Genomes and Genes
- Mutation analysis of the NSD1 gene in patients with autism spectrum disorders and macrocephalyJoseph D Buxbaum
Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, New York, USA
BMC Med Genet 8:68. 2007..Sotos syndrome has been described in a number of patients with autism spectrum disorders, suggesting that NSD1 could be involved in other cases of autism and macrocephaly...
- Shared executive dysfunctions in unaffected relatives of patients with autism and obsessive-compulsive disorderRichard Delorme
INSERM U513, Neurobiologie et Psychiatrie, Universite Paris XII, Creteil, France
Eur Psychiatry 22:32-8. 2007....
- Exploratory analysis of obsessive compulsive symptom dimensions in children and adolescents: a prospective follow-up studyRichard Delorme
INSERM U513, Faculte de Medecine, Universite Paris XII, Creteil, France
BMC Psychiatry 6:1. 2006..Although a phenotypic continuum from childhood to adulthood has been hypothesized, no factor analytic studies have been performed in juvenile patients, and the stability of OC dimensions in children and adolescents has not been assessed...
- Platelet serotonergic markers as endophenotypes for obsessive-compulsive disorderRichard Delorme
INSERM U 513, Faculte de Medecine, Creteil, France
Neuropsychopharmacology 30:1539-47. 2005..These alterations may serve as endophenotypic markers in OCD, and could contribute to the study of the biological mechanisms and genetic underpinnings of the disorder...
- Reduced 3-O-methyl-dopa levels in OCD patients and their unaffected parents is associated with the low activity M158 COMT alleleRichard Delorme
INSERM U955, Institut Mondor de Recherche Biomedicale, Psychiatric Genetics, Creteil, France
Am J Med Genet B Neuropsychiatr Genet 153:542-8. 2010..These findings further support a role of COMT in the susceptibility to OCD and provide evidence that 3-OMD levels could represent an endophenotype in OCD...
- Association between the dopamine receptor D4 (DRD4) gene and obsessive-compulsive disorderBruno Millet
INSERM E0117 Paris V, University Department of Psychiatry, Sainte Anne Hospital, Paris, France
Am J Med Genet B Neuropsychiatr Genet 116:55-9. 2003..The results suggest that the 2 allele or a nearby genetic variation could have a protective effect against OCD symptoms...
- No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjectsRichard Delorme
Human Genetics and Cognitive Functions, Pasteur Institute, Paris, France
Biol Psychiatry 60:202-3. 2006..1.4% in control subjects)...
- Early-onset obsessive-compulsive disorder: a subgroup with a specific clinical and familial pattern?Nadia Chabane
Service de Psychopathologie de l Enfant et de l Adolescent, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Paris, France
J Child Psychol Psychiatry 46:881-7. 2005..In this study, the specificity of early-onset OCD was investigated, focusing on the effect of gender, comorbid conditions and familial risk of tics and OCD by studying a population consisting exclusively of patients with early-onset OCD...
- Lack of evidence for association between serotonin transporter gene (5-HTTLPR) and obsessive-compulsive disorder by case control and family association study in humansNadia Chabane
University Department of Psychiatry, INSERM E0 117, Sainte Anne Hospital, Paris, France
Neurosci Lett 363:154-6. 2004..We also performed a family association study on 116 trios including an OCD patient (73 French and 43 German). No association was detected between the 5-HTTLPR polymorphism and OCD in either the case control study or the family study...
- Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorderRichard Delorme
INSERM U 513, Faculte de Medecine, 8 rue du General Sarrail, 94010 Creteil, France
Neuroreport 15:699-702. 2004..03), supporting a functional role for this variant. These findings suggest the need for further investigation of the role of GRIK2 in OCD...
- Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorderRichard Delorme
INSERM, U955, Institut Mondor de Recherche Biomedicale, PsychiatricGenetics, Creteil, France
BMC Med Genet 11:100. 2010..Therefore, the aim of this study was to search for microrearrangements in these two regions in OCD patients...
- Admixture analysis of age at onset in obsessive-compulsive disorderRichard Delorme
INSERM U513, Faculte de Medecine, Creteil, France
Psychol Med 35:237-43. 2005..If AAO is a clinical indicator of different biological subtypes, then subgroups based on distinct AAOs should have separate normal distributions as well as different clinical characteristics...
- Platelet serotonergic predictors of clinical improvement in obsessive compulsive disorderRichard Delorme
Service de Psychopathologie de l Enfant et de l Adolescent, AP HP, Hopital Robert Debre, Paris, France
J Clin Psychopharmacol 24:18-23. 2004..We tried to identify further peripheral serotonergic parameters that could help predict the clinical outcome of SRI treatment in a sample of patients with OCD...
- Four-factor structure of obsessive-compulsive disorder symptoms in children, adolescents, and adultsS Evelyn Stewart
Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 47:763-72. 2008..Identification of a category-based OCD symptom dimension structure that is validated for use across child, adolescent, and adult age groups is necessary to guide ongoing translational research...
- Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorderS Evelyn Stewart
Psychiatric Neurodevelopmental and Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Med Genet B Neuropsychiatr Genet 144:1027-33. 2007..Two separate proximal haplotypes in the glutamate transporter gene, SLC1A1, were recently reported to be associated with OCD among males, but replication is required...
- Expression and genetic variability of PCDH11Y, a gene specific to Homo sapiens and candidate for susceptibility to psychiatric disordersChristelle M Durand
Human Genetics and Cognitive Functions, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
Am J Med Genet B Neuropsychiatr Genet 141:67-70. 2006..These findings do not support the role of PCDH11Y, or more generally of a frequent specific Y chromosome, in the susceptibility to these neuropsychiatric disorders...
- A genetic family-based association study of OLIG2 in obsessive-compulsive disorderS Evelyn Stewart
Psychiatric Neuroscience Research Division, and Obsessive Compulsive Disorder Clinic, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
Arch Gen Psychiatry 64:209-14. 2007..The gene for oligodendrocyte lineage transcription factor 2 (OLIG2) is an essential regulator in the development of cells that produce white matter (myelin). The OLIG2 gene is also highly expressed in brain regions implicated in OCD...
- Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disordersChristelle M Durand
Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
Nat Genet 39:25-7. 2007..These mutations concern only a small number of individuals, but they shed light on one gene dosage-sensitive synaptic pathway that is involved in autism spectrum disorders...
- No association between DUP25 and anxiety disordersCharlotte Neergaard Henrichsen
Division de génétique médicale, Hopitaux Universitaires de Geneve, 1 rue Michel Servet 1211, Geneva 4, Switzerland
Am J Med Genet B Neuropsychiatr Genet 128:80-3. 2004..We have not detected any DUP25. Our results suggest that DUP25 is not common in people with anxiety disorders in the population tested here...
- [School phobia or school refusal: controversial concepts]Marie Christine Mouren
Service de Psychopathologie de l Enfant et de l Adolescent, Hopital Robert Debre, Paris 75019
Bull Acad Natl Med 190:1629-39; discussion 1639-41. 2006..Indeed, early detection and appropriate treatment can considerably improve these children's outcome...
- [Obsessive-compulsive disorder in children and adolescents]Nadia Chabane
Service de Psychiatrie de l Enfant et de l Adolescent, Hopital Robert Debre, 75935 Paris 19
Rev Prat 57:45-51. 2007..The ongoing refinement of cognitive-behaviour and pharmacological treatment approaches has increased the likelihood that many youngsters with OCD will lead satisfying and relatively normal lives...