Andre Delacourte

Summary

Country: France

Publications

  1. ncbi Tauopathies: recent insights into old diseases
    Andre Delacourte
    Inserm Unit 815, 1, Place de Verdun, 59045 Lille Cedex France
    Folia Neuropathol 43:244-57. 2005
  2. ncbi Tau pathology and neurodegeneration: an obvious but misunderstood link
    Andre Delacourte
    Inserm Unit 837 JPARC, Lille Cedex, France
    J Alzheimers Dis 14:437-40. 2008
  3. ncbi [From physiopathology to treatment of Alzheimer's disease]
    A Delacourte
    Unité Inserm 815, Lille, France
    Rev Neurol (Paris) 162:909-12. 2006
  4. ncbi The natural and molecular history of Alzheimer's disease
    Andre Delacourte
    Unit Inserm 422, 1, Place de Verdun, 59045 Lille Cedex, France
    J Alzheimers Dis 9:187-94. 2006
  5. ncbi [Animal models of Alzheimer's disease: a road full of pitfalls]
    Andre Delacourte
    Unite INSERM 422, Lille
    Psychol Neuropsychiatr Vieil 3:261-70. 2005
  6. ncbi Stable-tau overexpression in human neuroblastoma cells: an open door for explaining neuronal death in tauopathies
    Patrice Delobel
    INSERM U422, Institut de Médecine Prédictive et Recherche Thérapeutique, Place de Verdun, F 59045 Lille Cedex, France
    Ann N Y Acad Sci 1010:623-34. 2003
  7. ncbi Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies
    Valérie Vingtdeux
    INSERM, U837, Neurodegenerative Disorders and Neuronal Death, Lille, France
    J Biol Chem 282:18197-205. 2007
  8. ncbi Progressive decrease of amyloid precursor protein carboxy terminal fragments (APP-CTFs), associated with tau pathology stages, in Alzheimer's disease
    Nicolas Sergeant
    INSERM U422, 1 place de Verdun, 59045 Lille Cedex, France
    J Neurochem 81:663-72. 2002
  9. ncbi Neurofibrillary degeneration of the Alzheimer-type: an alternate pathway to neuronal apoptosis?
    Malika Hamdane
    INSERM U422, Institut de Médecine Prédictive et Recherche Thérapeutique, Place de Verdun, F 59045 Lille Cedex, France
    Biochem Pharmacol 66:1619-25. 2003
  10. ncbi Abnormal Tau phosphorylation of the Alzheimer-type also occurs during mitosis
    Patrice Delobel
    INSERM U422, Institut de Médecine Prédictive et Recherche Thérapeutique, Lille, France
    J Neurochem 83:412-20. 2002

Collaborators

  • Florence Pasquier
  • Claude Alain Maurage
  • Isabelle Landrieu
  • Stephanie Bombois
  • Karim Belarbi
  • Athena Andreadis
  • Katharina Schindowski
  • David Blum
  • Vincent Deramecourt
  • Nicolas Sergeant
  • Malika Hamdane
  • Luc Buee
  • Séverine Bégard
  • Patrice Delobel
  • Valérie Vingtdeux
  • Anne Véronique Sambo
  • Antoine Ghestem
  • Susanna Schraen-Maschke
  • Claire Marie Dhaenens
  • Eugeen Vanmechelen
  • Bernard Sablonniere
  • Anne Violleau
  • Anne Loyens
  • Marie Laure Caillet-Boudin
  • Jean Claude Beauvillain
  • Pierre Grognet
  • Alexis Bretteville
  • Olivier Leroy
  • Philippe Bertrand
  • Hervé Drobecq
  • Vesna Kostanjevecki
  • Caroline Smet
  • Guy Lippens
  • Christel Mailliot
  • Annick Wattez
  • Stephane Flament
  • Marie Christine Galas
  • Patrick Gele
  • Hervé Drobeck
  • Philippe Marambaud
  • Suzanna Schraen-Maschke
  • Marie Eve Grosjean
  • Marie Gompel
  • Edwige Van Brussel
  • Jesus Benavides
  • Carla Missiaen
  • Christian Sergheraert
  • Jean Phillipe David
  • Jean Michel Wieruszeski
  • Danie Champain
  • Dragos Horvath
  • Arnaud Leroy
  • Jean Pierre Vilain
  • Jean Philippe David
  • René Wintjens

Detail Information

Publications26

  1. ncbi Tauopathies: recent insights into old diseases
    Andre Delacourte
    Inserm Unit 815, 1, Place de Verdun, 59045 Lille Cedex France
    Folia Neuropathol 43:244-57. 2005
    ..In conclusion, we observe that most dementing disorders are tauopathies and that most demented patients have a tauopathy...
  2. ncbi Tau pathology and neurodegeneration: an obvious but misunderstood link
    Andre Delacourte
    Inserm Unit 837 JPARC, Lille Cedex, France
    J Alzheimers Dis 14:437-40. 2008
    ..In other words, sporadic tauopathies are mostly a destabilization of specific neuronal networks that should be modeled for an efficient therapeutic approach...
  3. ncbi [From physiopathology to treatment of Alzheimer's disease]
    A Delacourte
    Unité Inserm 815, Lille, France
    Rev Neurol (Paris) 162:909-12. 2006
    ..Because animal models are not perfectly relevant, at the end of the long and costly pathway of drug discovery, therapeutic trials are the only way to test these different hypotheses...
  4. ncbi The natural and molecular history of Alzheimer's disease
    Andre Delacourte
    Unit Inserm 422, 1, Place de Verdun, 59045 Lille Cedex, France
    J Alzheimers Dis 9:187-94. 2006
    ..Altogether, our molecular study suggests that AD is a tauopathy fueled by AbetaPP dysfunction. Restoring AbetaPP loss of function seems to be the most efficient therapeutic approach...
  5. ncbi [Animal models of Alzheimer's disease: a road full of pitfalls]
    Andre Delacourte
    Unite INSERM 422, Lille
    Psychol Neuropsychiatr Vieil 3:261-70. 2005
    ..Transgenic mice merely reflect partial aspects of the physiopathological process, impeding therapeutic approaches such as relevant drug tests on animals. But research is in progress.....
  6. ncbi Stable-tau overexpression in human neuroblastoma cells: an open door for explaining neuronal death in tauopathies
    Patrice Delobel
    INSERM U422, Institut de Médecine Prédictive et Recherche Thérapeutique, Place de Verdun, F 59045 Lille Cedex, France
    Ann N Y Acad Sci 1010:623-34. 2003
    ..Because truncated Tau generated during apoptosis are not commonly found in Tau aggregates, apoptotic processes may not be of interest in neurofibrillary degeneration...
  7. ncbi Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies
    Valérie Vingtdeux
    INSERM, U837, Neurodegenerative Disorders and Neuronal Death, Lille, France
    J Biol Chem 282:18197-205. 2007
    ..Together with recent data showing that amyloid-beta is also found in exosomes, our data show that multivesicular bodies are essential organelles for APP metabolism and that all APP metabolites can be secreted in the extracellular space...
  8. ncbi Progressive decrease of amyloid precursor protein carboxy terminal fragments (APP-CTFs), associated with tau pathology stages, in Alzheimer's disease
    Nicolas Sergeant
    INSERM U422, 1 place de Verdun, 59045 Lille Cedex, France
    J Neurochem 81:663-72. 2002
    ..Together, we show here for the first time a modification directly observed on APP-CTFs upstream of Abeta products and its relationship with tau pathology, which could reflect the basic aetiological mechanisms of AD...
  9. ncbi Neurofibrillary degeneration of the Alzheimer-type: an alternate pathway to neuronal apoptosis?
    Malika Hamdane
    INSERM U422, Institut de Médecine Prédictive et Recherche Thérapeutique, Place de Verdun, F 59045 Lille Cedex, France
    Biochem Pharmacol 66:1619-25. 2003
    ....
  10. ncbi Abnormal Tau phosphorylation of the Alzheimer-type also occurs during mitosis
    Patrice Delobel
    INSERM U422, Institut de Médecine Prédictive et Recherche Thérapeutique, Lille, France
    J Neurochem 83:412-20. 2002
    ..Our results not only demonstrate the involvement of mitotic kinases in Alzheimer-type Tau phosphorylation but also indicate that Xenopus oocyte could be a useful model to identify the kinases involved in this process...
  11. ncbi Intracellular pH regulates amyloid precursor protein intracellular domain accumulation
    Valérie Vingtdeux
    INSERM U815, Centre Jean Pierre Aubert, Neurodegenerative Disorders and Neuronal Death, 1, Place de Verdun, F 59045 Lille, France
    Neurobiol Dis 25:686-96. 2007
    ..Altogether, our data demonstrate for the first time that alkalizing drugs induce the accumulation of AICD, a mechanism likely mediated by the endosome/lysosome pathway...
  12. ncbi p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death
    Malika Hamdane
    INSERM U422, Institut de Médecine Prédictive et Recherche Thérapeutique, Universite de Lille 2, Place de Verdun, 59045 Lille Cedex, France
    J Cell Sci 118:1291-8. 2005
    ..Hence, Rb might be an appropriate candidate that connects Cdk5 to cell-cycle deregulation during neuronal cell death...
  13. ncbi Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach
    Nicolas Sergeant
    INSERM U422, Groupe VCDN, Equipe Protéomique, Lille, France
    J Neurochem 85:1581-91. 2003
    ....
  14. ncbi ETR-3 represses Tau exons 2/3 inclusion, a splicing event abnormally enhanced in myotonic dystrophy type I
    Olivier Leroy
    INSERM U815, Lille, France
    J Neurosci Res 84:852-9. 2006
    ..These results together with the analysis of Tau exon 6 and IR exon 11 splicing in brain, muscle, and cell models suggest that DM1 splicing alteration of several transcripts involves various factors...
  15. ncbi Diffuse form of argyrophilic grain disease: a new variant of four-repeat tauopathy different from limbic argyrophilic grain disease
    Claude Alain Maurage
    INSERM U422, Faculte de Medecine, Universite de Lille 2, 1 place de Verdun, 59045 Cedex, Lille, France
    Acta Neuropathol 106:575-83. 2003
    ..We suggest that "diffuse" AGD might be a subgroup of AGD, the specific profile of which is different from that of "limbic" AGD...
  16. doi Biochemistry of Tau in Alzheimer's disease and related neurological disorders
    Nicolas Sergeant
    INSERM, U837, Place de Verdun, 59045 Lille, France
    Expert Rev Proteomics 5:207-24. 2008
    ..Finally, recent advances in proteomics technology are essential to develop further therapeutic targets and early predictive and discriminative diagnostic assays for Alzheimer's disease and related disorders...
  17. ncbi Tau protein as a differential biomarker of tauopathies
    Nicolas Sergeant
    INSERM U422, 1, Place de Verdun, 59045 Lille Cedex, France
    Biochim Biophys Acta 1739:179-97. 2005
    ..They would hopefully find their application against Alzheimer's disease but also in all neurological disorders for which a dysfunction of Tau biology has been identified...
  18. ncbi Mitotic-like tau phosphorylation by p25-Cdk5 kinase complex
    Malika Hamdane
    INSERM U422, IMPRT, Place de Verdun, 59045 Lille, France and CNS Research, Aventis Pharma, 94400 Vitry sur Seine, France
    J Biol Chem 278:34026-34. 2003
    ..These data suggest that p25-Cdk5 is responsible for the mitotic-like phosphoepitopes present in NFT and argue for a critical role of Cdk5 in neurodegenerative mechanisms...
  19. ncbi Pin1: a therapeutic target in Alzheimer neurodegeneration
    Malika Hamdane
    INSERM U422, IMPRT, Place de Verdun, Lille, France
    J Mol Neurosci 19:275-87. 2002
    ..The involvement of Pin1 in the G0/G1 transition in neurons points to its function as a good target for the development of new therapeutic strategies in neurodegenerative disorders...
  20. ncbi Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism
    Valérie Vingtdeux
    Department of Cerebral Aging and Neurodegeneration, INSERM U422, 1, Place de Verdun, 59045 Lille, France
    Neurobiol Dis 20:625-37. 2005
    ..Altogether, our results demonstrated that phosphorylated CTFs can be the substrates of the gamma-secretase and that an increase in the phosphorylation of APP-CTFs facilitates their processing by gamma-secretase...
  21. ncbi In vitro models of age-related neurodegenerative disorders
    Andre Delacourte
    INSERM U422, Institut de Médecine Prédictive et Recherche Thérapeutique, Place de Verdun, 59045 Lille, France
    Exp Gerontol 38:1309-17. 2003
    ..In addition, the late onset of these pathologies links them to ageing processes. Cause or consequence? Experimental models, that allow us to dissect these pathophysiological defects, are presented...
  22. ncbi Tau aggregation in the hippocampal formation: an ageing or a pathological process?
    Andre Delacourte
    Unite INSERM 422, 1, Place de Verdun, 59045 Lille Cedex, France
    Exp Gerontol 37:1291-6. 2002
    ..Tauopathy in the entorhinal and hippocampal formation could be another type of pathological dysfunction of tau proteins, and a therapeutic target to delay AD. Relevant animal models are desperately needed to address this issue...
  23. ncbi Microtubule-associated protein tau gene: a risk factor in human neurodegenerative diseases
    Susanna Schraen-Maschke
    INSERM U422 and Département de Biochimie et de Biologie moléculaire, Faculte de Medecine, Universite de Lille 2, Place de Verdun, 59045, Lille Cedex, France
    Neurobiol Dis 15:449-60. 2004
    ..Hopefully, the identification of several genetic defects of the tau gene will be helpful in improving our understanding of the role of tau protein in the pathogenesis of various neurodegenerative diseases...
  24. ncbi Absence of beta-amyloid deposits after immunization in Alzheimer disease with Lewy body dementia
    Stephanie Bombois
    Department of Neurology, Resource and Research Memory Center, University Hospital, Lille, France
    Arch Neurol 64:583-7. 2007
    ....
  25. ncbi [Tau story: from frontotemporal dementia to other tauopathies]
    Luc Buee
    INSERM U422, Place de Verdun, F 59045 Lille, France
    J Soc Biol 196:103-8. 2002
    ..Conversely, recent data in myotonic dystrophy has demonstrated that indirect effect (CTG repeat expansion) leading to variations in tau alternative splicing also produce neurofibrillary degeneration...
  26. ncbi Association study of three polymorphisms of kinesin light-chain 1 gene with Alzheimer's disease
    Claire Marie Dhaenens
    Groupe Vieillissement Cérébral et Maladies Neurodégénératives, INSERM U422, Laboratoire G Biserte et Faculté de Médecine, Universite de Lille 2, Place de Verdun 59045, Lille Cedex, France
    Neurosci Lett 368:290-2. 2004
    ..73, 95% CI: 1.12-2.67, P = 0.012). No synergistic effects were found between the APOE epsilon 4 allele and KNS2 gene polymorphisms...