Research Topics
Genomes and Genes | G DelsolSummaryCountry: France Publications
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Publications
[Molecular abnormalities in lymphomas]G Delsol
Universite Paul Sabatier, CHU de Toulouse Purpan, Toulouse, France
Bull Cancer 97:1347-64. 2010..Lastly several lymphomas are associated with infectious agents that play a direct (EB virus, HTLV1) or indirect role (e.g. Helicobacter pylori in MALT lymphoma) in lymphomagenesis...
Oestrogen synthesis, oestrogen metabolism and functional oestrogen receptors in bovine aortic endothelial cellsF Bayard
INSERM U397, Institut Louis Bugnard, CHU Rangeuil, Toulouse, France
Ciba Found Symp 191:122-32; discussion 132-8. 1995....- A new monoclonal anti-CD3epsilon antibody reactive on paraffin sectionsL Alibaud
Unité de Physiopathologie Cellulaire et Moléculaire, CNRS UPR 2163, Institut Claude de Preval, IFR 30, CHU de Purpan, Toulouse, France
J Histochem Cytochem 48:1609-16. 2000..This new anti-CD3varepsilon antibody would be particularly useful for phenotyping T-cell lymphomas on routinely processed paraffin-embedded tissue sections... 
Expression of the ALK tyrosine kinase gene in neuroblastomaL Lamant
Department of Pathology, Centre Hospitalo Universitaire Purpan, Toulouse, France
Am J Pathol 156:1711-21. 2000..However, no correlation was evident between any known prognostic factors and the level of ALK expression...- CNA.42, a new monoclonal antibody directed against a fixative-resistant antigen of follicular dendritic reticulum cellsI Raymond
Department of Pathology and CIGH CNRS, CHU Purpan, Toulouse, France
Am J Pathol 151:1577-85. 1997..In daily diagnostic practice, CNA.42 MAb seems to be a suitable FDRC marker and possibly has an auxiliary role in recognizing T-cell lymphomas... - Synthetic phosphoantigens enhance human Vgamma9Vdelta2 T lymphocytes killing of non-Hodgkin's B lymphomaH Sicard
INSERM U395, Réponse Immunitaire et CMH, CHU Purpan, Toulouse, France
Mol Med 7:711-22. 2001..Vgamma9Vdelta2 T cells are strongly activated by natural compounds, from which powerful synthetic ligands have been derived. These synthetic antigens induce efficient Vgamma9Vdelta2 T cell responses in vitro... - The CBF.78 monoclonal antibody to human sialophorin has distinct properties giving new insights into the CD43 marker and its activation pathwayJ Tkaczuk
Department of Immunology, Rangueil Hospital, Toulouse, France
Tissue Antigens 54:1-15. 1999..Altogether these data support the hypothesis that there are at least 3 modes of interaction between PKC and CD43 pathways: each pathway is inhibitory towards the other but the CD43 one can also be synergistic... - Relation of follicular dendritic reticulum cells to Reed-Sternberg cells of Hodgkin's disease with emphasis on the expression of CD21 antigenG Delsol
Laboratoire d Anatomie Pathologique, CHU Purpan, Toulouse, France
Am J Pathol 142:1729-38. 1993..Whether FDRC might be the only cells involved in the conversion to RS cells by the loss or gain of antigens remains to be determined... - Coexpression of epithelial membrane antigen (EMA), Ki-1, and interleukin-2 receptor by anaplastic large cell lymphomas. Diagnostic value in so-called malignant histiocytosisG Delsol
Laboratoire d Anatomie Pathologique, CHU Purpan, Toulouse, France
Am J Pathol 130:59-70. 1988.... - Characterization of Epstein-Barr virus-infected cells in benign lymphadenopathy of patients seropositive for human immunodeficiency virusP Brousset
Department of Pathology, Centre Hospitalier Universitaire de Purpan, Toulouse, France
Hum Pathol 27:263-8. 1996.... - Further demonstration of the diversity of chromosomal changes involving 2p23 in ALK-positive lymphoma: 2 cases expressing ALK kinase fused to CLTCL (clathrin chain polypeptide-like)C Touriol
UPCM ERS 1590 CNRS, CHU Purpan, Toulouse, France
Blood 95:3204-7. 2000..These 2 cases, therefore, represent a hitherto undescribed mechanism of ALK activation in lymphoma and further illustrate the diversity of fusion partners for the ALK gene... - A new monoclonal anti-CD7 antibody reactive on paraffin sectionsT Al Saati
Department of Pathology and Unité de Physiopathologie Cellulaire et Moléculaire, CNRS UPR 2163, CHU Purpan, Toulouse, France
Appl Immunohistochem Mol Morphol 9:289-96. 2001..37 mAb in association with other anti-T cell antibodies working on paraffin sections could be of particular value in asserting the diagnosis of T cell lymphomas in routine histopathology... - Serpin A1 is overexpressed in ALK+ anaplastic large cell lymphoma and its expression correlates with extranodal disseminationM M Duplantier
Department of Oncogenesis and Signaling in Hematopoietic Cells, INSERM U 563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
Leukemia 20:1848-54. 2006..These data, together with the pattern of expression of serpin A1 we observed in ALK+ tumors, suggest that serpin A1 has an invasion-promoting effect in ALK+ ALCL... - Establishment of a novel anaplastic large-cell lymphoma-cell line (COST) from a 'small-cell variant' of ALCLL Lamant
Department of Oncogenesis and Signaling in Hematopoietic Cells, Inserm U-563, Centre de Physiopathologie de Toulouse-Purpan, Toulouse, France
Leukemia 18:1693-8. 2004.... - Elevated levels of PtdIns5P in NPM-ALK transformed cells: implication of PIKfyveS Coronas
INSERM, U563, Département Oncogénèse, Signalisation et Innovation thérapeutique, Toulouse, F 31300, France
Biochem Biophys Res Commun 372:351-5. 2008..These data suggest for the first time a role of PtdIns5P and PIKfyve in oncogenesis, potentially linking intracellular trafficking to cancer... - Reactive oxygen species and lipoxygenases regulate the oncogenicity of NPM-ALK-positive anaplastic large cell lymphomasK Thornber
INSERM, U563, Département Oncogénèse, Signalisation et Innovation thérapeutique, Toulouse, France
Oncogene 28:2690-6. 2009..Together, these data point to the ROS/LOX pathway as a potential new target for therapy in NPM-ALK-positive tumors... - "In situ-like" mantle cell lymphoma: a report of two casesP Richard
Department of Pathology, Purpan Hospital, INSERM U563 (CPTP, Centre Hospitalier Universitaire Purpan, Toulouse, France
J Clin Pathol 59:995-6. 2006..To the best of our knowledge, this is the first report on such a pattern of MCL, which is important to recognise, as it can be confused with lymphoid hyperplasia... - Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomasA Colomba
INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
Oncogene 27:2728-36. 2008..The use of Vav3-specific shRNA and a dominant negative Rac1 mutant demonstrates the central role of GTPases in NPM-ALK elicited motility and invasion... - Detection and characterization of human herpesvirus-8-infected cells in bone marrow biopsies of human immunodeficiency virus-positive patientsF Meggetto
Laboratoire d'Anatomie Pathologique, Centre Hospitalier Universitaire de Purpan, Toulouse, France
Hum Pathol 32:288-91. 2001..The local release of vIL-6 may play some role in the plasmacytosis observed in bone marrow in the acquired immunodeficiency syndrome. HUM PATHOL 32:288-291... - Antibody BNH9 detects red blood cell-related antigens on anaplastic large cell (CD30+) lymphomasG Delsol
Department of Anatomical Pathology, CHU Purpan, Toulouse, France
Br J Cancer 64:321-6. 1991..Expression of H and Y antigens was inducible on normal lymphocytes by mitogenic stimulation and by Epstein-Barr virus infection. The data suggest remarkable biological differences of ALC lymphomas within NHL and from HD... - A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1;2)(q25;p23) translocationL Lamant
Department of Pathology, Hematology Laboratory, and UPCM ERS 1590 CNRS, CHU Purpan, Toulouse, France
Blood 93:3088-95. 1999..The present cases of ALCL associated with a novel t(1;2)(q25;p23) demonstrate that at least one fusion partner other than NPM can activate the intracytoplasmic domain of the ALK kinase... - Telomerase activity might persist in the human thymus throughout lifeP Brousset
Laboratoire du Groupe d Etude des Lymphomes Malins, Centre Hospitalier Universitaire de Purpan, Toulouse, France
Mol Pathol 51:170-3. 1998..The two positive cases were patients aged 54 and 66 years. These results suggest strongly that the thymus can remain functional despite involution in elderly patients... - Hypoxia-microRNA-16 downregulation induces VEGF expression in anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphomasE Dejean
Centre de Recherches en Cancérologie de Toulouse, INSERM UMR 1037 Université Toulouse III Paul Sabatier, Toulouse, France
Leukemia 25:1882-90. 2011..Altogether, our results demonstrate, for the first time, the involvement of angiogenesis in ALK+ ALCL and strongly suggest an important role for hypoxia-miR-16 in regulating VEGF translation... - ALK-positive lymphoma: a single disease with a broad spectrum of morphologyD Benharroch
Department of Pathology and CIGH CNRS, CHU Purpan, Toulouse, France
Blood 91:2076-84. 1998..We conclude from this study that ALK-positive neoplasms represent a distinct entity. Because their morphology is often neither anaplastic nor large cell, we suggest that they should henceforward be referred to as ALK lymphomas... - Estrogen synthesis, estrogen metabolism, and functional estrogen receptors in rat arterial smooth muscle cells in cultureF Bayard
INSERM U397, Institut Louis Bugnard, CHU Rangueil, Toulouse, France
Endocrinology 136:1523-9. 1995..This in vitro model is convenient for studying the mechanisms of action of estrogen hormones that seem very peculiar in this cell population...