Michel de Lorgeril

Summary

Country: France

Publications

  1. ncbi request reprint Is moderate drinking as effective as cholesterol lowering in reducing mortality in high-risk coronary patients?
    Michel de Lorgeril
    Eur Heart J 29:4-6. 2008
  2. ncbi request reprint Is the use of cholesterol-lowering drugs for the prevention of cardiovascular complications in type 2 diabetics evidence-based? A systematic review
    Michel de Lorgeril
    Laboratoire Coeur and Nutrition, Universite Joseph Fourier CNRS, Faculte de Medecine, 38706 La Tronche, France
    Rev Recent Clin Trials 7:150-7. 2012
  3. ncbi request reprint Do statins increase and Mediterranean diet decrease the risk of breast cancer?
    Michel de Lorgeril
    Laboratoire TIMC IMAG, CNRS UMR 5525, PRETA Cœur and Nutrition, and Faculté de Médecine, Universite Joseph Fourier, Grenoble, France
    BMC Med 12:94. 2014
  4. pmc Helping women to good health: breast cancer, omega-3/omega-6 lipids, and related lifestyle factors
    Michel de Lorgeril
    Laboratoire TIMC IMAG, CNRS UMR 5525, PRETA Cœur and Nutrition, and Faculté de Médecine, Universite Joseph Fourier, Grenoble, France
    BMC Med 12:54. 2014
  5. ncbi request reprint Mediterranean diet and cardiovascular disease: historical perspective and latest evidence
    Michel de Lorgeril
    Laboratoire Cœur et Nutrition, TIMC IMAG CNRS 5525, Faculte de Medecine de Grenoble, Universite Joseph Fourier, 38054, La Tronche, France
    Curr Atheroscler Rep 15:370. 2013
  6. pmc Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: do statins inhibit omega-3?
    Michel de Lorgeril
    Laboratoire Coeur et Nutrition, TIMC IMAG CNRS 5525, Universite Joseph Fourier, Faculte de Medecine de Grenoble, 38054 La Tronche, France
    BMC Med 11:5. 2013
  7. pmc Commentary on the clinical management of metabolic syndrome: why a healthy lifestyle is important
    Michel de Lorgeril
    Laboratoire Cœur et Nutrition, TIMC IMAG CNRS 5525, Universite Joseph Fourier, Faculte de Medecine, 38054 La Tronche, Grenoble, France
    BMC Med 10:139. 2012
  8. doi request reprint Mediterranean diet in secondary prevention of CHD
    Michel de Lorgeril
    Laboratoire Cœur and Nutrition, TIMC IMAG, CNRS UMR 5525, Faculte de Medecine de Grenoble, Université de Grenoble, 38706 La Tronche, France
    Public Health Nutr 14:2333-7. 2011
  9. pmc New insights into the health effects of dietary saturated and omega-6 and omega-3 polyunsaturated fatty acids
    Michel de Lorgeril
    Laboratoire Cœur and Nutrition, TIMC IMAG, Universite Joseph Fourier CNRS, Faculte de Medecine, Grenoble, France
    BMC Med 10:50. 2012
  10. ncbi request reprint Cholesterol lowering and mortality: time for a new paradigm?
    Michel de Lorgeril
    Laboratoire Nutrition, Vieillissement et Maladies Cardiovasculaires, Faculte de Medecine, Domaine de la Merci, 38056 La Tronche, Grenoble, France
    Nutr Metab Cardiovasc Dis 16:387-90. 2006

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Is moderate drinking as effective as cholesterol lowering in reducing mortality in high-risk coronary patients?
    Michel de Lorgeril
    Eur Heart J 29:4-6. 2008
  2. ncbi request reprint Is the use of cholesterol-lowering drugs for the prevention of cardiovascular complications in type 2 diabetics evidence-based? A systematic review
    Michel de Lorgeril
    Laboratoire Coeur and Nutrition, Universite Joseph Fourier CNRS, Faculte de Medecine, 38706 La Tronche, France
    Rev Recent Clin Trials 7:150-7. 2012
    ..Official guidelines should be re-examined and reformulated by experts independent from the pharmaceutical industry...
  3. ncbi request reprint Do statins increase and Mediterranean diet decrease the risk of breast cancer?
    Michel de Lorgeril
    Laboratoire TIMC IMAG, CNRS UMR 5525, PRETA Cœur and Nutrition, and Faculté de Médecine, Universite Joseph Fourier, Grenoble, France
    BMC Med 12:94. 2014
    ..Physical exercise and healthy dietary habits are recommended to prevent breast cancer...
  4. pmc Helping women to good health: breast cancer, omega-3/omega-6 lipids, and related lifestyle factors
    Michel de Lorgeril
    Laboratoire TIMC IMAG, CNRS UMR 5525, PRETA Cœur and Nutrition, and Faculté de Médecine, Universite Joseph Fourier, Grenoble, France
    BMC Med 12:54. 2014
    ..Please see related article: http://www.biomedcentral.com/1471-2407/14/105/abstract. ..
  5. ncbi request reprint Mediterranean diet and cardiovascular disease: historical perspective and latest evidence
    Michel de Lorgeril
    Laboratoire Cœur et Nutrition, TIMC IMAG CNRS 5525, Faculte de Medecine de Grenoble, Universite Joseph Fourier, 38054, La Tronche, France
    Curr Atheroscler Rep 15:370. 2013
    ..Thus, in terms of evidence-based medicine, the full adoption of a modern version of the Mediterranean diet pattern can be considered one of the most effective approaches for the prevention of fatal and nonfatal CVD complications. ..
  6. pmc Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: do statins inhibit omega-3?
    Michel de Lorgeril
    Laboratoire Coeur et Nutrition, TIMC IMAG CNRS 5525, Universite Joseph Fourier, Faculte de Medecine de Grenoble, 38054 La Tronche, France
    BMC Med 11:5. 2013
    ..Thus, n-3 and statins are counteractive at several levels and statins appear to inhibit n-3...
  7. pmc Commentary on the clinical management of metabolic syndrome: why a healthy lifestyle is important
    Michel de Lorgeril
    Laboratoire Cœur et Nutrition, TIMC IMAG CNRS 5525, Universite Joseph Fourier, Faculte de Medecine, 38054 La Tronche, Grenoble, France
    BMC Med 10:139. 2012
    ..See related article http://www.biomedcentral.com/1741-7015/10/138/abstract...
  8. doi request reprint Mediterranean diet in secondary prevention of CHD
    Michel de Lorgeril
    Laboratoire Cœur and Nutrition, TIMC IMAG, CNRS UMR 5525, Faculte de Medecine de Grenoble, Université de Grenoble, 38706 La Tronche, France
    Public Health Nutr 14:2333-7. 2011
    ..To summarise our present knowledge on the Mediterranean diet in secondary prevention of CHD...
  9. pmc New insights into the health effects of dietary saturated and omega-6 and omega-3 polyunsaturated fatty acids
    Michel de Lorgeril
    Laboratoire Cœur and Nutrition, TIMC IMAG, Universite Joseph Fourier CNRS, Faculte de Medecine, Grenoble, France
    BMC Med 10:50. 2012
    ....
  10. ncbi request reprint Cholesterol lowering and mortality: time for a new paradigm?
    Michel de Lorgeril
    Laboratoire Nutrition, Vieillissement et Maladies Cardiovasculaires, Faculte de Medecine, Domaine de la Merci, 38056 La Tronche, Grenoble, France
    Nutr Metab Cardiovasc Dis 16:387-90. 2006
    ....
  11. ncbi request reprint The Mediterranean diet in secondary prevention of coronary heart disease
    Michel de Lorgeril
    Laboratoire Nutrition, Vieillissement et Maladies Cardiovasculaires, Universite Joseph Fourier, Grenoble, France
    Clin Invest Med 29:154-8. 2006
    ..These data underline the importance of the accompanying diet in any dietary strategy using fatty acid complements...
  12. ncbi request reprint Modified cretan Mediterranean diet in the prevention of coronary heart disease and cancer: An update
    Michel de Lorgeril
    Nutrition, Vieillissement et Maladies Cardiovasculaires NVMCV, UFR de Medecine, Domaine de la Merci, FR 38706 La Tronche Cedex, France
    World Rev Nutr Diet 97:1-32. 2007
  13. ncbi request reprint Essential polyunsaturated fatty acids, inflammation, atherosclerosis and cardiovascular diseases
    Michel de Lorgeril
    Laboratoire Nutrition, Vieillissement et Maladies Cardiovasculaires NVMCV, Faculte de Medecine, Universite Joseph Fourier, Grenoble, France
    Subcell Biochem 42:283-97. 2007
    ....
  14. ncbi request reprint Mediterranean diet and n-3 fatty acids in the prevention and treatment of cardiovascular disease
    Michel de Lorgeril
    PRETA TIMC, Equipe Coeur and Nutrition, CNRS UMR 5525 UJF INP, University Joseph Fourier, Grenoble, France
    J Cardiovasc Med (Hagerstown) 8:S38-41. 2007
    ..Plant and marine n-3 PUFAs are likely to be major mediators of the protective effect provided by traditional Mediterranean diets...
  15. ncbi request reprint Interactions of wine drinking with omega-3 fatty acids in patients with coronary heart disease: a fish-like effect of moderate wine drinking
    Michel de Lorgeril
    Laboratoire Coeur et Nutrition, PRETA TIMC IMAG, Faculte de Medecine, Universite Joseph Fourier de Grenoble, Grenoble, France
    Am Heart J 155:175-81. 2008
    ..However, there is little data evaluating the interactions of wine ethanol drinking with omega3 in CHD patients...
  16. ncbi request reprint The Mediterranean diet: rationale and evidence for its benefit
    Michel de Lorgeril
    TIMC PRETA, Coeur and Nutrition, CNRS UMR 5525, Faculte de Medecine, Domaine de la Merci, Université de Grenoble, 38706 La Tronche, France
    Curr Atheroscler Rep 10:518-22. 2008
    ..Many micro- and macronutrients characteristic of the Mediterranean diet interact in a synergistic way to induce states of resistance to chronic diseases. More research is required to understand these complex interplays...
  17. doi request reprint Cholesterol lowering, cardiovascular diseases, and the rosuvastatin-JUPITER controversy: a critical reappraisal
    Michel de Lorgeril
    Laboratoire Coeur and Nutrition, Faculty of Medicine, Université Joseph Fourier and Centre National de Recherche Scientifique, Grenoble, France
    Arch Intern Med 170:1032-6. 2010
    ....
  18. ncbi request reprint Wine drinking and risks of cardiovascular complications after recent acute myocardial infarction
    Michel de Lorgeril
    Laboratoire du Stress Cardiovasculaire et Pathologies Associées, Universite Joseph Fourier de Grenoble, France
    Circulation 106:1465-9. 2002
    ..Scientific data on the clinical impact of moderate alcohol consumption after a recent acute myocardial infarction (AMI) are limited, and the specific effect of wine ethanol has not been studied...
  19. ncbi request reprint Selenium and antioxidant defenses as major mediators in the development of chronic heart failure
    Michel de Lorgeril
    Laboratoire Nutrition, Vieillissement et Maladies Cardiovasculaires, NVMCV, Faculte de Medecine, Universite Joseph Fourier, Grenoble, France
    Heart Fail Rev 11:13-7. 2006
    ..Thus, selenium (through its role in selenoenzymes, thyroid hormones, and interactions with homocysteine and endothelial function) appears to be a major mediator in several pathways potentially contributing to CHF development...
  20. ncbi request reprint The Mediterranean-style diet for the prevention of cardiovascular diseases
    Michel de Lorgeril
    Laboratoire Nutrition, Vieillissement et Maladies Cardiovasculaires NVMCV, Universite Joseph Fourier, Grenoble, France
    Public Health Nutr 9:118-23. 2006
    ..To discuss present knowledge about Mediterranean diet and cardiovascular diseases...
  21. ncbi request reprint Alpha-linolenic acid and coronary heart disease
    M De Lorgeril
    Laboratoire Nutrition, Vieillissement et Maladies Cardiovasculaires NVMCV, UFR de Medecine et Pharmacie, Universite Joseph Fourier, Grenoble, France
    Nutr Metab Cardiovasc Dis 14:162-9. 2004
    ..To summarize our present knowledge about vegetable omega-3 fatty acids...
  22. ncbi request reprint Dietary prevention of coronary heart disease: focus on omega-6/omega-3 essential fatty acid balance
    Michel de Lorgeril
    Laboratoire du Stress Cardiovasculaire et Pathologies Associées, UFR de Medecine et Pharmacie, Grenoble, France
    World Rev Nutr Diet 92:57-73. 2003
  23. ncbi request reprint Mediterranean diet and the French paradox: two distinct biogeographic concepts for one consolidated scientific theory on the role of nutrition in coronary heart disease
    Michel de Lorgeril
    Laboratoire du Stress Cardiovasculaire et Pathologies Associées, Laboratoire de Biologie du Stress Oxydant, UFR de Medecine et Pharmacie, Grenoble, France
    Cardiovasc Res 54:503-15. 2002
  24. ncbi request reprint Use and misuse of dietary fatty acids for the prevention and treatment of coronary heart disease
    Michel de Lorgeril
    LSCPA, UFR de Medecine et Pharmacie, Domaine de la Merci, 38706 La Tronche, France
    Reprod Nutr Dev 44:283-8. 2004
    ....
  25. ncbi request reprint Dietary and blood antioxidants in patients with chronic heart failure. Insights into the potential importance of selenium in heart failure
    M De Lorgeril
    Laboratoire du Stress Cardiovasculaire et Pathologies Associées, UFR de Medecine et Pharmacie, Universite Joseph Fourier de Grenoble, Domaine de la Merci, 38706 La Tronche, Grenoble, France
    Eur J Heart Fail 3:661-9. 2001
    ..Chronic heart failure (CHF) seems to be associated with increased oxidative stress. However, the hypothesis that antioxidant nutrients may contribute to the clinical severity of the disease has never been investigated...
  26. ncbi request reprint Lipid-lowering drugs and essential omega-6 and omega-3 fatty acids in patients with coronary heart disease
    Michel de Lorgeril
    Laboratoire Nutrition, Vieillissement et Maladies Cardiovasculaires NVMCV, UFR de Medecine, Universite Joseph Fourier, Grenoble, France
    Nutr Metab Cardiovasc Dis 15:36-41. 2005
    ..There are only little data about the effects of lipid-lowering drugs (LLDs) on the metabolism of essential n-6 and n-3 fatty acids in patients with established coronary heart disease (CHD)...
  27. ncbi request reprint Effect of wine ethanol on serum iron and ferritin levels in patients with coronary heart disease
    M De Lorgeril
    Laboratoire du Stress Cardiovasculaire et Pathologies Associées, UFR de Medecine et Pharmacie, Domaine de la Merci, 38706 La Tronche, Grenoble, France
    Nutr Metab Cardiovasc Dis 11:176-80. 2001
    ..It has been suggested that the inhibition of iron absorption is one of the possible mechanisms of the CHD-protective effects of drinking...
  28. ncbi request reprint Dietary prevention of coronary heart disease: the Lyon diet heart study and after
    Michel de Lorgeril
    Laboratoire Nutrition, Vieillissement et Maladies Cardiovasculaires NVMCV, UFR de Medecine et Pharmacie, Universite Joseph Fourier, Grenoble, France
    World Rev Nutr Diet 95:103-14. 2005
  29. ncbi request reprint Diet as preventive medicine in cardiology
    M De Lorgeril
    Laboratoire du Stress Cardiovasculaire et Pathologies Associées, UFR de Medecine et Pharmacie, Grenoble, France
    Curr Opin Cardiol 15:364-70. 2000
    ..Their use is now encouraged either as supplements or as part of a Mediterranean-type diet...
  30. ncbi request reprint Resveratrol and non-ethanolic components of wine in experimental cardiology
    M De Lorgeril
    Laboratoire du Stress Cardiovasculaire et Pathologies Associées, Universite Joseph Fourier, Grenoble, France
    Nutr Metab Cardiovasc Dis 13:100-3. 2003
    ....
  31. ncbi request reprint Cardioprotective effect of chronic low dose ethanol drinking: insights into the concept of ethanol preconditioning
    Annabelle Guiraud
    Laboratoire Nutrition, Vieillissement et Maladies Cardiovasculaires NVMCV, Universite Joseph Fourier, Grenoble, France
    J Mol Cell Cardiol 36:561-6. 2004
    ..Further studies are required to elucidate the mechanisms of that protection...
  32. doi request reprint Protective effect of dietary n-3 polyunsaturated fatty acids on myocardial resistance to ischemia-reperfusion injury in rats
    Sabrina Zeghichi-Hamri
    Cœur and Nutrition, TIMC IMAG CNRS 5525, Universite Joseph Fourier, Faculte de Medecine, Domaine de la Merci, 38706 La Tronche, France
    Nutr Res 30:849-57. 2010
    ..In addition to increasing n-3 PUFA intake, an optimal dietary pattern aimed at reducing cardiovascular mortality should include a reduction of the intake of both saturated and n-6 PUFA...
  33. doi request reprint Interactions of ethanol drinking with n-3 fatty acids in rats: potential consequences for the cardiovascular system
    Annabelle Guiraud
    TIMC IMAG, CNRS UMR 5525, Laboratoire PRETA Coeur et Nutrition, Faculte de Medecine, Universite Joseph Fourier, Grenoble, France
    Br J Nutr 100:1237-44. 2008
    ..Further studies are warranted to investigate the mechanisms by which moderate ED alters the metabolism of n-3 and whether n-3 are the mediators of the ED-induced cardioprotection...
  34. ncbi request reprint Ethanol, wine, and experimental cardioprotection in ischemia/reperfusion: role of the prooxidant/antioxidant balance
    Andry Rakotovao
    Universite Joseph Fourier, Grenoble, France
    Antioxid Redox Signal 6:431-8. 2004
    ..There is no doubt that such an observation, if confirmed in human subjects, might open new perspectives in the prevention and treatment of ischemic coronary heart disease...
  35. doi request reprint Fish oil and heart health
    Joel de Leiris
    Coeur et Nutrition, Université de Grenoble, La Tronche, France
    J Cardiovasc Pharmacol 54:378-384. 2009
    ..On the other hand, fish in the diet (preferably oily fish, 1-2 meals/week) should be considered as part of a healthy diet low in saturated fat...
  36. doi request reprint Cholesterol lowering, sudden cardiac death and mortality
    Michel de Lorgeril
    Laboratoire TIMC IMAG CNRS UMR 5525, Groupe PRETA Coeur et Nutrition, Faculte de Medecine, La Tronche Grenoble, France
    Scand Cardiovasc J 42:264-7. 2008
    ....
  37. ncbi request reprint Chronic dietary intake of plant-derived anthocyanins protects the rat heart against ischemia-reperfusion injury
    Marie Claire Toufektsian
    Equipe PRETA Coeur et Nutrition, TIMC IMAG Unité Mixte de Recherche, Université Jospeh Fourier CNRS 5525, F 38000 Grenoble, France
    J Nutr 138:747-52. 2008
    ..Our findings suggest important potential health benefits of foods rich in anthocyanins and emphasize the need to develop anthocyanin-rich functional foods with protective activities for promoting human health...
  38. doi request reprint Dietary flavonoids increase plasma very long-chain (n-3) fatty acids in rats
    Marie Claire Toufektsian
    Laboratoire Cœur et Nutrition, TIMC IMAG CNRS UMR 5525, Faculte de Medecine, Universite Joseph Fourier, 38000 Grenoble, France
    J Nutr 141:37-41. 2011
    ..These data confirm previous clinical and epidemiological studies and provide new insights into the health benefits of flavonoids...
  39. ncbi request reprint A mediterranean diet is cost-effective in patients with previous myocardial infarction
    Kim Dalziel
    Nutrition, Vieillissement et Maladies Cardiovasculaires NVMCV, UFR de Medecine, Domaine de la Merci 38056 La Tronche, France
    J Nutr 136:1879-85. 2006
    ..Policy makers should strongly consider the generalizability of results to their own setting...
  40. ncbi request reprint Gluten and wheat intolerance today: are modern wheat strains involved?
    Michel de Lorgeril
    Laboratoire Cœur et Nutrition, Faculte de Medecine, TIMC IMAG CNRS 5525, Universite Joseph Fourier, Grenoble, France
    Int J Food Sci Nutr 65:577-81. 2014
    ..This is a critical medical and environmental issue which needs to be investigated by appropriate studies. ..
  41. ncbi request reprint Preischemic selenium status as a major determinant of myocardial infarct size in vivo in rats
    Stephane Tanguy
    Antioxid Redox Signal 6:792-6. 2004
    ..In conclusion, preischemic body selenium status is a major determinant of the outcome of myocardial ischemia in vivo in rats probably because it influences the cellular redox status...
  42. ncbi request reprint alpha-linolenic acid, coronary heart disease, and prostate cancer
    Michel de Lorgeril
    J Nutr 134:3385; author reply 3386. 2004
  43. ncbi request reprint Ethanol and cardiac function
    Joel de Leiris
    Am J Physiol Heart Circ Physiol 291:H1027-8. 2006
  44. ncbi request reprint Fish and N-3 fatty acids for the prevention and treatment of coronary heart disease: nutrition is not pharmacology
    Michel de Lorgeril
    Am J Med 112:316-9. 2002
  45. ncbi request reprint Effect of vitamins E and C on transplant-associated atherosclerosis
    Michel de Lorgeril
    Lancet 360:486-7, author reply 487. 2002
  46. ncbi request reprint Cardiovascular risk factors and global risk of fatal cardiovascular disease are positively correlated between partners of 802 married couples from different European countries. Report from the IMMIDIET project
    Augusto Di Castelnuovo
    Research Laboratories, John Paul II Centre for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy
    Thromb Haemost 98:648-55. 2007
    ..These concepts may have important public health consequences in targeting screening or disease prevention measures towards partners of people with cardiovascular risk...
  47. ncbi request reprint Importance of nutrition in chronic heart failure patients
    Michel de Lorgeril
    Eur Heart J 26:2215-7. 2005