeficiency virus infection in human macrophagesSylvie Jorajuria
CEA, Service de Neurovirologie, , CRSSA, EPHE, IPS, Fontenay-aux-Roses, France
Antimicrob Agents Chemother 48:1889-91. 2004..We show here that MRP1, MRP4, and MRP5 are expressed at the mRNA level in human monocyte-derived macrophages. HIV infection caused increased transcription of these MRPs; however, temporal differences in stimulation are reported... - Aluminum hydroxide adjuvant induces macrophage differentiation towards a specialized antigen-presenting cell typeAnne Cécile Rimaniol
SPI Bio, c o Service de Neurovirologie, 92265 Fontenay aux Roses Cedex, France
Vaccine 22:3127-35. 2004.... - Effects of the polyene antibiotic derivative MS-8209 on the astrocyte lysosomal system of scrapie-infected hamstersVladimir B Grigoriev
CEA, Service de Neurovirologie, DSV/DRM/CRSSA/EPHE, Fontenay aux Roses, France
J Mol Neurosci 18:271-81. 2002..The lysosomal system of these astrocytes could constitute a privileged target for MS-8209...