- HIV-1 replication in CD4+ T cell lines: the effects of adaptation on co-receptor use, tropism, and accessory gene functionN Dejucq
Wohl Virion Centre, Windeyer Institute of Medical Sciences, London, United Kingdom
J Leukoc Biol 68:331-7. 2000..g., vpu) not required for replication in rapidly dividing cell lines may also occur in vitro, abrogating replication in primary cell types such as macrophages. Such mutations, however, are normally selected against in vivo...
- T-cell line adaptation of human immunodeficiency virus type 1 strain SF162: effects on envelope, vpu and macrophage-tropismN Dejucq
The Wohl Virion Centre, Department of Immunology and Molecular Pathology, The Windeyer Institute of Medical Sciences, University College London, 46 Cleveland Street, London W1P 6DB, UK
J Gen Virol 81:2899-904. 2000..We discuss how V3 loop and vpu mutations acquired by replication in T-cell lines in vitro correlate with similar changes reported for primary isolates and HIV-1 sequences in vivo...
- Viruses in the mammalian male genital tract and their effects on the reproductive systemN Dejucq
GERM INSERM U435, Universite de Rennes I, Campus de Beaulieu, 35042 Rennes Cedex, France
Microbiol Mol Biol Rev 65:208-31 ; first and second pages, table of contents. 2001..Progress in all these domains is essential for the development of new treatment strategies to eradicate viruses and to correct the virus-induced dysfunction of the endocrine system...