Irwin Davidson

Summary

Country: France

Publications

  1. ncbi request reprint [TBP, a universal transcription factor?]
    Irwin Davidson
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, 1, rue Laurent Fries, 67404 Illkirch, France
    Med Sci (Paris) 20:575-9. 2004
  2. ncbi request reprint The genetics of TBP and TBP-related factors
    Irwin Davidson
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
    Trends Biochem Sci 28:391-8. 2003
  3. ncbi request reprint New insights into TAFs as regulators of cell cycle and signaling pathways
    Irwin Davidson
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, llkirch Cédex, France
    Cell Cycle 4:1486-90. 2005
  4. ncbi request reprint Proteolytic cleavage of ALF into alpha- and beta-subunits that form homologous and heterologous complexes with somatic TFIIA and TRF2 in male germ cells
    Raffaella Catena
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
    FEBS Lett 579:3401-10. 2005
  5. doi request reprint Trim24-repressed VL30 retrotransposons regulate gene expression by producing noncoding RNA
    Benjamin Herquel
    Department of Functional Genomics and Cancer, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Nat Struct Mol Biol 20:339-46. 2013
  6. ncbi request reprint Preparation, isolation and characterization of stage-specific spermatogenic cells for cellular and molecular analysis
    Noora Kotaja
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM, Universite Louis Pasteur, B P 163, 67404 Illkirch, Strasbourg, France
    Nat Methods 1:249-54. 2004
  7. ncbi request reprint The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation
    Jean Christophe Pointud
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
    J Cell Sci 116:1847-58. 2003
  8. ncbi request reprint Crystal structure of a subcomplex of human transcription factor TFIID formed by TATA binding protein-associated factors hTAF4 (hTAF(II)135) and hTAF12 (hTAF(II)20)
    Sebastiaan Werten
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Boite Postale, B P 163 67404 Illkirch Cédex Communauté Urbaine de Strasbourg, France
    J Biol Chem 277:45502-9. 2002
  9. ncbi request reprint Changes in intranuclear chromatin architecture induce bipolar nuclear localization of histone variant H1T2 in male haploid spermatids
    Raffaella Catena
    Institut de Genetique et de Biologie Molecularie et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
    Dev Biol 296:231-238. 2006
  10. pmc Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cells
    Igor Martianov
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM UdS, Illkirch, France
    BMC Genomics 11:530. 2010

Collaborators

  • Paolo Sassone-Corsi
  • Martti Parvinen
  • Dino Moras
  • Manuel Mark
  • Christelle Thibault
  • Stephane Viville
  • Sarah Kimmins
  • Natacha Rochel
  • Pierre Chambon
  • Albert J R Heck
  • Florence Cammas
  • Lionel Larue
  • Laurence Nieto
  • Arnaud Krebs
  • Doulaye Dembele
  • Steven L Sanders
  • Barbara Testoni
  • Igor Martianov
  • Benjamin Herquel
  • Tao Ye
  • Mohamed Amin Choukrallah
  • Stefano Brancorsini
  • Dominique Kobi
  • Raffaella Catena
  • Gabrielle Mengus
  • Khalid Ouararhni
  • Laszlo Tora
  • Emmanuel Moutier
  • Bernard Jost
  • Laurence Delacroix
  • Stephanie Legras
  • Anas Fadloun
  • Dana Koludrovic
  • Celine Keime
  • Gerard Benoit
  • Mathilde Raverdeau
  • Regine Losson
  • Jean Christophe Pointud
  • Noora Kotaja
  • Emilie Cler
  • Marius Teletin
  • Yann Gaël Gangloff
  • Sylvie Thuault
  • Angeliki Voulgari
  • Sebastiaan Werten
  • Ullas Kolthur-Seetharam
  • Alexandre Calon
  • Liesbeth Rooms
  • Alexander Pintzas
  • Pierre Jacques Hamard
  • Philippe Kieffer-Kwon
  • Anne Gansmuller
  • Christine Munz
  • Christophe Romier
  • P Anthony Weil
  • Doris B Kirschner
  • Stéphanie Le Gras
  • Thierry Lerouge
  • W W M Pim Pijnappel
  • Betty Féret
  • Aurore Gely-Pernot
  • Sylvia Urban
  • Judit Osz
  • Amandine Chatagnon
  • Christine Dennefeld
  • Diana Langer
  • Nikolai Mischerikow
  • Norbert B Ghyselinck
  • H Th Marc Timmers
  • Sarah Sanglier-Cianferani
  • Ali Hamiche
  • Mihaela Ignat
  • Alain Van Dorsselaer
  • Guillaume Béchade
  • Konstantin Khetchoumian
  • Frederic Plewniak
  • Anne Lise Steunou
  • Gioia Altobelli
  • Erikjan Rijkers
  • Wilfred van Ijcken
  • Olivier Poch
  • Isabelle Bertin
  • Patrick Schultz
  • Gabor Papai
  • Takehiko Sasazuki
  • Stella Voskou
  • Senji Shirasawa
  • Isabelle Duluc
  • Arup Kumar Indra
  • Christine Bole-Feysot

Detail Information

Publications36

  1. ncbi request reprint [TBP, a universal transcription factor?]
    Irwin Davidson
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, 1, rue Laurent Fries, 67404 Illkirch, France
    Med Sci (Paris) 20:575-9. 2004
    ..In mammals, the aminoterminal region of TBP plays a highly selective role in the maternal immunotolerance of pregnancy...
  2. ncbi request reprint The genetics of TBP and TBP-related factors
    Irwin Davidson
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
    Trends Biochem Sci 28:391-8. 2003
  3. ncbi request reprint New insights into TAFs as regulators of cell cycle and signaling pathways
    Irwin Davidson
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, llkirch Cédex, France
    Cell Cycle 4:1486-90. 2005
    ..TAF4 is however essential in the retinoic acid and cAMP signalling pathways acting as a cofactor for CREB and the retinoic acid receptor, but is a negative regulator of the ATF7 transcription factor...
  4. ncbi request reprint Proteolytic cleavage of ALF into alpha- and beta-subunits that form homologous and heterologous complexes with somatic TFIIA and TRF2 in male germ cells
    Raffaella Catena
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
    FEBS Lett 579:3401-10. 2005
    ..Our observations highlight how cleavage of ALF and coexpression with TFIIA and TRF2 increases the combinatorial possibilities for gene regulation at different developmental stages of spermatogenesis...
  5. doi request reprint Trim24-repressed VL30 retrotransposons regulate gene expression by producing noncoding RNA
    Benjamin Herquel
    Department of Functional Genomics and Cancer, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Nat Struct Mol Biol 20:339-46. 2013
    ..These data reinforce the role of the TRIM family of proteins in retroviral restriction and antiviral defense and provide an example of an ERV-derived oncogenic regulatory network...
  6. ncbi request reprint Preparation, isolation and characterization of stage-specific spermatogenic cells for cellular and molecular analysis
    Noora Kotaja
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM, Universite Louis Pasteur, B P 163, 67404 Illkirch, Strasbourg, France
    Nat Methods 1:249-54. 2004
  7. ncbi request reprint The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation
    Jean Christophe Pointud
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
    J Cell Sci 116:1847-58. 2003
    ....
  8. ncbi request reprint Crystal structure of a subcomplex of human transcription factor TFIID formed by TATA binding protein-associated factors hTAF4 (hTAF(II)135) and hTAF12 (hTAF(II)20)
    Sebastiaan Werten
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Boite Postale, B P 163 67404 Illkirch Cédex Communauté Urbaine de Strasbourg, France
    J Biol Chem 277:45502-9. 2002
    ....
  9. ncbi request reprint Changes in intranuclear chromatin architecture induce bipolar nuclear localization of histone variant H1T2 in male haploid spermatids
    Raffaella Catena
    Institut de Genetique et de Biologie Molecularie et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
    Dev Biol 296:231-238. 2006
    ..Our results show that intranuclear chromatin organization is critical for correct polar localization of H1T2 and that H1T2 can be a useful molecular marker revealing chromatin disorganization in spermatids...
  10. pmc Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cells
    Igor Martianov
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM UdS, Illkirch, France
    BMC Genomics 11:530. 2010
    ..The CREMτ activator isoform is selectively expressed in haploid spermatids and plays an essential role in murine spermiogenesis...
  11. pmc Interconversion between active and inactive TATA-binding protein transcription complexes in the mouse genome
    Mohamed Amin Choukrallah
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
    Nucleic Acids Res 40:1446-59. 2012
    ..We propose a novel regulatory mechanism involving formation of a partial preinitiation complex comprising B-TFIID that primes the promoter for productive preinitiation complex formation in mammalian cells...
  12. pmc Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis
    Igor Martianov
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, and Université Louis Pasteur, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
    Proc Natl Acad Sci U S A 102:2808-13. 2005
    ..Hence, H1T2 is a protein required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis...
  13. ncbi request reprint The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis
    Anas Fadloun
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
    Development 134:2947-58. 2007
    ..Together, our results show that TAF4 is an important regulator of keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity...
  14. pmc TAF4 inactivation in embryonic fibroblasts activates TGF beta signalling and autocrine growth
    Gabrielle Mengus
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, France
    EMBO J 24:2753-67. 2005
    ..Our study also shows that TAF4 is an essential cofactor for activation by the retinoic acid receptor and CREB, but not for Sp1 and the vitamin D3 receptor...
  15. ncbi request reprint TIPT, a male germ cell-specific partner of TRF2, is chromatin-associated and interacts with HP1
    Stefano Brancorsini
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, Strasbourg, France
    Cell Cycle 7:1415-22. 2008
    ..These findings indicate that TIPT could contribute to the precise timing of the molecular events in male germ cells, specifically by linking transcription to chromatin remodeling in round spermatids...
  16. ncbi request reprint Functional analysis of the TFIID-specific yeast TAF4 (yTAF(II)48) reveals an unexpected organization of its histone-fold domain
    Sylvie Thuault
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Boîte Postale 163 67404 Illkirch Cédex, Communaute Urbaine de Strasbourg, France
    J Biol Chem 277:45510-7. 2002
    ..These results reveal an unexpected and novel HFD organization in which the alpha3 helix is separated from the alpha2 helix by an extended loop containing a conserved functional domain...
  17. ncbi request reprint RNA polymerase II transcription in murine cells lacking the TATA binding protein
    Igor Martianov
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM ULP, B P 163, 67404 Illkirch Cedex, Communaute Urbaine de Strasbourg, France
    Science 298:1036-9. 2002
    ..Our results show a differential dependency of the RNA polymerases on TBP and provide evidence for TBP-independent pol II transcriptional mechanisms that allow reinitiation and maintenance of gene transcription in vivo...
  18. pmc Cell-specific nucleolar localization of TBP-related factor 2
    Philippe Kieffer-Kwon
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, 67404 Illkirch Cedex, France
    Mol Biol Cell 15:4356-68. 2004
    ..Although partially contradictory results have been reported, our data are consistent with a model where only small proportion of the cellular TBP remains associated with specific promoter loci during mitosis...
  19. pmc The TIF1α-related TRIM cofactors couple chromatin modifications to transcriptional regulation, signaling and tumor suppression
    Benjamin Herquel
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch Cedex, France
    Transcription 2:231-6. 2011
    ..The finding that they interact to form a multiprotein complex suggests new mechanisms to integrate multiple signaling pathways for tumor suppression...
  20. ncbi request reprint Testis-specific transcription mechanisms promoting male germ-cell differentiation
    Sarah Kimmins
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, BP 163, 67404 Illkirch, Strasbourg, France
    Reproduction 128:5-12. 2004
    ..In this review we summarize recent advances in the transcription machinery that is testis-specific, gene-selective and necessary for the process of spermatogenesis...
  21. pmc Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis
    Mathilde Raverdeau
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7104, Institut National de la Santé et de la Recherche Médicale Unité 964, Universite de Strasbourg, Illkirch, France
    Proc Natl Acad Sci U S A 109:16582-7. 2012
    ....
  22. pmc Retinoic acid receptors recognize the mouse genome through binding elements with diverse spacing and topology
    Emmanuel Moutier
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM UdS, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
    J Biol Chem 287:26328-41. 2012
    ..The differential ability of RAR-RXR bound to DR0 compared to DR2, DR5, and DR8 to mediate RA-dependent transcriptional activation indicates that half-site spacing allosterically regulates RAR function...
  23. doi request reprint Recent advances in understanding the structure and function of general transcription factor TFIID
    Emilie Cler
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1 rue Laurent Fries, 67404, Illkirch Cedex, France
    Cell Mol Life Sci 66:2123-34. 2009
    ..Finally, we highlight several genetic studies suggesting that TFIID is required for initiation of transcription, but not for maintaining transcription once a promoter is in an active state...
  24. ncbi request reprint Specialization of the general transcriptional machinery in male germ cells
    Ullas Kolthur-Seetharam
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, France
    Cell Cycle 7:3493-8. 2008
    ..Genetic and biochemical studies show that these paralogues play critical, but mechanistically distinct roles in Drosophila and mouse spermatogenesis...
  25. pmc seqMINER: an integrated ChIP-seq data interpretation platform
    Tao Ye
    Department of Functional Genomics and Cancer, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS UMR 7104, INSERM U 596, Universite de Strasbourg, BP 10142 67404 Illkirch Cedex, CU de Strasbourg, France
    Nucleic Acids Res 39:e35. 2011
    ....
  26. pmc Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma
    Benjamin Herquel
    Department of Functional Genomics and Cancer, Institut de Genetique et de Biologie Moleculaire et Cellulaire, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
    Proc Natl Acad Sci U S A 108:8212-7. 2011
    ..These results demonstrate that the TIF1-related subfamily of TRIM proteins interact both physically and functionally to modulate HCC formation in mice...
  27. pmc Distinct mutations in yeast TAF(II)25 differentially affect the composition of TFIID and SAGA complexes as well as global gene expression patterns
    Doris B Kirschner
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, F 67404 Illkirch Cedex, CU de Strasbourg, France
    Mol Cell Biol 22:3178-93. 2002
    ..Thus, different yTAF(II)25 mutations induce distinct phenotypes and affect the regulation of different subsets of genes, demonstrating that no individual TAF(II) mutant allele reflects the full range of its normal functions...
  28. doi request reprint Genome-wide analysis of POU3F2/BRN2 promoter occupancy in human melanoma cells reveals Kitl as a novel regulated target gene
    Dominique Kobi
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM UdS, Illkirch Cedex, France
    Pigment Cell Melanoma Res 23:404-18. 2010
    ..Our results suggest that POU3F2 may regulate the properties of melanoma cells via autocrine KIT ligand signalling...
  29. ncbi request reprint Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids
    Igor Martianov
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, B P 163, 67404 Illkirch Cedex, C U de Strasbourg, France
    Development 129:945-55. 2002
    ..This defect is likely to be the primary cause of spermatogenic failure in the TLF mutant mice...
  30. doi request reprint MITF, the Janus transcription factor of melanoma
    Dana Koludrovic
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM UdS, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
    Future Oncol 9:235-44. 2013
    ..These new studies depict an ever more complex function for MITF in melanoma...
  31. pmc Cell-specific interaction of retinoic acid receptors with target genes in mouse embryonic fibroblasts and embryonic stem cells
    Laurence Delacroix
    Immunologie et Maladies Infectieuses, GIGA 2, Bat B34, 1 ave de l Hôpital, 4000 Liege, Belgium
    Mol Cell Biol 30:231-44. 2010
    ....
  32. ncbi request reprint A functional interaction between ATF7 and TAF12 that is modulated by TAF4
    Pierre Jacques Hamard
    Ecole Superieure de Biotechnologie de Strasbourg, Universite Louis Pasteur, Parc d Innovation, UMR7100 CNRS ULP, Bd Sebastien Brant BP10413, 67412 Strasbourg, Illkirch Cedex, France
    Oncogene 24:3472-83. 2005
    ....
  33. doi request reprint TATA box-binding protein-associated factor 12 is important for RAS-induced transformation properties of colorectal cancer cells
    Angeliki Voulgari
    Laboratory of Signal Mediated Gene Expression, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48 Vasileos Konstantinou Avenue, Athens 11635, Greece
    Mol Cancer Res 6:1071-83. 2008
    ....
  34. pmc Functional interaction between the homeoprotein CDX1 and the transcriptional machinery containing the TATA-binding protein
    Alexandre Calon
    INSERM, U682 and University Louis Pasteur, Strasbourg, France
    Nucleic Acids Res 35:175-85. 2007
    ..However, the carboxy domains define the specificity of CDX1 and CDX2. Thus, intra-molecular interactions control the activity and partner recruitment of CDX1 and CDX2, leading to different molecular functions...
  35. ncbi request reprint TAF7 (TAFII55) plays a role in the transcription activation by c-Jun
    Christine Munz
    Division of Signal Transduction and Growth Control, Deutsches Krebforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    J Biol Chem 278:21510-6. 2003
    ..TAF7 interacts preferentially with DNA-bound phosphorylated c-Jun, suggesting that TAF7 represents a novel c-Jun co-activator mediating activation of AP-1 target genes in response to extracellular signals...
  36. ncbi request reprint TBP as a candidate gene for mental retardation in patients with subtelomeric 6q deletions
    Liesbeth Rooms
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Eur J Hum Genet 14:1090-6. 2006
    ..Cognitive and behavioural tests performed on previously described heterozygous tbp mice suggested that TBP is potentially involved in cognitive development...