Philippe Deloron

Summary

Country: France

Publications

  1. pmc Expression of the domain cassette 8 Plasmodium falciparum erythrocyte membrane protein 1 is associated with cerebral malaria in Benin
    Gwladys I Bertin
    Institut de recherche pour le developpement IRD, UMR216 Mère et Enfant face aux Infections Tropicales, Paris, France
    PLoS ONE 8:e68368. 2013
  2. pmc Reliability of rapid diagnostic tests in diagnosing pregnancy-associated malaria in north-eastern Tanzania
    Daniel T R Minja
    National Institute for Medical Research, Tanga Centre, Tanga, Tanzania
    Malar J 11:211. 2012
  3. pmc Possible association of the Plasmodium falciparum T1526C resa2 gene mutation with severe malaria
    Remy Durand
    Laboratoire de Parasitologie Mycologie, Hopital Avicenne, AP HP, 125 rue de Stalingrad, 93009 Bobigny Cedex, France
    Malar J 11:128. 2012
  4. pmc Malaria associated symptoms in pregnant women followed-up in Benin
    Bich Tram Huynh
    IRD UMR 216 Mère et enfant face aux infections tropicales, Faculte des sciences pharmaceutiques, 4 avenue de l Observatoire, 75270 Paris Cedex 06, France
    Malar J 10:72. 2011
  5. pmc Plasmodium falciparum exposure in utero, maternal age and parity influence the innate activation of foetal antigen presenting cells
    Nadine Fievet
    UR010, Mother and Child Health in the Tropics, Institut de recherche pour le developpement IRD, Cotonou, Benin
    Malar J 8:251. 2009
  6. pmc PfHRP2 and PfLDH antigen detection for monitoring the efficacy of artemisinin-based combination therapy (ACT) in the treatment of uncomplicated falciparum malaria
    Sandrine Houze
    Parasitology Laboratory EA209, AP HP, Bichat C, Bernard Hospital, Paris Descartes University, 75018 Paris, France
    Malar J 8:211. 2009
  7. pmc Sulfadoxine/pyrimethamine intermittent preventive treatment for malaria during pregnancy
    Philippe Deloron
    Institut de Recherche pour le Developpement, Paris, France
    Emerg Infect Dis 16:1666-70. 2010
  8. pmc What would PCR assessment change in the management of fevers in a malaria endemic area? A school-based study in Benin in children with and without fever
    Jean François Faucher
    Institut de Recherche pour le Developpement, UMR 216 Mother and Child face with Tropical infections Research Unit, Paris, France
    Malar J 9:224. 2010
  9. ncbi request reprint Dramatically decreased therapeutic efficacy of chloroquine and sulfadoxine-pyrimethamine, but not mefloquine, in southern Benin
    Agnes Aubouy
    Research Unit 010 UR010, Mother and Child Health in the Tropics, Development Research Institute IRD, Cotonou, Benin
    Trop Med Int Health 12:886-94. 2007
  10. pmc Consequences of gestational malaria on birth weight: finding the best timeframe for intermittent preventive treatment administration
    Bich Tram Huynh
    UMR216, Institut de Recherche pour le Developpement, Paris, France
    PLoS ONE 7:e35342. 2012

Collaborators

Detail Information

Publications48

  1. pmc Expression of the domain cassette 8 Plasmodium falciparum erythrocyte membrane protein 1 is associated with cerebral malaria in Benin
    Gwladys I Bertin
    Institut de recherche pour le developpement IRD, UMR216 Mère et Enfant face aux Infections Tropicales, Paris, France
    PLoS ONE 8:e68368. 2013
    ..The PfEMP-1 type expressed determines the adherence phenotype, and is associated with clinical outcome of infection...
  2. pmc Reliability of rapid diagnostic tests in diagnosing pregnancy-associated malaria in north-eastern Tanzania
    Daniel T R Minja
    National Institute for Medical Research, Tanga Centre, Tanga, Tanzania
    Malar J 11:211. 2012
    ..Polymerase chain reaction (PCR) is even more sensitive, but it is mainly used for research purposes. The accuracy and reliability of RDTs in diagnosing PAM was evaluated using microscopy and PCR...
  3. pmc Possible association of the Plasmodium falciparum T1526C resa2 gene mutation with severe malaria
    Remy Durand
    Laboratoire de Parasitologie Mycologie, Hopital Avicenne, AP HP, 125 rue de Stalingrad, 93009 Bobigny Cedex, France
    Malar J 11:128. 2012
    ..The proportion of P. falciparum isolates having a non-stop T1526C mutation in resa2 gene was evaluated and the association of this genotype with severity of malaria was investigated...
  4. pmc Malaria associated symptoms in pregnant women followed-up in Benin
    Bich Tram Huynh
    IRD UMR 216 Mère et enfant face aux infections tropicales, Faculte des sciences pharmaceutiques, 4 avenue de l Observatoire, 75270 Paris Cedex 06, France
    Malar J 10:72. 2011
    ..However, longitudinal cohort studies investigating the clinical presentation of malaria infection in pregnant women in stable endemic areas are lacking, and the few studies exploring this issue are unconclusive...
  5. pmc Plasmodium falciparum exposure in utero, maternal age and parity influence the innate activation of foetal antigen presenting cells
    Nadine Fievet
    UR010, Mother and Child Health in the Tropics, Institut de recherche pour le developpement IRD, Cotonou, Benin
    Malar J 8:251. 2009
    ....
  6. pmc PfHRP2 and PfLDH antigen detection for monitoring the efficacy of artemisinin-based combination therapy (ACT) in the treatment of uncomplicated falciparum malaria
    Sandrine Houze
    Parasitology Laboratory EA209, AP HP, Bichat C, Bernard Hospital, Paris Descartes University, 75018 Paris, France
    Malar J 8:211. 2009
    ....
  7. pmc Sulfadoxine/pyrimethamine intermittent preventive treatment for malaria during pregnancy
    Philippe Deloron
    Institut de Recherche pour le Developpement, Paris, France
    Emerg Infect Dis 16:1666-70. 2010
    ..The World Health Organization recently proposed conducting in vivo studies in pregnant women to evaluate molecular markers for detecting resistance precociously. Other possible alternative strategies are considered...
  8. pmc What would PCR assessment change in the management of fevers in a malaria endemic area? A school-based study in Benin in children with and without fever
    Jean François Faucher
    Institut de Recherche pour le Developpement, UMR 216 Mother and Child face with Tropical infections Research Unit, Paris, France
    Malar J 9:224. 2010
    ..Additional PCR data were analysed in order to touch patho-physiological issues, such as the usefulness of PCR in the management of malaria in an endemic area or the triggering of a malaria attack in children with submicroscopic malaria...
  9. ncbi request reprint Dramatically decreased therapeutic efficacy of chloroquine and sulfadoxine-pyrimethamine, but not mefloquine, in southern Benin
    Agnes Aubouy
    Research Unit 010 UR010, Mother and Child Health in the Tropics, Development Research Institute IRD, Cotonou, Benin
    Trop Med Int Health 12:886-94. 2007
    ..To evaluate the in vivo therapeutic efficacy of chloroquine (CQ), sulfadoxine-pyrimethamine (SP) and mefloquine (MQ) in children presenting with uncomplicated malaria in Benin...
  10. pmc Consequences of gestational malaria on birth weight: finding the best timeframe for intermittent preventive treatment administration
    Bich Tram Huynh
    UMR216, Institut de Recherche pour le Developpement, Paris, France
    PLoS ONE 7:e35342. 2012
    ..Pregnant women should be encouraged to attend antenatal visits early to get their first SP dose and a third dose of SP could be recommended to cover the whole duration of pregnancy and to avoid late infections of the placenta...
  11. pmc Demonstration of a high level of parasite population homology by quantification of Plasmodium falciparum alleles in matched peripheral, placental, and umbilical cord blood samples
    Sayeh Jafari-Guemouri
    Faculté de Phamacie, UR 010, Mother and Child Health in the Tropics, Institut de Recherche pour le Developpement, 75006 Paris, France
    J Clin Microbiol 43:2980-3. 2005
    ..However, identical alleles represented 80 to 95% of the overall parasite populations of each compartment, demonstrating much more homogenous parasite populations than previously thought...
  12. pmc Molecular markers of resistance to sulphadoxine-pyrimethamine during intermittent preventive treatment of pregnant women in Benin
    Gwladys Bertin
    Institut de recherche pour le developpement IRD, Mère et enfant face aux infections tropicales UMR216, Paris Cedex, France
    Malar J 10:196. 2011
    ..falciparum-infected pregnant women before first and second IPTp administration, and at delivery...
  13. pmc Plasmodium falciparum population dynamics in a cohort of pregnant women in Senegal
    Juliette Guitard
    Institut de Recherche pour le Developpement, Universite Paris Descartes, France
    Malar J 9:165. 2010
    ..VAR2CSA is the main candidate for a pregnancy malaria vaccine, but vaccine development may be complicated by its sequence polymorphism...
  14. doi request reprint First-trimester Plasmodium falciparum infections display a typical "placental" phenotype
    Justin Doritchamou
    PRES Sorbonne Paris Cité, Faculte de Pharmacie, Universite Paris Descartes, Paris, France
    J Infect Dis 206:1911-9. 2012
    ..The principal ligand associated with the binding to chondroitin sulfate A (CSA) that allows placental sequestration of IEs is a P. falciparum erythrocyte membrane protein 1 (PfEMP1) family member encoded by the var2csa gene...
  15. doi request reprint Differential adhesion-inhibitory patterns of antibodies raised against two major variants of the NTS-DBL2X region of VAR2CSA
    Justin Doritchamou
    PRES Sorbonne Paris Cité, Faculte de Pharmacie, Universite Paris Descartes, France Institut de Recherche pour le Développement, UMR216 Mère et Enfant face aux Infections Tropicales, Paris, France Centre d Etude et de Recherche sur le paludisme associé à la Grossesse et à l Enfance, Université d Abomey Calavi, Cotonou, Benin
    Vaccine 31:4516-22. 2013
    ..An ultimate challenge is to define epitopes in this region that induce a broad cross-reactive adhesion inhibitory antibody response...
  16. ncbi request reprint Prediction of Plasmodium falciparum placental infection according to the time of infection during pregnancy
    Gilles Cottrell
    Institut de recherche pour le developpement IRD, UR010, Mother and Child Health in the Tropics, Universite Paris Descartes, Paris, France
    Acta Trop 98:255-60. 2006
    ..An earlier initiation of malaria prevention might improve its efficacy...
  17. ncbi request reprint High level of var2csa transcription by Plasmodium falciparum isolated from the placenta
    Nicaise G Tuikue Ndam
    Institut de Recherche pour le Developpement, UR010, Mother and Child Health in the Tropics, Universite Paris Descartes, Paris, France
    J Infect Dis 192:331-5. 2005
    ..These findings support the idea that VAR2CSA plays a crucial role in PAM and strengthen the rationale for the development of VAR2CSA-based vaccines...
  18. pmc Differential evolution of anti-VAR2CSA- IgG3 in primigravidae and multigravidae pregnant women infected by Plasmodium falciparum
    Juliette Guitard
    Institut de recherche pour le developpement IRD, UR010, Mother and Child Health in the Tropics, Universite Paris Descartes, France
    Malar J 7:10. 2008
    ..Pregnant women develop protective anti-VSA IgG1 and IgG3 when infected by Plasmodium falciparum. The major target of IgG from serum of infected pregnant women is VAR2CSA...
  19. doi request reprint Comparison of sulfadoxine-pyrimethamine, unsupervised artemether-lumefantrine, and unsupervised artesunate-amodiaquine fixed-dose formulation for uncomplicated plasmodium falciparum malaria in Benin: a randomized effectiveness noninferiority trial
    Jean François Faucher
    Institut de recherche pour le developpement IRD, Mother and Child Health in the Tropics Research Unit, Cotonou, Benin
    J Infect Dis 200:57-65. 2009
    ..We compared sulfadoxine-pyrimethamine (SP) with unsupervised artemether-lumefantrine (AL) and unsupervised amodiaquine-artesunate (ASAQ) fixed-dose formulation for the treatment of uncomplicated malaria in children in Benin...
  20. ncbi request reprint Variable adhesion abilities and overlapping antigenic properties in placental Plasmodium falciparum isolates
    Nicaise G Tuikue Ndam
    Institut de recherche pour le developpement IRD, UR010, Mother and Child Health in the Tropics, Faculte de Pharmacie, Paris, France
    J Infect Dis 190:2001-9. 2004
    ....
  21. pmc Plasmodium falciparum parasites causing cerebral malaria share variant surface antigens, but are they specific?
    Nabila Kheliouen
    Institut de Recherche pour le Développement IRD UMR216, Mother and Child faced with tropical infections Unit, Paris, 75006, France
    Malar J 9:220. 2010
    ..This study investigated the antibody response specifically directed against VSA expressed by parasites isolated from individuals presenting a given type of clinical presentation...
  22. doi request reprint Differential protein expression profiles between Plasmodium falciparum parasites isolated from subjects presenting with pregnancy-associated malaria and uncomplicated malaria in Benin
    Gwladys I Bertin
    Institut de Recherche pour le Developpement, UMR216 Mère et Enfant face aux Infections Tropicales
    J Infect Dis 208:1987-97. 2013
    ..During intra-erythrocytic maturation, the infected erythrocyte (iE) membrane is modified by insertion of parasite-derived proteins, primarily consisting of variant surface antigens such as P. falciparum erythrocyte membrane protein-1...
  23. pmc Plasmodium falciparum transcriptome analysis reveals pregnancy malaria associated gene expression
    Nicaise Tuikue Ndam
    Institut de Recherche pour le Developpement, UR010 at Université Paris Descartes, Mother and Child Health in the Tropics, Faculte de Pharmacie, Paris, France
    PLoS ONE 3:e1855. 2008
    ..Recent advances on the molecular basis of virulence and immune evasion have helped identify var2csa as a PAM-specific var gene...
  24. pmc Malaria and gravidity interact to modify maternal haemoglobin concentrations during pregnancy
    Smaila Ouédraogo
    Mère et Enfant Face aux Infections Tropicales, IRD Unité mixte de recherche 216, Paris, France
    Malar J 11:348. 2012
    ..This study aimed to evaluate the impact of gravidity on the variation of haemoglobin during pregnancy according to the timing of gestation...
  25. ncbi request reprint High prevalence of Plasmodium falciparum pfcrt K76T mutation in pregnant women taking chloroquine prophylaxis in Senegal
    Gwladys Bertin
    Institut de Recherche pour le Developpement, UR010, Mother and Child Health in the Tropics, Faculte de Pharmacie, 75006 Paris, France
    J Antimicrob Chemother 55:788-91. 2005
    ..The aim of this study was to compare the prevalence rate of pfcrt T76 mutation in P. falciparum isolates from infected pregnant and non-pregnant individuals from Senegal...
  26. ncbi request reprint Development of cellular immune responses to Plasmodium falciparum blood stage antigens from birth to 36 months of age in Cameroon
    Jean Yves Le Hesran
    Institut de recherche pour le developpement IRD, UR 010, Mother and Health in the Tropics, Faculte de Pharmacie, 75006 Paris, France
    Acta Trop 98:261-9. 2006
    ..These results suggest that P. falciparum specific immune responses are first oriented towards a Th2-type of response, and later switch to Th1-type of response...
  27. ncbi request reprint Plasmodium falciparum genotype population dynamics in asymptomatic children from Senegal
    Sayeh Jafari-Guemouri
    UR 010, Mother and Child Health in the Tropics, Institut de recherche pour le developpement IRD, Faculte de Pharmacie, 4, avenue de l Observatoire, Paris, France
    Microbes Infect 8:1663-70. 2006
    ..A single peripheral blood sampling does not reflect the total parasite load. Repeated sampling is needed to have a more detailed scheme of parasite population dynamics and a better knowledge of the true complexity of an infection...
  28. ncbi request reprint IL-12 producing monocytes and IFN-gamma and TNF-alpha producing T-lymphocytes are increased in placentas infected by Plasmodium falciparum
    Ibrahima Diouf
    UR 010, Mother and Child Health in the Tropics, Institut de recherche pour le developpement IRD, BP 1386, Dakar, Senegal
    J Reprod Immunol 74:152-62. 2007
    ..TNF-alpha production by CD4+ and CD8+ T-cells is up-regulated in P. falciparum-infected placentas, suggesting that T-cells actively participate to inflammatory responses...
  29. doi request reprint Functional and immunological characterization of the var2CSA-DBL5epsilon domain of a placental Plasmodium falciparum isolate
    Stéphane Gangnard
    Institut Pasteur, Unité d Immunologie Structurale, CNRS URA2185, Paris, France
    Mol Biochem Parasitol 173:115-22. 2010
    ..The presence of universal epitopes thus supports DBL5epsilon as an interesting component of var2CSA to be considered for vaccine development...
  30. ncbi request reprint Maternally transmitted antibodies to pregnancy-associated variant antigens on the surface of erythrocytes infected with Plasmodium falciparum: relation to child susceptibility to malaria
    Michel Cot
    Mother and Child Health in the Tropics, Research Institute for Development, Hopital Tenon, Paris, France
    Am J Epidemiol 157:203-9. 2003
    ....
  31. pmc Plasmodium falciparum variability and immune evasion proceed from antigenicity of consensus sequences from DBL6ε; generalization to all DBL from VAR2CSA
    Philippe Deloron
    Institut de Recherche pour le Developpement, Mother and Child Faced with Tropical Infections Research Unit, UMR216, Paris, France
    PLoS ONE 8:e54882. 2013
    ..In addition, we identified consensus sequences in other var genes expressed by non-PAM parasites. This finding paves the way for vaccine design against other pathologies caused by P. falciparum...
  32. pmc Dynamics in the Cytoadherence Phenotypes of Plasmodium falciparum Infected Erythrocytes Isolated during Pregnancy
    Justin Doritchamou
    PRES Sorbonne Paris Cité, Faculte de Pharmacie, Universite Paris Descartes, Paris, France UMR216 Mère et enfant face aux infections tropicales, Institut de Recherche pour le Developpement, Paris, France Centre d Etude et de Recherche sur le paludisme associé à la Grossesse et à l Enfance, Université d Abomey Calavi, Cotonou, Benin
    PLoS ONE 9:e98577. 2014
    ....
  33. doi request reprint G6PD A-variant influences the antibody responses to Plasmodium falciparum MSP2
    David Courtin
    Institut de recherche pour le developpement IRD, Unité Mixte de Recherche UMR 216 Mère et enfant face aux infections tropicales, 75006 Paris, France
    Infect Genet Evol 11:1287-92. 2011
    ..We speculate that cell-mediated immune activity may explain the clinical protection afforded by this genetic trait...
  34. pmc Plasmodium falciparum Polymorphisms associated with ex vivo drug susceptibility and clinical effectiveness of artemisinin-based combination therapies in Benin
    Sabina Dahlström
    Institut de Médecine et d Epidémiologie Appliquée, Bichat C Bernard Hospital, Paris, France
    Antimicrob Agents Chemother 58:1-10. 2014
    ..Surveillance based on clinical, ex vivo, molecular, and pharmacological data is warranted. ..
  35. doi request reprint Electroporation-mediated genetic vaccination for antigen mapping: application to Plasmodium falciparum VAR2CSA protein
    Bita Bordbar
    Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
    Bioelectrochemistry 87:132-7. 2012
    ..Immunizing mice and rabbit with DNA plasmids encoding different fragments of VAR2CSA leads to high titer antisera. Moreover an N-terminal region of the protein was found to induce protective functional antibodies...
  36. pmc Can treatment of malaria be restricted to parasitologically confirmed malaria? A school-based study in Benin in children with and without fever
    Jean François Faucher
    Institut de Recherche pour le Développement IRD UMR 216 Mother and Child face to tropical infections, Paris, France
    Malar J 9:104. 2010
    ....
  37. pmc Placental malaria-associated suppression of parasite-specific immune response in neonates has no major impact on systemic CD4 T cell homeostasis
    Valérie Soulard
    Faculte de Pharmacie, Institut de Recherche pour le Développement UMR216 Santé de la Mère et l Enfant en Milieu Tropical, Universite Paris Descartes, 4 avenue de l Observatoire, 75006 Paris, France
    Infect Immun 79:2801-9. 2011
    ..Additionally, our results suggest that, as in adults, effector and regulatory CD4(+) T cell populations are tightly coregulated in all neonates, irrespective of the maternal infection status...
  38. ncbi request reprint Do African immigrants living in France have long-term malarial immunity?
    Olivier Bouchaud
    Department of Infectious and Tropical Diseases, and Parasitology, Hopital Bichat Claude Bernard, Paris, France
    Am J Trop Med Hyg 72:21-5. 2005
    ..falciparum. These results suggest the persistence of acquired immunity to P. falciparum malaria after several years of non-exposure in African immigrants...
  39. doi request reprint Prevalence and factors related to antibiotic prescription in Benin: a school-based study
    Kobto G Koura
    IRD UMR216, Mère et Enfant Face aux Infections Tropicales, Paris, France
    Acta Trop 127:87-90. 2013
    ..05 (0.03-0.11); P<10(-3)] were negatively related to antibiotic usage. Further clinical surveys and trials aimed at rationalizing antibiotics usage in this area should focus on the management of acute respiratory illnesses...
  40. pmc Impact of pregnancy-associated malaria on infant malaria infection in southern Benin
    Sophie Borgella
    Centre d étude et de recherche sur le paludisme associé à la grossesse et à l enfance CERPAGE, Faculte des Sciences de la Sante, Université d Abomey Calavi, Cotonou, Benin Institut de Recherche pour le Développement, UMR 216, Mère et Enfant Face aux Infections Tropicales, Paris, France PRES Sorbonne Paris Cité, Universite Paris Descartes, Faculte de Pharmacie, Paris, France
    PLoS ONE 8:e80624. 2013
    ..Infants of mothers with placental Plasmodium falciparum infections at delivery are themselves more susceptible to malaria attacks or to infection in early life...
  41. pmc Influence of the timing of malaria infection during pregnancy on birth weight and on maternal anemia in Benin
    Bich Tram Huynh
    Institut de Recherche pour le Developpement, Mère et Enfant Face aux Infections Tropicales, Paris, France
    Am J Trop Med Hyg 85:214-20. 2011
    ..In the future, a vaccine against pregnancy-associated malaria parasites could protect the women in early pregnancy, which seems to be a high-risk period...
  42. pmc Towards the rational design of a candidate vaccine against pregnancy associated malaria: conserved sequences of the DBL6epsilon domain of VAR2CSA
    Cyril Badaut
    Mother and Child Faced with Tropical Infections Research Unit, Institut de Recherche pour le Developpement, UMR216, Paris, France
    PLoS ONE 5:e11276. 2010
    ..The DBL6epsilon domain could constitute a very attractive basis for a vaccine candidate but its reported variability necessitates, for antigenic characterisations, identifying and classifying commonalities across isolates...
  43. ncbi request reprint Correlations between treatment outcome and both anti-MSP119 antibody response and erythrocyte-related genetic factors in Plasmodium falciparum malaria
    Agnes Aubouy
    Centre International de Recherches Medicales de Franceville CIRMF, Gabon
    Infect Genet Evol 7:147-54. 2007
    ..The interference between drug efficacy, immunity and human genetic factors needs further investigation to be elucidated...
  44. pmc Submicroscopic infections with Plasmodium falciparum during pregnancy and their association with circulating cytokine, chemokine, and cellular profiles
    Samad A Ibitokou
    Centre d Etude et de Recherche sur le Paludisme Associé à la Grossesse et à l Enfance, Faculte des Sciences de la Sante, Université d Abomey Calavi, Cotonou, Benin Institut de Recherche pour le Développement, UMR 216, Mère et Enfant Face aux Infections Tropicales, Paris, France PRES Sorbonne Paris Cité, Universite Paris Descartes, Faculte de Pharmacie, Paris, France
    Clin Vaccine Immunol 21:859-66. 2014
    ..falciparum infections during pregnancy, but this marker alone does not identify all submicroscopic infections. Reliably identifying such occult infections will require more sensitive and specific methods. ..
  45. ncbi request reprint Genetic diversity of VAR2CSA ID1-DBL2Xb in worldwide Plasmodium falciparum populations: impact on vaccine design for placental malaria
    Bita Bordbar
    PRES Sorbonne Paris Cité, Universite Paris Descartes, Paris, France Institut de Recherche pour le Développement IRD, UMR216 Mère et Enfant face aux Infections Tropicales, Paris, France
    Infect Genet Evol 25:81-92. 2014
    ....
  46. pmc Cellular immune response to Plasmodium falciparum after pregnancy is related to previous placental infection and parity
    Nadine Fievet
    UR R010, Mother and Child Health in the Tropics, Institut de recherche pour le developpement IRD, Faculte de Pharmacie, 75006 Paris, France
    Malar J 1:16. 2002
    ..Malaria infection during pregnancy allows the acquisition of antibodies against placental parasites, these antibodies are thought to be involved in protection during subsequent pregnancies...
  47. pmc Peripheral blood cell signatures of Plasmodium falciparum infection during pregnancy
    Samad Ibitokou
    Centre d étude et de recherche sur le paludisme associé à la grossesse et à l enfance CERPAGE, Faculte des Sciences de la Sante, Université d Abomey Calavi, Cotonou, Benin
    PLoS ONE 7:e49621. 2012
    ....
  48. doi request reprint Identification of Id1-DBL2X of VAR2CSA as a key domain inducing highly inhibitory and cross-reactive antibodies
    Bita Bordbar
    Universite Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France
    Vaccine 30:1343-8. 2012
    ..In order to identifying the shortest fragment of VAR2CSA carrying major protective epitopes able to elicit inhibitory antibodies, we performed a refined antigenic mapping of NTS-DBL1X-Id1-DBL2X through a DNA vaccination technique...