Olivier Dereure

..This study shows that increased liver iron content is not a constant finding in patients with porphyria cutanea tarda, especially in women, and that it is not a prerequisite for the efficiency of phlebotomy...

..To investigate the efficacy and safety of an hyaluronic acid (HA)-impregnated gauze pad compared with a hydrocolloid (HC) dressing, in patients with leg ulcer of venous or mixed aetiology...

..To investigate the efficacy and safety of hyaluronic acid in the local treatment of leg ulcers of venous or mixed aetiology, compared with a neutral vehicle...

..Although treatment continues to be symptomatic in most cases, recent advances in basic research have raised new hopes regarding targeted therapies, notably in progeria...

..The search for dominant T-cell clones has been scarcely reported, although the presence of such clones might be expected in disorders showing immune responses directed against a variety of autoantigens...

..Some of these fundamental breakthroughs might result in practical interventions although in an undefined future...

..A single mucous membrane is most often involved, mainly in the mouth. Such mucous lesions are generally ominous with regard to the general outcome of the disease...

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..However, no similar data are available for the cutaneous counterpart of this particular lymphoproliferation...

..Procedures based on polymerase chain reaction (PCR) are the most sensitive to detect clonality, but heteroduplex analysis is less sensitive than other methods such as denaturing gradient gel electrophoresis...

..Narrowband ultraviolet B (UVB) phototherapy is increasingly used in mycosis fungoides (MF)...

..By contrast, very few data are available with regard to distant skin reactions, particularly inflammatory lesions on other parts of the body...

..We report on a new "frontier" case, remarkable in its clinical pattern and its high sensitivity to antimalarial drugs...

..This study confirms frequent detection of a dominant gene rearrangement in peripheral blood in MF patients and shows that PCR may remain positive in lesional sites even when skin lesions are successfully treated...

..To evaluate concordance with compression therapy in ambulatory patients with venous leg ulcers...

..However, we recently observed a further example of haemorrhagic-like cutaneous metastasis, a quite infrequent clinical pattern, remarkable for the multiplicity of lesions...

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..MCPyV was detected in at least 1 sample from virtually all participants. Viral loads were higher in samples from patients with MCC...

..These results support the hypothesis that Fas defects may play a role in the pathogenesis of MF...

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..The peculiar female proneness for cancer whatever its localization and the risk of multiple neoplasias have already been reported in NF1 patients and could be true for malignant melanoma as well...

..At a lower level, this treatment was effective and deserves further investigations to define its indications in metastatic melanoma patients...

..TT virus might play a role as a cofactor in the clinical emergence of Kaposi's sarcoma in patients infected with Human herpes virus 8, perhaps by immunosuppressive effects or by a common transmission pathway for these two viruses...

..To our knowledge, this is the first reported instance of phrynoderma related to a chronic intestinal parasitic infection by Giardia intestinalis with intestinal malabsorption as a likely consequence...

..It may be difficult to rule out the last two diagnoses and making the diagnosis usually requires full excision of the lesion, comprehensive histologic analysis, and careful follow-up...

..In conclusion, topical diclofenac could be worth considering in the management of genital PK with numerous lesions...

..Several hypotheses can be discussed in this peculiar observation, among which a direct role of radiotherapy in the occurrence of cutaneous lesions cannot be ruled out...

..In both cases, long term remission was obtained with non aggressive therapies. This rare condition must be added to newly described forms of MF with epidermal hyperplasia such as keratosis lichenoides chronica like MF and pilotropic MF...

..The potential involvement of these viruses, alone or in combination, in skin proliferative disorders and oncogenesis is another crucial issue to be elucidated...

..This information should be taken into consideration when making therapeutic choices...

..Better training of oncologists by using a dermatological atlas would improve inter-observer agreement...

..However, like in other infections with tuberculous or non-tuberculous mycobacteria, long-term treatment (at least 6 months) was necessary to prevent relapses...

..Despite great progress in understanding the mechanisms underlying genetic hemochromatosis, data on the prevalence and the penetrance of the disorder are conflicting...

..54; 95% confidence interval, 0.30-0.97; P=0.039). This mild regimen allows a 70% reduction of the cumulative doses of CS and improves BP patients' outcome...

..The response to treatment was evaluated upon the dermatologist's observation, which highlights the need of validated tools to evaluate patients' disability and response to treatment...

..This study aimed to develop a rapid automated method for sequencing the main genes involved...

..To assess the rate of objective response to pegylated liposomal doxorubicin hydrochloride (Caelyx) in patients with advanced or refractory cutaneous T-cell lymphoma (CTCL)...