Pascal Demoly

Summary

Country: France

Publications

  1. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
  2. pmc EAACI: A European Declaration on Immunotherapy. Designing the future of allergen specific immunotherapy
    Moises A Calderon
    Section of Allergy and Clinical Immunology, Imperial College, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    Clin Transl Allergy 2:20. 2012
  3. pmc Drug provocation tests: up-date and novel approaches
    Anca Mirela Chiriac
    Allergy Unit, Hopital Arnaud de Villeneuve, 371 Avenue du Doyen Giraud, Montpellier, 34295, France
    Allergy Asthma Clin Immunol 9:12. 2013
  4. pmc Assessment of disease control in allergic rhinitis
    Pascal Demoly
    Allergy Division, Pulmonary Department, INSERM U657 EA2415, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France
    Clin Transl Allergy 3:7. 2013
  5. pmc Comprehensive allergy work-up is mandatory in cystic fibrosis patients who report a history suggestive of drug allergy to beta-lactam antibiotics
    Silvia Caimmi
    Allergy Unit, Deépartement de Pneumologie et Addictologie, Hopital Arnaud de Villeneuve, University Hospital of Montpellier and Inserm U657, 37, avenue du Doyen Gaston Giraud, 34295, Montpellier Cedex 5, France
    Clin Transl Allergy 2:10. 2012
  6. ncbi request reprint [Contribution of epidemiology to the prevention of drug allergies]
    Pascal Demoly
    Pneumologie et Addictologie, INSERM U657, Hopital Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France
    Bull Acad Natl Med 195:1335-42; discussion 1342-4. 2011
  7. doi request reprint Budesonide/formoterol maintenance and reliever therapy versus conventional best practice
    Pascal Demoly
    University Hospital of Montpellier and INSERM U, Hopital Arnaud de Villeneuve, France
    Respir Med 103:1623-32. 2009
  8. doi request reprint Desloratadine for the treatment of cypress pollen-induced allergic rhinitis
    Pascal Demoly
    Allergy Department, INSERM U657, Maladies Respiratoires, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France
    Ann Allergy Asthma Immunol 103:260-6. 2009
  9. doi request reprint Dosing and efficacy in specific immunotherapy
    P Demoly
    University Hospital of Montpellier Inserm U657, Montpellier, France
    Allergy 66:38-40. 2011
  10. doi request reprint Validation of a self-questionnaire for assessing the control of allergic rhinitis
    P Demoly
    Allergy Department, INSERM U657, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France
    Clin Exp Allergy 41:860-8. 2011

Collaborators

Detail Information

Publications42

  1. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
    ..Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein...
  2. pmc EAACI: A European Declaration on Immunotherapy. Designing the future of allergen specific immunotherapy
    Moises A Calderon
    Section of Allergy and Clinical Immunology, Imperial College, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    Clin Transl Allergy 2:20. 2012
    ....
  3. pmc Drug provocation tests: up-date and novel approaches
    Anca Mirela Chiriac
    Allergy Unit, Hopital Arnaud de Villeneuve, 371 Avenue du Doyen Giraud, Montpellier, 34295, France
    Allergy Asthma Clin Immunol 9:12. 2013
    ..Novel (or sometimes, simply renewed) approaches arise, awaiting to be either validated or refuted in larger studies in the future. Instead of covering the whole topic of DPTs, this paper will address these recent and challenging aspects...
  4. pmc Assessment of disease control in allergic rhinitis
    Pascal Demoly
    Allergy Division, Pulmonary Department, INSERM U657 EA2415, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France
    Clin Transl Allergy 3:7. 2013
    ..We conclude that there is a need for research in which severity is compared with control in terms of their effects on patient management...
  5. pmc Comprehensive allergy work-up is mandatory in cystic fibrosis patients who report a history suggestive of drug allergy to beta-lactam antibiotics
    Silvia Caimmi
    Allergy Unit, Deépartement de Pneumologie et Addictologie, Hopital Arnaud de Villeneuve, University Hospital of Montpellier and Inserm U657, 37, avenue du Doyen Gaston Giraud, 34295, Montpellier Cedex 5, France
    Clin Transl Allergy 2:10. 2012
    ..abstract:..
  6. ncbi request reprint [Contribution of epidemiology to the prevention of drug allergies]
    Pascal Demoly
    Pneumologie et Addictologie, INSERM U657, Hopital Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France
    Bull Acad Natl Med 195:1335-42; discussion 1342-4. 2011
    ..This review examines the place of interventional epidemiology in the field of drug allergy, taking as examples both myorelaxant-induced anaphylaxis and abacavir-induced DRESS...
  7. doi request reprint Budesonide/formoterol maintenance and reliever therapy versus conventional best practice
    Pascal Demoly
    University Hospital of Montpellier and INSERM U, Hopital Arnaud de Villeneuve, France
    Respir Med 103:1623-32. 2009
    ..29; P<0.01) while risk of remaining uncontrolled decreased (25% versus 29%, OR 0.81; P<0.01). Budesonide/formoterol maintenance and reliever therapy improves key aspects of asthma control versus physicians' choice of CBP...
  8. doi request reprint Desloratadine for the treatment of cypress pollen-induced allergic rhinitis
    Pascal Demoly
    Allergy Department, INSERM U657, Maladies Respiratoires, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France
    Ann Allergy Asthma Immunol 103:260-6. 2009
    ..Few studies have been conducted to assess treatment options for patients with sensitivities to cypress pollens, important triggers of allergic rhinitis (AR) in the Mediterranean region...
  9. doi request reprint Dosing and efficacy in specific immunotherapy
    P Demoly
    University Hospital of Montpellier Inserm U657, Montpellier, France
    Allergy 66:38-40. 2011
    ..However, our analysis of the available studies concluded that every product requires its own dose-response relationship study...
  10. doi request reprint Validation of a self-questionnaire for assessing the control of allergic rhinitis
    P Demoly
    Allergy Department, INSERM U657, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France
    Clin Exp Allergy 41:860-8. 2011
    ..Allergic rhinitis affects the lives of patients for whom discomfort is, in most cases, significantly improved by pharmacological treatment...
  11. ncbi request reprint [Allergen-specific immunotherapy or desensitization]
    Pascal Demoly
    Unité d Exploration des Allergies, Maladies Respiratoires, Hopital Arnaud de Villeneuve, CHU de Montpellier et Inserm U657, 34295 Montpellier Cedex 5, France
    Bull Acad Natl Med 193:1127-44; discussion 1144-5. 2009
    ..More information is also needed on patient selection, the treatment duration, and dosing schedules...
  12. ncbi request reprint [Nasal allergy and asthma: one or two diseases?]
    Pascal Demoly
    Maladies Respiratoires, INSERM U454, IFR3, Hopital Arnaud de Villeneuve, CHU de Montpellier, 34295 Montpellier cedex 05
    Bull Acad Natl Med 189:1461-73. 2005
    ....
  13. doi request reprint Impact of allergic rhinitis symptoms on quality of life in primary care
    Philippe Jean Bousquet
    University Hospital, CHU de Montpellier, Montpellier, France
    Int Arch Allergy Immunol 160:393-400. 2013
    ..Allergic rhinitis (AR) impairs quality of life (QoL), sleep and work. The Allergic Rhinitis and its Impact on Asthma (ARIA) classification is widely used, but the impact of the different symptoms on QoL is not clear...
  14. doi request reprint The Consolidated Standards of Reporting Trials (CONSORT) Statement applied to allergen-specific immunotherapy with inhalant allergens: a Global Allergy and Asthma European Network (GA(2)LEN) article
    Philippe J Bousquet
    Department of Respiratory Diseases, University Hospital of Montpellier, Montpellier, France
    J Allergy Clin Immunol 127:49-56, 56.e1-11. 2011
    ..Randomized trials provide evidence to inform treatment decisions. The Consolidated Standards of Reporting Trials (CONSORT) Statement is a set of recommendations for the reporting of trials...
  15. doi request reprint Safety of cefuroxime as an alternative in patients with a proven hypersensitivity to penicillins: a DAHD cohort survey
    Silvia Caimmi
    Exploration des Allergies, Clinique des Maladies Respiratoires and INSERM U657, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, 371 Avenue du Doyen Gaston Giraud, Montpellier Cedex 5, France
    Int Arch Allergy Immunol 153:53-60. 2010
    ..In patients sensitized to beta-lactams, a safe beta-lactam alternative is often needed. The objective was to assess the safety of cefuroxime in patients with a proven beta-lactam allergy...
  16. ncbi request reprint Epidemiology of hypersensitivity drug reactions
    Eva Rebelo Gomes
    Allergy Department, INSERM U454 IFR3, Arnaud de Villeneuve Hospital, University Hospital of Montpellier, Montpellier, France
    Curr Opin Allergy Clin Immunol 5:309-16. 2005
    ..This review summarizes current knowledge on the incidence, prevalence, mortality and risk factors for these reactions in different populations...
  17. ncbi request reprint Accuracy of a pharmacovigilance algorithm in diagnosing drug hypersensitivity reactions
    Said Benahmed
    Exploration des Allergies, Maladies Respiratoires, and Département d Information Médicale, Hopital Arnaud de Villeneuve, Montpellier, France
    Arch Intern Med 165:1500-5. 2005
    ..This study was performed to evaluate the diagnostic accuracy of a pharmacovigilance algorithm in patients with 1 or more histories suggestive of drug hypersensitivity...
  18. ncbi request reprint Comparison of pharmacovigilance algorithms in drug hypersensitivity reactions
    Said Benahmed
    Exploration des Allergies Maladies Respiratoires, INSERM U454 IFR3, Hopital Arnaud de Villeneuve, CHU Montpellier, 34295 Montpellier Cedex 5, France
    Eur J Clin Pharmacol 61:537-41. 2005
    ..A firm diagnosis of drug hypersensitivity, because it may re-induce the reaction, is seldom confirmed. Causality assessment algorithms are therefore of interest...
  19. ncbi request reprint Treatment of allergic rhinitis during pregnancy
    Pascal Demoly
    Department of Respiratory Medicine, INSERM U454, Hospital Arnaud de Villeneuve, University Hospital of Montpellier, 34295 Cedex 5 Montpellier, France
    Drugs 63:1813-20. 2003
    ..There are no such data available for intra-nasal decongestants. Finally, pregnancy is not considered as a contraindication for the continuation of allergen specific immunotherapy...
  20. doi request reprint How Can We Better Classify NSAID Hypersensitivity Reactions? - Validation from a Large Database
    Silvia Caimmi
    Allergy Department and INSERM U657, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France
    Int Arch Allergy Immunol 159:306-12. 2012
    ..It allows clinicians to identify patients at a high risk, based on the clinical history and clinical manifestations. Moreover, it is helpful for a better understanding and teaching of these reactions...
  21. ncbi request reprint Update on beta-lactam allergy diagnosis
    Pascal Demoly
    Exploration des Allergies, Maladies Respiratoires, INSERM U454 IFR3, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, 34295 Montpellier Cedex 5, France
    Curr Allergy Asthma Rep 5:9-14. 2005
    ..In this review, we describe the general guidelines for evaluating subjects in whom there is suspicion of allergic reactions to beta-lactams...
  22. doi request reprint Safety of intranasal corticosteroids in acute rhinosinusitis
    Pascal Demoly
    Clinical Department of Allergology, Maladies Respiratoires, INSERM U657, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier Cedex 5, France
    Am J Otolaryngol 29:403-13. 2008
    ....
  23. ncbi request reprint Immunotherapy: clinical trials--optimal trial and clinical outcomes
    Philippe Jean Bousquet
    Clinique des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Centre Hospitalier Universitaire, Montpellier, France
    Curr Opin Allergy Clin Immunol 7:561-6. 2007
    ..Although specific immunotherapy was introduced a century ago, very few trials meet the criteria for pivotal studies. The paper reviews the methods which should be used to investigate specific immunotherapy...
  24. doi request reprint Update in drug allergy: novel drugs with novel reaction patterns
    Marta Rubio
    Allergy Department and INSERM U657, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France
    Curr Opin Allergy Clin Immunol 10:457-62. 2010
    ..This review summarizes current knowledge on the epidemiology, mechanisms, and clinical and in-vitro diagnosis of these reactions...
  25. ncbi request reprint Managing asthma during pregnancy
    Pascal Demoly
    Exploration des Allergies Maladies Respiratoires, INSERM U454, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, 34295 Montpellier Cedex 5, France
    Lancet 365:1212-3. 2005
  26. ncbi request reprint Confirmation of the diagnosis of natural rubber latex allergy by the Basotest method
    Marie Laure Hemery
    Unit, Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Montpellier, France
    Int Arch Allergy Immunol 136:53-7. 2005
    ..The aim of this study was to evaluate the performance (specificity and sensitivity) of Basotest in the diagnosis of natural rubber latex allergy...
  27. ncbi request reprint [ERAP, a pharmaco-epidemiologic survey on perennial allergic rhinitis in every day medical practice in France]
    Pascal Demoly
    Service des Maladies Respiratoires, INSERM U454 IFR3, Hopital Arnaud de Villeneuve, CHU de Montpellier, 34
    Presse Med 32:1066-73. 2003
    ..In order to gain knowledge on the management of perennial allergic rhinitis by the practitioners in France, a survey (Enquête épidémiologique sur la rhinite allergique per-annuelle en pratique quotidienne--ERAP) was developed...
  28. doi request reprint [Respiratory allergies]
    Anca Mirela Chiriac
    Hopital Arnaud de Villeneuve, Département de Pneumologie et Addictologie, INSERM U657, 34295 Montpellier Cedex 5, France
    Presse Med 42:395-404. 2013
    ..In terms of route of administration, sublingual immunotherapy represents a good alternative to subcutaneous immunotherapy, considering its proven efficacy and better safety profile...
  29. ncbi request reprint Classification and epidemiology of hypersensitivity drug reactions
    Pascal Demoly
    Allergy Department, Maladies Respiratoires and INSERM U454 IFR3, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, 34295 Montpellier Cedex 5, France
    Immunol Allergy Clin North Am 24:345-56, v. 2004
    ..True epidemiologic data are limited, and most of the available information on the incidence, mortality, and socioeconomic impact should be discussed with caution...
  30. ncbi request reprint Anaphylactic reactions--value of skin and provocation tests
    Pascal Demoly
    Exploration des Allergies, Maladies Respiratoires, INSERM U454, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, 34295 Montpellier, France
    Toxicology 209:221-3. 2005
    ..These tools are currently being evaluated by the European Network of Drug Allergy, under the aegis of the EAACI drug hypersensitivity group of interest...
  31. ncbi request reprint Effects of carbamazepine and metabolites on IL-2, IL-5, IL-6, IL-10 and IFN-γ secretion in epileptic patients: the influence of co-medication
    Olivier Mathieu
    Département de Pharmacologie Médicale et Toxicologie, Centre Hospitalier Régional Universitaire de Montpellier, 191, Avenue Gaston Giraud, 34295 Montpellier Cedex 5, France
    Pharmacol Rep 63:86-94. 2011
    ....
  32. ncbi request reprint [Hypersensitivity to insulin]
    Djamel Messaad
    Exploration des Allergies, Maladies Respiratoires, INSERM U454 IFR3, Hopital Arnaud de Villeneuve, CHU, Montpellier
    Presse Med 33:631-8. 2004
    ..This frequency has decreased from 1 to 55% with non purified insulins and to 0.1 to 2% with newly generated insulins...
  33. ncbi request reprint Drug provocation tests in patients with a history suggesting an immediate drug hypersensitivity reaction
    Djamel Messaad
    Hopital Arnaud de Villeneuve, Montpellier, France
    Ann Intern Med 140:1001-6. 2004
    ..Drug hypersensitivity reactions are common and can be life-threatening. Confirmation of the diagnosis should be rigorous and based on clinical history and a physical examination, possibly followed by skin tests and drug provocation tests...
  34. doi request reprint Montelukast in guidelines and beyond
    Jean Bousquet
    Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, 371 Avenue Doyen Gaston Giraud, 34275 Montpellier, Cedex 5, France
    Adv Ther 26:575-87. 2009
    ..This review includes new studies that have not yet been considered in guidelines...
  35. ncbi request reprint The relation between asthma and allergic rhinitis
    Pascal Demoly
    Exploration des Allergies Maladies Respiratoires INSERM U454, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, 34295 Montpellier Cedex 5, France
    Lancet 368:711-3. 2006
  36. ncbi request reprint [Drug allergy and hypersensitivity. Risk factors]
    Pascal Demoly
    Exploration des Allergies Maladies Respiratoires, INSERM, Hopital Arnaud de Villeneuve, avenue du Doyen Gaston Giraud, 34295 Montpellier 5, France
    Bull Acad Natl Med 190:1733-42; discussion 1742-4. 2006
    ..An ongoing study by our group points to a role of polymorphisms within the IL-10 promoter and in the IL-4Ralpha gene in immediate reactions to beta-lactams...
  37. ncbi request reprint [Identifying and understanding drug allergies]
    Pascal Demoly
    Inserm U 454 IFR3, Hopital Arnaud de Villeneuve, Avenue Gaston Giraud, 34295 Montpellier, France
    Med Sci (Paris) 19:327-36. 2003
    ....
  38. ncbi request reprint IFN-gamma-mediated inhibition of human IgE synthesis by IL-21 is associated with a polymorphism in the IL-21R gene
    Jerome Pene
    Institut National de la Sante et de la Recherche Medicale, Unite 454, Centre Hospitalier Universitaire St Eloi, Montpellier, France
    J Immunol 177:5006-13. 2006
    ....
  39. ncbi request reprint Asthma therapy during pregnancy
    Pascal Demoly
    Exploration des Allergies Maladies Respiratoires INSERM U454, Hopital Arnaud de Villeneuve, Institut Universitaire de Recherche Clinique de Montpellier, University Hospital of Montpellier, 34295 Montpellier Cedex 5, France
    Expert Opin Pharmacother 4:1019-23. 2003
    ..Usually, there is at least one 'safe' drug from each major class used to control symptoms. We will review the current literature on this subject...
  40. ncbi request reprint [Drug allergies and drug hypersensitivities]
    Pascal Demoly
    Unité d Exploration des Allergies, maladies respiratoires Inserm, Hopital Arnaud de Villeneuve, CHU de Montpellier, 34295 Montpellier Cedex 5
    Rev Prat 57:1326-30. 2007
    ..Biological tests are being evaluated. When properly performed in specialised centres, a firm diagnosis is often possible and safe alternative medication can be proposed...
  41. ncbi request reprint Drug allergy diagnosis work up
    Pascal Demoly
    Maladies Respiratoires, INSERM U454, Hopital Arnaud de Villeneuve, CHU de Montpellier, F 34295 Montpellier, France
    Allergy 57:37-40. 2002
    ..These tools are currently being evaluated by the European Network of Drug Allergy, under the aegis of the EAACI drug hypersensitivity group of interest...
  42. ncbi request reprint Overexpression of the human glucocorticoid receptor alpha and beta isoforms inhibits AP-1 and NF-kappaB activities hormone independently
    Claire Gougat
    Institut National de la Santé et de la Recherche Médicale U454 IFR3 and Service des Maladies Respiratoires, CHU de Montpellier, 34295 Montpellier Cedex 5, France
    J Mol Med (Berl) 80:309-18. 2002
    ..This property was not shared by the closely related mineralocorticoid receptor. Our results suggest that overexpression of either GRalpha or GRbeta may have an anti-inflammatory effect...