Research Topics
Genomes and Genes
| Irwin DavidsonSummaryCountry: France Publications
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Detail Information
Publications
[TBP, a universal transcription factor?]Irwin Davidson
Institut de Genetique et de Biologie Moleculaire et Cellulaire, 1, rue Laurent Fries, 67404 Illkirch, France
Med Sci (Paris) 20:575-9. 2004..In mammals, the aminoterminal region of TBP plays a highly selective role in the maternal immunotolerance of pregnancy...- New insights into TAFs as regulators of cell cycle and signaling pathwaysIrwin Davidson
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, llkirch Cédex, France
Cell Cycle 4:1486-90. 2005..TAF4 is however essential in the retinoic acid and cAMP signalling pathways acting as a cofactor for CREB and the retinoic acid receptor, but is a negative regulator of the ATF7 transcription factor... - The genetics of TBP and TBP-related factorsIrwin Davidson
, CNRS/INSERM/ULP, 1 rue Laurent Fries, , France
Trends Biochem Sci 28:391-8. 2003 - Proteolytic cleavage of ALF into alpha- and beta-subunits that form homologous and heterologous complexes with somatic TFIIA and TRF2 in male germ cellsRaffaella Catena
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
FEBS Lett 579:3401-10. 2005..Our observations highlight how cleavage of ALF and coexpression with TFIIA and TRF2 increases the combinatorial possibilities for gene regulation at different developmental stages of spermatogenesis... - Crystal structure of a subcomplex of human transcription factor TFIID formed by TATA binding protein-associated factors hTAF4 (hTAF(II)135) and hTAF12 (hTAF(II)20)Sebastiaan Werten
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Boite Postale, B P 163 67404 Illkirch Cédex Communauté Urbaine de Strasbourg, France
J Biol Chem 277:45502-9. 2002.... 
Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cellsIgor Martianov
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM UdS, Illkirch, France
BMC Genomics 11:530. 2010..The CREMτ activator isoform is selectively expressed in haploid spermatids and plays an essential role in murine spermiogenesis...- The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermisAnas Fadloun
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
Development 134:2947-58. 2007..Together, our results show that TAF4 is an important regulator of keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity... - Preparation, isolation and characterization of stage-specific spermatogenic cells for cellular and molecular analysisNoora Kotaja
, CNRS-INSERM, , B.P. 163, 67404 Illkirch, Strasbourg, France
Nat Methods 1:249-54. 2004 - Interconversion between active and inactive TATA-binding protein transcription complexes in the mouse genomeMohamed Amin Choukrallah
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
Nucleic Acids Res 40:1446-59. 2012..We propose a novel regulatory mechanism involving formation of a partial preinitiation complex comprising B-TFIID that primes the promoter for productive preinitiation complex formation in mammalian cells... - TIPT, a male germ cell-specific partner of TRF2, is chromatin-associated and interacts with HP1Stefano Brancorsini
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, Strasbourg, France
Cell Cycle 7:1415-22. 2008..These findings indicate that TIPT could contribute to the precise timing of the molecular events in male germ cells, specifically by linking transcription to chromatin remodeling in round spermatids... - Functional analysis of the TFIID-specific yeast TAF4 (yTAF(II)48) reveals an unexpected organization of its histone-fold domainSylvie Thuault
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Boîte Postale 163 67404 Illkirch Cédex, Communaute Urbaine de Strasbourg, France
J Biol Chem 277:45510-7. 2002..These results reveal an unexpected and novel HFD organization in which the alpha3 helix is separated from the alpha2 helix by an extended loop containing a conserved functional domain... - TAF4 inactivation in embryonic fibroblasts activates TGF beta signalling and autocrine growthGabrielle Mengus
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, France
EMBO J 24:2753-67. 2005..Our study also shows that TAF4 is an essential cofactor for activation by the retinoic acid receptor and CREB, but not for Sp1 and the vitamin D3 receptor... - Changes in intranuclear chromatin architecture induce bipolar nuclear localization of histone variant H1T2 in male haploid spermatidsRaffaella Catena
Institut de Genetique et de Biologie Molecularie et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
Dev Biol 296:231-238. 2006..Our results show that intranuclear chromatin organization is critical for correct polar localization of H1T2 and that H1T2 can be a useful molecular marker revealing chromatin disorganization in spermatids... - The TIF1α-related TRIM cofactors couple chromatin modifications to transcriptional regulation, signaling and tumor suppressionBenjamin Herquel
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch Cedex, France
Transcription 2:231-6. 2011..The finding that they interact to form a multiprotein complex suggests new mechanisms to integrate multiple signaling pathways for tumor suppression... - Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesisIgor Martianov
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, and Université Louis Pasteur, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
Proc Natl Acad Sci U S A 102:2808-13. 2005..Hence, H1T2 is a protein required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis... - Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosisMathilde Raverdeau
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7104, Institut National de la Santé et de la Recherche Médicale Unité 964, Universite de Strasbourg, Illkirch, France
Proc Natl Acad Sci U S A 109:16582-7. 2012.... - Retinoic acid receptors recognize the mouse genome through binding elements with diverse spacing and topologyEmmanuel Moutier
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM UdS, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
J Biol Chem 287:26328-41. 2012..The differential ability of RAR-RXR bound to DR0 compared to DR2, DR5, and DR8 to mediate RA-dependent transcriptional activation indicates that half-site spacing allosterically regulates RAR function... - seqMINER: an integrated ChIP-seq data interpretation platformTao Ye
Department of Functional Genomics and Cancer, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS UMR 7104, INSERM U 596, Universite de Strasbourg, BP 10142 67404 Illkirch Cedex, CU de Strasbourg, France
Nucleic Acids Res 39:e35. 2011.... 
Recent advances in understanding the structure and function of general transcription factor TFIIDEmilie Cler
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404, Illkirch Cedex, France
Cell Mol Life Sci 66:2123-34. 2009..Finally, we highlight several genetic studies suggesting that TFIID is required for initiation of transcription, but not for maintaining transcription once a promoter is in an active state...- Specialization of the general transcriptional machinery in male germ cellsUllas Kolthur-Seetharam
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, France
Cell Cycle 7:3493-8. 2008..Genetic and biochemical studies show that these paralogues play critical, but mechanistically distinct roles in Drosophila and mouse spermatogenesis... - RNA polymerase II transcription in murine cells lacking the TATA binding proteinIgor Martianov
Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM ULP, B P 163, 67404 Illkirch Cedex, Communaute Urbaine de Strasbourg, France
Science 298:1036-9. 2002..Our results show a differential dependency of the RNA polymerases on TBP and provide evidence for TBP-independent pol II transcriptional mechanisms that allow reinitiation and maintenance of gene transcription in vivo... - The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiationJean Christophe Pointud
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
J Cell Sci 116:1847-58. 2003.... - Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinomaBenjamin Herquel
Department of Functional Genomics and Cancer, Institut de Genetique et de Biologie Moleculaire et Cellulaire, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
Proc Natl Acad Sci U S A 108:8212-7. 2011..These results demonstrate that the TIF1-related subfamily of TRIM proteins interact both physically and functionally to modulate HCC formation in mice... - Testis-specific transcription mechanisms promoting male germ-cell differentiationSarah Kimmins
, , BP 163, 67404 Illkirch, Strasbourg, France
Reproduction 128:5-12. 2004..In this review we summarize recent advances in the transcription machinery that is testis-specific, gene-selective and necessary for the process of spermatogenesis... - Cell-specific nucleolar localization of TBP-related factor 2Philippe Kieffer-Kwon
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, 67404 Illkirch Cedex, France
Mol Biol Cell 15:4356-68. 2004..Although partially contradictory results have been reported, our data are consistent with a model where only small proportion of the cellular TBP remains associated with specific promoter loci during mitosis... - Genome-wide analysis of POU3F2/BRN2 promoter occupancy in human melanoma cells reveals Kitl as a novel regulated target geneDominique Kobi
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM UdS, Illkirch Cedex, France
Pigment Cell Melanoma Res 23:404-18. 2010..Our results suggest that POU3F2 may regulate the properties of melanoma cells via autocrine KIT ligand signalling... - Distinct mutations in yeast TAF(II)25 differentially affect the composition of TFIID and SAGA complexes as well as global gene expression patternsDoris B Kirschner
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, F 67404 Illkirch Cedex, CU de Strasbourg, France
Mol Cell Biol 22:3178-93. 2002..Thus, different yTAF(II)25 mutations induce distinct phenotypes and affect the regulation of different subsets of genes, demonstrating that no individual TAF(II) mutant allele reflects the full range of its normal functions... - Cell-specific interaction of retinoic acid receptors with target genes in mouse embryonic fibroblasts and embryonic stem cellsLaurence Delacroix
Immunologie et Maladies Infectieuses, GIGA 2, Bat B34, 1 ave de l Hôpital, 4000 Liege, Belgium
Mol Cell Biol 30:231-44. 2010.... - A functional interaction between ATF7 and TAF12 that is modulated by TAF4Pierre Jacques Hamard
Ecole Superieure de Biotechnologie de Strasbourg, Universite Louis Pasteur, Parc d Innovation, UMR7100 CNRS ULP, Bd Sebastien Brant BP10413, 67412 Strasbourg, Illkirch Cedex, France
Oncogene 24:3472-83. 2005.... - Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatidsIgor Martianov
Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, B P 163, 67404 Illkirch Cedex, C U de Strasbourg, France
Development 129:945-55. 2002..This defect is likely to be the primary cause of spermatogenic failure in the TLF mutant mice... - TATA box-binding protein-associated factor 12 is important for RAS-induced transformation properties of colorectal cancer cellsAngeliki Voulgari
Laboratory of Signal Mediated Gene Expression, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48 Vasileos Konstantinou Avenue, Athens 11635, Greece
Mol Cancer Res 6:1071-83. 2008.... - TAF7 (TAFII55) plays a role in the transcription activation by c-JunChristine Munz
Division of Signal Transduction and Growth Control, Deutsches Krebforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
J Biol Chem 278:21510-6. 2003..TAF7 interacts preferentially with DNA-bound phosphorylated c-Jun, suggesting that TAF7 represents a novel c-Jun co-activator mediating activation of AP-1 target genes in response to extracellular signals... - Functional interaction between the homeoprotein CDX1 and the transcriptional machinery containing the TATA-binding proteinAlexandre Calon
INSERM, U682 and University Louis Pasteur, Strasbourg, France
Nucleic Acids Res 35:175-85. 2007..However, the carboxy domains define the specificity of CDX1 and CDX2. Thus, intra-molecular interactions control the activity and partner recruitment of CDX1 and CDX2, leading to different molecular functions... - TBP as a candidate gene for mental retardation in patients with subtelomeric 6q deletionsLiesbeth Rooms
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Eur J Hum Genet 14:1090-6. 2006..Cognitive and behavioural tests performed on previously described heterozygous tbp mice suggested that TBP is potentially involved in cognitive development...