Xavier de Lamballerie

Summary

Country: France

Publications

  1. pmc Estimating Chikungunya prevalence in La Réunion Island outbreak by serosurveys: two methods for two critical times of the epidemic
    Patrick Gerardin
    Centre d Investigation Clinique Epidémiologie Clinique de La Réunion, Institut National de la Sante et de la Recherche Medicale, Groupe Hospitalier Sud Reunion, Saint Pierre
    BMC Infect Dis 8:99. 2008
  2. doi request reprint On chikungunya acute infection and chloroquine treatment
    Xavier de Lamballerie
    Unite des Virus Emergents, Université de la Méditerranée and Institut de Recherche pour le Développement, Marseille, France
    Vector Borne Zoonotic Dis 8:837-9. 2008
  3. pmc Massilia virus, a novel Phlebovirus (Bunyaviridae) isolated from sandflies in the Mediterranean
    Remi N Charrel
    Unite des Virus Emergents, UMR 190 Emergence des Pathologies Virales, Université de la Méditerranée and Institut de Recherche pour le Développement, Marseille, France
    Vector Borne Zoonotic Dis 9:519-30. 2009
  4. doi request reprint Phylogeny of the genus Arenavirus
    Remi N Charrel
    Unité des Virus Emergents UMR190, Universite de la Méditerranee Institut de Recherche pour le Développement, Marseille, France
    Curr Opin Microbiol 11:362-8. 2008
  5. pmc Novel virus influenza A (H1N1sw) in South-Eastern France, April-August 2009
    Antoine Nougairede
    Unité Mixte de Recherche 190 Unité des Virus Emergents, Université de la Méditerranée et Institut de Recherche pour le Développement, Marseille, France
    PLoS ONE 5:e9214. 2010
  6. doi request reprint Genomics and evolution of Aedes-borne flaviviruses
    Gilda Grard
    Unite des Virus Emergents, UMR 190 Pathologies Virales Emergentes, Institut de Recherche pour le Développement Université de la Méditerranée, Faculte de Medecine de Marseille, 27 Boulevard Jean Moulin, 13005 Marseille, France
    J Gen Virol 91:87-94. 2010
  7. pmc Mouse-to-human transmission of variant lymphocytic choriomeningitis virus
    Sébastien Emonet
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 13:472-5. 2007
  8. pmc Flavivirus RNA in phlebotomine sandflies
    Gregory Moureau
    Unite des Virus Emergents, UMR 190 Emergence des Pathologies Virales, Université de la Méditerranée and Institut de Recherche pour le Développement, Marseille, France
    Vector Borne Zoonotic Dis 10:195-7. 2010
  9. pmc Cocirculation of 2 genotypes of Toscana virus, southeastern France
    Remi N Charrel
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 13:465-8. 2007
  10. doi request reprint A simple method for molecular detection of Swine-origin and human-origin influenza a virus
    Laetitia Ninove
    Unite des Virus Emergents, Faculte de Medecine de Marseille, Université de la Méditerranée and Institut de Recherche pour le Développement, Marseille, France
    Vector Borne Zoonotic Dis 10:237-40. 2010

Collaborators

Detail Information

Publications41

  1. pmc Estimating Chikungunya prevalence in La Réunion Island outbreak by serosurveys: two methods for two critical times of the epidemic
    Patrick Gerardin
    Centre d Investigation Clinique Epidémiologie Clinique de La Réunion, Institut National de la Sante et de la Recherche Medicale, Groupe Hospitalier Sud Reunion, Saint Pierre
    BMC Infect Dis 8:99. 2008
    ..The aim of this study was to refine clinical estimates provided by a regional surveillance-system using a two-stage serological assessment as gold standard...
  2. doi request reprint On chikungunya acute infection and chloroquine treatment
    Xavier de Lamballerie
    Unite des Virus Emergents, Université de la Méditerranée and Institut de Recherche pour le Développement, Marseille, France
    Vector Borne Zoonotic Dis 8:837-9. 2008
    ..01). In conclusion, our results suggest that there is currently no justification for the use of chloroquine to treat acute chikungunya infections...
  3. pmc Massilia virus, a novel Phlebovirus (Bunyaviridae) isolated from sandflies in the Mediterranean
    Remi N Charrel
    Unite des Virus Emergents, UMR 190 Emergence des Pathologies Virales, Université de la Méditerranée and Institut de Recherche pour le Développement, Marseille, France
    Vector Borne Zoonotic Dis 9:519-30. 2009
    ..In conclusion, Massilia virus is proposed as a member of the Sandfly fever Naples virus complex; its public health importance has yet to be determined...
  4. doi request reprint Phylogeny of the genus Arenavirus
    Remi N Charrel
    Unité des Virus Emergents UMR190, Universite de la Méditerranee Institut de Recherche pour le Développement, Marseille, France
    Curr Opin Microbiol 11:362-8. 2008
    ....
  5. pmc Novel virus influenza A (H1N1sw) in South-Eastern France, April-August 2009
    Antoine Nougairede
    Unité Mixte de Recherche 190 Unité des Virus Emergents, Université de la Méditerranée et Institut de Recherche pour le Développement, Marseille, France
    PLoS ONE 5:e9214. 2010
    ..In April 2009, the first cases of pandemic (H1N1)-2009 influenza [H1N1sw] virus were detected in France. Virological surveillance was undertaken in reference laboratories of the seven French Defence Zones...
  6. doi request reprint Genomics and evolution of Aedes-borne flaviviruses
    Gilda Grard
    Unite des Virus Emergents, UMR 190 Pathologies Virales Emergentes, Institut de Recherche pour le Développement Université de la Méditerranée, Faculte de Medecine de Marseille, 27 Boulevard Jean Moulin, 13005 Marseille, France
    J Gen Virol 91:87-94. 2010
    ....
  7. pmc Mouse-to-human transmission of variant lymphocytic choriomeningitis virus
    Sébastien Emonet
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 13:472-5. 2007
    ..LCMV was detected in mice trapped at the patient's home, and 12 isolates were recovered. Genetic analysis showed that human and mouse LCMVs were identical and that this LCMV strain was highly divergent from previously characterized LCMV...
  8. pmc Flavivirus RNA in phlebotomine sandflies
    Gregory Moureau
    Unite des Virus Emergents, UMR 190 Emergence des Pathologies Virales, Université de la Méditerranée and Institut de Recherche pour le Développement, Marseille, France
    Vector Borne Zoonotic Dis 10:195-7. 2010
    ..Accordingly, we propose their designation as phlebotomine-associated flaviviruses...
  9. pmc Cocirculation of 2 genotypes of Toscana virus, southeastern France
    Remi N Charrel
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 13:465-8. 2007
    ..The vector of TOSV in France was unknown. We detected TOSV RNA in 2 (female Phlebotomus perniciosus) of 61 pools of sandflies captured in southeastern France. Two genotypes of TOSV were identified...
  10. doi request reprint A simple method for molecular detection of Swine-origin and human-origin influenza a virus
    Laetitia Ninove
    Unite des Virus Emergents, Faculte de Medecine de Marseille, Université de la Méditerranée and Institut de Recherche pour le Développement, Marseille, France
    Vector Borne Zoonotic Dis 10:237-40. 2010
    ....
  11. ncbi request reprint Chikungunya outbreaks--the globalization of vectorborne diseases
    Remi N Charrel
    Unite des Virus Emergents, Faculte de Medecine, Universite de la Mediterranee, Marseilles, France
    N Engl J Med 356:769-71. 2007
  12. ncbi request reprint Distribution and genetic analysis of TTV and TTMV major phylogenetic groups in French blood donors
    Philippe Biagini
    Unite des Virus Emergents, Etablissement Francais du Sang Alpes Mediterranee, Marseille, France
    J Med Virol 78:298-304. 2006
    ....
  13. pmc Epidemiologic relationship between Toscana virus infection and Leishmania infantum due to common exposure to Phlebotomus perniciosus sandfly vector
    Laurence Bichaud
    UMR 190, IRD Université de la Méditerranée Aix Marseille 2, Marseille, France
    PLoS Negl Trop Dis 5:e1328. 2011
    ..e. that the actual risk exposure area is smaller than the mean of distance between patients in our study (245 m)...
  14. doi request reprint Isolation of toscana virus from the cerebrospinal fluid of a man with meningitis in marseille, france, 2010
    Antoine Nougairede
    1 UMR_D 190 Emergence des Pathologies Virales, Aix Marseille University, IRD French Institute of Research for Development, EHESP French School of Public Health, Marseille, France
    Vector Borne Zoonotic Dis 13:685-8. 2013
    ..This case report supports that virus isolation should be attempted whenever possible because this remains the gold standard technique for diagnosis of arthropod-borne viral infections. ..
  15. pmc Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come?
    Xavier de Lamballerie
    Institut de Recherche pour le Développement UMR190 Unité des Virus Emergents, Universite de la Mediterranee, Marseille, France
    Virol J 5:33. 2008
    ..This disconcerting and current unique example of "evolutionary convergence" occurring in nature illustrates rapid pathogen adaptation to ecological perturbation, driven directly as a consequence of human activities...
  16. ncbi request reprint Antiviral treatment of chikungunya virus infection
    Xavier de Lamballerie
    Unite des Virus Emergents, UMR190 IRD Université de la Méditerranée Assistance Publique Hôpitaux de Marseille, Faculte de Medecine, Marseille, France
    Infect Disord Drug Targets 9:101-4. 2009
    ..We review here the main perspectives of chikungunya antiviral treatment...
  17. doi request reprint In vitro antiviral activity of arbidol against Chikungunya virus and characteristics of a selected resistant mutant
    Ilenia Delogu
    Unite des Virus Emergents, UMR190 Emergence des pathologies virales Université de la Méditerranée, Institut de Recherche pour le Developpement, EHSP French School of Public Health, Faculte de Medecine, Marseille, France
    Antiviral Res 90:99-107. 2011
    ..Finally, our results demonstrated the effective in vitro antiviral activity of ARB against CHIKV and gave some tracks to understand the molecular basis of ARB activity...
  18. pmc A retrospective overview of enterovirus infection diagnosis and molecular epidemiology in the public hospitals of Marseille, France (1985-2005)
    Charlene Y Q Tan
    UMR190 Unite des Virus Emergents, Universite de la Méditerranee Institut de Recherche pour le Développement, Marseille, France
    PLoS ONE 6:e18022. 2011
    ..Phylogenetic analysis in the VP1, 2C and 3D regions also provided evidence for recombination events amongst clinical isolates. In particular, it identified isolates with dissimilar VP1 but almost identical nonstructural regions...
  19. pmc RNA and DNA bacteriophages as molecular diagnosis controls in clinical virology: a comprehensive study of more than 45,000 routine PCR tests
    Laetitia Ninove
    UMR190, Université de la Méditerranée and Institut de Recherche pour le Développement, Marseille, France
    PLoS ONE 6:e16142. 2011
    ..The high rate of inhibitors observed in a variety of specimen types should stimulate the elaboration of improved technical protocols for the extraction and amplification of nucleic acids...
  20. ncbi request reprint Prevalence of Toscana virus antibodies in volunteer blood donors and patients with central nervous system infections in southeastern France
    Xavier de Lamballerie
    Universite de la Mediterranee, Marseille, France
    Vector Borne Zoonotic Dis 7:275-7. 2007
    ....
  21. pmc Low diversity of Alkhurma hemorrhagic fever virus, Saudi Arabia, 1994-1999
    Remi N Charrel
    Universite de la Mediterranee, Unite des Virus Emergents, Marseille, France
    Emerg Infect Dis 11:683-8. 2005
    ..Evaluation of divergence times showed that AHFV and KFDV ancestral lineage diverged 66-177 years ago, and the diversity observed within the studied AHFV strains reflected a 4- to 72-year period of evolution...
  22. pmc Point of care strategy for rapid diagnosis of novel A/H1N1 influenza virus
    Antoine Nougairede
    Fédération de Microbiologie, Assistance Publique Hopitaux de Marseille, Marseille, France
    PLoS ONE 5:e9215. 2010
    ....
  23. pmc Chikungunya fever: a clinical and virological investigation of outpatients on Reunion Island, South-West Indian Ocean
    Simon Djamel Thiberville
    UMR 190, Emergence des Pathologies Virales, Aix Marseille Univ IRD EHESP French School of Public Health, University Hospital Institute for Infectious Disease and Tropical Medicine, Marseille, France
    PLoS Negl Trop Dis 7:e2004. 2013
    ..Although almost all patients are outpatients, medical investigations mainly focused on hospitalised patients...
  24. pmc Sheep-to-human transmission of Orf virus during Eid al-Adha religious practices, France
    Antoine Nougairede
    Aix Marseille University, Marseille, France
    Emerg Infect Dis 19:102-5. 2013
    ..Prevention and control of this underdiagnosed disease can be achieved by educating physicians, slaughterhouse workers, and persons participating in Eid al-Adha...
  25. pmc Revolutionizing clinical microbiology laboratory organization in hospitals with in situ point-of-care
    Stephan Cohen-Bacrie
    Fédération de Microbiologie Clinique, Assistance Publique des Hôpitaux de Marseille Pôle des Maladies Infectieuses, Hopital La Timone, Marseille, France
    PLoS ONE 6:e22403. 2011
    ..Clinical microbiology may direct decisions regarding hospitalization, isolation and anti-infective therapy, but it is not effective at the time of early care. Point-of-care (POC) tests have been developed for this purpose...
  26. pmc Alkhurma hemorrhagic fever virus in Ornithodoros savignyi ticks
    Remi N Charrel
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 13:153-5. 2007
    ..One Ornithodoros savignyi tick from Saudi Arabia contained AHFV RNA. This is the first direct evidence that AHFV is a tickborne flavivirus and confirms the association between human AHFV cases and tickbite history...
  27. pmc Molecular and serological evidence for the presence of novel phleboviruses in sandflies from northern algeria
    Gregory Moureau
    Unité des Virus Emergents UMR190 Université de la Méditerranée Institute of Research for Development, Marseille, France
    Open Virol J 4:15-21. 2010
    ..Seroprevalence studies conducted on sera from populations living in the same areas indicated that humans can be infected by these viruses...
  28. ncbi request reprint Phylogeny and evolution of old world arenaviruses
    Sébastien Emonet
    Unité des Virus Emergents EA3292, IFR48, IRD UR178, Universite de la Mediterranee, Marseille, France
    Virology 350:251-7. 2006
    ..No evidence for significant evolutionary events such as intra- or intersegmental recombination was obtained...
  29. pmc Likely correlation between sources of information and acceptability of A/H1N1 swine-origin influenza virus vaccine in Marseille, France
    Antoine Nougairede
    Fédération de Microbiologie, Hopital de la Timone, Assistance Publique Hopitaux de Marseille, Marseille, France
    PLoS ONE 5:e11292. 2010
    ..In France, there was a reluctance to accept vaccination against the A/H1N1 pandemic influenza virus despite government recommendation and investment in the vaccine programme...
  30. doi request reprint Role of host cell factors in flavivirus infection: Implications for pathogenesis and development of antiviral drugs
    Boris Pastorino
    Unite des Virus Emergents, UMR190 Emergence des pathologies virales Université de la Méditerranée, Institut de Recherche pour le Developpement, Faculte de Medecine, Marseille, France
    Antiviral Res 87:281-94. 2010
    ..The role of host cellular factors will be examined in the context of protection and/or pathogenesis resulting from flavivirus infection, with particular emphasis on West Nile virus and dengue virus...
  31. pmc Genotype distribution and molecular epidemiology of hepatitis C virus in blood donors from southeast France
    Jean Francois Cantaloube
    Unite des Virus Emergents, Etablissement de Transfusion Sanguine Alpes Méditerranée, 149 bd Baille, 13005 Marseille, France
    J Clin Microbiol 43:3624-9. 2005
    ....
  32. pmc Random codon re-encoding induces stable reduction of replicative fitness of Chikungunya virus in primate and mosquito cells
    Antoine Nougairede
    Aix Marseille Univ, IRD French Institute of Research for Development, EHESP French School of Public Health, UMR_D 190 Emergence des Pathologies Virales, Marseille, France
    PLoS Pathog 9:e1003172. 2013
    ..In conclusion, random codon re-encoding provides important information on the evolution and genetic stability of CHIKV viruses and could be exploited to develop a safe, live attenuated CHIKV vaccine...
  33. doi request reprint Isolation and characterization of a new strain of lymphocytic choriomeningitis virus from rodents in southwestern France
    Ines N Yama
    Unité des Virus Emergents UMR190 Emergence des Pathologies Virales, IRD, Université de la Méditerranée II, Marseille, France
    Vector Borne Zoonotic Dis 12:893-903. 2012
    ..Genetic and phylogenetic analyses comparing LCMV HP65-2009 with 26 other LCMV strains showed that it represents a novel highly-divergent strain within the group of Mus musculus-associated LCMV...
  34. pmc Climate-based models for understanding and forecasting dengue epidemics
    Elodie Descloux
    UMR190, Emergence of Viral Pathologies, Institute of Research for the Development, Aix Marseille University, Marseille, France
    PLoS Negl Trop Dis 6:e1470. 2012
    ..The objectives of this study were to analyze and model the relationships between climate, Aedes aegypti vectors and dengue outbreaks in Noumea (New Caledonia), and to provide an early warning system...
  35. pmc The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription
    Benjamin Morin
    Architecture et Fonction des Macromolecules Biologiques, CNRS and Universités d Aix Marseille I et II, UMR 6098, ESIL case 925, Marseille, France
    PLoS Pathog 6:e1001038. 2010
    ..We show that this endonuclease domain is conserved and active across the virus families Arenaviridae, Bunyaviridae and Orthomyxoviridae and propose that the arenavirus NL1 domain is the Arenaviridae cap-snatching endonuclease...
  36. pmc Emergence of Toscana virus in Europe
    Remi N Charrel
    Unite des Virus Emergents, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13005 Marseille, France
    Emerg Infect Dis 11:1657-63. 2005
    ..Despite increasing evidence of its major role in medicine as an emerging cause of CNS infections, TOSV remains an unstudied pathogen, and few physicians are aware of its potential to cause CNS infections...
  37. doi request reprint Reclassification of giant viruses composing a fourth domain of life in the new order Megavirales
    Philippe Colson
    Aix Marseille Universite, Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Marseille, France
    Intervirology 55:321-32. 2012
    ..We propose here to define a new viral order named Megavirales...
  38. ncbi request reprint Sequences of flavivirus-related RNA viruses persist in DNA form integrated in the genome of Aedes spp. mosquitoes
    Sandrine Crochu
    Unite des Virus Emergents, Faculte de Medecine de Marseille, IFR48 IRD UR034, 27 Boulevard Jean Moulin, 13005 Marseille, France
    J Gen Virol 85:1971-80. 2004
    ..This finding has major implications regarding evolution, as it represents an entirely different mechanism by which genetic diversity may be generated in eukaryotic cells distinct from accepted processes...
  39. ncbi request reprint [West Nile virus, an emerging arbovirus]
    Remi N Charrel
    Unite des Virus Emergents, Faculte de Medecine, Marseille
    Presse Med 33:1521-6. 2004
    ..We describe the situation in France following the equine epizooty that occurred in 2000, and the surveillance modalities initiated at that time...
  40. ncbi request reprint Arenaviruses other than Lassa virus
    Remi N Charrel
    Unite des Virus Emergents, EA 3292, IRD UR 034, IFR 48, Faculte de Medecine, 27 Boulevard Jean Moulin, Marseille 13005, France
    Antiviral Res 57:89-100. 2003
    ....
  41. pmc Molecular epidemiology of yellow fever in Bolivia from 1999 to 2008
    Cécile Baronti
    Unité des Virus Emergents UMR190, Université de la Méditerranée and Institut de Recherche pour le Développement, Marseille, France
    Vector Borne Zoonotic Dis 11:277-84. 2011
    ..However, the very significant spread of the Aedes aegypti mosquito across Bolivian cities threatens the country with the reappearance of an urban YFV transmission cycle and thus is required a sustained epidemiological surveillance...