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Genomes and Genes | Xavier de LamballerieSummaryCountry: France Publications
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Publications
Estimating Chikungunya prevalence in La Réunion Island outbreak by serosurveys: two methods for two critical times of the epidemicPatrick Gerardin
Centre d Investigation Clinique Epidémiologie Clinique de La Réunion, Institut National de la Sante et de la Recherche Medicale, Groupe Hospitalier Sud Reunion, Saint Pierre
BMC Infect Dis 8:99. 2008..The aim of this study was to refine clinical estimates provided by a regional surveillance-system using a two-stage serological assessment as gold standard...
On chikungunya acute infection and chloroquine treatmentXavier de Lamballerie
Unite des Virus Emergents, Université de la Méditerranée and Institut de Recherche pour le Développement, Marseille, France
Vector Borne Zoonotic Dis 8:837-9. 2008..01). In conclusion, our results suggest that there is currently no justification for the use of chloroquine to treat acute chikungunya infections...- Phylogeny of the genus ArenavirusRemi N Charrel
Unité des Virus Emergents UMR190, Universite de la Méditerranee Institut de Recherche pour le Développement, Marseille, France
Curr Opin Microbiol 11:362-8. 2008.... - Massilia virus, a novel Phlebovirus (Bunyaviridae) isolated from sandflies in the MediterraneanRemi N Charrel
Unite des Virus Emergents, UMR 190 Emergence des Pathologies Virales, Université de la Méditerranée and Institut de Recherche pour le Développement, Marseille, France
Vector Borne Zoonotic Dis 9:519-30. 2009..In conclusion, Massilia virus is proposed as a member of the Sandfly fever Naples virus complex; its public health importance has yet to be determined... - Novel virus influenza A (H1N1sw) in South-Eastern France, April-August 2009Antoine Nougairede
Unité Mixte de Recherche 190 Unité des Virus Emergents, Université de la Méditerranée et Institut de Recherche pour le Développement, Marseille, France
PLoS ONE 5:e9214. 2010..In April 2009, the first cases of pandemic (H1N1)-2009 influenza [H1N1sw] virus were detected in France. Virological surveillance was undertaken in reference laboratories of the seven French Defence Zones... - Genomics and evolution of Aedes-borne flavivirusesGilda Grard
Unite des Virus Emergents, UMR 190 Pathologies Virales Emergentes, Institut de Recherche pour le Développement Université de la Méditerranée, Faculte de Medecine de Marseille, 27 Boulevard Jean Moulin, 13005 Marseille, France
J Gen Virol 91:87-94. 2010.... - Mouse-to-human transmission of variant lymphocytic choriomeningitis virusSébastien Emonet
Universite de la Mediterranee, Marseille, France
Emerg Infect Dis 13:472-5. 2007..LCMV was detected in mice trapped at the patient's home, and 12 isolates were recovered. Genetic analysis showed that human and mouse LCMVs were identical and that this LCMV strain was highly divergent from previously characterized LCMV... - A simple method for molecular detection of Swine-origin and human-origin influenza a virusLaetitia Ninove
Unite des Virus Emergents, Faculte de Medecine de Marseille, Université de la Méditerranée and Institut de Recherche pour le Développement, Marseille, France
Vector Borne Zoonotic Dis 10:237-40. 2010.... - Cocirculation of 2 genotypes of Toscana virus, southeastern FranceRemi N Charrel
Universite de la Mediterranee, Marseille, France
Emerg Infect Dis 13:465-8. 2007..The vector of TOSV in France was unknown. We detected TOSV RNA in 2 (female Phlebotomus perniciosus) of 61 pools of sandflies captured in southeastern France. Two genotypes of TOSV were identified... 
Distribution and genetic analysis of TTV and TTMV major phylogenetic groups in French blood donorsPhilippe Biagini
Unite des Virus Emergents, Etablissement Francais du Sang Alpes Mediterranee, Marseille, France
J Med Virol 78:298-304. 2006....- Epidemiologic relationship between Toscana virus infection and Leishmania infantum due to common exposure to Phlebotomus perniciosus sandfly vectorLaurence Bichaud
UMR 190, IRD Université de la Méditerranée Aix Marseille 2, Marseille, France
PLoS Negl Trop Dis 5:e1328. 2011..e. that the actual risk exposure area is smaller than the mean of distance between patients in our study (245 m)... - Flavivirus RNA in phlebotomine sandfliesGregory Moureau
Unite des Virus Emergents, UMR 190 Emergence des Pathologies Virales, Université de la Méditerranée and Institut de Recherche pour le Développement, Marseille, France
Vector Borne Zoonotic Dis 10:195-7. 2010..Accordingly, we propose their designation as phlebotomine-associated flaviviruses... - Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come?Xavier de Lamballerie
Institut de Recherche pour le Développement UMR190 Unité des Virus Emergents, Universite de la Mediterranee, Marseille, France
Virol J 5:33. 2008..This disconcerting and current unique example of "evolutionary convergence" occurring in nature illustrates rapid pathogen adaptation to ecological perturbation, driven directly as a consequence of human activities... - Chikungunya outbreaks--the globalization of vectorborne diseasesRemi N Charrel
Unite des Virus Emergents, Faculte de Medecine, Universite de la Mediterranee, Marseilles, France
N Engl J Med 356:769-71. 2007 - A retrospective overview of enterovirus infection diagnosis and molecular epidemiology in the public hospitals of Marseille, France (1985-2005)Charlene Y Q Tan
UMR190 Unite des Virus Emergents, Universite de la Méditerranee Institut de Recherche pour le Développement, Marseille, France
PLoS ONE 6:e18022. 2011..Phylogenetic analysis in the VP1, 2C and 3D regions also provided evidence for recombination events amongst clinical isolates. In particular, it identified isolates with dissimilar VP1 but almost identical nonstructural regions... - In vitro antiviral activity of arbidol against Chikungunya virus and characteristics of a selected resistant mutantIlenia Delogu
Unite des Virus Emergents, UMR190 Emergence des pathologies virales Université de la Méditerranée, Institut de Recherche pour le Developpement, EHSP French School of Public Health, Faculte de Medecine, Marseille, France
Antiviral Res 90:99-107. 2011..Finally, our results demonstrated the effective in vitro antiviral activity of ARB against CHIKV and gave some tracks to understand the molecular basis of ARB activity... - Antiviral treatment of chikungunya virus infectionXavier de Lamballerie
Unite des Virus Emergents, UMR190 IRD Université de la Méditerranée Assistance Publique Hôpitaux de Marseille, Faculte de Medecine, Marseille, France
Infect Disord Drug Targets 9:101-4. 2009..We review here the main perspectives of chikungunya antiviral treatment... - Prevalence of Toscana virus antibodies in volunteer blood donors and patients with central nervous system infections in southeastern FranceXavier de Lamballerie
Universite de la Mediterranee, Marseille, France
Vector Borne Zoonotic Dis 7:275-7. 2007.... - RNA and DNA bacteriophages as molecular diagnosis controls in clinical virology: a comprehensive study of more than 45,000 routine PCR testsLaetitia Ninove
UMR190, Université de la Méditerranée and Institut de Recherche pour le Développement, Marseille, France
PLoS ONE 6:e16142. 2011..The high rate of inhibitors observed in a variety of specimen types should stimulate the elaboration of improved technical protocols for the extraction and amplification of nucleic acids... - Alkhurma hemorrhagic fever virus in Ornithodoros savignyi ticksRemi N Charrel
Universite de la Mediterranee, Marseille, France
Emerg Infect Dis 13:153-5. 2007..One Ornithodoros savignyi tick from Saudi Arabia contained AHFV RNA. This is the first direct evidence that AHFV is a tickborne flavivirus and confirms the association between human AHFV cases and tickbite history... - Revolutionizing clinical microbiology laboratory organization in hospitals with in situ point-of-careStephan Cohen-Bacrie
Fédération de Microbiologie Clinique, Assistance Publique des Hôpitaux de Marseille Pôle des Maladies Infectieuses, Hopital La Timone, Marseille, France
PLoS ONE 6:e22403. 2011..Clinical microbiology may direct decisions regarding hospitalization, isolation and anti-infective therapy, but it is not effective at the time of early care. Point-of-care (POC) tests have been developed for this purpose... - Molecular and serological evidence for the presence of novel phleboviruses in sandflies from northern algeriaGregory Moureau
Unité des Virus Emergents UMR190 Université de la Méditerranée Institute of Research for Development, Marseille, France
Open Virol J 4:15-21. 2010..Seroprevalence studies conducted on sera from populations living in the same areas indicated that humans can be infected by these viruses... - Point of care strategy for rapid diagnosis of novel A/H1N1 influenza virusAntoine Nougairede
Fédération de Microbiologie, Assistance Publique Hopitaux de Marseille, Marseille, France
PLoS ONE 5:e9215. 2010.... - Likely correlation between sources of information and acceptability of A/H1N1 swine-origin influenza virus vaccine in Marseille, FranceAntoine Nougairede
Fédération de Microbiologie, Hopital de la Timone, Assistance Publique Hopitaux de Marseille, Marseille, France
PLoS ONE 5:e11292. 2010..In France, there was a reluctance to accept vaccination against the A/H1N1 pandemic influenza virus despite government recommendation and investment in the vaccine programme... - Role of host cell factors in flavivirus infection: Implications for pathogenesis and development of antiviral drugsBoris Pastorino
Unite des Virus Emergents, UMR190 Emergence des pathologies virales Université de la Méditerranée, Institut de Recherche pour le Developpement, Faculte de Medecine, Marseille, France
Antiviral Res 87:281-94. 2010..The role of host cellular factors will be examined in the context of protection and/or pathogenesis resulting from flavivirus infection, with particular emphasis on West Nile virus and dengue virus... - Isolation and characterization of a new strain of lymphocytic choriomeningitis virus from rodents in southwestern FranceInes N Yama
Unité des Virus Emergents UMR190 Emergence des Pathologies Virales, IRD, Université de la Méditerranée II, Marseille, France
Vector Borne Zoonotic Dis 12:893-903. 2012..Genetic and phylogenetic analyses comparing LCMV HP65-2009 with 26 other LCMV strains showed that it represents a novel highly-divergent strain within the group of Mus musculus-associated LCMV... - Climate-based models for understanding and forecasting dengue epidemicsElodie Descloux
UMR190, Emergence of Viral Pathologies, Institute of Research for the Development, Aix Marseille University, Marseille, France
PLoS Negl Trop Dis 6:e1470. 2012..The objectives of this study were to analyze and model the relationships between climate, Aedes aegypti vectors and dengue outbreaks in Noumea (New Caledonia), and to provide an early warning system... - The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcriptionBenjamin Morin
Architecture et Fonction des Macromolecules Biologiques, CNRS and Universités d Aix Marseille I et II, UMR 6098, ESIL case 925, Marseille, France
PLoS Pathog 6:e1001038. 2010..We show that this endonuclease domain is conserved and active across the virus families Arenaviridae, Bunyaviridae and Orthomyxoviridae and propose that the arenavirus NL1 domain is the Arenaviridae cap-snatching endonuclease... - Phylogeny and evolution of old world arenavirusesSébastien Emonet
Unité des Virus Emergents EA3292, IFR48, IRD UR178, Universite de la Mediterranee, Marseille, France
Virology 350:251-7. 2006..No evidence for significant evolutionary events such as intra- or intersegmental recombination was obtained... - Emergence of Toscana virus in EuropeRemi N Charrel
Unite des Virus Emergents, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13005 Marseille, France
Emerg Infect Dis 11:1657-63. 2005..Despite increasing evidence of its major role in medicine as an emerging cause of CNS infections, TOSV remains an unstudied pathogen, and few physicians are aware of its potential to cause CNS infections... - Reclassification of giant viruses composing a fourth domain of life in the new order MegaviralesPhilippe Colson
Aix Marseille Universite, Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Marseille, France
Intervirology 55:321-32. 2012..We propose here to define a new viral order named Megavirales... - Genotype distribution and molecular epidemiology of hepatitis C virus in blood donors from southeast FranceJean Francois Cantaloube
Unite des Virus Emergents, Etablissement de Transfusion Sanguine Alpes Méditerranée, 149 bd Baille, 13005 Marseille, France
J Clin Microbiol 43:3624-9. 2005.... - Low diversity of Alkhurma hemorrhagic fever virus, Saudi Arabia, 1994-1999Remi N Charrel
Universite de la Mediterranee, Unite des Virus Emergents, Marseille, France
Emerg Infect Dis 11:683-8. 2005..Evaluation of divergence times showed that AHFV and KFDV ancestral lineage diverged 66-177 years ago, and the diversity observed within the studied AHFV strains reflected a 4- to 72-year period of evolution... - [West Nile virus, an emerging arbovirus]Remi N Charrel
Unite des Virus Emergents, Faculte de Medecine, Marseille
Presse Med 33:1521-6. 2004..We describe the situation in France following the equine epizooty that occurred in 2000, and the surveillance modalities initiated at that time... - Molecular epidemiology of yellow fever in Bolivia from 1999 to 2008Cécile Baronti
Unité des Virus Emergents UMR190, Université de la Méditerranée and Institut de Recherche pour le Développement, Marseille, France
Vector Borne Zoonotic Dis 11:277-84. 2011..However, the very significant spread of the Aedes aegypti mosquito across Bolivian cities threatens the country with the reappearance of an urban YFV transmission cycle and thus is required a sustained epidemiological surveillance... - Arenaviruses other than Lassa virusRemi N Charrel
Unite des Virus Emergents, EA 3292, IRD UR 034, IFR 48, Faculte de Medecine, 27 Boulevard Jean Moulin, Marseille 13005, France
Antiviral Res 57:89-100. 2003....