Xavier Delavenne

Summary

Country: France

Publications

  1. doi UPLC MS/MS assay for routine quantification of dabigatran - a direct thrombin inhibitor - in human plasma
    Xavier Delavenne
    Laboratory of Pharmacology and Toxicology, University Hospital, F 42055 Saint Etienne, France
    J Pharm Biomed Anal 58:152-6. 2012
  2. ncbi Quantification of total and unbound tranexamic acid in human plasma by ultrafiltration liquid chromatography/tandem mass spectrometry: application to pharmacokinetic analysis
    Xavier Delavenne
    Laboratory of Pharmacology and Toxicology, University Hospital, F 42055 Saint Etienne, France Thrombosis Research Group EA 3065, University Jean Monnet, F 42023 Saint Etienne, France Electronic address
    J Pharm Biomed Anal 91:32-6. 2014
  3. doi [New oral anticoagulant pharmacology]
    Xavier Delavenne
    CHU de Saint Etienne, Hopital Nord, Laboratoire de Pharmacologie Toxicologie, 42055 Saint Etienne, France Université Jean Monnet, Groupe de Recherche sur la Thrombose, EA3065, Saint Etienne, France Electronic address
    Presse Med 42:1206-12. 2013
  4. pmc A semi-mechanistic absorption model to evaluate drug-drug interaction with dabigatran: application with clarithromycin
    Xavier Delavenne
    Laboratoire de Pharmacologie Toxicologie, University Hospital of Saint Etienne, Saint Etienne, France
    Br J Clin Pharmacol 76:107-13. 2013
  5. doi Rapid determination of apixaban concentration in human plasma by liquid chromatography/tandem mass spectrometry: application to pharmacokinetic study
    Xavier Delavenne
    Laboratory of Pharmacology and Toxicology, University Hospital, F 42055 Saint Etienne, France
    J Pharm Biomed Anal 78:150-3. 2013
  6. ncbi Pharmacokinetics of fondaparinux 1.5 mg once daily in a real-world cohort of patients with renal impairment undergoing major orthopaedic surgery
    Xavier Delavenne
    Thrombosis Research Group EA 3065, University Jean Monnet, 42023, Saint Etienne, France
    Eur J Clin Pharmacol 68:1403-10. 2012
  7. ncbi Investigation of PK-PD drug-drug interaction between acenocoumarol and amoxicillin plus clavulanic acid
    X Delavenne
    Faculte de Medecine, Université Jean Monnet, EA3065, Saint Etienne, France
    Fundam Clin Pharmacol 23:127-35. 2009
  8. doi HPLC MS/MS method for quantification of meprobamate in human plasma: application to 24/7 clinical toxicology
    Xavier Delavenne
    Laboratory of Pharmacology and Toxicology, University Hospital, F 42055 Saint Etienne, France
    J Chromatogr B Analyt Technol Biomed Life Sci 879:215-8. 2011
  9. doi UPLC MS/MS method for quantification of mycophenolic acid and metabolites in human plasma: Application to pharmacokinetic study
    Xavier Delavenne
    Laboratory of Pharmacology and Toxicology, University Hospital, F 42055 Saint Etienne, France
    Clin Chim Acta 412:59-65. 2011
  10. doi Population pharmacokinetics of fondaparinux administered at prophylactic doses after major orthopaedic surgery in everyday practice
    Xavier Delavenne
    Thrombosis Research Group EA 3065, University Jean Monnet, Saint Etienne, France
    Thromb Haemost 104:252-60. 2010

Collaborators

Detail Information

Publications16

  1. doi UPLC MS/MS assay for routine quantification of dabigatran - a direct thrombin inhibitor - in human plasma
    Xavier Delavenne
    Laboratory of Pharmacology and Toxicology, University Hospital, F 42055 Saint Etienne, France
    J Pharm Biomed Anal 58:152-6. 2012
    ..3% and accuracy was within 93.8% and 108.8% for all QC levels (5, 75 and 400 μg/L). The lower limit of quantification was 2 μg/L. Total analysis time was to 10 min including sample preparation...
  2. ncbi Quantification of total and unbound tranexamic acid in human plasma by ultrafiltration liquid chromatography/tandem mass spectrometry: application to pharmacokinetic analysis
    Xavier Delavenne
    Laboratory of Pharmacology and Toxicology, University Hospital, F 42055 Saint Etienne, France Thrombosis Research Group EA 3065, University Jean Monnet, F 42023 Saint Etienne, France Electronic address
    J Pharm Biomed Anal 91:32-6. 2014
    ..Ultrafiltration allowed confirming the weak binding to plasma proteins and confirming that total plasma TXA concentration is measured by this assay. ..
  3. doi [New oral anticoagulant pharmacology]
    Xavier Delavenne
    CHU de Saint Etienne, Hopital Nord, Laboratoire de Pharmacologie Toxicologie, 42055 Saint Etienne, France Université Jean Monnet, Groupe de Recherche sur la Thrombose, EA3065, Saint Etienne, France Electronic address
    Presse Med 42:1206-12. 2013
    ..In some clinical situations (risk of too high or too low exposure), a specific dose is proposed. ..
  4. pmc A semi-mechanistic absorption model to evaluate drug-drug interaction with dabigatran: application with clarithromycin
    Xavier Delavenne
    Laboratoire de Pharmacologie Toxicologie, University Hospital of Saint Etienne, Saint Etienne, France
    Br J Clin Pharmacol 76:107-13. 2013
    ..The aim of this study was to develop a PK/PD model to assess drug-drug interactions between dabigatran and P-gp modulators, using the example of clarithromycin, a strong inhibitor of P-gp...
  5. doi Rapid determination of apixaban concentration in human plasma by liquid chromatography/tandem mass spectrometry: application to pharmacokinetic study
    Xavier Delavenne
    Laboratory of Pharmacology and Toxicology, University Hospital, F 42055 Saint Etienne, France
    J Pharm Biomed Anal 78:150-3. 2013
    ..0 to 105.8% at all quality control levels. Sample analysis time was less than 10 min including sample preparation. The present method was successfully applied to a pharmacokinetic study following oral administration of apixaban...
  6. ncbi Pharmacokinetics of fondaparinux 1.5 mg once daily in a real-world cohort of patients with renal impairment undergoing major orthopaedic surgery
    Xavier Delavenne
    Thrombosis Research Group EA 3065, University Jean Monnet, 42023, Saint Etienne, France
    Eur J Clin Pharmacol 68:1403-10. 2012
    ..5 mg. As the drug is mainly eliminated by the kidneys, a reduced dosage (1.5 mg once daily) was developed for patients with renal impairment...
  7. ncbi Investigation of PK-PD drug-drug interaction between acenocoumarol and amoxicillin plus clavulanic acid
    X Delavenne
    Faculte de Medecine, Université Jean Monnet, EA3065, Saint Etienne, France
    Fundam Clin Pharmacol 23:127-35. 2009
    ..No covariate, including antibiotic treatment effect, significantly affected PT. Drug-drug interaction was demonstrated at the PK level, without any PD corollary...
  8. doi HPLC MS/MS method for quantification of meprobamate in human plasma: application to 24/7 clinical toxicology
    Xavier Delavenne
    Laboratory of Pharmacology and Toxicology, University Hospital, F 42055 Saint Etienne, France
    J Chromatogr B Analyt Technol Biomed Life Sci 879:215-8. 2011
    ..Total analysis time was reduced to 6 min including sample preparation. The present method is successfully applied to 24/7 clinical toxicology and demonstrated its usefulness to detect meprobamate poisoning...
  9. doi UPLC MS/MS method for quantification of mycophenolic acid and metabolites in human plasma: Application to pharmacokinetic study
    Xavier Delavenne
    Laboratory of Pharmacology and Toxicology, University Hospital, F 42055 Saint Etienne, France
    Clin Chim Acta 412:59-65. 2011
    ....
  10. doi Population pharmacokinetics of fondaparinux administered at prophylactic doses after major orthopaedic surgery in everyday practice
    Xavier Delavenne
    Thrombosis Research Group EA 3065, University Jean Monnet, Saint Etienne, France
    Thromb Haemost 104:252-60. 2010
    ..A body weight less than 50 kg and moderate renal failure increased drug exposure. Although the population pharmacokinetic model of fondaparinux was described, this one requires to be validated in everyday practice...
  11. doi Ultra-performance LC MS/MS method for quantification of clopidogrel active metabolite
    Xavier Delavenne
    Laboratory of Pharmacology and Toxicology, University Hospital, Saint Etienne, France
    J Sep Sci 33:1968-72. 2010
    ..The present method was successfully applied to a clopidogrel active metabolite pharmacokinetic study following oral administration to healthy volunteers...
  12. ncbi Investigation of drug-drug interactions between clopidogrel and fluoxetine
    Xavier Delavenne
    Laboratoire de Pharmacologie Toxicologie, CHU Saint Etienne, F 42055, Saint Etienne, France Université de Lyon, F 42023, Saint Etienne, France Groupe de Recherche sur la Thrombose, EA3065, Universite de Saint Etienne, Jean Monnet, F 42023, Saint Etienne, France
    Fundam Clin Pharmacol 27:683-9. 2013
    ..9 and 22.4% lower after fluoxetine co-administration. The platelet reactivity index measured by the flow cytometric VASP method was 36.8% lower when clopidogrel was administered in conjunction with fluoxetine...
  13. ncbi Mycophenolate sodium dosing in combination with tacrolimus: pharmacokinetic evaluation of a novel regimen in de novo tacrolimus-treated kidney transplant patients
    Bertrand Pons
    Université Jean Monnet, Saint Etienne, France
    Clin Nephrol 77:425-31. 2012
    ..We pharmacologically evaluated in tacrolimus-treated recipients a novel dosing regimen of MPA with an initial high dose followed by a gradual decrease over time...
  14. doi PK evaluation of fondaparinux sodium for the treatment of thrombosis
    Xavier Delavenne
    Université Jean Monnet, EA3065, F 42023 Saint Etienne, France
    Expert Opin Drug Metab Toxicol 10:269-77. 2014
    ..Fondaparinux sodium (pentasaccharide) was the first of a new class of antithrombotic agents developed for the prevention and treatment of venous thromboembolism (VTE), blocking thrombin generation by selectively inhibiting factor Xa...
  15. doi [Severe meprobamate poisoning: description of 146 cases in a French department]
    Bérenger Mounier
    Urgences Médico chirurgicales, Hopital Nord, CHU, Saint Etienne, France
    Therapie 67:183-9. 2012
    ..Mortality rate was 3%. Our results did not find any significant between-group difference, either in regard of clinical or biological severity criteria. These data argue for a cessation of marketing of all meprobamate-based specialities...
  16. doi Prevalence of poor biological response to clopidogrel: a systematic review
    Nora Mallouk
    Universite de Lyon, EA3065, Université Jean Monnet, Saint Etienne, France
    Thromb Haemost 107:494-506. 2012
    ..This meta-analysis shows that the prevalence of poor biological response depends on the assay employed, the cut-off value and on various unidentified additional factors...