Carole Di Giorgio

Summary

Country: France

Publications

  1. doi request reprint Alternative and complementary antileishmanial treatments: assessment of the antileishmanial activity of 27 Lebanese plants, including 11 endemic species
    Carole Di Giorgio
    Laboratoire de Parasitologie Hygiène et Zoologie, Faculte de Pharmacie, Universite de la Mediterranee, Marseille, France
    J Altern Complement Med 14:157-62. 2008
  2. ncbi request reprint Synthesis and antileishmanial activity of 6-mono-substituted and 3,6-di-substituted acridines obtained by acylation of proflavine
    Carole Di Giorgio
    Laboratoire de Parasitologie, Hygiene et Zoologie, Faculte de Pharmacie, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Eur J Med Chem 42:1277-84. 2007
  3. ncbi request reprint Antileishmanial activity of quinovic acid glycosides and cadambine acid isolated from Nauclea diderrichii
    Carole Di Giorgio
    Laboratoire de Parasitologie, Hygiene et Zoologie, Faculte de Pharmacie, Marseille, France
    Planta Med 72:1396-402. 2006
  4. ncbi request reprint Synthesis and antileishmanial activities of 4,5-di-substituted acridines as compared to their 4-mono-substituted homologues
    Di Giorgio Carole
    Laboratoire de Parasitologie, Hygiene et Zoologie, Faculte de Pharmacie, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Bioorg Med Chem 13:5560-8. 2005
  5. ncbi request reprint In vitro antileishmanial activity of diphyllin isolated from Haplophyllum bucharicum
    Carole Di Giorgio
    Laboratoire de Parasitologie Hygiène et Zoologie, Faculte de Pharmacie, Marseille, France
    Planta Med 71:366-9. 2005
  6. pmc In vitro activities of 7-substituted 9-chloro and 9-amino-2-methoxyacridines and their bis- and tetra-acridine complexes against Leishmania infantum
    Carole Di Giorgio
    Laboratoire de Parasitologie, Hygiene et Zoologie, Faculte de Pharmacie, Marseille, France
    Antimicrob Agents Chemother 47:174-80. 2003
  7. pmc Flow cytometric detection of Leishmania parasites in human monocyte-derived macrophages: application to antileishmanial-drug testing
    C Di Giorgio
    Laboratoire de Parasitologie, Hygiene et Zoologie, Faculte de Pharmacie, Marseille Cedex 05, France
    Antimicrob Agents Chemother 44:3074-8. 2000
  8. doi request reprint Organic pollution and genotoxicity of sediments of the Palun marshes (Berre lagoon, France)
    Carole Di Giorgio
    Univ de la Méditerranée, Facultés de Médecine et Pharmacie, Marseille Cedex 05, France
    J Environ Qual 39:558-67. 2010
  9. ncbi request reprint Antiparasitic activity of highly conjugated pyrimidine-2,4-dione derivatives
    Nadine Azas
    Laboratoire de Parasitologie, EA 864, Faculte de Pharmacie, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    Farmaco 58:1263-70. 2003
  10. pmc In vitro activities of position 2 substitution-bearing 6-nitro- and 6-amino-benzothiazoles and their corresponding anthranilic acid derivatives against Leishmania infantum and Trichomonas vaginalis
    Florence Delmas
    Laboratoire de Parasitologie, Hygiene et Zoologie, Faculte de Pharmacie, Université d Aix Marseille II, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    Antimicrob Agents Chemother 46:2588-94. 2002

Collaborators

  • Wei Liu
  • Emmanuel Wafo
  • Nadine Azas
  • E De Clercq
  • F Delmas
  • Michel De Meo
  • Anais Berthelot-Ricou
  • Mélanie Aye
  • Alain Botta
  • Celine Botta
  • Jeanne Perrin
  • Blandine Courbiere
  • Yves Jammes
  • Philippe Barthelemy
  • Khuraman Mustafayeva
  • O Ridoux
  • Anne Sophie Sabatier
  • Assia Aouadene
  • Di Giorgio Carole
  • Pascal Rathelot
  • Christelle Brerro-Saby
  • Jean Guillaume Steinberg
  • Benoit P Pichon
  • Isabelle Berque-Bestel
  • Mourad Mekaouche
  • Ahissan Aimé
  • Evelyne Ollivier
  • Riad Elias
  • Yusif Kerimov
  • Luc Sarrazin
  • Xavier Moreau
  • Laetitia De Jong
  • Fabrice Garcia
  • Alain Thiery
  • Delmas Florence
  • De Méo Michel
  • Timon David Pierre
  • Galy Jean-Pierre
  • Chiron Julien
  • Jean Séverine
  • Dumenil Gérard
  • Nikoyan Anna
  • Jose Maldonado
  • Patrice Vanelle
  • Hussein El-Kashef
  • Pierre Timon-David
  • E Kemertelidze
  • R Elias
  • P Timon-David
  • G Dekanosidze
  • V Mshvildadze
  • G Balansard
  • M Drancourt
  • C Foucault

Detail Information

Publications26

  1. doi request reprint Alternative and complementary antileishmanial treatments: assessment of the antileishmanial activity of 27 Lebanese plants, including 11 endemic species
    Carole Di Giorgio
    Laboratoire de Parasitologie Hygiène et Zoologie, Faculte de Pharmacie, Universite de la Mediterranee, Marseille, France
    J Altern Complement Med 14:157-62. 2008
    ..clypeata, and O. aucheriana were shown to induce nitrous oxide (NO) production by human macrophages. Further experiments should be performed in order to purify and characterize the chemical compounds responsible for these activities...
  2. ncbi request reprint Synthesis and antileishmanial activity of 6-mono-substituted and 3,6-di-substituted acridines obtained by acylation of proflavine
    Carole Di Giorgio
    Laboratoire de Parasitologie, Hygiene et Zoologie, Faculte de Pharmacie, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Eur J Med Chem 42:1277-84. 2007
    ....
  3. ncbi request reprint Antileishmanial activity of quinovic acid glycosides and cadambine acid isolated from Nauclea diderrichii
    Carole Di Giorgio
    Laboratoire de Parasitologie, Hygiene et Zoologie, Faculte de Pharmacie, Marseille, France
    Planta Med 72:1396-402. 2006
    ..The association of cadambine acid with amphotericin B demonstrated an interesting synergism, suggesting that cadambine acid could be used as a complement of such conventional therapy...
  4. ncbi request reprint Synthesis and antileishmanial activities of 4,5-di-substituted acridines as compared to their 4-mono-substituted homologues
    Di Giorgio Carole
    Laboratoire de Parasitologie, Hygiene et Zoologie, Faculte de Pharmacie, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Bioorg Med Chem 13:5560-8. 2005
    ....
  5. ncbi request reprint In vitro antileishmanial activity of diphyllin isolated from Haplophyllum bucharicum
    Carole Di Giorgio
    Laboratoire de Parasitologie Hygiène et Zoologie, Faculte de Pharmacie, Marseille, France
    Planta Med 71:366-9. 2005
    ..This property was mainly due to modulation of macrophage phagocytosis and, to a lesser extent, it also involved interference with surface molecules of the promastigote membrane...
  6. pmc In vitro activities of 7-substituted 9-chloro and 9-amino-2-methoxyacridines and their bis- and tetra-acridine complexes against Leishmania infantum
    Carole Di Giorgio
    Laboratoire de Parasitologie, Hygiene et Zoologie, Faculte de Pharmacie, Marseille, France
    Antimicrob Agents Chemother 47:174-80. 2003
    ....
  7. pmc Flow cytometric detection of Leishmania parasites in human monocyte-derived macrophages: application to antileishmanial-drug testing
    C Di Giorgio
    Laboratoire de Parasitologie, Hygiene et Zoologie, Faculte de Pharmacie, Marseille Cedex 05, France
    Antimicrob Agents Chemother 44:3074-8. 2000
    ..mexicana, L. donovani) could be detected by this technique in other host-cell models such as mouse peritoneal macrophages and suggested that the flow cytometric method could be a valid alternative to the conventional method...
  8. doi request reprint Organic pollution and genotoxicity of sediments of the Palun marshes (Berre lagoon, France)
    Carole Di Giorgio
    Univ de la Méditerranée, Facultés de Médecine et Pharmacie, Marseille Cedex 05, France
    J Environ Qual 39:558-67. 2010
    ..Overall, the two runnels in the Palun marshes were found to be polluted by many organic compounds that originate from direct human activities and pose a significant genotoxic risk...
  9. ncbi request reprint Antiparasitic activity of highly conjugated pyrimidine-2,4-dione derivatives
    Nadine Azas
    Laboratoire de Parasitologie, EA 864, Faculte de Pharmacie, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    Farmaco 58:1263-70. 2003
    ..Antiparasitic activities of the corresponding azomethines were assessed against Plasmodium falciparum, Trichomonas vaginalis and Leishmania infantum compared to their toxicity versus human cells...
  10. pmc In vitro activities of position 2 substitution-bearing 6-nitro- and 6-amino-benzothiazoles and their corresponding anthranilic acid derivatives against Leishmania infantum and Trichomonas vaginalis
    Florence Delmas
    Laboratoire de Parasitologie, Hygiene et Zoologie, Faculte de Pharmacie, Université d Aix Marseille II, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
    Antimicrob Agents Chemother 46:2588-94. 2002
    ....
  11. doi request reprint Effects of UVA and visible light on the photogenotoxicity of benzo[a]pyrene and pyrene
    Celine Botta
    Laboratoire de biogénotoxicologie et mutagenèse Environnementale EA 1784, FR 3098 ECCOREV, Faculte de Pharmacie, Aix Marseille Universite, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Environ Toxicol 24:492-505. 2009
    ..Visible light is suggested to photoactivate PAH by a mechanism which is mainly based on oxidative reactions...
  12. doi request reprint Genotoxicity assessment of mouse oocytes by comet assay before vitrification and after warming with three vitrification protocols
    Anais Berthelot-Ricou
    Biogénotoxicologie, Santée Humaine and Environnement UMR 6116, IMBE, Aix Marseille Universite, FR CNRS 3098, ECCOREV, Marseille, France
    Fertil Steril 100:882-8. 2013
    ..To assess the genotoxicity of three oocyte vitrification protocols...
  13. doi request reprint Assessment of 1,2-propanediol (PrOH) genotoxicity on mouse oocytes by comet assay
    Anais Berthelot-Ricou
    Laboratoire de Biogénotoxicologie et Mutagenèse Environnementale, Fédération de Recherche CNRS 3098 ECCOREV, Facultés de Médecine et Pharmacie, Université de Méditerranée, Marseille, France
    Fertil Steril 96:1002-7. 2011
    ..To assess the genotoxicity of 1,2-propanediol (PrOH) on mouse oocytes by comet assay...
  14. ncbi request reprint Synthesis and antileishmanial activity of (1,3-benzothiazol-2-yl) amino-9-(10H)-acridinone derivatives
    Florence Delmas
    Laboratoire de Parasitologie, Hygiene et Zoologie, Faculte de Pharmacie, Universite de Marseille, 27, Bd Jean Moulin, 13385 Marseille Cedex 5, France
    Eur J Med Chem 39:685-90. 2004
    ....
  15. doi request reprint DNA-damaging, mutagenic, and clastogenic activities of gentiopicroside isolated from Cephalaria kotschyi roots
    Khuraman Mustafayeva
    Laboratoire de Pharmacognosie, Ethnopharmacologie et Homeopathie, UMR MD3, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
    J Nat Prod 73:99-103. 2010
    ..Similarly, the clastogenicity without S9 mix was 0.99 MNC microg(-1) mL and 0.38 MNC microg(-1) mL with S9 mix in the micronucleus assay. The interaction of 1 with DNA is probably through the involvement of oxidative DNA lesions...
  16. ncbi request reprint 1,3-Diphenylpyrazoles: synthesis and antiparasitic activities of azomethine derivatives
    Pascal Rathelot
    Laboratoire de Chimie Organique, UMR CNRS 6517, Faculte de Pharmacie, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    Eur J Med Chem 37:671-9. 2002
    ..In the most cases, nitrated compounds were found to be more efficient than non-nitrated ones against Plasmodium falciparum, Trichomonas vaginalis and Leishmania infantum...
  17. doi request reprint Evaluation of the mutagenic/clastogenic potential of 3,6-di-substituted acridines targeted for anticancer chemotherapy
    Carole Di Giorgio
    Laboratoire de biogénotoxicologie et mutagenèse Environnementale EA 1784, FR 3098 ECCOREV, Universite Aix Marseille, Faculte de Pharmacie, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Food Chem Toxicol 49:2773-9. 2011
    ..They led to the synthesis of the promising 3-acetamido-6-(4-fluorobenzamido)acridine, which displayed a strong cytotoxic activity and was not mutagenic...
  18. doi request reprint Evaluation of the genotoxicity of river sediments from industrialized and unaffected areas using a battery of short-term bioassays
    Assia Aouadene
    Laboratoire de Biogénotoxicologie et Mutagenèse Environnementale, Universite de la Mediterranee, Facultés de Médecine et Pharmacie, Marseille, France
    Environ Mol Mutagen 49:283-99. 2008
    ..The genotoxicity ranking determined by the comet assay + S9 matched the ranking of total and carcinogenic PAH concentrations, and this assay was found to be the most sensitive...
  19. doi request reprint Comparison of two extraction procedures for the assessment of sediment genotoxicity: implication of polar organic compounds
    Carole Di Giorgio
    Laboratoire de Biogénotoxicologie et Mutagenèse Environnementale, EA 1784, FR ECCOREV, Universite de la Mediterranee, Facultés de Médecine et Pharmacie, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Mutat Res 725:1-12. 2011
    ..The necessity to use appropriate extraction solvents to accurately evaluate the genotoxic hazard of aquatic sediments is also highlighted...
  20. doi request reprint Genotoxicity of visible light (400-800 nm) and photoprotection assessment of ectoin, L-ergothioneine and mannitol and four sunscreens
    Celine Botta
    Laboratoire de biogénotoxicologie et mutagenèse Environnementale EA 1784, Facultés de Médecine et Pharmacie, Universite de la Mediterranee, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    J Photochem Photobiol B 91:24-34. 2008
    ..There is a need to complement sunscreen formulations with additional molecules to obtain a complete internal and external photoprotection against both UVA and visible lights...
  21. doi request reprint Comet assay on mouse oocytes: an improved technique to evaluate genotoxic risk on female germ cells
    Anais Berthelot-Ricou
    Laboratoire de Biogénotoxicologie et Mutagenèse Environnementale, Fédération de Recherche CNRS 3098 ECCOREV Université de la Méditerranée Aix Marseille II, Facultés de Médecine et Pharmacie, Marseille, France
    Fertil Steril 95:1452-7. 2011
    ..To develop and validate an efficient comet assay on mouse oocytes without depellucidation...
  22. pmc Purification of Encephalitozoon cultures contaminated by mycoplasmas by murine intraperitoneal inoculation
    O Ridoux
    Unité des Rickettsies CNRS UPRES A 6020, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    J Clin Microbiol 36:2380-2. 1998
    ..Mycoplasma-free microsporidia were isolated from the brains and spleens of inoculated mice 24 h postinoculation by using the centrifugation shell vial system. Identification was confirmed by direct sequencing of PCR-amplified 16S rRNA...
  23. doi request reprint Genotoxicity of intraperitoneal injection of lipoamphiphile CdSe/ZnS quantum dots in rats
    Mélanie Aye
    UMR MD2 Dysoxia Hyperactivity, Aix Marseille Universite, Faculte de Medecine, Marseille, France Laboratoire de Mutagenèse et Toxicologie Environnementales, Institut Méditerranéen de Biodiversité et d Ecologie, Aix Marseille Universite, Faculte de Pharmacie, Marseille, France
    Mutat Res 758:48-55. 2013
    ..In conclusion, the QDs exerted significant genotoxic effects in the brain and liver, even in the absence of any associated oxidative stress and inflammatory processes...
  24. ncbi request reprint DNA-damaging activity and mutagenicity of 16 newly synthesized thiazolo[5,4-a]acridine derivatives with high photo-inducible cytotoxicity
    Carole Di Giorgio
    Laboratoire de biogénotoxicologie et mutagenèse Environnementale EA 1784, Facultés de Médecine et Pharmacie, Universite de la Mediterranee, 27 Bd Jean Moulin, Marseille Cedex 05, France
    Mutat Res 650:104-14. 2008
    ..Overall, the results of this study confirm that acridines are predominantly genotoxic via a DNA-intercalating mechanism in the dark, while DNA-adducts were probably induced following photo-activation...
  25. doi request reprint Genotoxic and mutagenic effects of lipid-coated CdSe/ZnS quantum dots
    Mélanie Aye
    Laboratoire de Mutagenèse Environnementale, Institut Méditerranéen de Biodiversité et d Ecologie, Aix Marseille Universite, Marseille Cedex, France
    Mutat Res 750:129-38. 2013
    ..The present results clearly point to the genotoxic properties and the risk of long-term adverse effects of such a nanoplatform if used for human anticancer therapy and diagnosis in the future...
  26. ncbi request reprint In vitro antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A(1), in association with pentamidine and amphotericin B
    O Ridoux
    Laboratoire de Parasitologie, , 27 Bd. Jean Moulin, 13385 Marseille, France
    Phytother Res 15:298-301. 2001
    ..The results demonstrated moreover that the action of saponins on promastigote membrane was cumulative with those of amphotericin B...