Richard Delorme

Summary

Country: France

Publications

  1. pmc Mutation analysis of the NSD1 gene in patients with autism spectrum disorders and macrocephaly
    Joseph D Buxbaum
    Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, New York, USA
    BMC Med Genet 8:68. 2007
  2. pmc Shared executive dysfunctions in unaffected relatives of patients with autism and obsessive-compulsive disorder
    Richard Delorme
    INSERM U513, Neurobiologie et Psychiatrie, Universite Paris XII, Creteil, France
    Eur Psychiatry 22:32-8. 2007
  3. pmc Exploratory analysis of obsessive compulsive symptom dimensions in children and adolescents: a prospective follow-up study
    Richard Delorme
    INSERM U513, Faculte de Medecine, Universite Paris XII, Creteil, France
    BMC Psychiatry 6:1. 2006
  4. pmc Platelet serotonergic markers as endophenotypes for obsessive-compulsive disorder
    Richard Delorme
    INSERM U 513, Faculte de Medecine, Creteil, France
    Neuropsychopharmacology 30:1539-47. 2005
  5. doi request reprint Reduced 3-O-methyl-dopa levels in OCD patients and their unaffected parents is associated with the low activity M158 COMT allele
    Richard Delorme
    INSERM U955, Institut Mondor de Recherche Biomedicale, Psychiatric Genetics, Creteil, France
    Am J Med Genet B Neuropsychiatr Genet 153:542-8. 2010
  6. ncbi request reprint Association between the dopamine receptor D4 (DRD4) gene and obsessive-compulsive disorder
    Bruno Millet
    INSERM E0117 Paris V, University Department of Psychiatry, Sainte Anne Hospital, Paris, France
    Am J Med Genet B Neuropsychiatr Genet 116:55-9. 2003
  7. ncbi request reprint No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects
    Richard Delorme
    Human Genetics and Cognitive Functions, Pasteur Institute, Paris, France
    Biol Psychiatry 60:202-3. 2006
  8. ncbi request reprint Early-onset obsessive-compulsive disorder: a subgroup with a specific clinical and familial pattern?
    Nadia Chabane
    Service de Psychopathologie de l Enfant et de l Adolescent, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Paris, France
    J Child Psychol Psychiatry 46:881-7. 2005
  9. ncbi request reprint Lack of evidence for association between serotonin transporter gene (5-HTTLPR) and obsessive-compulsive disorder by case control and family association study in humans
    Nadia Chabane
    University Department of Psychiatry, INSERM E0 117, Sainte Anne Hospital, Paris, France
    Neurosci Lett 363:154-6. 2004
  10. ncbi request reprint Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder
    Richard Delorme
    INSERM U 513, Faculte de Medecine, 8 rue du General Sarrail, 94010 Creteil, France
    Neuroreport 15:699-702. 2004

Detail Information

Publications21

  1. pmc Mutation analysis of the NSD1 gene in patients with autism spectrum disorders and macrocephaly
    Joseph D Buxbaum
    Laboratory of Molecular Neuropsychiatry, Mount Sinai School of Medicine, New York, USA
    BMC Med Genet 8:68. 2007
    ..Sotos syndrome has been described in a number of patients with autism spectrum disorders, suggesting that NSD1 could be involved in other cases of autism and macrocephaly...
  2. pmc Shared executive dysfunctions in unaffected relatives of patients with autism and obsessive-compulsive disorder
    Richard Delorme
    INSERM U513, Neurobiologie et Psychiatrie, Universite Paris XII, Creteil, France
    Eur Psychiatry 22:32-8. 2007
    ....
  3. pmc Exploratory analysis of obsessive compulsive symptom dimensions in children and adolescents: a prospective follow-up study
    Richard Delorme
    INSERM U513, Faculte de Medecine, Universite Paris XII, Creteil, France
    BMC Psychiatry 6:1. 2006
    ..Although a phenotypic continuum from childhood to adulthood has been hypothesized, no factor analytic studies have been performed in juvenile patients, and the stability of OC dimensions in children and adolescents has not been assessed...
  4. pmc Platelet serotonergic markers as endophenotypes for obsessive-compulsive disorder
    Richard Delorme
    INSERM U 513, Faculte de Medecine, Creteil, France
    Neuropsychopharmacology 30:1539-47. 2005
    ..These alterations may serve as endophenotypic markers in OCD, and could contribute to the study of the biological mechanisms and genetic underpinnings of the disorder...
  5. doi request reprint Reduced 3-O-methyl-dopa levels in OCD patients and their unaffected parents is associated with the low activity M158 COMT allele
    Richard Delorme
    INSERM U955, Institut Mondor de Recherche Biomedicale, Psychiatric Genetics, Creteil, France
    Am J Med Genet B Neuropsychiatr Genet 153:542-8. 2010
    ..These findings further support a role of COMT in the susceptibility to OCD and provide evidence that 3-OMD levels could represent an endophenotype in OCD...
  6. ncbi request reprint Association between the dopamine receptor D4 (DRD4) gene and obsessive-compulsive disorder
    Bruno Millet
    INSERM E0117 Paris V, University Department of Psychiatry, Sainte Anne Hospital, Paris, France
    Am J Med Genet B Neuropsychiatr Genet 116:55-9. 2003
    ..The results suggest that the 2 allele or a nearby genetic variation could have a protective effect against OCD symptoms...
  7. ncbi request reprint No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects
    Richard Delorme
    Human Genetics and Cognitive Functions, Pasteur Institute, Paris, France
    Biol Psychiatry 60:202-3. 2006
    ..1.4% in control subjects)...
  8. ncbi request reprint Early-onset obsessive-compulsive disorder: a subgroup with a specific clinical and familial pattern?
    Nadia Chabane
    Service de Psychopathologie de l Enfant et de l Adolescent, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Paris, France
    J Child Psychol Psychiatry 46:881-7. 2005
    ..In this study, the specificity of early-onset OCD was investigated, focusing on the effect of gender, comorbid conditions and familial risk of tics and OCD by studying a population consisting exclusively of patients with early-onset OCD...
  9. ncbi request reprint Lack of evidence for association between serotonin transporter gene (5-HTTLPR) and obsessive-compulsive disorder by case control and family association study in humans
    Nadia Chabane
    University Department of Psychiatry, INSERM E0 117, Sainte Anne Hospital, Paris, France
    Neurosci Lett 363:154-6. 2004
    ..We also performed a family association study on 116 trios including an OCD patient (73 French and 43 German). No association was detected between the 5-HTTLPR polymorphism and OCD in either the case control study or the family study...
  10. ncbi request reprint Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder
    Richard Delorme
    INSERM U 513, Faculte de Medecine, 8 rue du General Sarrail, 94010 Creteil, France
    Neuroreport 15:699-702. 2004
    ..03), supporting a functional role for this variant. These findings suggest the need for further investigation of the role of GRIK2 in OCD...
  11. pmc Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorder
    Richard Delorme
    INSERM, U955, Institut Mondor de Recherche Biomedicale, PsychiatricGenetics, Creteil, France
    BMC Med Genet 11:100. 2010
    ..Therefore, the aim of this study was to search for microrearrangements in these two regions in OCD patients...
  12. ncbi request reprint Admixture analysis of age at onset in obsessive-compulsive disorder
    Richard Delorme
    INSERM U513, Faculte de Medecine, Creteil, France
    Psychol Med 35:237-43. 2005
    ..If AAO is a clinical indicator of different biological subtypes, then subgroups based on distinct AAOs should have separate normal distributions as well as different clinical characteristics...
  13. ncbi request reprint Platelet serotonergic predictors of clinical improvement in obsessive compulsive disorder
    Richard Delorme
    Service de Psychopathologie de l Enfant et de l Adolescent, AP HP, Hopital Robert Debre, Paris, France
    J Clin Psychopharmacol 24:18-23. 2004
    ..We tried to identify further peripheral serotonergic parameters that could help predict the clinical outcome of SRI treatment in a sample of patients with OCD...
  14. doi request reprint Four-factor structure of obsessive-compulsive disorder symptoms in children, adolescents, and adults
    S Evelyn Stewart
    Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 47:763-72. 2008
    ..Identification of a category-based OCD symptom dimension structure that is validated for use across child, adolescent, and adult age groups is necessary to guide ongoing translational research...
  15. ncbi request reprint Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder
    S Evelyn Stewart
    Psychiatric Neurodevelopmental and Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 144:1027-33. 2007
    ..Two separate proximal haplotypes in the glutamate transporter gene, SLC1A1, were recently reported to be associated with OCD among males, but replication is required...
  16. ncbi request reprint Expression and genetic variability of PCDH11Y, a gene specific to Homo sapiens and candidate for susceptibility to psychiatric disorders
    Christelle M Durand
    Human Genetics and Cognitive Functions, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Am J Med Genet B Neuropsychiatr Genet 141:67-70. 2006
    ..These findings do not support the role of PCDH11Y, or more generally of a frequent specific Y chromosome, in the susceptibility to these neuropsychiatric disorders...
  17. ncbi request reprint A genetic family-based association study of OLIG2 in obsessive-compulsive disorder
    S Evelyn Stewart
    Psychiatric Neuroscience Research Division, and Obsessive Compulsive Disorder Clinic, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Arch Gen Psychiatry 64:209-14. 2007
    ..The gene for oligodendrocyte lineage transcription factor 2 (OLIG2) is an essential regulator in the development of cells that produce white matter (myelin). The OLIG2 gene is also highly expressed in brain regions implicated in OCD...
  18. pmc Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders
    Christelle M Durand
    Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
    Nat Genet 39:25-7. 2007
    ..These mutations concern only a small number of individuals, but they shed light on one gene dosage-sensitive synaptic pathway that is involved in autism spectrum disorders...
  19. ncbi request reprint No association between DUP25 and anxiety disorders
    Charlotte Neergaard Henrichsen
    Division de génétique médicale, Hopitaux Universitaires de Geneve, 1 rue Michel Servet 1211, Geneva 4, Switzerland
    Am J Med Genet B Neuropsychiatr Genet 128:80-3. 2004
    ..We have not detected any DUP25. Our results suggest that DUP25 is not common in people with anxiety disorders in the population tested here...
  20. ncbi request reprint [School phobia or school refusal: controversial concepts]
    Marie Christine Mouren
    Service de Psychopathologie de l Enfant et de l Adolescent, Hopital Robert Debre, Paris 75019
    Bull Acad Natl Med 190:1629-39; discussion 1639-41. 2006
    ..Indeed, early detection and appropriate treatment can considerably improve these children's outcome...
  21. ncbi request reprint [Obsessive-compulsive disorder in children and adolescents]
    Nadia Chabane
    Service de Psychiatrie de l Enfant et de l Adolescent, Hopital Robert Debre, 75935 Paris 19
    Rev Prat 57:45-51. 2007
    ..The ongoing refinement of cognitive-behaviour and pharmacological treatment approaches has increased the likelihood that many youngsters with OCD will lead satisfying and relatively normal lives...