Emmanuelle Delagoutte

Summary

Country: France

Publications

  1. pmc Single-stranded DNA-binding protein in vitro eliminates the orientation-dependent impediment to polymerase passage on CAG/CTG repeats
    Emmanuelle Delagoutte
    Génotoxicologie et Cycle Cellulaire, Institut Curie, CNRS, Universite Paris Sud 11, 91405 Orsay Cedex, France
    J Biol Chem 283:13341-56. 2008
  2. pmc A newly identified essential complex, Dre2-Tah18, controls mitochondria integrity and cell death after oxidative stress in yeast
    Laurence Vernis
    Régulation de la Réplication de l ADN des Eucaryotes, UMR2027 CNRS Institut Curie, INSERM, Universite Paris Sud, Orsay, France
    PLoS ONE 4:e4376. 2009
  3. doi request reprint Single-stranded DNA binding proteins unwind the newly synthesized double-stranded DNA of model miniforks
    Emmanuelle Delagoutte
    Institut Jacques Monod, UMR7592, Pathologies de la réplication de l ADN, CNRS, Paris, France
    Biochemistry 50:932-44. 2011
  4. ncbi request reprint The isomerization of the UvrB-DNA preincision complex couples the UvrB and UvrC activities
    Emmanuelle Delagoutte
    CNRS, Cancérogenèse Moléculaire et Structurale, ESBS conventionnée avec I Université Louis Pasteur de Strasbourg UPR 9003, Boulevard Sebastien Brandt, 67400 Strasbourg Illkirch, France
    J Mol Biol 320:73-84. 2002
  5. ncbi request reprint Macromolecular complexes that unwind nucleic acids
    Peter H von Hippel
    Institute of Molecular Biology and Department of Chemistry, University of Oregon, Eugene 97403, USA
    Bioessays 25:1168-77. 2003
  6. ncbi request reprint Inactivation of the 3'-5' exonuclease of the replicative T4 DNA polymerase allows translesion DNA synthesis at an abasic site
    Nicolas Tanguy Le Gac
    Institut de Pharmacologie et Biologie Structurale, CNRS UMR 5089, 205 route de Narbonne, 31077 Toulouse Cedex 4, France
    J Mol Biol 336:1023-34. 2004
  7. pmc Accessory proteins assist exonuclease-deficient bacteriophage T4 DNA polymerase in replicating past an abasic site
    Giuseppina Blanca
    Institut de Pharmacologie et Biologie Structurale CNRS UMR 5089, 205 route de Narbonne, 31077 Toulouse Cedex 4, France
    Biochem J 402:321-9. 2007
  8. ncbi request reprint Function and assembly of the bacteriophage T4 DNA replication complex: interactions of the T4 polymerase with various model DNA constructs
    Emmanuelle Delagoutte
    Institute of Molecular Biology and Department of Chemistry, University of Oregon, Eugene, Oregon 97403, USA
    J Biol Chem 278:25435-47. 2003
  9. ncbi request reprint Helicase mechanisms and the coupling of helicases within macromolecular machines. Part II: Integration of helicases into cellular processes
    Emmanuelle Delagoutte
    Institute of Molecular Biology and Department of Chemistry, University of Oregon, Eugene, OR 97403, USA
    Q Rev Biophys 36:1-69. 2003
  10. ncbi request reprint Mechanistic studies of the T4 DNA (gp41) replication helicase: functional interactions of the C-terminal Tails of the helicase subunits with the T4 (gp59) helicase loader protein
    Emmanuelle Delagoutte
    Institute of Molecular Biology and Department of Chemistry, University of Oregon, Eugene, OR 97403, USA
    J Mol Biol 347:257-75. 2005

Collaborators

Detail Information

Publications10

  1. pmc Single-stranded DNA-binding protein in vitro eliminates the orientation-dependent impediment to polymerase passage on CAG/CTG repeats
    Emmanuelle Delagoutte
    Génotoxicologie et Cycle Cellulaire, Institut Curie, CNRS, Universite Paris Sud 11, 91405 Orsay Cedex, France
    J Biol Chem 283:13341-56. 2008
    ..To prevent uncoupling, the TNR template is pushed out and by-passed. Hairpins do not cause the block, but appear to occur as a consequence of polymerase pass-over...
  2. pmc A newly identified essential complex, Dre2-Tah18, controls mitochondria integrity and cell death after oxidative stress in yeast
    Laurence Vernis
    Régulation de la Réplication de l ADN des Eucaryotes, UMR2027 CNRS Institut Curie, INSERM, Universite Paris Sud, Orsay, France
    PLoS ONE 4:e4376. 2009
    ..Our results are in favour of an oxidative stress-induced cell death in yeast that involves mitochondria and is controlled by the newly identified Dre2-Tah18 complex...
  3. doi request reprint Single-stranded DNA binding proteins unwind the newly synthesized double-stranded DNA of model miniforks
    Emmanuelle Delagoutte
    Institut Jacques Monod, UMR7592, Pathologies de la réplication de l ADN, CNRS, Paris, France
    Biochemistry 50:932-44. 2011
    ..Taken together, our results position the SSB protein as a potential key player in the reversal of a stalled replication fork and in gap repair-mediated repetitive sequence expansion...
  4. ncbi request reprint The isomerization of the UvrB-DNA preincision complex couples the UvrB and UvrC activities
    Emmanuelle Delagoutte
    CNRS, Cancérogenèse Moléculaire et Structurale, ESBS conventionnée avec I Université Louis Pasteur de Strasbourg UPR 9003, Boulevard Sebastien Brandt, 67400 Strasbourg Illkirch, France
    J Mol Biol 320:73-84. 2002
    ..We propose that the isomerization reaction is responsible for coupling UvrB and UvrC activities and that this reaction corresponds to the binding of ATP...
  5. ncbi request reprint Macromolecular complexes that unwind nucleic acids
    Peter H von Hippel
    Institute of Molecular Biology and Department of Chemistry, University of Oregon, Eugene 97403, USA
    Bioessays 25:1168-77. 2003
    ....
  6. ncbi request reprint Inactivation of the 3'-5' exonuclease of the replicative T4 DNA polymerase allows translesion DNA synthesis at an abasic site
    Nicolas Tanguy Le Gac
    Institut de Pharmacologie et Biologie Structurale, CNRS UMR 5089, 205 route de Narbonne, 31077 Toulouse Cedex 4, France
    J Mol Biol 336:1023-34. 2004
    ....
  7. pmc Accessory proteins assist exonuclease-deficient bacteriophage T4 DNA polymerase in replicating past an abasic site
    Giuseppina Blanca
    Institut de Pharmacologie et Biologie Structurale CNRS UMR 5089, 205 route de Narbonne, 31077 Toulouse Cedex 4, France
    Biochem J 402:321-9. 2007
    ..The capacity to separate these distinct functions in a single DNA polymerase provides insight into the biochemical requirements for translesion DNA synthesis...
  8. ncbi request reprint Function and assembly of the bacteriophage T4 DNA replication complex: interactions of the T4 polymerase with various model DNA constructs
    Emmanuelle Delagoutte
    Institute of Molecular Biology and Department of Chemistry, University of Oregon, Eugene, Oregon 97403, USA
    J Biol Chem 278:25435-47. 2003
    ..We suggest that changes in the kinetics and thermodynamics of these steps by auxiliary replication proteins constitute a basic mechanism for protein coupling within the replication complex...
  9. ncbi request reprint Helicase mechanisms and the coupling of helicases within macromolecular machines. Part II: Integration of helicases into cellular processes
    Emmanuelle Delagoutte
    Institute of Molecular Biology and Department of Chemistry, University of Oregon, Eugene, OR 97403, USA
    Q Rev Biophys 36:1-69. 2003
    ....
  10. ncbi request reprint Mechanistic studies of the T4 DNA (gp41) replication helicase: functional interactions of the C-terminal Tails of the helicase subunits with the T4 (gp59) helicase loader protein
    Emmanuelle Delagoutte
    Institute of Molecular Biology and Department of Chemistry, University of Oregon, Eugene, OR 97403, USA
    J Mol Biol 347:257-75. 2005
    ....