Benjamin Dehay

Summary

Country: France

Publications

  1. pmc Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate
    Marie Hélène Canron
    Univ de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F 33000 Bordeaux, France
    Sci Rep 2:910. 2012
  2. doi Lysosomal impairment in Parkinson's disease
    Benjamin Dehay
    Institute of Neurodegenerative Diseases, University of Bordeaux Segalen, Centre National de Recherche Scientifique Unité Mixte de Recherche 5293, Bordeaux, France
    Mov Disord 28:725-32. 2013
  3. pmc Lysosomal dysfunction in Parkinson disease: ATP13A2 gets into the groove
    Benjamin Dehay
    Institut des Maladies Neurodégénératives, Universite de Bordeaux, CNRS UMR 5293, Bordeaux, France
    Autophagy 8:1389-91. 2012
  4. pmc Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration
    Benjamin Dehay
    Insitute of Neurodegenerative Diseases, University of Bordeaux Segalen, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5293, 33076 Bordeaux, France
    Proc Natl Acad Sci U S A 109:9611-6. 2012
  5. ncbi New animal models of Parkinson's disease
    Benjamin Dehay
    Université Victor Segalen Bordeaux II, Centre National de la Recherche Scientifique, Institute of Neurodegenerative Diseases, Bordeaux, France
    Mov Disord 26:1198-1205. 2011
  6. pmc Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques
    Benjamin Dehay
    Univ de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F 33000 Bordeaux, France
    Sci Rep 2:253. 2012
  7. ncbi Multiple system atrophy: a prototypical synucleinopathy for disease-modifying therapeutic strategies
    Pierre Olivier Fernagut
    Univ de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F 33000 Bordeaux, France CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F 33000 Bordeaux, France
    Neurobiol Dis 67:133-9. 2014
  8. pmc PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking
    Gregory Porras
    Universite de Bordeaux, Institut des Maladies Neurodégénératives, Bordeaux, France
    J Clin Invest 122:3977-89. 2012

Collaborators

Detail Information

Publications8

  1. pmc Age-dependent α-synuclein aggregation in the Microcebus murinus lemur primate
    Marie Hélène Canron
    Univ de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F 33000 Bordeaux, France
    Sci Rep 2:910. 2012
    ..Microcebus murinus may provide a model to study age-associated α-synucleinopathy and for testing putative therapeutic interventions for both Alzheimer's and Parkinson's diseases...
  2. doi Lysosomal impairment in Parkinson's disease
    Benjamin Dehay
    Institute of Neurodegenerative Diseases, University of Bordeaux Segalen, Centre National de Recherche Scientifique Unité Mixte de Recherche 5293, Bordeaux, France
    Mov Disord 28:725-32. 2013
    ....
  3. pmc Lysosomal dysfunction in Parkinson disease: ATP13A2 gets into the groove
    Benjamin Dehay
    Institut des Maladies Neurodégénératives, Universite de Bordeaux, CNRS UMR 5293, Bordeaux, France
    Autophagy 8:1389-91. 2012
    ..Our results unravel an instrumental role of ATP13A2 in lysosomal function and in cell viability. Altogether, our results validate ATP13A2 as a likely therapeutic target against PD degeneration...
  4. pmc Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration
    Benjamin Dehay
    Insitute of Neurodegenerative Diseases, University of Bordeaux Segalen, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5293, 33076 Bordeaux, France
    Proc Natl Acad Sci U S A 109:9611-6. 2012
    ..Our results unravel an instrumental role of ATP13A2 deficiency on lysosomal function and cell viability and demonstrate the feasibility and therapeutic potential of modulating ATP13A2 levels in the context of PD...
  5. ncbi New animal models of Parkinson's disease
    Benjamin Dehay
    Université Victor Segalen Bordeaux II, Centre National de la Recherche Scientifique, Institute of Neurodegenerative Diseases, Bordeaux, France
    Mov Disord 26:1198-1205. 2011
    ..The present nonexhaustive review looks at invertebrate and mammalian models of Parkinson's disease generated in the last three years...
  6. pmc Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques
    Benjamin Dehay
    Univ de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F 33000 Bordeaux, France
    Sci Rep 2:253. 2012
    ..The present data pave the way to large-scale genetic modelling of brain diseases in the rhesus macaque...
  7. ncbi Multiple system atrophy: a prototypical synucleinopathy for disease-modifying therapeutic strategies
    Pierre Olivier Fernagut
    Univ de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F 33000 Bordeaux, France CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F 33000 Bordeaux, France
    Neurobiol Dis 67:133-9. 2014
    ..In this personal view, we will review evidence, and discuss why MSA could prove the most relevant clinical model for assessing treatments that target mechanisms operating in all synucleinopathies...
  8. pmc PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking
    Gregory Porras
    Universite de Bordeaux, Institut des Maladies Neurodégénératives, Bordeaux, France
    J Clin Invest 122:3977-89. 2012
    ..These findings indicate that altering D1R trafficking via synapse-associated scaffolding proteins may be useful in the treatment of dyskinesia in Parkinson's patients...