Emmanuel Deval

Summary

Country: France

Publications

  1. doi request reprint Acid-sensing ion channels in postoperative pain
    Emmanuel Deval
    Institut de Pharmacologie Moleculaire et Cellulaire, Unité Mixte de Recherche 6097 Centre National de la Recherche Scientifique Université de Nice Sophia Antipolis, 06560 Valbonne, France
    J Neurosci 31:6059-66. 2011
  2. doi request reprint Acid-sensing ion channels (ASICs): pharmacology and implication in pain
    Emmanuel Deval
    Institut de Pharmacologie Moléculaire et Cellulaire IPMC, UMR 6097 CNRS Université de Nice Sophia Antipolis UNS, 660, route des Lucioles, 06560 Valbonne, France
    Pharmacol Ther 128:549-58. 2010
  3. ncbi request reprint ASIC2b-dependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1
    Emmanuel Deval
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UNSA UMR 6097, Institut Paul Hamel, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 279:19531-9. 2004
  4. pmc ASIC3, a sensor of acidic and primary inflammatory pain
    Emmanuel Deval
    Institut de Pharmacologie Moleculaire et Cellulaire, UMR 6097 CNRS Université de Nice Sophia Antipolis, Sophia Antipolis, Valbonne, France
    EMBO J 27:3047-55. 2008
  5. ncbi request reprint Regulation of sensory neuron-specific acid-sensing ion channel 3 by the adaptor protein Na+/H+ exchanger regulatory factor-1
    Emmanuel Deval
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UNSA UMR 6097, Institut Paul Hamel, 660 route des Lucioles, Sophia Antipolis, Valbonne 06560, France
    J Biol Chem 281:1796-807. 2006
  6. pmc Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions
    Anne Delaunay
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, UMR 7275, 06560 Valbonne, France
    Proc Natl Acad Sci U S A 109:13124-9. 2012
  7. pmc A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons
    Sylvie Diochot
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut Paul Hamel, Sophia Antipolis, Valbonne, France
    EMBO J 23:1516-25. 2004
  8. ncbi request reprint Venom toxins in the exploration of molecular, physiological and pathophysiological functions of acid-sensing ion channels
    Anne Baron
    CNRS, Institut de Pharmacologie Moleculaire et Cellulaire, UMR 7275, 06560 Valbonne, France Université de Nice Sophia Antipolis, 06560 Valbonne, France LabEx Ion Channel Science and Therapeutics, 06560 Valbonne, France
    Toxicon 75:187-204. 2013
  9. ncbi request reprint Protein kinase C stimulates the acid-sensing ion channel ASIC2a via the PDZ domain-containing protein PICK1
    Anne Baron
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UMR6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 277:50463-8. 2002
  10. doi request reprint Acid-sensing ion channel 3 in retinal function and survival
    Mohammed Ettaiche
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Universite de Nice Sophia Antipolis, Valbonne, France
    Invest Ophthalmol Vis Sci 50:2417-26. 2009

Collaborators

Detail Information

Publications15

  1. doi request reprint Acid-sensing ion channels in postoperative pain
    Emmanuel Deval
    Institut de Pharmacologie Moleculaire et Cellulaire, Unité Mixte de Recherche 6097 Centre National de la Recherche Scientifique Université de Nice Sophia Antipolis, 06560 Valbonne, France
    J Neurosci 31:6059-66. 2011
    ..The specific homomeric ASIC1a blocker PcTx1 has no effect on spontaneous flinching, when applied peripherally. Together, these data demonstrate a significant role for peripheral ASIC3-containing channels in postoperative pain...
  2. doi request reprint Acid-sensing ion channels (ASICs): pharmacology and implication in pain
    Emmanuel Deval
    Institut de Pharmacologie Moléculaire et Cellulaire IPMC, UMR 6097 CNRS Université de Nice Sophia Antipolis UNS, 660, route des Lucioles, 06560 Valbonne, France
    Pharmacol Ther 128:549-58. 2010
    ..Targeting ASIC channels at different levels of the nervous system could therefore be an interesting strategy for the relief of pain...
  3. ncbi request reprint ASIC2b-dependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1
    Emmanuel Deval
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UNSA UMR 6097, Institut Paul Hamel, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 279:19531-9. 2004
    ..This regulation by PKC requires PICK-1 (protein interacting with C kinase), a PDZ domain-containing protein, which interacts with the ASIC2b C terminus...
  4. pmc ASIC3, a sensor of acidic and primary inflammatory pain
    Emmanuel Deval
    Institut de Pharmacologie Moleculaire et Cellulaire, UMR 6097 CNRS Université de Nice Sophia Antipolis, Sophia Antipolis, Valbonne, France
    EMBO J 27:3047-55. 2008
    ..Peripheral ASIC3 channels are thus essential sensors of acidic pain and integrators of molecular signals produced during inflammation where they contribute to primary hyperalgesia...
  5. ncbi request reprint Regulation of sensory neuron-specific acid-sensing ion channel 3 by the adaptor protein Na+/H+ exchanger regulatory factor-1
    Emmanuel Deval
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UNSA UMR 6097, Institut Paul Hamel, 660 route des Lucioles, Sophia Antipolis, Valbonne 06560, France
    J Biol Chem 281:1796-807. 2006
    ..Given the importance of the ASIC3 sustained current in nociceptor excitability, it is likely that NHERF-1 participates in channel functions associated with nociception and mechanosensation...
  6. pmc Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions
    Anne Delaunay
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, UMR 7275, 06560 Valbonne, France
    Proc Natl Acad Sci U S A 109:13124-9. 2012
    ..0 and 8.0, a property likely to participate in the fine tuning of neuronal membrane potential and to neuron sensitization in various pH environments...
  7. pmc A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons
    Sylvie Diochot
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut Paul Hamel, Sophia Antipolis, Valbonne, France
    EMBO J 23:1516-25. 2004
    ..The ASIC3-like current in primary cultured sensory neurons is partly and reversibly inhibited by APETx2 with an IC50 of 216 nM, probably due to the mixed inhibitions of various co-expressed ASIC3-containing channels...
  8. ncbi request reprint Venom toxins in the exploration of molecular, physiological and pathophysiological functions of acid-sensing ion channels
    Anne Baron
    CNRS, Institut de Pharmacologie Moleculaire et Cellulaire, UMR 7275, 06560 Valbonne, France Université de Nice Sophia Antipolis, 06560 Valbonne, France LabEx Ion Channel Science and Therapeutics, 06560 Valbonne, France
    Toxicon 75:187-204. 2013
    ....
  9. ncbi request reprint Protein kinase C stimulates the acid-sensing ion channel ASIC2a via the PDZ domain-containing protein PICK1
    Anne Baron
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UMR6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 277:50463-8. 2002
    ..These data provide the first demonstration of a regulation of ASICs by protein kinase phosphorylation and its potentiation by the partner protein PICK1...
  10. doi request reprint Acid-sensing ion channel 3 in retinal function and survival
    Mohammed Ettaiche
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Universite de Nice Sophia Antipolis, Valbonne, France
    Invest Ophthalmol Vis Sci 50:2417-26. 2009
    ..The authors analyzed the expression in rodent retina of ASIC3, a sensor of extracellular acidosis, and used ASIC3 knockout mice to explore its role in retinal function and survival...
  11. ncbi request reprint The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons
    Naohiko Anzai
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UMR6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 277:16655-61. 2002
    ..e. mainly in the small nociceptive neurons. CIPP is thus a scaffolding protein that could both enhance the surface expression of ASIC3 and bring together ASIC3 and functionally related proteins in the membrane of sensory neurons...
  12. pmc Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design
    Jean Mazella
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique CNRS, Universite de Nice Sophia Antipolis, Valbonne, France
    PLoS Biol 8:e1000355. 2010
    ..Spadin can be regarded as the first natural antidepressant peptide identified. It corresponds to a new concept to address the treatment of depression...
  13. ncbi request reprint Silencing acid-sensing ion channel 1a alters cone-mediated retinal function
    Mohammed Ettaiche
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6097, Universtité de Nice Sophia Antipolis, Sophia Antipolis, 06560 Valbonne, France
    J Neurosci 26:5800-9. 2006
    ....
  14. ncbi request reprint FMRFamide-gated sodium channel and ASIC channels: a new class of ionotropic receptors for FMRFamide and related peptides
    Eric Lingueglia
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS Université de Nice Sophia Antipolis UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    Peptides 27:1138-52. 2006
    ..Available data also raises the possibility of the existence of still unknown FMRFamide related endogenous peptides acting as direct agonists for ASICs...
  15. ncbi request reprint Current perspectives on acid-sensing ion channels: new advances and therapeutic implications
    Jacques Noel
    Institut de Pharmacologie Moleculaire et Cellulaire, Institut de NeuroMédecine Moléculaire IPMC IN2M CNRS University of Nice Sophia Antipolis, UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    Expert Rev Clin Pharmacol 3:331-46. 2010
    ..ASICs, therefore, emerge as new potential therapeutic targets in the management of psychiatric disorders, stroke, neurodegenerative diseases and pain...