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Species | Pascal DemolySummaryCountry: France Publications
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Publications
Drug provocation tests: up-date and novel approachesAnca Mirela Chiriac
Allergy Unit, Hopital Arnaud de Villeneuve, 371 Avenue du Doyen Giraud, Montpellier, 34295, France
Allergy Asthma Clin Immunol 9:12. 2013..Novel (or sometimes, simply renewed) approaches arise, awaiting to be either validated or refuted in larger studies in the future. Instead of covering the whole topic of DPTs, this paper will address these recent and challenging aspects...- Assessment of disease control in allergic rhinitisPascal Demoly
Allergy Division, Pulmonary Department, INSERM U657 EA2415, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France
Clin Transl Allergy 3:7. 2013..We conclude that there is a need for research in which severity is compared with control in terms of their effects on patient management... 
Comprehensive allergy work-up is mandatory in cystic fibrosis patients who report a history suggestive of drug allergy to beta-lactam antibioticsSilvia Caimmi
Allergy Unit, Deépartement de Pneumologie et Addictologie, Hopital Arnaud de Villeneuve, University Hospital of Montpellier and Inserm U657, 37, avenue du Doyen Gaston Giraud, 34295, Montpellier Cedex 5, France
Clin Transl Allergy 2:10. 2012..abstract:..
[Contribution of epidemiology to the prevention of drug allergies]Pascal Demoly
Pneumologie et Addictologie, INSERM U657, Hopital Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France
Bull Acad Natl Med 195:1335-42; discussion 1342-4. 2011..This review examines the place of interventional epidemiology in the field of drug allergy, taking as examples both myorelaxant-induced anaphylaxis and abacavir-induced DRESS...- Desloratadine for the treatment of cypress pollen-induced allergic rhinitisPascal Demoly
Allergy Department, INSERM U657, Maladies Respiratoires, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France
Ann Allergy Asthma Immunol 103:260-6. 2009..Few studies have been conducted to assess treatment options for patients with sensitivities to cypress pollens, important triggers of allergic rhinitis (AR) in the Mediterranean region... - Budesonide/formoterol maintenance and reliever therapy versus conventional best practicePascal Demoly
University Hospital of Montpellier and INSERM U, Hopital Arnaud de Villeneuve, France
Respir Med 103:1623-32. 2009..29; P<0.01) while risk of remaining uncontrolled decreased (25% versus 29%, OR 0.81; P<0.01). Budesonide/formoterol maintenance and reliever therapy improves key aspects of asthma control versus physicians' choice of CBP... - Dosing and efficacy in specific immunotherapyP Demoly
University Hospital of Montpellier Inserm U657, Montpellier, France
Allergy 66:38-40. 2011..However, our analysis of the available studies concluded that every product requires its own dose-response relationship study... - Validation of a self-questionnaire for assessing the control of allergic rhinitisP Demoly
Allergy Department, INSERM U657, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France
Clin Exp Allergy 41:860-8. 2011..Allergic rhinitis affects the lives of patients for whom discomfort is, in most cases, significantly improved by pharmacological treatment... - [Allergen-specific immunotherapy or desensitization]Pascal Demoly
Unité d Exploration des Allergies, Maladies Respiratoires, Hopital Arnaud de Villeneuve, CHU de Montpellier et Inserm U657, 34295 Montpellier Cedex 5, France
Bull Acad Natl Med 193:1127-44; discussion 1144-5. 2009..More information is also needed on patient selection, the treatment duration, and dosing schedules... - [Nasal allergy and asthma: one or two diseases?]Pascal Demoly
Maladies Respiratoires, INSERM U454, IFR3, Hopital Arnaud de Villeneuve, CHU de Montpellier, 34295 Montpellier cedex 05
Bull Acad Natl Med 189:1461-73. 2005.... - The Consolidated Standards of Reporting Trials (CONSORT) Statement applied to allergen-specific immunotherapy with inhalant allergens: a Global Allergy and Asthma European Network (GA(2)LEN) articlePhilippe J Bousquet
Department of Respiratory Diseases, University Hospital of Montpellier, Montpellier, France
J Allergy Clin Immunol 127:49-56, 56.e1-11. 2011..Randomized trials provide evidence to inform treatment decisions. The Consolidated Standards of Reporting Trials (CONSORT) Statement is a set of recommendations for the reporting of trials... - Safety of cefuroxime as an alternative in patients with a proven hypersensitivity to penicillins: a DAHD cohort surveySilvia Caimmi
Exploration des Allergies, Clinique des Maladies Respiratoires and INSERM U657, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, 371 Avenue du Doyen Gaston Giraud, Montpellier Cedex 5, France
Int Arch Allergy Immunol 153:53-60. 2010..In patients sensitized to beta-lactams, a safe beta-lactam alternative is often needed. The objective was to assess the safety of cefuroxime in patients with a proven beta-lactam allergy... - Comparison of pharmacovigilance algorithms in drug hypersensitivity reactionsSaid Benahmed
Exploration des Allergies Maladies Respiratoires, INSERM U454 IFR3, Hopital Arnaud de Villeneuve, CHU Montpellier, 34295 Montpellier Cedex 5, France
Eur J Clin Pharmacol 61:537-41. 2005..A firm diagnosis of drug hypersensitivity, because it may re-induce the reaction, is seldom confirmed. Causality assessment algorithms are therefore of interest... - Accuracy of a pharmacovigilance algorithm in diagnosing drug hypersensitivity reactionsSaid Benahmed
Exploration des Allergies, Maladies Respiratoires, , , Montpellier, France
Arch Intern Med 165:1500-5. 2005..CONCLUSION: A pharmacovigilance algorithm is not accurate for the diagnosis of drug hypersensitivity reactions and cannot replace drug allergy testing... - Epidemiology of hypersensitivity drug reactionsEva Rebelo Gomes
Allergy Department, INSERM U454 - IFR3, Arnaud de Villeneuve Hospital, University Hospital of Montpellier, Montpellier, France
Curr Opin Allergy Clin Immunol 5:309-16. 2005..Such studies will be helpful in identifying patients at risk of developing such reactions, in particular severe reactions, and implementing early preventive measures... - Treatment of allergic rhinitis during pregnancyPascal Demoly
Department of Respiratory Medicine, INSERM U454, Hospital Arnaud de Villeneuve, University Hospital of Montpellier, 34295 Cedex 5 Montpellier, France
Drugs 63:1813-20. 2003..There are no such data available for intra-nasal decongestants. Finally, pregnancy is not considered as a contraindication for the continuation of allergen specific immunotherapy... - How Can We Better Classify NSAID Hypersensitivity Reactions? - Validation from a Large DatabaseSilvia Caimmi
Allergy Department and INSERM U657, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France
Int Arch Allergy Immunol 159:306-12. 2012..It allows clinicians to identify patients at a high risk, based on the clinical history and clinical manifestations. Moreover, it is helpful for a better understanding and teaching of these reactions... - Update on beta-lactam allergy diagnosisPascal Demoly
Exploration des Allergies, Maladies Respiratoires, INSERM U454 IFR3, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, 34295 Montpellier Cedex 5, France
Curr Allergy Asthma Rep 5:9-14. 2005..In this review, we describe the general guidelines for evaluating subjects in whom there is suspicion of allergic reactions to beta-lactams... - Safety of intranasal corticosteroids in acute rhinosinusitisPascal Demoly
Clinical Department of Allergology, Maladies Respiratoires, INSERM U657, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier Cedex 5, France
Am J Otolaryngol 29:403-13. 2008.... - Immunotherapy: clinical trials--optimal trial and clinical outcomesPhilippe Jean Bousquet
Clinique des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Centre Hospitalier Universitaire, Montpellier, France
Curr Opin Allergy Clin Immunol 7:561-6. 2007..Although specific immunotherapy was introduced a century ago, very few trials meet the criteria for pivotal studies. The paper reviews the methods which should be used to investigate specific immunotherapy... - Managing asthma during pregnancyPascal Demoly
Exploration des Allergies-Maladies Respiratoires, INSERM U454, , University Hospital of Montpellier, 34295 Montpellier Cedex 5, France
Lancet 365:1212-3. 2005 - Update in drug allergy: novel drugs with novel reaction patternsMarta Rubio
Allergy Department and INSERM U657, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France
Curr Opin Allergy Clin Immunol 10:457-62. 2010..This review summarizes current knowledge on the epidemiology, mechanisms, and clinical and in-vitro diagnosis of these reactions... - Confirmation of the diagnosis of natural rubber latex allergy by the Basotest methodMarie Laure Hemery
Unit, Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Montpellier, France
Int Arch Allergy Immunol 136:53-7. 2005..The aim of this study was to evaluate the performance (specificity and sensitivity) of Basotest in the diagnosis of natural rubber latex allergy... - [ERAP, a pharmaco-epidemiologic survey on perennial allergic rhinitis in every day medical practice in France]Pascal Demoly
Service des Maladies Respiratoires, INSERM U454 IFR3, Hopital Arnaud de Villeneuve, CHU de Montpellier, 34
Presse Med 32:1066-73. 2003..In order to gain knowledge on the management of perennial allergic rhinitis by the practitioners in France, a survey (Enquête épidémiologique sur la rhinite allergique per-annuelle en pratique quotidienne--ERAP) was developed... - Impact of allergic rhinitis symptoms on quality of life in primary carePhilippe Jean Bousquet
University Hospital, CHU de Montpellier, Montpellier, France
Int Arch Allergy Immunol 160:393-400. 2013..45, 95% CI: 1.028-2.042). Sneezing and rhinorrhea did not impact RQLQ. Conclusions: This study confirmed that ocular symptoms and, to a lesser degree, nasal obstruction and pruritus have a significant impact on QoL... - Effects of carbamazepine and metabolites on IL-2, IL-5, IL-6, IL-10 and IFN-γ secretion in epileptic patients: the influence of co-medicationOlivier Mathieu
Département de Pharmacologie Médicale et Toxicologie, Centre Hospitalier Régional Universitaire de Montpellier, 191, Avenue Gaston Giraud, 34295 Montpellier Cedex 5, France
Pharmacol Rep 63:86-94. 2011.... - Montelukast in guidelines and beyondJean Bousquet
Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, 371 Avenue Doyen Gaston Giraud, 34275 Montpellier, Cedex 5, France
Adv Ther 26:575-87. 2009..This review includes new studies that have not yet been considered in guidelines... - The relation between asthma and allergic rhinitisPascal Demoly
Exploration des Allergies-Maladies Respiratoires-INSERM U454, , University Hospital of Montpellier, 34295 Montpellier Cedex 5, France
Lancet 368:711-3. 2006 - Anaphylactic reactions--value of skin and provocation testsPascal Demoly
Exploration des Allergies, Maladies Respiratoires, INSERM U454, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, 34295 Montpellier, France
Toxicology 209:221-3. 2005..These tools are currently being evaluated by the European Network of Drug Allergy, under the aegis of the EAACI drug hypersensitivity group of interest... - Classification and epidemiology of hypersensitivity drug reactionsPascal Demoly
Allergy Department, Maladies Respiratoires and INSERM U454 IFR3, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, 34295 Montpellier Cedex 5, France
Immunol Allergy Clin North Am 24:345-56, v. 2004..True epidemiologic data are limited, and most of the available information on the incidence, mortality, and socioeconomic impact should be discussed with caution... - [Hypersensitivity to insulin]Djamel Messaad
Exploration des Allergies, Maladies Respiratoires, INSERM U454 IFR3, Hopital Arnaud de Villeneuve, CHU, Montpellier
Presse Med 33:631-8. 2004..Finally, the switch to another insulin or even a tolerance induction with the least skin test reactive insulin as a last resource. The most severe systemic reactions are an indication for tolerance induction... - Drug provocation tests in patients with a history suggesting an immediate drug hypersensitivity reactionDjamel Messaad
Hopital Arnaud de Villeneuve, Montpellier, France
Ann Intern Med 140:1001-6. 2004..CONCLUSIONS: Drug provocation tests in individuals with suspected drug allergy performed in carefully controlled settings can confirm drug hypersensitivity... - [Drug allergy and hypersensitivity. Risk factors]Pascal Demoly
Exploration des Allergies - Maladies Respiratoires, INSERM, , avenue du Doyen Gaston Giraud, 34295 Montpellier 5, France
Bull Acad Natl Med 190:1733-42; discussion 1742-4. 2006..An ongoing study by our group points to a role of polymorphisms within the IL-10 promoter and in the IL-4Ralpha gene in immediate reactions to beta-lactams... - [Identifying and understanding drug allergies]Pascal Demoly
Inserm U 454 IFR3, Hopital Arnaud de Villeneuve, Avenue Gaston Giraud, 34295 Montpellier, France
Med Sci (Paris) 19:327-36. 2003.... - [Drug allergies and drug hypersensitivities]Pascal Demoly
Unité d Exploration des Allergies, maladies respiratoires Inserm, Hopital Arnaud de Villeneuve, CHU de Montpellier, 34295 Montpellier Cedex 5
Rev Prat 57:1326-30. 2007..Biological tests are being evaluated. When properly performed in specialised centres, a firm diagnosis is often possible and safe alternative medication can be proposed... - IFN-gamma-mediated inhibition of human IgE synthesis by IL-21 is associated with a polymorphism in the IL-21R geneJerome Pene
Institut National de la Sante et de la Recherche Medicale, Unite 454, Centre Hospitalier Universitaire St Eloi, Montpellier, France
J Immunol 177:5006-13. 2006.... - Asthma therapy during pregnancyPascal Demoly
Exploration des Allergies Maladies Respiratoires INSERM U454, Hopital Arnaud de Villeneuve, Institut Universitaire de Recherche Clinique de Montpellier, University Hospital of Montpellier, 34295 Montpellier Cedex 5, France
Expert Opin Pharmacother 4:1019-23. 2003..Usually, there is at least one 'safe' drug from each major class used to control symptoms. We will review the current literature on this subject... - [Respiratory allergies]Anca Mirela Chiriac
Hopital Arnaud de Villeneuve, Département de Pneumologie et Addictologie, INSERM U657, 34295 Montpellier Cedex 5, France
Presse Med 42:395-404. 2013..In terms of route of administration, sublingual immunotherapy represents a good alternative to subcutaneous immunotherapy, considering its proven efficacy and better safety profile... - Drug allergy diagnosis work upPascal Demoly
Maladies Respiratoires, INSERM U454, , CHU de Montpellier, F-34295 Montpellier, France
Allergy 57:37-40. 2002..These tools are currently being evaluated by the European Network of Drug Allergy, under the aegis of the EAACI drug hypersensitivity group of interest... - Overexpression of the human glucocorticoid receptor alpha and beta isoforms inhibits AP-1 and NF-kappaB activities hormone independentlyClaire Gougat
, CHU de Montpellier, 34295 Montpellier Cedex 5, France
J Mol Med 80:309-18. 2002..This property was not shared by the closely related mineralocorticoid receptor. Our results suggest that overexpression of either GRalpha or GRbeta may have an anti-inflammatory effect...