Genomes and Genes
- Tauopathies: recent insights into old diseasesAndre Delacourte
Inserm Unit 815, 1, Place de Verdun, 59045 Lille Cedex France
Folia Neuropathol 43:244-57. 2005..In conclusion, we observe that most dementing disorders are tauopathies and that most demented patients have a tauopathy...
- Tau pathology and neurodegeneration: an obvious but misunderstood linkAndre Delacourte
Inserm Unit 837 JPARC, Lille Cedex, France
J Alzheimers Dis 14:437-40. 2008..In other words, sporadic tauopathies are mostly a destabilization of specific neuronal networks that should be modeled for an efficient therapeutic approach...
- [From physiopathology to treatment of Alzheimer's disease]A Delacourte
Unité Inserm 815, Lille, France
Rev Neurol (Paris) 162:909-12. 2006..Because animal models are not perfectly relevant, at the end of the long and costly pathway of drug discovery, therapeutic trials are the only way to test these different hypotheses...
- The natural and molecular history of Alzheimer's diseaseAndre Delacourte
Unit Inserm 422, 1, Place de Verdun, 59045 Lille Cedex, France
J Alzheimers Dis 9:187-94. 2006..Altogether, our molecular study suggests that AD is a tauopathy fueled by AbetaPP dysfunction. Restoring AbetaPP loss of function seems to be the most efficient therapeutic approach...
- [Animal models of Alzheimer's disease: a road full of pitfalls]Andre Delacourte
Unite INSERM 422, Lille
Psychol Neuropsychiatr Vieil 3:261-70. 2005..Transgenic mice merely reflect partial aspects of the physiopathological process, impeding therapeutic approaches such as relevant drug tests on animals. But research is in progress.....
- Neurofibrillary degeneration of the Alzheimer-type: an alternate pathway to neuronal apoptosis?Malika Hamdane
INSERM U422, Institut de Médecine Prédictive et Recherche Thérapeutique, Place de Verdun, F 59045 Lille Cedex, France
Biochem Pharmacol 66:1619-25. 2003....
- p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell deathMalika Hamdane
INSERM U422, Institut de Médecine Prédictive et Recherche Thérapeutique, Universite de Lille 2, Place de Verdun, 59045 Lille Cedex, France
J Cell Sci 118:1291-8. 2005..Hence, Rb might be an appropriate candidate that connects Cdk5 to cell-cycle deregulation during neuronal cell death...
- Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodiesValérie Vingtdeux
INSERM, U837, Neurodegenerative Disorders and Neuronal Death, Lille, France
J Biol Chem 282:18197-205. 2007..Together with recent data showing that amyloid-beta is also found in exosomes, our data show that multivesicular bodies are essential organelles for APP metabolism and that all APP metabolites can be secreted in the extracellular space...
- Intracellular pH regulates amyloid precursor protein intracellular domain accumulationValérie Vingtdeux
INSERM U815, Centre Jean Pierre Aubert, Neurodegenerative Disorders and Neuronal Death, 1, Place de Verdun, F 59045 Lille, France
Neurobiol Dis 25:686-96. 2007..Altogether, our data demonstrate for the first time that alkalizing drugs induce the accumulation of AICD, a mechanism likely mediated by the endosome/lysosome pathway...
- Biochemistry of Tau in Alzheimer's disease and related neurological disordersNicolas Sergeant
INSERM, U837, Place de Verdun, 59045 Lille, France
Expert Rev Proteomics 5:207-24. 2008..Finally, recent advances in proteomics technology are essential to develop further therapeutic targets and early predictive and discriminative diagnostic assays for Alzheimer's disease and related disorders...
- Mitotic-like tau phosphorylation by p25-Cdk5 kinase complexMalika Hamdane
INSERM U422, IMPRT, Place de Verdun, 59045 Lille, France and CNS Research, Aventis Pharma, 94400 Vitry sur Seine, France
J Biol Chem 278:34026-34. 2003..These data suggest that p25-Cdk5 is responsible for the mitotic-like phosphoepitopes present in NFT and argue for a critical role of Cdk5 in neurodegenerative mechanisms...
- Pin1: a therapeutic target in Alzheimer neurodegenerationMalika Hamdane
INSERM U422, IMPRT, Place de Verdun, Lille, France
J Mol Neurosci 19:275-87. 2002..The involvement of Pin1 in the G0/G1 transition in neurons points to its function as a good target for the development of new therapeutic strategies in neurodegenerative disorders...
- Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanismValérie Vingtdeux
Department of Cerebral Aging and Neurodegeneration, INSERM U422, 1, Place de Verdun, 59045 Lille, France
Neurobiol Dis 20:625-37. 2005..Altogether, our results demonstrated that phosphorylated CTFs can be the substrates of the gamma-secretase and that an increase in the phosphorylation of APP-CTFs facilitates their processing by gamma-secretase...
- In vitro models of age-related neurodegenerative disordersAndre Delacourte
INSERM U422, Institut de Médecine Prédictive et Recherche Thérapeutique, Place de Verdun, 59045 Lille, France
Exp Gerontol 38:1309-17. 2003..In addition, the late onset of these pathologies links them to ageing processes. Cause or consequence? Experimental models, that allow us to dissect these pathophysiological defects, are presented...
- Tau aggregation in the hippocampal formation: an ageing or a pathological process?Andre Delacourte
Unite INSERM 422, 1, Place de Verdun, 59045 Lille Cedex, France
Exp Gerontol 37:1291-6. 2002..Tauopathy in the entorhinal and hippocampal formation could be another type of pathological dysfunction of tau proteins, and a therapeutic target to delay AD. Relevant animal models are desperately needed to address this issue...
- Absence of beta-amyloid deposits after immunization in Alzheimer disease with Lewy body dementiaStephanie Bombois
Department of Neurology, Resource and Research Memory Center, University Hospital, Lille, France
Arch Neurol 64:583-7. 2007....
- [Tau story: from frontotemporal dementia to other tauopathies]Luc Buee
INSERM U422, Place de Verdun, F 59045 Lille, France
J Soc Biol 196:103-8. 2002..Conversely, recent data in myotonic dystrophy has demonstrated that indirect effect (CTG repeat expansion) leading to variations in tau alternative splicing also produce neurofibrillary degeneration...
- Association study of three polymorphisms of kinesin light-chain 1 gene with Alzheimer's diseaseClaire Marie Dhaenens
Groupe Vieillissement Cérébral et Maladies Neurodégénératives, INSERM U422, Laboratoire G Biserte et Faculté de Médecine, Universite de Lille 2, Place de Verdun 59045, Lille Cedex, France
Neurosci Lett 368:290-2. 2004..73, 95% CI: 1.12-2.67, P = 0.012). No synergistic effects were found between the APOE epsilon 4 allele and KNS2 gene polymorphisms...