Jean Francois Dhainaut

Summary

Country: France

Publications

  1. ncbi request reprint Dynamic evolution of coagulopathy in the first day of severe sepsis: relationship with mortality and organ failure
    Jean Francois Dhainaut
    Department of Intensive Care, Cochin Hospital, AP HP, Cochin Institute, Cochin Port Royal Medical School, Paris V University, Paris, France
    Crit Care Med 33:341-8. 2005
  2. ncbi request reprint The clinical evaluation committee in a large multicenter phase 3 trial of drotrecogin alfa (activated) in patients with severe sepsis (PROWESS): role, methodology, and results
    Jean Francois Dhainaut
    Department of Intensive Care, Cochin Hospital, Cochin Institute, Cochin Port Royal Medical School, Paris V University, France
    Crit Care Med 31:2291-301. 2003
  3. ncbi request reprint High-volume hemofiltration after out-of-hospital cardiac arrest: a randomized study
    Ivan Laurent
    Medical ICU, Cochin Teaching Hospital, Rene Descartes University, Paris, France
    J Am Coll Cardiol 46:432-7. 2005
  4. ncbi request reprint Drotrecogin alfa (activated) in the treatment of severe sepsis patients with multiple-organ dysfunction: data from the PROWESS trial
    Jean Francois Dhainaut
    Department of Intensive Care, Cochin Hospital AP HP, Cochin Institute, Cochin Port Royal Medical School, Paris V University, 27 rue due Faubourg Saint Jacques, 75679, Paris Cedex 14, France
    Intensive Care Med 29:894-903. 2003
  5. ncbi request reprint Brain natriuretic peptide: A marker of myocardial dysfunction and prognosis during severe sepsis
    Julien Charpentier
    Medical Intensive Care Unit, Groupe Hospitalier Cochin Saint Vincent de Paul La Roche Guyon, Paris, France
    Crit Care Med 32:660-5. 2004
  6. ncbi request reprint Reversible myocardial dysfunction in survivors of out-of-hospital cardiac arrest
    Ivan Laurent
    Medical Intensive Care Unit, Cochin Port Royal Hospital, Rene Descartes University, Paris, France
    J Am Coll Cardiol 40:2110-6. 2002
  7. ncbi request reprint Soluble thrombomodulin, plasma-derived unactivated protein C, and recombinant human activated protein C in sepsis
    Jean Francois Dhainaut
    Medical Intensive Care Unit, Cochin St V de Paul Hospital, AP HP, Cochin Institut Cochin Port Royal Medical School, University of Paris V, France
    Crit Care Med 30:S318-24. 2002
  8. ncbi request reprint Protein C/activated protein C pathway: overview of clinical trial results in severe sepsis
    Jean Francois Dhainaut
    Intensive Care and Emergency Department, Cochin University Hospital, AP HP, University of Paris 5, Paris, France
    Crit Care Med 32:S194-201. 2004
  9. pmc Risk factors for post-ICU red blood cell transfusion: a prospective study
    Sophie Marque
    Medical Intensive Care Unit, Cochin Hospital, rue du Faubourg Saint Jacques, F 75679 Paris cedex 14, France
    Crit Care 10:R129. 2006
  10. ncbi request reprint The era of genomics: impact on sepsis clinical trial design
    Alain Cariou
    Medical Intensive Care Unit and Cochin Institute of Molecular Genetics, Cochin St Vincent de Paul University Hospital, Paris, France
    Crit Care Med 30:S341-8. 2002

Detail Information

Publications40

  1. ncbi request reprint Dynamic evolution of coagulopathy in the first day of severe sepsis: relationship with mortality and organ failure
    Jean Francois Dhainaut
    Department of Intensive Care, Cochin Hospital, AP HP, Cochin Institute, Cochin Port Royal Medical School, Paris V University, Paris, France
    Crit Care Med 33:341-8. 2005
    ..To determine whether changes in coagulation biomarkers during the first day of severe sepsis correlate with progression from single to multiple organ failure and subsequent death...
  2. ncbi request reprint The clinical evaluation committee in a large multicenter phase 3 trial of drotrecogin alfa (activated) in patients with severe sepsis (PROWESS): role, methodology, and results
    Jean Francois Dhainaut
    Department of Intensive Care, Cochin Hospital, Cochin Institute, Cochin Port Royal Medical School, Paris V University, France
    Crit Care Med 31:2291-301. 2003
    ..The objective of this study was to perform a blinded, critical, integrated review of data from the 1,690 severe sepsis patients from 164 medical centers enrolled in the PROWESS trial using a Clinical Evaluation Committee...
  3. ncbi request reprint High-volume hemofiltration after out-of-hospital cardiac arrest: a randomized study
    Ivan Laurent
    Medical ICU, Cochin Teaching Hospital, Rene Descartes University, Paris, France
    J Am Coll Cardiol 46:432-7. 2005
    ..The study examined the effect of isovolumic high-volume hemofiltration (HF) alone or combined with mild hypothermia (HT) on survival after out-of-hospital cardiac arrest (OHCA) with initial ventricular fibrillation or asystole...
  4. ncbi request reprint Drotrecogin alfa (activated) in the treatment of severe sepsis patients with multiple-organ dysfunction: data from the PROWESS trial
    Jean Francois Dhainaut
    Department of Intensive Care, Cochin Hospital AP HP, Cochin Institute, Cochin Port Royal Medical School, Paris V University, 27 rue due Faubourg Saint Jacques, 75679, Paris Cedex 14, France
    Intensive Care Med 29:894-903. 2003
    ..We report study's data on efficacy and safety in patients with multiple-organ dysfunction...
  5. ncbi request reprint Brain natriuretic peptide: A marker of myocardial dysfunction and prognosis during severe sepsis
    Julien Charpentier
    Medical Intensive Care Unit, Groupe Hospitalier Cochin Saint Vincent de Paul La Roche Guyon, Paris, France
    Crit Care Med 32:660-5. 2004
    ..To investigate the value of brain natriuretic peptide plasma levels as a marker of systolic myocardial dysfunction during severe sepsis and septic shock...
  6. ncbi request reprint Reversible myocardial dysfunction in survivors of out-of-hospital cardiac arrest
    Ivan Laurent
    Medical Intensive Care Unit, Cochin Port Royal Hospital, Rene Descartes University, Paris, France
    J Am Coll Cardiol 40:2110-6. 2002
    ..The aim of the study was to assess the hemodynamic status of survivors of out-of-hospital cardiac arrest (OHCA)...
  7. ncbi request reprint Soluble thrombomodulin, plasma-derived unactivated protein C, and recombinant human activated protein C in sepsis
    Jean Francois Dhainaut
    Medical Intensive Care Unit, Cochin St V de Paul Hospital, AP HP, Cochin Institut Cochin Port Royal Medical School, University of Paris V, France
    Crit Care Med 30:S318-24. 2002
    ..To review the physiologic and biochemical mechanisms and the rationale for the use of soluble thrombomodulin, plasma-derived protein C, and recombinant human activated protein C in sepsis...
  8. ncbi request reprint Protein C/activated protein C pathway: overview of clinical trial results in severe sepsis
    Jean Francois Dhainaut
    Intensive Care and Emergency Department, Cochin University Hospital, AP HP, University of Paris 5, Paris, France
    Crit Care Med 32:S194-201. 2004
    ..To review the results from clinical trials of treatments for severe sepsis involving the protein C/activated protein C pathway...
  9. pmc Risk factors for post-ICU red blood cell transfusion: a prospective study
    Sophie Marque
    Medical Intensive Care Unit, Cochin Hospital, rue du Faubourg Saint Jacques, F 75679 Paris cedex 14, France
    Crit Care 10:R129. 2006
    ..This study aims identifies risk factors for RBC transfusion after discharge from the ICU...
  10. ncbi request reprint The era of genomics: impact on sepsis clinical trial design
    Alain Cariou
    Medical Intensive Care Unit and Cochin Institute of Molecular Genetics, Cochin St Vincent de Paul University Hospital, Paris, France
    Crit Care Med 30:S341-8. 2002
    ..This article aims to address the predictable impact of genetics on the design of clinical trials in the field of critical care medicine, with emphasis on the pathophysiology of sepsis and its treatment...
  11. ncbi request reprint Adjunctive therapies in sepsis: an evidence-based review
    Alain Cariou
    Department of Intensive Care and Emergency Medicine, Cochin Hospital, University of Paris 5, Paris, France
    Crit Care Med 32:S562-70. 2004
    ....
  12. ncbi request reprint Underlying disorders and their impact on the host response to infection
    Jean Francois Dhainaut
    Intensive Care and Emergency Department, Cochin University Hospital, Rene Descartes University, Paris, France
    Clin Infect Dis 41:S481-9. 2005
    ..Although innate immunity seems not to be actually blunted in patients with underlying disorders, the underlying disorder itself contributes to the severity of the physiological response to sepsis, thereby resulting in a worse outcome...
  13. ncbi request reprint Drotrecogin alfa (activated) (recombinant human activated protein C) reduces host coagulopathy response in patients with severe sepsis
    Jean Francois Dhainaut
    Service de Reanimation Medicale, Centre Hospitalo Universitaire Cochin Port Royal, AP HP, Paris V University, Paris, France
    Thromb Haemost 90:642-53. 2003
    ..These latter two effects may occur at the local or cellular level. The systemic biomarkers reported here might not be the most appropriate approach to demonstrate these potential effects of drotrecogin alfa (activated)...
  14. pmc Cost-effectiveness of activated protein C in real-life clinical practice
    Jean Francois Dhainaut
    Department of Intensive Care, Cochin Port Royal University Hospital, AP HP, Rene Descartes University, Paris 5, Paris, France
    Crit Care 11:R99. 2007
    ..We evaluated the cost-effectiveness of rhAPC in patients with severe sepsis and multiple organ failure in real-life intensive care practice...
  15. ncbi request reprint Detecting life-threatening lactic acidosis related to nucleoside-analog treatment of human immunodeficiency virus-infected patients, and treatment with L-carnitine
    Yann Erick Claessens
    Medical Intensive Care Unit, Cochin Hospital, 27 rue du Faubourg Saint Jacques, F 75679 Paris cedex 14, France
    Crit Care Med 31:1042-7. 2003
    ....
  16. ncbi request reprint International integrated database for the evaluation of severe sepsis (INDEPTH): clinical evaluation committee report on the safety of drotrecogin alfa (activated) therapy
    Jean Francois Dhainaut
    Hopital Cochin, Paris, France
    Curr Med Res Opin 24:1187-97. 2008
    ..The results of safety analyses are reported...
  17. pmc How emergency departments might alert for prehospital heat-related excess mortality?
    Yann Erick Claessens
    Paris Descartes University, Faculty of Medicine, Assistance Publique Hopitaux de Paris, Department of Emergency Medicine, Hopital Cochin, Paris Cedex 14, France
    Crit Care 10:R156. 2006
    ..Our objective was to develop a real-time surveillance model based on ED data to detect excessive heat-related mortality as early as possible...
  18. pmc Diagnosis and treatment of severe sepsis
    Yann Erick Claessens
    Pôle Réanimations Urgences, Hopital Cochin, rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, Paris, France
    Crit Care 11:S2. 2007
    ..We summarize the main proposals made by the Surviving Sepsis Campaign and focus on the difficulties associated with making a proper diagnosis and supplying adequate treatment promptly to septic patients...
  19. pmc Unprecedented heat-related deaths during the 2003 heat wave in Paris: consequences on emergency departments
    Jean Francois Dhainaut
    Professor, Emergency and Intensive Care Department, Cochin Port Royal University Hospital, AP HP, University Paris 5, France
    Crit Care 8:1-2. 2004
    ..Indeed, simple preventice measures before hospital admissions are only able to reduce mortality which mostly occurred at home and in nursing homes...
  20. ncbi request reprint Influence of overweight on ICU mortality: a prospective study
    Cyril Goulenok
    Service de Reanimation Medicale, hôpital Cochin Port Royal, Paris, France
    Chest 125:1441-5. 2004
    ..We conducted a prospective study in order to examine the relationship between body mass index (BMI) and mortality among these patients...
  21. ncbi request reprint Successful cardiopulmonary resuscitation after cardiac arrest as a "sepsis-like" syndrome
    Christophe Adrie
    Medical ICU, Cochin Hospital, Paris, France
    Circulation 106:562-8. 2002
    ..We investigated the immunoinflammatory profile of patients successfully resuscitated after cardiac arrest, representing a model of whole-body ischemia/reperfusion syndrome...
  22. doi request reprint Can metabolic abnormalities after a fall predict short term mortality in elderly patients?
    Frederic Bloch
    Department of Gerontology, Hôpital Broca AP HP, Paris, France
    Eur J Epidemiol 24:357-62. 2009
    ..As metabolic abnormalities can be an indirect marker of a long delay before emergency medical care, this study underscored the importance of early warning system for the frailest old individuals in order to prevent such complications...
  23. ncbi request reprint Aspiration pneumonitis and Newton's law of gravitation
    Guillaume Der Sahakian
    Department of Emergency Medicine, Cochin Hospital, Paris Descartes University, Assistance Publique Paris, Cochin Hospital, 75679 Paris Cedex 14, France
    Am J Emerg Med 25:987.e1-2. 2007
  24. ncbi request reprint Continuous venovenous haemodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: a multicentre randomised trial
    Christophe Vinsonneau
    Department of Intensive Care, Cochin Port Royal University Hospital, Rene Descartes University, Paris, France
    Lancet 368:379-85. 2006
    ..In this study, we compare the effect of intermittent haemodialysis and continuous venovenous haemodiafiltration on survival rates in critically ill patients with acute renal failure as part of multiple-organ dysfunction syndrome...
  25. ncbi request reprint Health network to improve elderly patients' flow in emergency department
    Khalil Takun
    Emergency Department, Cochin University Hospital, rue du Faubourg Saint Jacques, Paris, France
    Eur J Emerg Med 13:260-3. 2006
    ..Our study, based on this organization, analyses the outcome of such a system...
  26. doi request reprint Do ED staffs have a role to play in the prevention of repeat falls in elderly patients?
    Frederic Bloch
    Department of Gerontology, Hopital Broca, 54 rue Pascal, Paris, France
    Am J Emerg Med 27:303-7. 2009
    ..The aim of this study was to determine the factors influencing 6-month independence...
  27. doi request reprint Appropriateness of diagnosis and orientation of 996 consecutive patients admitted in an emergency department with flow-based organization
    Jean Christophe Allo
    Department of Emergency Medicine, Cochin Hospital, Paris Cedex, France
    Eur J Emerg Med 16:23-8. 2009
    ..Our Emergency Department (ED) was reorganized in the year 2000 based on the optimization of patients' flow. In this model, the emergency team had to refer patients to units fitting best to their condition with minimal delays...
  28. ncbi request reprint Pharmacokinetic-pharmacodynamic analysis of drotrecogin alfa (activated) in patients with severe sepsis
    William L Macias
    Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Ind 46285, USA
    Clin Pharmacol Ther 72:391-402. 2002
    ..We aimed to characterize the pharmacokinetics and pharmacodynamics of drotrecogin alfa (activated) (recombinant human activated protein C) in patients with severe sepsis...
  29. ncbi request reprint Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
    ..To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004...
  30. ncbi request reprint Systemic host responses in severe sepsis analyzed by causative microorganism and treatment effects of drotrecogin alfa (activated)
    Steven M Opal
    Brown University School of Medicine, Providence, RI, USA
    Clin Infect Dis 37:50-8. 2003
    ..Results demonstrate that DrotAA, administered as an adjunct to standard anti-infective therapy, can improve the rate of survival for patients who develop severe sepsis regardless of causative microorganism...
  31. ncbi request reprint Survival advantage associated with heterozygous factor V Leiden mutation in patients with severe sepsis and in mouse endotoxemia
    Bryce A Kerlin
    Blood Research Institute, Blood Center of Southeast Wisconsin and Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Blood 102:3085-92. 2003
    ..76). The findings suggest that FV Leiden constitutes a rare example of a balanced gene polymorphism that maintains the FV Leiden mutation in the general gene pool due to a survival advantage of VL+/- in severe sepsis...
  32. ncbi request reprint Recombinant human platelet-activating factor acetylhydrolase for treatment of severe sepsis: results of a phase III, multicenter, randomized, double-blind, placebo-controlled, clinical trial
    Steven Opal
    Division of Infectious Diseases, Brown Medical School, Providence, RI, USA
    Crit Care Med 32:332-41. 2004
    ..A previous clinical trial with recombinant human PAF-AH (rPAF-AH, Pafase) suggested that this treatment may decrease 28-day all-cause mortality in patients with severe sepsis. The current study was undertaken to confirm this result...
  33. pmc Protein C concentrations in severe sepsis: an early directional change in plasma levels predicts outcome
    Andrew F Shorr
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC, USA
    Crit Care 10:R92. 2006
    ..The objective of this study was to determine whether early directional changes in protein C levels correlate with outcome...
  34. ncbi request reprint Only activated protein C treatment and not protein C has demonstrated an improvement in survival in severe sepsis
    S Betty Yan
    Crit Care Med 32:618; author reply 618-9. 2004
  35. ncbi request reprint Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: further evidence for survival and safety and implications for early treatment
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital and University of Brussels, Brussels, Belgium
    Crit Care Med 33:2266-77. 2005
    ..To provide further evidence for the efficacy and safety of drotrecogin alfa (activated) treatment in severe sepsis...
  36. ncbi request reprint Sources of variability on the estimate of treatment effect in the PROWESS trial: implications for the design and conduct of future studies in severe sepsis
    William L Macias
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
    Crit Care Med 32:2385-91. 2004
    ..To elucidate sources of variability in the estimate of treatment effects in a successful phase 3 trial in severe sepsis and to assess their implications on the design of future clinical trials...
  37. ncbi request reprint Severe community-acquired pneumonia as a cause of severe sepsis: data from the PROWESS study
    Pierre Francois Laterre
    Head of Intensive Care Unit, Cliniques Universitaires Saint Luc Service des Urgences et des Soins Intensifs, UCL, Brussels, Belgium
    Crit Care Med 33:952-61. 2005
    ....
  38. ncbi request reprint Hospital mortality and resource use in subgroups of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trial
    Pierre Francois Laterre
    Department of Critical Care, St Luc University Hospital, UCL, Brussels, Belgium
    Crit Care Med 32:2207-18. 2004
    ..To compare differences in hospital mortality and resource use in adult severe sepsis subjects randomized to receive drotrecogin alfa (activated) (DrotAA) or placebo in the PROWESS trial...
  39. pmc Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, One Cooper Plaza, 393 Dorrance, Camden 08103, NJ, USA
    Intensive Care Med 34:17-60. 2008
    ..To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock," published in 2004...
  40. pmc The PIRO concept: R is for response
    Herwig Gerlach
    Department of Anaesthesiology and Intensive Care Medicine, Vivantes Klinikum Neukoelln, Germany
    Crit Care 7:256-9. 2003