Research Topics
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Publications
Synthesis and antileishmanial activity of 6-mono-substituted and 3,6-di-substituted acridines obtained by acylation of proflavineCarole Di Giorgio
Laboratoire de Parasitologie, Hygiene et Zoologie, Faculte de Pharmacie, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
Eur J Med Chem 42:1277-84. 2007....- Synthesis and antileishmanial activities of 4,5-di-substituted acridines as compared to their 4-mono-substituted homologuesDi Giorgio Carole
Laboratoire de Parasitologie, Hygiene et Zoologie, Faculte de Pharmacie, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
Bioorg Med Chem 13:5560-8. 2005.... - In vitro antileishmanial activity of diphyllin isolated from Haplophyllum bucharicumCarole Di Giorgio
Laboratoire de Parasitologie Hygiène et Zoologie, Faculte de Pharmacie, Marseille, France
Planta Med 71:366-9. 2005..This property was mainly due to modulation of macrophage phagocytosis and, to a lesser extent, it also involved interference with surface molecules of the promastigote membrane... - Alternative and complementary antileishmanial treatments: assessment of the antileishmanial activity of 27 Lebanese plants, including 11 endemic speciesCarole Di Giorgio
Laboratoire de Parasitologie Hygiène et Zoologie, Faculte de Pharmacie, Universite de la Mediterranee, Marseille, France
J Altern Complement Med 14:157-62. 2008..clypeata, and O. aucheriana were shown to induce nitrous oxide (NO) production by human macrophages. Further experiments should be performed in order to purify and characterize the chemical compounds responsible for these activities... - In vitro activities of 7-substituted 9-chloro and 9-amino-2-methoxyacridines and their bis- and tetra-acridine complexes against Leishmania infantumCarole Di Giorgio
Laboratoire de Parasitologie, Hygiene et Zoologie, Faculte de Pharmacie, Marseille, France
Antimicrob Agents Chemother 47:174-80. 2003.... - Flow cytometric detection of Leishmania parasites in human monocyte-derived macrophages: application to antileishmanial-drug testingC Di Giorgio
Laboratoire de Parasitologie, Hygiene et Zoologie, Faculte de Pharmacie, Marseille Cedex 05, France
Antimicrob Agents Chemother 44:3074-8. 2000..mexicana, L. donovani) could be detected by this technique in other host-cell models such as mouse peritoneal macrophages and suggested that the flow cytometric method could be a valid alternative to the conventional method... - Antileishmanial activity of quinovic acid glycosides and cadambine acid isolated from Nauclea diderrichiiCarole Di Giorgio
Laboratoire de Parasitologie, Hygiene et Zoologie, Faculte de Pharmacie, Marseille, France
Planta Med 72:1396-402. 2006..The association of cadambine acid with amphotericin B demonstrated an interesting synergism, suggesting that cadambine acid could be used as a complement of such conventional therapy... - Organic pollution and genotoxicity of sediments of the Palun marshes (Berre lagoon, France)Carole Di Giorgio
Univ de la Méditerranée, Facultés de Médecine et Pharmacie, Marseille Cedex 05, France
J Environ Qual 39:558-67. 2010..Overall, the two runnels in the Palun marshes were found to be polluted by many organic compounds that originate from direct human activities and pose a significant genotoxic risk... - In vitro activities of position 2 substitution-bearing 6-nitro- and 6-amino-benzothiazoles and their corresponding anthranilic acid derivatives against Leishmania infantum and Trichomonas vaginalisFlorence Delmas
Laboratoire de Parasitologie, , , , 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
Antimicrob Agents Chemother 46:2588-94. 2002.... - Effects of UVA and visible light on the photogenotoxicity of benzo[a]pyrene and pyreneCeline Botta
Laboratoire de biogénotoxicologie et mutagenèse Environnementale EA 1784, FR 3098 ECCOREV, Faculte de Pharmacie, Aix Marseille Universite, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
Environ Toxicol 24:492-505. 2009..Visible light is suggested to photoactivate PAH by a mechanism which is mainly based on oxidative reactions... - Assessment of 1,2-propanediol (PrOH) genotoxicity on mouse oocytes by comet assayAnais Berthelot-Ricou
Laboratoire de Biogénotoxicologie et Mutagenèse Environnementale, Fédération de Recherche CNRS 3098 ECCOREV, Facultés de Médecine et Pharmacie, Université de Méditerranée, Marseille, France
Fertil Steril 96:1002-7. 2011..To assess the genotoxicity of 1,2-propanediol (PrOH) on mouse oocytes by comet assay... - Synthesis and antileishmanial activity of (1,3-benzothiazol-2-yl) amino-9-(10H)-acridinone derivativesFlorence Delmas
Laboratoire de Parasitologie, , , , 27, Bd. Jean Moulin, 13385 Marseille Cedex 5, France
Eur J Med Chem 39:685-90. 2004.... - DNA-damaging, mutagenic, and clastogenic activities of gentiopicroside isolated from Cephalaria kotschyi rootsKhuraman Mustafayeva
Laboratoire de Pharmacognosie, Ethnopharmacologie et Homeopathie, UMR MD3, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
J Nat Prod 73:99-103. 2010..Similarly, the clastogenicity without S9 mix was 0.99 MNC microg(-1) mL and 0.38 MNC microg(-1) mL with S9 mix in the micronucleus assay. The interaction of 1 with DNA is probably through the involvement of oxidative DNA lesions... - Evaluation of the mutagenic/clastogenic potential of 3,6-di-substituted acridines targeted for anticancer chemotherapyCarole Di Giorgio
Laboratoire de biogénotoxicologie et mutagenèse Environnementale EA 1784, FR 3098 ECCOREV, Universite Aix Marseille, Faculte de Pharmacie, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
Food Chem Toxicol 49:2773-9. 2011..They led to the synthesis of the promising 3-acetamido-6-(4-fluorobenzamido)acridine, which displayed a strong cytotoxic activity and was not mutagenic... - Antiparasitic activity of highly conjugated pyrimidine-2,4-dione derivativesNadine Azas
Laboratoire de Parasitologie, EA 864, Faculte de Pharmacie, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
Farmaco 58:1263-70. 2003..Antiparasitic activities of the corresponding azomethines were assessed against Plasmodium falciparum, Trichomonas vaginalis and Leishmania infantum compared to their toxicity versus human cells... - Evaluation of the genotoxicity of river sediments from industrialized and unaffected areas using a battery of short-term bioassaysAssia Aouadene
Laboratoire de Biogénotoxicologie et Mutagenèse Environnementale, Universite de la Mediterranee, Facultés de Médecine et Pharmacie, Marseille, France
Environ Mol Mutagen 49:283-99. 2008..The genotoxicity ranking determined by the comet assay + S9 matched the ranking of total and carcinogenic PAH concentrations, and this assay was found to be the most sensitive... - Comparison of two extraction procedures for the assessment of sediment genotoxicity: implication of polar organic compoundsCarole Di Giorgio
Laboratoire de Biogénotoxicologie et Mutagenèse Environnementale, EA 1784, FR ECCOREV, Universite de la Mediterranee, Facultés de Médecine et Pharmacie, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
Mutat Res 725:1-12. 2011..The necessity to use appropriate extraction solvents to accurately evaluate the genotoxic hazard of aquatic sediments is also highlighted... - Genotoxicity of visible light (400-800 nm) and photoprotection assessment of ectoin, L-ergothioneine and mannitol and four sunscreensCeline Botta
Laboratoire de biogénotoxicologie et mutagenèse Environnementale EA 1784, Facultés de Médecine et Pharmacie, Universite de la Mediterranee, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
J Photochem Photobiol B 91:24-34. 2008..There is a need to complement sunscreen formulations with additional molecules to obtain a complete internal and external photoprotection against both UVA and visible lights... - 1,3-Diphenylpyrazoles: synthesis and antiparasitic activities of azomethine derivativesPascal Rathelot
Laboratoire de Chimie Organique, UMR CNRS 6517, , 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
Eur J Med Chem 37:671-9. 2002..In the most cases, nitrated compounds were found to be more efficient than non-nitrated ones against Plasmodium falciparum, Trichomonas vaginalis and Leishmania infantum... - Comet assay on mouse oocytes: an improved technique to evaluate genotoxic risk on female germ cellsAnais Berthelot-Ricou
Laboratoire de Biogénotoxicologie et Mutagenèse Environnementale, Fédération de Recherche CNRS 3098 ECCOREV Université de la Méditerranée Aix Marseille II, Facultés de Médecine et Pharmacie, Marseille, France
Fertil Steril 95:1452-7. 2011..To develop and validate an efficient comet assay on mouse oocytes without depellucidation... - Purification of Encephalitozoon cultures contaminated by mycoplasmas by murine intraperitoneal inoculationO Ridoux
Unité des Rickettsies CNRS UPRES A 6020, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
J Clin Microbiol 36:2380-2. 1998..Mycoplasma-free microsporidia were isolated from the brains and spleens of inoculated mice 24 h postinoculation by using the centrifugation shell vial system. Identification was confirmed by direct sequencing of PCR-amplified 16S rRNA... - DNA-damaging activity and mutagenicity of 16 newly synthesized thiazolo[5,4-a]acridine derivatives with high photo-inducible cytotoxicityCarole Di Giorgio
Laboratoire de biogénotoxicologie et mutagenèse Environnementale EA 1784, Facultés de Médecine et Pharmacie, Universite de la Mediterranee, 27 Bd Jean Moulin, Marseille Cedex 05, France
Mutat Res 650:104-14. 2008..Overall, the results of this study confirm that acridines are predominantly genotoxic via a DNA-intercalating mechanism in the dark, while DNA-adducts were probably induced following photo-activation... - In vitro antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A(1), in association with pentamidine and amphotericin BO Ridoux
Laboratoire de Parasitologie, , 27 Bd. Jean Moulin, 13385 Marseille, France
Phytother Res 15:298-301. 2001..The results demonstrated moreover that the action of saponins on promastigote membrane was cumulative with those of amphotericin B...