Denis J David

Summary

Country: France

Publications

  1. doi request reprint Implications of the functional integration of adult-born hippocampal neurons in anxiety-depression disorders
    Denis J David
    Faculte de Pharmacie, Universite Paris Sud, Chatenay Malabry, France
    Neuroscientist 16:578-91. 2010
  2. pmc Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression
    Denis J David
    Université Paris Sud EA 3544, Faculte de Pharmacie, Chatenay Malabry Cedex F 92296, France
    Neuron 62:479-93. 2009
  3. doi request reprint Synergistic neurochemical and behavioural effects of acute intrahippocampal injection of brain-derived neurotrophic factor and antidepressants in adult mice
    Thierry Deltheil
    Universite Paris Sud, EA 3544, Faculte de Pharmacie, Chatenay Malabry, France
    Int J Neuropsychopharmacol 12:905-15. 2009
  4. pmc Blockade of the high-affinity noradrenaline transporter (NET) by the selective 5-HT reuptake inhibitor escitalopram: an in vivo microdialysis study in mice
    Hai T Nguyen
    Laboratoire de Neuropharmacologie, Faculte de Pharmacie, Universite Paris Sud XI, Chatenay Malabry, France
    Br J Pharmacol 168:103-16. 2013
  5. ncbi request reprint Interest of using genetically manipulated mice as models of depression to evaluate antidepressant drugs activity: a review
    Alain M Gardier
    Fac Pharmacie, Univ Paris Sud, EA 3544, Chatenay Malabry Cedex F 92296, France
    Fundam Clin Pharmacol 23:23-42. 2009
  6. doi request reprint Ventral hippocampal molecular pathways and impaired neurogenesis associated with 5-HT₁A and 5-HT₁B receptors disruption in mice
    Lin Xia
    Univ Paris Sud, EA3544, Faculte de Pharmacie, Chatenay Malabry F 92296, France
    Neurosci Lett 521:20-5. 2012
  7. doi request reprint Functional status of somatodendritic serotonin 1A autoreceptor after long-term treatment with fluoxetine in a mouse model of anxiety/depression based on repeated corticosterone administration
    Quentin Rainer
    Equipe d Accueil 3544, Laboratoire de Neuropharmacologie, Universite Paris XI, Chatenay Malabry, France
    Mol Pharmacol 81:106-12. 2012
  8. ncbi request reprint Serotonin transporter in substance P (neurokinin 1) receptor knock-out mice
    Denis J David
    Laboratoire de Neuropharmacologie Tour D1, 2eme etage, EA 3544 MJENR, Faculté de Pharmacie IFR75 ISIT Institut de Signalisation et d Innovation Thérapeutique, Universite Paris Sud, 5 rue J B Clement, F92296 Châtenay Malabry, France
    Eur J Pharmacol 492:41-8. 2004
  9. ncbi request reprint Consequences of changes in BDNF levels on serotonin neurotransmission, 5-HT transporter expression and function: studies in adult mice hippocampus
    Thierry Deltheil
    Univ Paris Sud, EA 3544, Fac Pharmacie, Chatenay Malabry Cedex F 92296, France
    Pharmacol Biochem Behav 90:174-83. 2008
  10. ncbi request reprint Beneficial behavioural and neurogenic effects of agomelatine in a model of depression/anxiety
    Quentin Rainer
    Université Paris Sud EA3544, Laboratoire Neuropharmacologie, Faculte de Pharmacie, Chatenay Malabry, France
    Int J Neuropsychopharmacol 15:321-35. 2012

Collaborators

Detail Information

Publications15

  1. doi request reprint Implications of the functional integration of adult-born hippocampal neurons in anxiety-depression disorders
    Denis J David
    Faculte de Pharmacie, Universite Paris Sud, Chatenay Malabry, France
    Neuroscientist 16:578-91. 2010
    ..Finally, we reveal that the behavioral effects of fluoxetine are mediated through both neurogenesis-dependent and -independent actions...
  2. pmc Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression
    Denis J David
    Université Paris Sud EA 3544, Faculte de Pharmacie, Chatenay Malabry Cedex F 92296, France
    Neuron 62:479-93. 2009
    ..Importantly, mice deficient in one of these genes, beta-arrestin 2, displayed a reduced response to fluoxetine in multiple tasks, suggesting that beta-arrestin signaling is necessary for the antidepressant effects of fluoxetine...
  3. doi request reprint Synergistic neurochemical and behavioural effects of acute intrahippocampal injection of brain-derived neurotrophic factor and antidepressants in adult mice
    Thierry Deltheil
    Universite Paris Sud, EA 3544, Faculte de Pharmacie, Chatenay Malabry, France
    Int J Neuropsychopharmacol 12:905-15. 2009
    ..Thus a BDNF+SSRI combination may offer new alternatives to treat mood disorders...
  4. pmc Blockade of the high-affinity noradrenaline transporter (NET) by the selective 5-HT reuptake inhibitor escitalopram: an in vivo microdialysis study in mice
    Hai T Nguyen
    Laboratoire de Neuropharmacologie, Faculte de Pharmacie, Universite Paris Sud XI, Chatenay Malabry, France
    Br J Pharmacol 168:103-16. 2013
    ..some also enhance, to a lesser extent, extracellular levels of noradrenaline ([NA](ext)). However, the mechanisms by which SSRIs activate noradrenergic transmission in the brain remain to be determined...
  5. ncbi request reprint Interest of using genetically manipulated mice as models of depression to evaluate antidepressant drugs activity: a review
    Alain M Gardier
    Fac Pharmacie, Univ Paris Sud, EA 3544, Chatenay Malabry Cedex F 92296, France
    Fundam Clin Pharmacol 23:23-42. 2009
    ....
  6. doi request reprint Ventral hippocampal molecular pathways and impaired neurogenesis associated with 5-HT₁A and 5-HT₁B receptors disruption in mice
    Lin Xia
    Univ Paris Sud, EA3544, Faculte de Pharmacie, Chatenay Malabry F 92296, France
    Neurosci Lett 521:20-5. 2012
    ..Furthermore, immunohistochemistry experiments studying adult hippocampal neurogenesis in adult 5-HT(1A/1B)(-/-) mice showed a decreased survival, but not proliferation of newborn cells in our model...
  7. doi request reprint Functional status of somatodendritic serotonin 1A autoreceptor after long-term treatment with fluoxetine in a mouse model of anxiety/depression based on repeated corticosterone administration
    Quentin Rainer
    Equipe d Accueil 3544, Laboratoire de Neuropharmacologie, Universite Paris XI, Chatenay Malabry, France
    Mol Pharmacol 81:106-12. 2012
    ..These results provide cellular explanations for the antidepressant effects produced by SSRIs in subjects with pathological conditions but not in naive animals or healthy volunteers...
  8. ncbi request reprint Serotonin transporter in substance P (neurokinin 1) receptor knock-out mice
    Denis J David
    Laboratoire de Neuropharmacologie Tour D1, 2eme etage, EA 3544 MJENR, Faculté de Pharmacie IFR75 ISIT Institut de Signalisation et d Innovation Thérapeutique, Universite Paris Sud, 5 rue J B Clement, F92296 Châtenay Malabry, France
    Eur J Pharmacol 492:41-8. 2004
    ....
  9. ncbi request reprint Consequences of changes in BDNF levels on serotonin neurotransmission, 5-HT transporter expression and function: studies in adult mice hippocampus
    Thierry Deltheil
    Univ Paris Sud, EA 3544, Fac Pharmacie, Chatenay Malabry Cedex F 92296, France
    Pharmacol Biochem Behav 90:174-83. 2008
    ..Thus, the neurochemical sight of this question will be addressed here by examining the consequences of either a constitutive decrease or increase in brain BDNF protein levels on hippocampal extracellular levels of 5-HT in conscious mice...
  10. ncbi request reprint Beneficial behavioural and neurogenic effects of agomelatine in a model of depression/anxiety
    Quentin Rainer
    Université Paris Sud EA3544, Laboratoire Neuropharmacologie, Faculte de Pharmacie, Chatenay Malabry, France
    Int J Neuropsychopharmacol 15:321-35. 2012
    ....
  11. doi request reprint Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice
    Jean Philippe Guilloux
    Univ Paris Sud, EA3544, Faculte de Pharmacie, Chatenay Malabry F 92296, France
    Neuropharmacology 73:147-59. 2013
    ..Vortioxetine effects were observed at low levels of 5-HT transporter occupancy, suggesting an alternative mechanism of action to 5-HT reuptake inhibition...
  12. ncbi request reprint Improved efficacy of fluoxetine in increasing hippocampal 5-hydroxytryptamine outflow in 5-HT(1B) receptor knock-out mice
    Isabelle Malagié
    Laboratoire de Neuropharmacologie UPRES EAD MENRT, Faculté de Pharmacie IFR ISIT Institut de Signalisation et d Innovation Thérapeutique, Universite Paris Sud, Tour D1 2eme etage 5 rue 1 B Clement, 92296, Chatenay Malabry Cedex, France
    Eur J Pharmacol 443:99-104. 2002
    ..Alternative mechanisms, e.g., changes in 5-HT transporter and/or 5-HT(1A) receptor density in 5-HT(1B) receptor knock-out mice could also explain these findings...
  13. pmc Rapid Anxiolytic Effects of a 5-HT4 Receptor Agonist Are Mediated by a Neurogenesis-Independent Mechanism
    Indira Mendez-David
    Univ Paris Sud, EA3544, Faculte de Pharmacie, Chatenay Malabry, France
    Neuropsychopharmacology 39:1366-78. 2014
    ..5-HT4 receptor stimulation could represent an innovative and rapid onset therapeutic approach to treat depression with comorbid anxiety. ..
  14. doi request reprint Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis
    Karim Ben M'barek
    Institut Curie, CNRS UMR 3306, INSERM U1005, Orsay 91405, France
    J Neurosci 33:8608-20. 2013
    ..These results support the notion that huntingtin participates in anxiety and depression-like behavior and is thus relevant to the etiology of mood disorders and anxiety/depression in HD...