Celine Demougeot


Country: France


  1. request reprint
    Demougeot C, Prigent Tessier A, Bagnost T, André C, Guillaume Y, Bouhaddi M, et al. Time course of vascular arginase expression and activity in spontaneously hypertensive rats. Life Sci. 2007;80:1128-34 pubmed
    ..They also demonstrated a close relationship between arginase activity and BP, thus making arginase a promising target for antihypertensive therapy. ..
  2. Bordy R, Quirié A, Marie C, Wendling D, Totoson P, Demougeot C. Vascular Arginase Is a Relevant Target to Improve Cerebrovascular Endothelial Dysfunction in Rheumatoid Arthritis: Evidence from the Model of Adjuvant-Induced Arthritis. Transl Stroke Res. 2019;: pubmed publisher
    ..Arginase inhibition appears as a promising therapy beyond anti-rheumatic drugs for reducing the risk of cerebrovascular diseases in RA. ..
  3. Wisutthathum S, Demougeot C, Totoson P, Adthapanyawanich K, Ingkaninan K, Temkitthawon P, et al. Eulophia macrobulbon extract relaxes rat isolated pulmonary artery and protects against monocrotaline-induced pulmonary arterial hypertension. Phytomedicine. 2018;50:157-165 pubmed publisher
    ..PAH is improved by EM extract acting through PA relaxation mediated through endothelial NO, reduced Ca2+-mobilization, and reduced PA wall thickness and right ventricular hypertrophy. ..
  4. request reprint
    Bordy R, Verhoeven F, Tournier Nappey M, Wendling D, Demougeot C, Totoson P. Methotrexate did not improve endothelial function in rheumatoid arthritis: a study in rats with adjuvant-induced arthritis. Clin Exp Rheumatol. 2019;37:81-88 pubmed
    ..Overall data suggest that mechanisms other than the ED reduction are likely involved, and remain to be elucidated to better understand the cardiovascular benefits of methotrexate in rheumatoid arthritis. ..
  5. Bordy R, Totoson P, Prati C, Marie C, Wendling D, Demougeot C. Microvascular endothelial dysfunction in rheumatoid arthritis. Nat Rev Rheumatol. 2018;14:404-420 pubmed publisher
    ..Such findings could have important implications in the cardiovascular risk management of patients with RA. ..
  6. Mossiat C, Laroche D, Prati C, Pozzo T, Demougeot C, Marie C. Association between arthritis score at the onset of the disease and long-term locomotor outcome in adjuvant-induced arthritis in rats. Arthritis Res Ther. 2015;17:184 pubmed publisher
    ..Decreased ankle mobility can be considered a driver of locomotion impairment in AIA. In this model, the severity of the initial inflammatory symptoms had a good prognostic value for long-term locomotor outcome. ..
  7. Totoson P, Maguin Gaté K, Prigent Tessier A, Monnier A, Verhoeven F, Marie C, et al. Etanercept improves endothelial function via pleiotropic effects in rat adjuvant-induced arthritis. Rheumatology (Oxford). 2016;55:1308-17 pubmed publisher
    ..These results suggest that etanercept could be a good choice for patients with rheumatoid arthritis at high risk of CV events. ..
  8. Tom E, Girard Thernier C, Demougeot C. The Janus face of chlorogenic acid on vascular reactivity: A study on rat isolated vessels. Phytomedicine. 2016;23:1037-42 pubmed publisher
  9. Verhoeven F, Prati C, Maguin Gaté K, Wendling D, Demougeot C. Glucocorticoids and endothelial function in inflammatory diseases: focus on rheumatoid arthritis. Arthritis Res Ther. 2016;18:258 pubmed
    ..The present review summarizes the available data on the impact of GCs on endothelial function, both in normal and inflammatory conditions, with a special focus on RA patients. ..

More Information


  1. Pham T, Liagre B, Girard Thernier C, Demougeot C. Research of novel anticancer agents targeting arginase inhibition. Drug Discov Today. 2018;23:871-878 pubmed publisher
    ..Among them, some molecules have shown their anticancer effects. The perspectives of arginase inhibitors as new anticancer agents will be discussed. ..
  2. Srimachai S, Devaux S, Demougeot C, Kumphune S, Ullrich N, Niggli E, et al. Bacopa monnieri extract increases rat coronary flow and protects against myocardial ischemia/reperfusion injury. BMC Complement Altern Med. 2017;17:117 pubmed publisher
    ..monnieri. B. monnieri improves myocardial function following ischemia/reperfusion injury through recovery of coronary blood flow, contractile force and decrease in infarct size. Thus this may lead to a novel cardioprotectant strategy. ..
  3. Moretto J, Guglielmetti A, Tournier Nappey M, Martin H, Prigent Tessier A, Marie C, et al. Effects of a chronic l-arginine supplementation on the arginase pathway in aged rats. Exp Gerontol. 2017;90:52-60 pubmed publisher
    ..Moreover, our data argue against the use of the measurement of plasma l-arginine/l-ornithine ratio to estimate arginase activity in aged patients. ..
  4. Verhoeven F, Totoson P, Marie C, Prigent Tessier A, Wendling D, Tournier Nappey M, et al. Diclofenac but not celecoxib improves endothelial function in rheumatoid arthritis: A study in adjuvant-induced arthritis. Atherosclerosis. 2017;266:136-144 pubmed publisher