Michel de Lorgeril

..Thus, n-3 and statins are counteractive at several levels and statins appear to inhibit n-3...

..See related article http://www.biomedcentral.com/1741-7015/10/138/abstract...

..To summarise our present knowledge on the Mediterranean diet in secondary prevention of CHD...

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..Official guidelines should be re-examined and reformulated by experts independent from the pharmaceutical industry...

..These data underline the importance of the accompanying diet in any dietary strategy using fatty acid complements...

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..Thus, selenium (through its role in selenoenzymes, thyroid hormones, and interactions with homocysteine and endothelial function) appears to be a major mediator in several pathways potentially contributing to CHF development...

..To discuss present knowledge about Mediterranean diet and cardiovascular diseases...

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..Plant and marine n-3 PUFAs are likely to be major mediators of the protective effect provided by traditional Mediterranean diets...

..However, there is little data evaluating the interactions of wine ethanol drinking with omega3 in CHD patients...

..Many micro- and macronutrients characteristic of the Mediterranean diet interact in a synergistic way to induce states of resistance to chronic diseases. More research is required to understand these complex interplays...

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..There are only little data about the effects of lipid-lowering drugs (LLDs) on the metabolism of essential n-6 and n-3 fatty acids in patients with established coronary heart disease (CHD)...

..Their use is now encouraged either as supplements or as part of a Mediterranean-type diet...

..It has been suggested that the inhibition of iron absorption is one of the possible mechanisms of the CHD-protective effects of drinking...

..Chronic heart failure (CHF) seems to be associated with increased oxidative stress. However, the hypothesis that antioxidant nutrients may contribute to the clinical severity of the disease has never been investigated...

..Scientific data on the clinical impact of moderate alcohol consumption after a recent acute myocardial infarction (AMI) are limited, and the specific effect of wine ethanol has not been studied...

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..To summarize our present knowledge about vegetable omega-3 fatty acids...

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..Further studies are required to elucidate the mechanisms of that protection...

..In addition to increasing n-3 PUFA intake, an optimal dietary pattern aimed at reducing cardiovascular mortality should include a reduction of the intake of both saturated and n-6 PUFA...

..Further studies are warranted to investigate the mechanisms by which moderate ED alters the metabolism of n-3 and whether n-3 are the mediators of the ED-induced cardioprotection...

..There is no doubt that such an observation, if confirmed in human subjects, might open new perspectives in the prevention and treatment of ischemic coronary heart disease...

..On the other hand, fish in the diet (preferably oily fish, 1-2 meals/week) should be considered as part of a healthy diet low in saturated fat...

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..Our findings suggest important potential health benefits of foods rich in anthocyanins and emphasize the need to develop anthocyanin-rich functional foods with protective activities for promoting human health...

..These data confirm previous clinical and epidemiological studies and provide new insights into the health benefits of flavonoids...

..Policy makers should strongly consider the generalizability of results to their own setting...

..In conclusion, preischemic body selenium status is a major determinant of the outcome of myocardial ischemia in vivo in rats probably because it influences the cellular redox status...

..These concepts may have important public health consequences in targeting screening or disease prevention measures towards partners of people with cardiovascular risk...