Richard Delorme

Summary

Country: France

Publications

  1. pmc Exploratory analysis of obsessive compulsive symptom dimensions in children and adolescents: a prospective follow-up study
    Richard Delorme
    INSERM U513, Faculte de Medecine, Universite Paris XII, Creteil, France
    BMC Psychiatry 6:1. 2006
  2. ncbi No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects
    Richard Delorme
    Human Genetics and Cognitive Functions, Pasteur Institute, Paris, France
    Biol Psychiatry 60:202-3. 2006
  3. pmc Platelet serotonergic markers as endophenotypes for obsessive-compulsive disorder
    Richard Delorme
    INSERM U 513, Faculte de Medecine, Creteil, France
    Neuropsychopharmacology 30:1539-47. 2005
  4. ncbi Admixture analysis of age at onset in obsessive-compulsive disorder
    Richard Delorme
    INSERM U513, Faculte de Medecine, Creteil, France
    Psychol Med 35:237-43. 2005
  5. ncbi Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder
    Richard Delorme
    INSERM U 513, Faculte de Medecine, 8 rue du General Sarrail, 94010 Creteil, France
    Neuroreport 15:699-702. 2004
  6. ncbi Lack of evidence for association between serotonin transporter gene (5-HTTLPR) and obsessive-compulsive disorder by case control and family association study in humans
    Nadia Chabane
    University Department of Psychiatry, INSERM E0 117, Sainte Anne Hospital, Paris, France
    Neurosci Lett 363:154-6. 2004
  7. ncbi Platelet serotonergic predictors of clinical improvement in obsessive compulsive disorder
    Richard Delorme
    Service de Psychopathologie de l Enfant et de l Adolescent, AP HP, Hopital Robert Debre, Paris, France
    J Clin Psychopharmacol 24:18-23. 2004
  8. doi Heterozygous FA2H mutations in autism spectrum disorders
    Isabelle Scheid
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    BMC Med Genet 14:124. 2013
  9. doi Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders
    Pauline Chaste
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    J Pineal Res 51:394-9. 2011
  10. pmc An investigation of ribosomal protein L10 gene in autism spectrum disorders
    Xiaohong Gong
    Human Genetics and Cognitive Functions, CNRS URA 2182 Genes, Synapses and Cognition, Institut Pasteur, Paris, France
    BMC Med Genet 10:7. 2009

Detail Information

Publications39

  1. pmc Exploratory analysis of obsessive compulsive symptom dimensions in children and adolescents: a prospective follow-up study
    Richard Delorme
    INSERM U513, Faculte de Medecine, Universite Paris XII, Creteil, France
    BMC Psychiatry 6:1. 2006
    ..Although a phenotypic continuum from childhood to adulthood has been hypothesized, no factor analytic studies have been performed in juvenile patients, and the stability of OC dimensions in children and adolescents has not been assessed...
  2. ncbi No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects
    Richard Delorme
    Human Genetics and Cognitive Functions, Pasteur Institute, Paris, France
    Biol Psychiatry 60:202-3. 2006
    ..1.4% in control subjects)...
  3. pmc Platelet serotonergic markers as endophenotypes for obsessive-compulsive disorder
    Richard Delorme
    INSERM U 513, Faculte de Medecine, Creteil, France
    Neuropsychopharmacology 30:1539-47. 2005
    ..These alterations may serve as endophenotypic markers in OCD, and could contribute to the study of the biological mechanisms and genetic underpinnings of the disorder...
  4. ncbi Admixture analysis of age at onset in obsessive-compulsive disorder
    Richard Delorme
    INSERM U513, Faculte de Medecine, Creteil, France
    Psychol Med 35:237-43. 2005
    ..If AAO is a clinical indicator of different biological subtypes, then subgroups based on distinct AAOs should have separate normal distributions as well as different clinical characteristics...
  5. ncbi Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder
    Richard Delorme
    INSERM U 513, Faculte de Medecine, 8 rue du General Sarrail, 94010 Creteil, France
    Neuroreport 15:699-702. 2004
    ..03), supporting a functional role for this variant. These findings suggest the need for further investigation of the role of GRIK2 in OCD...
  6. ncbi Lack of evidence for association between serotonin transporter gene (5-HTTLPR) and obsessive-compulsive disorder by case control and family association study in humans
    Nadia Chabane
    University Department of Psychiatry, INSERM E0 117, Sainte Anne Hospital, Paris, France
    Neurosci Lett 363:154-6. 2004
    ..We also performed a family association study on 116 trios including an OCD patient (73 French and 43 German). No association was detected between the 5-HTTLPR polymorphism and OCD in either the case control study or the family study...
  7. ncbi Platelet serotonergic predictors of clinical improvement in obsessive compulsive disorder
    Richard Delorme
    Service de Psychopathologie de l Enfant et de l Adolescent, AP HP, Hopital Robert Debre, Paris, France
    J Clin Psychopharmacol 24:18-23. 2004
    ..We tried to identify further peripheral serotonergic parameters that could help predict the clinical outcome of SRI treatment in a sample of patients with OCD...
  8. doi Heterozygous FA2H mutations in autism spectrum disorders
    Isabelle Scheid
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    BMC Med Genet 14:124. 2013
    ..We hypothesized that rare deleterious heterozygous mutations of FA2H might constitute risk factors for ASD...
  9. doi Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders
    Pauline Chaste
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    J Pineal Res 51:394-9. 2011
    ..These genetic and functional results represent the first comprehensive ascertainment of melatonin signaling deficiency in ADHD...
  10. pmc An investigation of ribosomal protein L10 gene in autism spectrum disorders
    Xiaohong Gong
    Human Genetics and Cognitive Functions, CNRS URA 2182 Genes, Synapses and Cognition, Institut Pasteur, Paris, France
    BMC Med Genet 10:7. 2009
    ..To confirm these initial findings, we re-sequenced RPL10 exons and quantified mRNA transcript level of RPL10 in our samples...
  11. ncbi Expression and genetic variability of PCDH11Y, a gene specific to Homo sapiens and candidate for susceptibility to psychiatric disorders
    Christelle M Durand
    Human Genetics and Cognitive Functions, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Am J Med Genet B Neuropsychiatr Genet 141:67-70. 2006
    ..These findings do not support the role of PCDH11Y, or more generally of a frequent specific Y chromosome, in the susceptibility to these neuropsychiatric disorders...
  12. pmc Mutation screening of NOS1AP gene in a large sample of psychiatric patients and controls
    Richard Delorme
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    BMC Med Genet 11:108. 2010
    ..Previous genetic and functional studies explored the role of NOS1AP in these psychiatric conditions, but only a limited number explored the sequence variability of NOS1AP...
  13. doi Reduced 3-O-methyl-dopa levels in OCD patients and their unaffected parents is associated with the low activity M158 COMT allele
    Richard Delorme
    INSERM U955, Institut Mondor de Recherche Biomedicale, Psychiatric Genetics, Creteil, France
    Am J Med Genet B Neuropsychiatr Genet 153:542-8. 2010
    ..These findings further support a role of COMT in the susceptibility to OCD and provide evidence that 3-OMD levels could represent an endophenotype in OCD...
  14. pmc Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorder
    Richard Delorme
    INSERM, U955, Institut Mondor de Recherche Biomedicale, PsychiatricGenetics, Creteil, France
    BMC Med Genet 11:100. 2010
    ..Therefore, the aim of this study was to search for microrearrangements in these two regions in OCD patients...
  15. doi Analysis of X chromosome inactivation in autism spectrum disorders
    Xiaohong Gong
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    Am J Med Genet B Neuropsychiatr Genet 147:830-5. 2008
    ..We propose that the XCI profile could be a useful criteria to prioritize families for mutation screening of X-linked candidate genes...
  16. pmc Shared executive dysfunctions in unaffected relatives of patients with autism and obsessive-compulsive disorder
    Richard Delorme
    INSERM U513, Neurobiologie et Psychiatrie, Universite Paris XII, Creteil, France
    Eur Psychiatry 22:32-8. 2007
    ....
  17. pmc Genetic and functional analyses of SHANK2 mutations suggest a multiple hit model of autism spectrum disorders
    Claire S Leblond
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    PLoS Genet 8:e1002521. 2012
    ..A better knowledge of these genetic interactions will be necessary to understand the complex inheritance pattern of ASD...
  18. pmc Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders
    Christelle M Durand
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    Nat Genet 39:25-7. 2007
    ..These mutations concern only a small number of individuals, but they shed light on one gene dosage-sensitive synaptic pathway that is involved in autism spectrum disorders...
  19. ncbi Key role for gene dosage and synaptic homeostasis in autism spectrum disorders
    Roberto Toro
    Human Genetics and Cognitive Functions, Institut Pasteur, 75015 Paris, France
    Trends Genet 26:363-72. 2010
    ..Understanding the mechanisms that regulate synaptic homeostasis should shed new light on the causes of ASD and could provide a means to modulate the severity of the symptoms...
  20. ncbi Association between the dopamine receptor D4 (DRD4) gene and obsessive-compulsive disorder
    Bruno Millet
    INSERM E0117 Paris V, University Department of Psychiatry, Sainte Anne Hospital, Paris, France
    Am J Med Genet B Neuropsychiatr Genet 116:55-9. 2003
    ..The results suggest that the 2 allele or a nearby genetic variation could have a protective effect against OCD symptoms...
  21. pmc Autism multiplex family with 16p11.2p12.2 microduplication syndrome in monozygotic twins and distal 16p11.2 deletion in their brother
    Anne Claude Tabet
    AP HP, Robert Debre Hospital, Department of Genetics, Cytogenetics Unit, Paris, France
    Eur J Hum Genet 20:540-6. 2012
    ..We discuss the clinical and genetic implications of two different 16p chromosomal rearrangements in this family, and suggest that the 16p11.2 deletion in the father predisposed to the formation of the duplication in his twin children...
  22. pmc Variations of the candidate SEZ6L2 gene on Chromosome 16p11.2 in patients with autism spectrum disorders and in human populations
    Marina Konyukh
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    PLoS ONE 6:e17289. 2011
    ..2. The analysis of rare variations of 8 candidate genes among the 27 genes located in this region suggested SEZ6L2 as a compelling candidate...
  23. doi Progress toward treatments for synaptic defects in autism
    Richard Delorme
    Institut Pasteur, Human Genetics and Cognitive Functions Unit, Paris, France
    Nat Med 19:685-94. 2013
    ..We propose, given the clinical heterogeneity of ASD, that specific 'synaptic clinical trials' should be designed and launched with the aim of establishing whether phenotype 'reversals' could also occur in humans...
  24. ncbi Early-onset obsessive-compulsive disorder: a subgroup with a specific clinical and familial pattern?
    Nadia Chabane
    Service de Psychopathologie de l Enfant et de l Adolescent, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Paris, France
    J Child Psychol Psychiatry 46:881-7. 2005
    ..In this study, the specificity of early-onset OCD was investigated, focusing on the effect of gender, comorbid conditions and familial risk of tics and OCD by studying a population consisting exclusively of patients with early-onset OCD...
  25. pmc Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with intellectual disability
    Cecile Pagan
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    BMC Med Genet 12:17. 2011
    ..Thus the aim of the study was to ascertain the genetic variability of ASMT in a large cohort of patients with ID and controls...
  26. pmc Heterogeneous pattern of selective pressure for PRRT2 in human populations, but no association with autism spectrum disorders
    Guillaume Huguet
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France CNRS URA 2182 Genes, Synapses and Cognition, Institut Pasteur, Paris, France University Denis Diderot Paris 7, Paris, France
    PLoS ONE 9:e88600. 2014
    ....
  27. pmc High-functioning autism spectrum disorder and fragile X syndrome: report of two affected sisters
    Pauline Chaste
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    Mol Autism 3:5. 2012
    ..abstract:..
  28. doi The emerging role of SHANK genes in neuropsychiatric disorders
    Audrey Guilmatre
    Human Genetics and Cognitive Functions Unit, Institut Pasteur, Paris, France CNRS URA 2182 Genes, Synapses and Cognition, Institut Pasteur, Paris, France Human Genetics and Cognitive Functions, University Paris Diderot, Sorbonne Paris Cité, Paris, France
    Dev Neurobiol 74:113-22. 2014
    ..Altogether, this review describes the clinical trajectories associated with different mutations of the SHANK genes and provides information to further investigate the role of the SHANK genes in neuropsychiatric disorders...
  29. doi Brain iron levels in attention-deficit/hyperactivity disorder: a pilot MRI study
    Samuele Cortese
    Child and Adolescent Psychopathology Unit, Robert Debre Hospital, Paris VII University, Paris, France
    World J Biol Psychiatry 13:223-31. 2012
    ..The secondary aim was to assess the correlation between serum ferritin and BI levels...
  30. pmc Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population
    Pauline Chaste
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    PLoS ONE 5:e11495. 2010
    ..Our results represent the first functional ascertainment of melatonin receptors in humans and constitute a basis for future structure-function studies and for interpreting genetic data on the melatonin pathway in patients...
  31. ncbi Screening for genomic rearrangements and methylation abnormalities of the 15q11-q13 region in autism spectrum disorders
    Christel Depienne
    INSERM U679, AP HP, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Biol Psychiatry 66:349-59. 2009
    ..However, the prevalence of these disorders in ASD is unknown. The aim of this study was to assess the frequency of 15q11-q13 rearrangements in a large sample of patients ascertained for ASD...
  32. pmc Should metabolic diseases be systematically screened in nonsyndromic autism spectrum disorders?
    Manuel Schiff
    APHP, Reference Center for Inherited Metabolic Disease, Hopital Robert Debre, Paris, France
    PLoS ONE 6:e21932. 2011
    ..In rare cases, however, ASD may be considered as nonsyndromic at the onset of a related IMD...
  33. ncbi No association between DUP25 and anxiety disorders
    Charlotte Neergaard Henrichsen
    Division de génétique médicale, Hopitaux Universitaires de Geneve, 1 rue Michel Servet 1211, Geneva 4, Switzerland
    Am J Med Genet B Neuropsychiatr Genet 128:80-3. 2004
    ..We have not detected any DUP25. Our results suggest that DUP25 is not common in people with anxiety disorders in the population tested here...
  34. ncbi A genetic family-based association study of OLIG2 in obsessive-compulsive disorder
    S Evelyn Stewart
    Psychiatric Neuroscience Research Division, and Obsessive Compulsive Disorder Clinic, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Arch Gen Psychiatry 64:209-14. 2007
    ..The gene for oligodendrocyte lineage transcription factor 2 (OLIG2) is an essential regulator in the development of cells that produce white matter (myelin). The OLIG2 gene is also highly expressed in brain regions implicated in OCD...
  35. ncbi Four-factor structure of obsessive-compulsive disorder symptoms in children, adolescents, and adults
    S Evelyn Stewart
    Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 47:763-72. 2008
    ..Identification of a category-based OCD symptom dimension structure that is validated for use across child, adolescent, and adult age groups is necessary to guide ongoing translational research...
  36. ncbi Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder
    S Evelyn Stewart
    Psychiatric Neurodevelopmental and Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 144:1027-33. 2007
    ..Two separate proximal haplotypes in the glutamate transporter gene, SLC1A1, were recently reported to be associated with OCD among males, but replication is required...
  37. pmc Mutation analysis of the NSD1 gene in patients with autism spectrum disorders and macrocephaly
    Joseph D Buxbaum
    Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, New York, USA
    BMC Med Genet 8:68. 2007
    ..Sotos syndrome has been described in a number of patients with autism spectrum disorders, suggesting that NSD1 could be involved in other cases of autism and macrocephaly...
  38. ncbi [Obsessive-compulsive disorder in children and adolescents]
    Nadia Chabane
    Service de Psychiatrie de l Enfant et de l Adolescent, Hopital Robert Debre, 75935 Paris 19
    Rev Prat 57:45-51. 2007
    ..The ongoing refinement of cognitive-behaviour and pharmacological treatment approaches has increased the likelihood that many youngsters with OCD will lead satisfying and relatively normal lives...
  39. ncbi [School phobia or school refusal: controversial concepts]
    Marie Christine Mouren
    Service de Psychopathologie de l Enfant et de l Adolescent, Hopital Robert Debre, Paris 75019
    Bull Acad Natl Med 190:1629-39; discussion 1639-41. 2006
    ..Indeed, early detection and appropriate treatment can considerably improve these children's outcome...