Research Topics
Species | Jacques de BlicSummaryCountry: France Publications
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Publications
[Post-infectious bronchiolitis obliterans]J De Blic
Service de pneumologie et allergologie pédiatriques, Universite Paris Descartes, Hopital Necker Enfants Malades, Assistance Publique des Hopitaux de Paris, 75015 Paris, France
Rev Mal Respir 30:152-60. 2013..Several authors have published clinical cases describing presumed efficacy of systemic corticosteroids but the data are scarce...
[When and how to modify the management of asthma in children over the age of 4]J De Blic
Service de pneumologie et allergologie pédiatriques, Hopital Necker Enfants Malades, Paris, France
Rev Mal Respir 26:827-35. 2009....- Control of asthma in children: still unacceptable? A French cross-sectional studyJacques de Blic
Université Paris Descartes Hôpital Necker Enfants Malades, Service de Pneumologie et d Allergologie Pediatriques, 149 rue de Sevres, Paris, France
Respir Med 103:1383-91. 2009..The goal of asthma management focuses on adequate control of asthma, although little is known about the optimal level of asthma control to be reached. The ELIOS study was conducted in France to address this lack of information... - Salmeterol/fluticasone propionate vs. double dose fluticasone propionate on lung function and asthma control in childrenJacques de Blic
Université Paris Descartes Necker Enfant Malades Hospital, 75015 Paris, France
Pediatr Allergy Immunol 20:763-71. 2009.... - [Follow up of asthmatic children: definition and measurement tools]J De Blic
Service de pneumologie et allergologie pédiatriques, Hopital Necker Enfants Malades, Paris, France
Rev Mal Respir 25:695-704. 2008..Among the non-invasive measurements of airway inflammation the measurement of expired nitric oxide (NO) is the best established. The measurement of expired NO could improve some paraclinical parameters that are not monitored routinely... - [Asthma control level in asthmatic children followed in general practice medicine in France: results of ER'ASTHME study]J De Blic
Service de pneumologie et allergologie pédiatrique, Assistance Publique Hopitaux de Paris, Hopital Necker Enfants Malades, Paris, France
Arch Pediatr 14:1069-75. 2007..The ER'Asthme survey has been set up to assess asthma control among asthmatic patients visiting their general practitioner and to determine the clinical and therapeutic associated factors... - [Therapeutical compliance in asthmatic children. Recommendations for clinical practice]J De Blic
, , Paris
Rev Mal Respir 24:419-25. 2007 - The use of imaging techniques for assessing severe childhood asthmaJacques de Blic
Universite Paris Descartes, Assistance Publique des Hopitaux de Paris, Service de Pneumologie et d Allergologie Pediatriques, Hopital Necker Enfants Malades, Paris, France
J Allergy Clin Immunol 119:808-10. 2007.... - [Lung diseases in children]J De Blic
, , Paris
Rev Mal Respir 23:2S52-4. 2006 - High-resolution computed tomography scan and airway remodeling in children with severe asthmaJacques de Blic
Service de Pneumologie et d Allergologie Pediatriques, Hopital Necker Enfants Malades, Universite Rene Descartes, Paris, France
J Allergy Clin Immunol 116:750-4. 2005..Children with severe asthma have a significantly higher bronchial wall thickness (BWT) on high-resolution computed tomography scan than control children... - Levocetirizine in children: evidenced efficacy and safety in a 6-week randomized seasonal allergic rhinitis trialJacques de Blic
Hopital des Enfants Malades, Paris, Cedex 15, France
Pediatr Allergy Immunol 16:267-75. 2005..The 6-wk duration of this study was longer than the usual 2-4-wk duration for similar studies and shows that levocetirizine controls SAR symptoms in children over the entire pollen season... 
Loss-of-function mutations in LRRC6, a gene essential for proper axonemal assembly of inner and outer dynein arms, cause primary ciliary dyskinesiaEsther Kott
INSERM UMR_S933, Universite Pierre et Marie Curie Paris 6, Paris, France
Am J Hum Genet 91:958-64. 2012..The evolutionarily conserved LRRC6, therefore, emerges as an additional player in DA assembly, a process that is essential for proper axoneme building and that appears to be much more complex than was previously thought...- Familial interstitial disease with I73T mutation: A mid- and long-term studyRola Abou Taam
Universite Paris Descartes, Assistance Publique des Hopitaux de Paris, Hopital Necker Enfants Malades, Paris, France
Pediatr Pulmonol 44:167-75. 2009..To describe the long-term course and the management in children of chronic interstitial lung disease associated with I73T mutation... - Characteristics of disorders associated with genetic mutations of surfactant protein CGuillaume Thouvenin
INSERM UMR_S U938, Paris, France
Arch Dis Child 95:449-54. 2010..To present diagnosis and treatment modalities of children with interstitial lung disease associated with frequent or rare surfactant protein C gene (SFTPC) mutation... - Relationship between bronchial hyperresponsiveness and impaired lung function after infantile asthmaChristophe Delacourt
Laboratoire d Explorations Fonctionnelles Respiratoires, Service de pneumologie et allergologie pédiatriques, Hopital des Enfants Malades, Paris, France
PLoS ONE 2:e1180. 2007..Wheezing that persists from infancy to 9 years of age is associated with BHR and to impaired lung function. BHR itself is predictive of impaired lung function in children, strongly pointing to early airway remodeling in infantile asthma... - Laronidase for cardiopulmonary disease in Hurler syndrome 12 years after bone marrow transplantationVassili Valayannopoulos
Reference Center for Inherited Metabolic Disorders, Necker Enfants Malades Hospital, 149 rue de Sevres, 75015 Paris, France
Pediatrics 126:e1242-7. 2010..He went from using a wheelchair to having full ambulation, he no longer required daytime ventilation, and his quality-of-life scores (Child Health Assessment Questionnaire) significantly improved... - Diffuse lymphoplasmacytic bronchiolitis in cartilage-hair hypoplasiaCéline Bailly-Botuha
Universite Paris Descartes, Lyon, France
J Pediatr 152:429-33. 2008..Clarithromycin substantially improved respiratory symptoms and pulmonary function, allowing children to return home... - Mutation of SFTPC in infantile pulmonary alveolar proteinosis with or without fibrosing lung diseaseMohammed Tredano
Service de Biochimie et Biologie Moléculaire, hôpital d enfants Armand Trousseau AP HP, Paris, France
Am J Med Genet A 126:18-26. 2004..This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience.wiley.com/jpages/0148-7299/suppmat/index.html... - [Asthma in child]Jacques de Blic
, , Paris
Rev Prat 55:2189-95. 2005 - Thoracic CT in pediatric patients with difficult-to-treat asthmaValentine Marchac
, , , 75015 Paris, France
AJR Am J Roentgenol 179:1245-52. 2002..CT evidence of bronchial wall thickening might help to identify patients with a higher risk of airway remodeling... - Difficult asthma in children: an analysis of airway inflammationJacques de Blic
, , Paris, France
J Allergy Clin Immunol 113:94-100. 2004..The high levels of IFNgamma suggest that this T(H)1 cytokine may modulate the local inflammatory response... - Diagnostic value of high-resolution CT in the evaluation of chronic infiltrative lung disease in childrenStephanie Vrielynck
Service de pneumologie et allergologie pédiatriques, Hopital Necker Enfants Malades, Assistance Publique des Hopitaux de Paris, 149 rue de Sevres, 75015 Paris, France
AJR Am J Roentgenol 191:914-20. 2008..The purpose of this study was to evaluate the accuracy of CT in the diagnosis of chronic infiltrative lung disease in children... - [Difficulties in the assessment of dyspnea and respiratory function in general practice]Nicolas Roche
Pneumologie et Réanimation, Hotel Dieu, Universite Paris Descartes, F 75181 Paris 04, France
Presse Med 38:1041-8. 2009..Dyspnea is one of the principal signs of chronic respiratory diseases... - Bronchoalveolar cells in children < 3 years old with severe recurrent wheezingMuriel Le Bourgeois
Service de Pneumologie et d Allergologie Pediatriques, Hopital Necker Enfants Malades, Paris, France
Chest 122:791-7. 2002..These children were compared with 17 children aged 6 to 36 months (mean, 15.1 +/- 7.5 months) with various nonwheezing pulmonary diseases. Children were included as control subjects if they had no endobronchial inflammation and no atopy... - Allergic rhinitis and its consequences on quality of sleep: An unexplored areaDamien Leger
Centre du Sommeil et de la Vigilance de l Hôtel Dieu, Assistance Publique Hopitaux de Paris, Paris, France
Arch Intern Med 166:1744-8. 2006..The objective of our study was to assess, in patients with AR, whether duration and severity of AR are associated with sleep impairment... - Airway inflammation and asthma treatment modalitiesThuong Nhân Pham Thi
Pediatric Allergology and Pneumology Dpt, Necker Enfants Malades Hospital, 149 rue de Sevres, 75743 Paris, France
Pediatr Pulmonol Suppl 26:229-33. 2004 - Multiplex Ligation-dependent Probe Amplification improves the detection rate of NKX2.1 mutations in patients affected by brain-lung-thyroid syndromeRaphaël Teissier
INSERM U845, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
Horm Res Paediatr 77:146-51. 2012..NKX2.1 mutations have been identified in patients displaying complete or partial brain-lung-thyroid syndrome, which can include benign hereditary chorea (BHC), hypothyroidism and/or lung disease... - Long term respiratory outcomes of congenital diaphragmatic hernia, esophageal atresia, and cardiovascular anomaliesChristophe Delacourt
Pediatric Pulmonology, APHP, Necker Enfants Malades, Paris, France
Semin Fetal Neonatal Med 17:105-11. 2012..These are best recognized in a structured multidisciplinary follow-up clinic so that they can be actively managed... - Immunotherapy in young childrenPierre Scheinmann
, Paris, France
Clin Allergy Immunol 18:567-83. 2004 - Impairment of nitric oxide output of conducting airways in primary ciliary dyskinesiaBruno Mahut
Service de pneumologie allergologie pédiatrique, Hopital Necker Enfants Malades, Assistance Publique Hôpitaux des Paris, Paris, France
Pediatr Pulmonol 41:158-63. 2006..05). In conclusion, the impairment of NO output is less pronounced in the lower than in the upper (nasal) respiratory tract in PCD. A decrease in maximal NO output from conducting airways is associated with limited airflow impairment... - Delineation of CCDC39/CCDC40 mutation spectrum and associated phenotypes in primary ciliary dyskinesiaSylvain Blanchon
Institut National de la Santé et de la Recherche Médicale UMR_S933, Universite Pierre et Marie Curie Paris 6, and Assistance Publique Hopitaux de Paris, Hopital Armand Trousseau, Service de génétique et d embryologie médicales, Paris, France
J Med Genet 49:410-6. 2012..Aiming to delineate the CCDC39/CCDC40 mutation spectrum and associated phenotypes, this study screened a large cohort of patients with IDA defects, in whom clinical and ciliary phenotypes were accurately described... - Microbiological diagnosis of empyema in children: comparative evaluations by culture, polymerase chain reaction, and pneumococcal antigen detection in pleural fluidsAlban Le Monnier
Assistance Publique-Hopitaux de Paris, Paris, France
Clin Infect Dis 42:1135-40. 2006..Broad-range 16S rDNA PCR has value in detecting bacterial agents responsible for culture-negative pleural empyema... - Pulmonary alveolar proteinosis in childrenJacques de Blic
Service de pneumologie et allergologie pédiatriques, Hopital Necker Enfants Malades, 149 rue de Sèvres 75015, Paris, France
Paediatr Respir Rev 5:316-22. 2004..Recent studies have implicated GM-CSF and/or its receptor but the exact underlying mechanisms are still unknown. Therapeutic lung lavages are the only effective treatment for severe cases... - DC-SIGN induction in alveolar macrophages defines privileged target host cells for mycobacteria in patients with tuberculosisLudovic Tailleux
Institut Pasteur, Unite de Genetique Mycobacterienne, Paris, France
PLoS Med 2:e381. 2005.... - Retrospective French nationwide survey of childhood aggressive vascular anomalies of bone, 1988-2009Sébastien Héritier
Service d hématologie oncologie pédiatrique, Centre de référence des histiocytoses, AP HP Hôpital Armand Trousseau, Paris, France
Orphanet J Rare Dis 5:3. 2010..To document the epidemiological, clinical, histological and radiological characteristics of aggressive vascular abnormalities of bone in children... - Analysis of 40 sporadic or familial neonatal and pediatric cases with severe unexplained respiratory distress: relationship to SFTPBMohammed Tredano
Service de Biochimie et Biologie Moléculaire, hôpital d enfants Armand Trousseau AP HP, Paris, France
Am J Med Genet A 119:324-39. 2003..When disease loci are identified, patient genotyping will be crucial as a diagnostic aid, for devising proper treatment, and as a basis for genetic counseling...