M Deckert

Summary

Country: France

Publications

  1. ncbi request reprint The immunological synapse and Rho GTPases
    M Deckert
    INSERM Unit 576, Hopital de l Archet, BP3079, 06202 Nice, France
    Curr Top Microbiol Immunol 291:61-90. 2005
  2. doi request reprint Technical Advance: Actin CytoFRET, a novel FRET flow cytometry method for detection of actin dynamics in resting and activated T cell
    Frederic Larbret
    1 INSERM U1065 C3M, Team Microenvironment, Signaling and Cancer, Batiment Universitaire ARCHIMED, 151 Route de Ginestière BP 23194, 06204 Nice Cedex 3, France
    J Leukoc Biol 94:531-9. 2013
  3. ncbi request reprint [The adaptor protein 3BP2 in leukocyte signaling]
    Marcel Deckert
    INSERM U576, Régulation des réponses immune et inflammatoire, Hopital de l Archet, route Saint Antoine de Ginestiere, 06202 Nice, France
    Med Sci (Paris) 22:1081-6. 2006
  4. ncbi request reprint Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis
    Severine Le Bras
    Institut National de la Sante Et de la Recherche Medicale Unite 576, Hopital de l Archet, Cedex 3, 06202 Nice, France
    J Biol Chem 279:15550-60. 2004
  5. ncbi request reprint The adaptor protein 3BP2 associates with VAV guanine nucleotide exchange factors to regulate NFAT activation by the B-cell antigen receptor
    Isabelle Foucault
    Institut National de la Sante Et de la Recherche Medicale Unite 576, Nice, France
    Blood 105:1106-13. 2005
  6. ncbi request reprint Abl-SH3 binding protein 2, 3BP2, interacts with CIN85 and HIP-55
    Severine Le Bras
    Institut National de la Sante et de la Recherche Medicale, Universite de Nice Sophia Antipolis, UMR 576, Hopital de l Archet, route Saint Antoine de Ginestiere, Nice Cedex 3, F 06202, France
    FEBS Lett 581:967-74. 2007
  7. ncbi request reprint Vav1 couples T cell receptor to serum response factor-dependent transcription via a MEK-dependent pathway
    Celine Charvet
    INSERM U343, IFR50, Hopital de l Archet, 06202 Nice Cedex 3, France
    J Biol Chem 277:15376-84. 2002
  8. ncbi request reprint Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte
    S Tartare-Deckert
    INSERM Unité 343, IFR50, Hopital de l Archet, 06202 Nice, Cedex 3, France
    J Biol Chem 276:20849-57. 2001
  9. ncbi request reprint Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases
    Celine Charvet
    INSERM U343, IFR50, Hopital de l Archet, 06202 Nice, France
    Oncogene 22:4557-68. 2003
  10. pmc 3BP2 adapter protein is required for receptor activator of NFκB ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells
    Amel Guezguez
    INSERM, UMR576, Hopital de l Archet, Nice F 06202, France
    J Biol Chem 285:20952-63. 2010

Collaborators

  • Oreste Acuto
  • M Ticchioni
  • Robert Rottapel
  • Amnon Altman
  • Celine Charvet
  • Alain Bernard
  • Severine Le Bras
  • Isabelle Foucault
  • Frederic Larbret
  • Amel Guezguez
  • Cheol Moon
  • Elodie Guillemot
  • Sophie Tartare-Deckert
  • Frédéric Brau
  • Nicholas Dubois
  • Karim Mahiddine
  • Valerie Verhasselt
  • S Tartare-Deckert
  • Xavier Mouska
  • Alice Baudot
  • Virginie Prod'homme
  • Claudine Blin-Wakkach
  • Jean Philippe Breittmayer
  • Arnaud Foussat
  • Chrystelle Brignone
  • M N Monthouel
  • I Foucault
  • E Van Obberghen

Detail Information

Publications12

  1. ncbi request reprint The immunological synapse and Rho GTPases
    M Deckert
    INSERM Unit 576, Hopital de l Archet, BP3079, 06202 Nice, France
    Curr Top Microbiol Immunol 291:61-90. 2005
    ..This review summarizes recent advances in our understanding of how Rho GTPase-dependent pathways control T lymphocyte motility, polarization and activation...
  2. doi request reprint Technical Advance: Actin CytoFRET, a novel FRET flow cytometry method for detection of actin dynamics in resting and activated T cell
    Frederic Larbret
    1 INSERM U1065 C3M, Team Microenvironment, Signaling and Cancer, Batiment Universitaire ARCHIMED, 151 Route de Ginestière BP 23194, 06204 Nice Cedex 3, France
    J Leukoc Biol 94:531-9. 2013
    ..In conclusion, the flow cytometric FRET analysis of actin polymerization represents a new technical advance to study the dynamics of actin regulation in intact cells. ..
  3. ncbi request reprint [The adaptor protein 3BP2 in leukocyte signaling]
    Marcel Deckert
    INSERM U576, Régulation des réponses immune et inflammatoire, Hopital de l Archet, route Saint Antoine de Ginestiere, 06202 Nice, France
    Med Sci (Paris) 22:1081-6. 2006
    ..Recently, the 3bp2/sh3bp2 locus was shown to be mutated in a rare human disease involved in cranial-facial development called cherubism, suggesting a role for 3BP2 in regulating osteoclast and hematopoietic cell function...
  4. ncbi request reprint Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis
    Severine Le Bras
    Institut National de la Sante Et de la Recherche Medicale Unite 576, Hopital de l Archet, Cedex 3, 06202 Nice, France
    J Biol Chem 279:15550-60. 2004
    ..Our findings show that HIP-55 is a key novel component of the immunological synapse that modulates T cell activation by connecting actin cytoskeleton and TCRs to gene activation and endocytic processes...
  5. ncbi request reprint The adaptor protein 3BP2 associates with VAV guanine nucleotide exchange factors to regulate NFAT activation by the B-cell antigen receptor
    Isabelle Foucault
    Institut National de la Sante Et de la Recherche Medicale Unite 576, Nice, France
    Blood 105:1106-13. 2005
    ..Finally, evidence was provided that 3BP2 functionally cooperates with Vav proteins and Rho GTPases to activate NFATs. Our results show that 3BP2 may regulate BCR-mediated gene activation through Vav proteins...
  6. ncbi request reprint Abl-SH3 binding protein 2, 3BP2, interacts with CIN85 and HIP-55
    Severine Le Bras
    Institut National de la Sante et de la Recherche Medicale, Universite de Nice Sophia Antipolis, UMR 576, Hopital de l Archet, route Saint Antoine de Ginestiere, Nice Cedex 3, F 06202, France
    FEBS Lett 581:967-74. 2007
    ..Together, our data suggest an unexpected role of 3BP2 in endocytic and cytoskeletal regulation through its interaction with CIN85 and HIP-55...
  7. ncbi request reprint Vav1 couples T cell receptor to serum response factor-dependent transcription via a MEK-dependent pathway
    Celine Charvet
    INSERM U343, IFR50, Hopital de l Archet, 06202 Nice Cedex 3, France
    J Biol Chem 277:15376-84. 2002
    ..This report establishes Vav proteins as a direct link between antigen receptors and SRF-dependent early gene expression...
  8. ncbi request reprint Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte
    S Tartare-Deckert
    INSERM Unité 343, IFR50, Hopital de l Archet, 06202 Nice, Cedex 3, France
    J Biol Chem 276:20849-57. 2001
    ..Taken together, our results indicate that Vav1 and Vav2 exert overlapping but nonidentical functions in T cells. The negative regulatory pathway elicited by Vav2 might play an important role in regulating lymphocyte activation processes...
  9. ncbi request reprint Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases
    Celine Charvet
    INSERM U343, IFR50, Hopital de l Archet, 06202 Nice, France
    Oncogene 22:4557-68. 2003
    ..Together, these results indicate that the proteolytic cleavage of FOXO3a by caspases may represent a novel regulatory mechanism of FOXO3a activity during death receptors signaling...
  10. pmc 3BP2 adapter protein is required for receptor activator of NFκB ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells
    Amel Guezguez
    INSERM, UMR576, Hopital de l Archet, Nice F 06202, France
    J Biol Chem 285:20952-63. 2010
    ..Together, this study demonstrates that wild type 3BP2 is a key regulator of RANK-mediated macrophage differentiation into osteoclast through Src and NFATc1 activation...
  11. ncbi request reprint Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a
    M Ticchioni
    Departement d Immunologie, Hopital de l Archet, Universite de Nice Sophia Antipolis, Nice, France
    Oncogene 26:7081-91. 2007
    ....
  12. ncbi request reprint Signaling through ZAP-70 is required for CXCL12-mediated T-cell transendothelial migration
    Michel Ticchioni
    INSERM U343 and Laboratoire d Immunologie, Hopital de l Archet, Nice, France
    Blood 99:3111-8. 2002
    ..We conclude that cross-talk between the ZAP-70 signaling pathway and the chemokine receptor CXCR4 is required for T-cell migration...