Yves Dauvilliers

Summary

Country: France

Publications

  1. pmc Low vitamin D in narcolepsy with cataplexy
    Bertrand Carlander
    Department of Neurology, Hopital Gui de Chauliac, CHU Montpellier, Montpellier, France
    PLoS ONE 6:e20433. 2011
  2. pmc Insomnia, daytime sleepiness and cardio-cerebrovascular diseases in the elderly: a 6-year prospective study
    Isabelle Jaussent
    INSERM, U1061, Montpellier, France
    PLoS ONE 8:e56048. 2013
  3. pmc Reward-based behaviors and emotional processing in human with narcolepsy-cataplexy
    Sophie Bayard
    Department of Neurology, National Reference Network for Narcolepsy, Gui de Chauliac Hospital, CHU Montpellier, Inserm U1061, University of Montpellier 1 Montpellier, France
    Front Behav Neurosci 7:50. 2013
  4. doi request reprint Cerebrospinal fluid and serum cytokine profiles in narcolepsy with cataplexy: a case-control study
    Yves Dauvilliers
    CHU Montpellier, Service de Neurologie, Unite des troubles du sommeil, Hopital Gui de Chauliac, Montpellier, France National Reference Network for Orphan Diseases Narcolepsy, Idiopathic Hypersomnia and Kleine Levin Syndrome, France INSERM, U1061, F 34000 Montpellier, France Université Montpellier 1, F 34000 Montpellier, France Pôle Gérontologie CHU Montpellier, M2H Euromov, Universite Montpellier 1, France Electronic address
    Brain Behav Immun 37:260-6. 2014
  5. doi request reprint Increased risk of narcolepsy in children and adults after pandemic H1N1 vaccination in France
    Yves Dauvilliers
    Sleep Disorder Centre, Neurology Department, Gui de Chauliac Hospital, CHU Montpellier, INSERM, U1061, Montpellier, France
    Brain 136:2486-96. 2013
  6. pmc Hypnotics and mortality in an elderly general population: a 12-year prospective study
    Isabelle Jaussent
    INSERM, U1061, Montpellier F 34000, France
    BMC Med 11:212. 2013
  7. doi request reprint Rapid eye movement sleep behavior disorder and rapid eye movement sleep without atonia in narcolepsy
    Yves Dauvilliers
    National Reference Network for Orphan Diseases Narcolepsy, Idiopathic Hypersomnia, and Klein Levine syndrome, Montpellier, France
    Sleep Med 14:775-81. 2013
  8. pmc Family history of idiopathic REM behavior disorder: a multicenter case-control study
    Yves Dauvilliers
    Department of Neurology, Hopital Gui de Chauliac, Inserm U1061, Montpellier, France
    Neurology 80:2233-5. 2013
  9. pmc Hypersomnia and depressive symptoms: methodological and clinical aspects
    Yves Dauvilliers
    Centre de référence national sur les maladies rares narcolepsie, Hypersomnie Idiopathique, Syndrome de Kleine Levin, Service de Neurologie, Unite des troubles du sommeil, Hopital Gui de Chauliac, 80 avenue Augustin Fliche, Montpellier Cedex 5 34295, France
    BMC Med 11:78. 2013
  10. pmc Normal cerebrospinal fluid histamine and tele-methylhistamine levels in hypersomnia conditions
    Yves Dauvilliers
    Sleep Unit, Department of Neurology, Gui de Chauliac Hospital, CHU Montpellier, National Reference Network for Orphan Diseases Narcolepsy, Hypersomnia, Kleine Levin Syndrome, France
    Sleep 35:1359-66. 2012

Detail Information

Publications92

  1. pmc Low vitamin D in narcolepsy with cataplexy
    Bertrand Carlander
    Department of Neurology, Hopital Gui de Chauliac, CHU Montpellier, Montpellier, France
    PLoS ONE 6:e20433. 2011
    ..Here we investigated whether NC can be associated with 25-hydroxyvitamin D (25(OH)D) level deficiency in patients with NC compared with gender- and age-matched normal controls...
  2. pmc Insomnia, daytime sleepiness and cardio-cerebrovascular diseases in the elderly: a 6-year prospective study
    Isabelle Jaussent
    INSERM, U1061, Montpellier, France
    PLoS ONE 8:e56048. 2013
    ..To examine 1) the associations between history of cardio-cerebrovascular diseases (CVD) and insomnia complaints and excessive daytime sleepiness (EDS), and 2) the relationships between sleep complaints and future CVD in persons over 65...
  3. pmc Reward-based behaviors and emotional processing in human with narcolepsy-cataplexy
    Sophie Bayard
    Department of Neurology, National Reference Network for Narcolepsy, Gui de Chauliac Hospital, CHU Montpellier, Inserm U1061, University of Montpellier 1 Montpellier, France
    Front Behav Neurosci 7:50. 2013
    ..Inclusion of patients with other central hypersomnias without hypocretin deficiency will provide answer to the major question of the role of the hypocretin system in reward-based behaviors and emotional processing in humans...
  4. doi request reprint Cerebrospinal fluid and serum cytokine profiles in narcolepsy with cataplexy: a case-control study
    Yves Dauvilliers
    CHU Montpellier, Service de Neurologie, Unite des troubles du sommeil, Hopital Gui de Chauliac, Montpellier, France National Reference Network for Orphan Diseases Narcolepsy, Idiopathic Hypersomnia and Kleine Levin Syndrome, France INSERM, U1061, F 34000 Montpellier, France Université Montpellier 1, F 34000 Montpellier, France Pôle Gérontologie CHU Montpellier, M2H Euromov, Universite Montpellier 1, France Electronic address
    Brain Behav Immun 37:260-6. 2014
    ....
  5. doi request reprint Increased risk of narcolepsy in children and adults after pandemic H1N1 vaccination in France
    Yves Dauvilliers
    Sleep Disorder Centre, Neurology Department, Gui de Chauliac Hospital, CHU Montpellier, INSERM, U1061, Montpellier, France
    Brain 136:2486-96. 2013
    ....
  6. pmc Hypnotics and mortality in an elderly general population: a 12-year prospective study
    Isabelle Jaussent
    INSERM, U1061, Montpellier F 34000, France
    BMC Med 11:212. 2013
    ....
  7. doi request reprint Rapid eye movement sleep behavior disorder and rapid eye movement sleep without atonia in narcolepsy
    Yves Dauvilliers
    National Reference Network for Orphan Diseases Narcolepsy, Idiopathic Hypersomnia, and Klein Levine syndrome, Montpellier, France
    Sleep Med 14:775-81. 2013
    ....
  8. pmc Family history of idiopathic REM behavior disorder: a multicenter case-control study
    Yves Dauvilliers
    Department of Neurology, Hopital Gui de Chauliac, Inserm U1061, Montpellier, France
    Neurology 80:2233-5. 2013
    ..To compare the frequency of proxy-reported REM sleep behavior disorder (RBD) among relatives of patients with polysomnogram-diagnosed idiopathic RBD (iRBD) in comparison to controls using a large multicenter clinic-based cohort...
  9. pmc Hypersomnia and depressive symptoms: methodological and clinical aspects
    Yves Dauvilliers
    Centre de référence national sur les maladies rares narcolepsie, Hypersomnie Idiopathique, Syndrome de Kleine Levin, Service de Neurologie, Unite des troubles du sommeil, Hopital Gui de Chauliac, 80 avenue Augustin Fliche, Montpellier Cedex 5 34295, France
    BMC Med 11:78. 2013
    ..Further interventional studies are needed to explore whether management of sleep complaints improves mood symptoms in hypersomnia disorders and, conversely, whether management of mood complaints improves sleep symptoms in mood disorders...
  10. pmc Normal cerebrospinal fluid histamine and tele-methylhistamine levels in hypersomnia conditions
    Yves Dauvilliers
    Sleep Unit, Department of Neurology, Gui de Chauliac Hospital, CHU Montpellier, National Reference Network for Orphan Diseases Narcolepsy, Hypersomnia, Kleine Levin Syndrome, France
    Sleep 35:1359-66. 2012
    ....
  11. doi request reprint Myotonic dystrophy type 1, daytime sleepiness and REM sleep dysregulation
    Yves A Dauvilliers
    National Reference Network for Narcolepsy, Sleep Disorders Center, Department of Neurology, Hopital Gui de Chauliac, Inserm U1061, UM1, Montpellier, France
    Sleep Med Rev 16:539-45. 2012
    ....
  12. pmc Non-dipping blood pressure profile in narcolepsy with cataplexy
    Yves Dauvilliers
    Sleep Unit, Department of Neurology, Hopital Gui de Chauliac, CHU Montpellier, National Reference Network for Narcolepsy, Montpellier, France
    PLoS ONE 7:e38977. 2012
    ....
  13. ncbi request reprint A monozygotic twin pair discordant for narcolepsy and CSF hypocretin-1
    Y Dauvilliers
    Neurology B, Sleep Wake Disorder Center, Gui de Chauliac Hospital, Montpellier, France
    Neurology 62:2137-8. 2004
  14. ncbi request reprint Reversal of symptomatic tumoral narcolepsy, with normalization of CSF hypocretin level
    Y Dauvilliers
    Neurology Department, Gui de Chauliac Hospital, National Reference Network for Orphan Diseases, Narcolepsy and Idiopathic Hypersomnia, Montpellier, France
    Neurology 69:1300-1. 2007
  15. ncbi request reprint Effect of age on MSLT results in patients with narcolepsy-cataplexy
    Y Dauvilliers
    Centre d Etude du Sommeil, Hopital Gui de Chauliac, and INSERM E 0361, Hôpital La Colombière, Montpellier, France
    Neurology 62:46-50. 2004
    ..To measure the effect of age on Multiple Sleep Latency Test (MSLT)characteristics, sleep latency, and number of sleep-onset REM periods (SOREMP) in two large populations of narcoleptic patients with similar genetic backgrounds...
  16. ncbi request reprint Dissociation in circadian rhythms in a pseudohypersomnia form of fatal familial insomnia
    Y Dauvilliers
    Service de Neurologie B, Hopital Gui de Chauliac, 80 avenue Augustin Fliche, 34295 Montpellier Cedex 5, France
    Neurology 63:2416-8. 2004
    ..There was profound alteration in the sleep-wake cycle with a clear dissociation in the disappearance of circadian and neuroendocrine rhythms, findings unrelated to abnormalities in the hypocretinergic system...
  17. ncbi request reprint Family studies in insomnia
    Yves Dauvilliers
    Service de Neurologie B, Hopital Gui de Chauliac, 80 avenue Augustin Fliche, Montpellier Cedex 5 34295, France
    J Psychosom Res 58:271-8. 2005
    ..The aim of this study is to evaluate the prevalence of insomnia among first-degree relatives of chronic insomniacs and to compare the symptoms between sporadic and familial insomnia...
  18. ncbi request reprint Narcolepsy with cataplexy
    Yves Dauvilliers
    Neurologie, CHU Montpellier Hôpital Gui de Chauliac and INSERM U888, Montpellier France
    Lancet 369:499-511. 2007
    ..Because narcolepsy is an under-recognised disease, it is important that general practitioners and other primary health-care workers identify abnormal daytime sleepiness early...
  19. ncbi request reprint The genetic basis of sleep disorders
    Yves Dauvilliers
    Department of Neurology, Hopital Gui de Chauliac, CHU Montpellier, INSERM U888, 34295 Montpellier, France
    Curr Pharm Des 14:3386-95. 2008
    ..We reviewed here the role of genetic basis in most of key sleep disorders...
  20. doi request reprint [Narcolepsy with cataplexy]
    Y Dauvilliers
    Service de Neurologie, Hopital Gui de Chauliac, CHU de Montpellier, Montpellier Cedex 5, France
    Rev Neurol (Paris) 164:634-45. 2008
    ..The current therapeutic target is oriented towards hypocretine agonists, histamine (an arousal system) H3 antagonists and immunosuppressants...
  21. ncbi request reprint [Neurodegenerative, autoimmune and genetic processes of human and animal narcolepsy]
    Y Dauvilliers
    Service de Neurologie B, Hopital Gui de Chauliac, Montpellier
    Rev Neurol (Paris) 159:6S83-7. 2003
    ..Treatment has not evolved significantly over the last few years. However, new drugs, such as hypocretin agonists, are currently being developed...
  22. ncbi request reprint [Sleep in fibromyalgia: review of clinical and polysomnographic data]
    Y Dauvilliers
    Service de Neurologie B, Hopital Gui de Chauliac, 80, avenue Augustin Fliche, 34295 Montpellier, France
    Neurophysiol Clin 31:18-33. 2001
    ..Several factors such as psychological, environmental, genetic factor, altered serotonin metabolism and altered sleep physiology are involved in the pathogenesis of fibromyalgia...
  23. doi request reprint A brain PET study in patients with narcolepsy-cataplexy
    Yves Dauvilliers
    Service de Neurologie, Unite des troubles du sommeil, CHU Montpellier, France
    J Neurol Neurosurg Psychiatry 81:344-8. 2010
    ..To investigate brain changes in both basal and cataplectic conditions in awake patients with narcolepsy-cataplexy...
  24. doi request reprint Insomnia in patients with neurodegenerative conditions
    Yves Dauvilliers
    Hopital Gui de Chauliac, Service de Neurologie, Gui de Chauliac Hospital, CHU Montpellier, INSERM U888, 80 av Augustin Fliche, 34295 Montpellier Cedex 5, France
    Sleep Med 8:S27-34. 2007
    ..Medications causing sleep problems should be withdrawn or doses and/or timing adjusted, whenever possible. Several pharmacological options are available to relieve the symptoms of insomnia as short-term treatment...
  25. ncbi request reprint Severity of narcolepsy among French of different ethnic origins (south of France and Martinique)
    Yves Dauvilliers
    Sleep and Wake Disorder Center Neurology B Unit, Gui de Chauliac Hospital, Montpellier, France
    Sleep 25:50-5. 2002
    ..The aim of the study was to describe the clinical and polygraphical characteristics of narcoleptics, with and without cataplexy and to assess HLA predisposition across two different ethnic populations...
  26. ncbi request reprint Month of birth as a risk factor for narcolepsy
    Yves Dauvilliers
    Service de Neurologie B, Unite des troubles du sommeil, Hôpital Gui de Chauliac Montpellier, France
    Sleep 26:663-5. 2003
    ..The aim of the study was to find out whether there is a seasonality of month of birth in narcoleptic patients...
  27. ncbi request reprint Age at onset of narcolepsy in two large populations of patients in France and Quebec
    Y Dauvilliers
    Service de Neurologie B, Unite des troubles du sommeil, Hopital Gui de Chauliac, Montpellier, France
    Neurology 57:2029-33. 2001
    ..Narcolepsy usually starts around adolescence; however, there is great variability in the clinical presentation of narcolepsy...
  28. doi request reprint High pain frequency in narcolepsy with cataplexy
    Yves Dauvilliers
    Department of Neurology, Hopital Gui de Chauliac, CHU Montpellier, National Reference Network for Orphan Diseases Narcolepsy, Montpellier, France
    Sleep Med 12:572-7. 2011
    ..The aims of the present multicenter case-control study were to look at the frequency of pain in NC and to study the determinants and impact of pain on narcolepsy symptoms and quality of life (QoL)...
  29. pmc CSF hypocretin-1 levels in narcolepsy, Kleine-Levin syndrome, and other hypersomnias and neurological conditions
    Y Dauvilliers
    Service de Neurologie B, Hopital Gui de Chauliac, Montpellier, France
    J Neurol Neurosurg Psychiatry 74:1667-73. 2003
    ..To determine the role of CSF hypocretin-1 in narcolepsy with and without cataplexy, Kleine-Levin syndrome (KLS), idiopathic and other hypersomnias, and several neurological conditions...
  30. pmc Functional impairment in adult sleepwalkers: a case-control study
    Regis Lopez
    Sleep Unit, Department of Neurology, Gui de Chauliac Hospital, National Reference Network for Narcolepsy, CHU Montpellier, France
    Sleep 36:345-51. 2013
    ..To investigate the restorative quality of sleep and daytime functioning in sleepwalking adult patients in comparison with controls...
  31. pmc Excessive sleepiness is predictive of cognitive decline in the elderly
    Isabelle Jaussent
    INSERM, U1061, Montpellier, France
    Sleep 35:1201-7. 2012
    ..To examine the association of sleep complaints reported at baseline (insomnia complaints and excessive daytime sleepiness (EDS)) and medication, with cognitive decline in community-dwelling elderly...
  32. ncbi request reprint Determinants of excessive daytime sleepiness in a French community-dwelling elderly population
    Norifumi Tsuno
    INSERM Unité 888, Hôpital La Colombière, 39 Avenue Charles Flahault, Montpellier Cedex 5, France
    J Sleep Res 16:364-71. 2007
    ..A multivariate analysis revealed that the lifetime prevalence of manic and hypomanic episodes, snoring and gender (male) were independently associated with EDS. No independent association with other psychiatric disorders was found...
  33. pmc Insomnia and daytime sleepiness are risk factors for depressive symptoms in the elderly
    Isabelle Jaussent
    INSERM, U1061, Montpellier, F 34000 France
    Sleep 34:1103-10. 2011
    ..However, these associations have not been investigated in community-dwelling elderly taking into account insomnia symptoms, EDS, and sleep medication...
  34. pmc Daytime sleepiness and REM sleep characteristics in myotonic dystrophy: a case-control study
    Huan Yu
    Service de Neurologie, Hopital Gui de Chauliac, 80 avenue Augustin Fliche, Montpellier Cedex 5, France
    Sleep 34:165-70. 2011
    ..Our objectives were to compare polysomnographic and multiple sleep latency test (MSLT) parameters, and both tonic and phasic components of REM sleep between DM1 and controls...
  35. pmc Decision making in narcolepsy with cataplexy
    Sophie Bayard
    Service de Neurologie, Unite des troubles du sommeil, Hôpital Gui de Chauliac Montpellier, France
    Sleep 34:99-104. 2011
    ..The hypocretin system plays a crucial role in sleep, wakefulness, and energy homeostasis, and is also involved in emotion regulation, reward processing, and addiction...
  36. pmc Comorbidity and medication in REM sleep behavior disorder: a multicenter case-control study
    Birgit Frauscher
    From the Department of Neurology B F, D G, T M, B H, Innsbruck Medical University, Austria Danish Center for Sleep Medicine P J, University of Copenhagen, Denmark Department of Neurology Y E S J, Washington University School of Medicine, St Louis, MO Department of Neurology R B P, McGill University, Montreal General Hospital, Canada Unité des Pathologies du Sommeil I A, S L S, Hopital Pitie Salpetriere, APHP, and Inserm U975 CRICM Pierre and Marie Curie University, Paris Sleep Unit V C D C, Y D, Department of Neurology, Hopital Gui de Chauliac, Montpellier, Inserm U1061, Montpellier, France Sleep Disorders Center M L F, Department of Neurosciences, University of Turin, Italy UFR Medecine M L F, EA 7280, University Clermont 1, France Sleep Disorders Center L F S, M Z, Universita Vita Salute San Raffaele, Milan, Italy Neurology Service A I, J S, Hospital Clinic de Barcelona
    Neurology 82:1076-9. 2014
    ..This controlled study investigated associations between comorbidity and medication in patients with polysomnographically confirmed idiopathic REM sleep behavior disorder (iRBD), using a large multicenter clinic-based cohort...
  37. ncbi request reprint Effect of cognitive behavioural therapy for insomnia on sleep architecture and sleep EEG power spectra in psychophysiological insomnia
    Katerina Cervena
    Sleep and wake disorder unit, Gui de Chauliac Hospital, Montpellier, France
    J Sleep Res 13:385-93. 2004
    ..In conclusion CBT-I improves both subjective and objective sleep quality of sleep. CBT-I may enhance sleep pressure and improve homeostatic sleep regulation...
  38. pmc Insomnia symptoms in older adults: associated factors and gender differences
    Isabelle Jaussent
    INSERM, U888, Univ Montpellier 1, Montpellier, INSERM, U897, Univ Bordeaux 2, Bordeaux, France
    Am J Geriatr Psychiatry 19:88-97. 2011
    ..g., difficulty with initiating sleep (DIS), difficulty with maintaining sleep (DMS), and early morning awakening (EMA)...
  39. ncbi request reprint [Narcolepsy, from Westphal to hypocretin]
    Yves Dauvilliers
    Faculte de Medecine, Hopital Gui de Chauliac, Montpellier
    Presse Med 33:1593-600. 2004
    ..Current therapeutic research is oriented towards hypocretin agonists and immunosuppressors...
  40. doi request reprint Facial expression recognition and emotional regulation in narcolepsy with cataplexy
    Sophie Bayard
    Service de Neurologie, Unite des troubles du sommeil, Hôpital Gui de Chauliac Montpellier, Montpellier Cedex 5, France
    J Sleep Res 22:170-7. 2013
    ..The absence of alteration of perceived affective valence remains a major clinical interest in narcolepsy with cataplexy, and it supports the argument for optimal behaviour and social functioning in narcolepsy with cataplexy...
  41. ncbi request reprint Molecular genetics and treatment of narcolepsy
    Yves Dauvilliers
    Service de Neurologie B, Hôpital Gui de Chauliac and INSERM E0361, Montpellier France, and Center for Integrative Genomics, University of Lausanne, Lausanne Dorigny, Switzerland
    Ann Med 38:252-62. 2006
    ..Recent pilot open trials with intravenous immunoglobulins appear an effective treatment of cataplexy if applied at early stages of narcolepsy. Finally, the discovery of hypocretin deficiency might open up new treatment perspectives...
  42. pmc REM sleep characteristics in narcolepsy and REM sleep behavior disorder
    Yves Dauvilliers
    Department of Neurology, Hopital Gui de Chauliac, INSERM, U888, Universite de Montpellier 1, Montpellier, France
    Sleep 30:844-9. 2007
    ....
  43. ncbi request reprint Periodic leg movements during sleep and wakefulness in narcolepsy
    Yves Dauvilliers
    Department of Neurology, Hopital Gui de Chauliac, INSERM U888, Universite de Montpellier, Montpellier, France
    J Sleep Res 16:333-9. 2007
    ..These results suggest that PLMS represent an intrinsic feature of narcolepsy...
  44. ncbi request reprint Suggested immobilization test for diagnosis of restless legs syndrome in Parkinson's disease
    Valerie Cochen De Cock
    Unite des troubles du sommeil, Service de Neurologie, Hopital Gui de Chauliac, Montpellier, France
    Mov Disord 27:743-9. 2012
    ..The sensory SIT is a simple test that may help diagnose RLS in patients with PD...
  45. doi request reprint Ventilatory disorders and facial growth: benefits of early genioplasty
    Laure Frapier
    Service d ODF, INSERM U888, UFR Odontologie, Universite Montpellier I, Montpellier Cedex 5, France
    Int Orthod 9:20-41. 2011
    ....
  46. pmc Decision-making, reward-seeking behaviors and dopamine agonist therapy in restless legs syndrome
    Sophie Bayard
    Service de Neurologie, Unite des troubles du sommeil, Hôpital Gui de Chauliac Montpellier, France Inserm U1061, Montpellier, France Centre de Référence National sur les Maladies Rares Narcolepsie, Hypersomnie Idiopathique, Syndrome de Kleine Levin, France
    Sleep 36:1501-7. 2013
    ....
  47. pmc Effect of psychostimulants on impulsivity and risk taking in narcolepsy with cataplexy
    Sophie Bayard
    Service de Neurologie, Unite des troubles du sommeil, Hôpital Gui de Chauliac Montpellier, France
    Sleep 36:1335-40. 2013
    ..Drug-free patients with NC present alterations in reward processing, but changes with psychostimulants remain unknown...
  48. pmc Executive control of attention in narcolepsy
    Sophie Bayard
    National Reference Network for Narcolepsy, Department of Neurology, Hopital Gui de Chauliac, CHU Montpellier, Montpellier, France
    PLoS ONE 7:e33525. 2012
    ....
  49. pmc Hypocretin and human African trypanosomiasis
    Yves Dauvilliers
    Department of Neurology, University Hospital Gui de Chauliac, INSERM U888, Reference Centre for Narcolepsy, Montpellier France
    Sleep 31:348-54. 2008
    ..g.) human African trypanosomiasis (HAT) at different stages of evolution and to measure and compare cerebrospinal fluid (CSF) levels of hypocretin-1 with narcoleptic patients and neurologic controls...
  50. doi request reprint Pharmacotherapy options for cataplexy
    Regis Lopez
    Gui de Chauliac Hospital, National Reference Network for Narcolepsy, Sleep Wake Disorders Center, Department of Neurology, CHU Montpellier, Inserm U1061, 80 avenue Augustin Fliche, 34295 Montpellier Cedex 5, France
    Expert Opin Pharmacother 14:895-903. 2013
    ..Pathophysiological studies have shown that the disease is caused by the early loss of hypothalamic hypocretin neurons...
  51. ncbi request reprint Differential diagnosis in hypersomnia
    Yves Dauvilliers
    Neurology Department, Gui de Chauliac Hospital, 80 avenue Augustin Fliche, INSERM E0361 34295, Montpellier, Cedex 5, France
    Curr Neurol Neurosci Rep 6:156-62. 2006
    ....
  52. ncbi request reprint Restless legs syndrome in narcolepsy: a side effect of sodium oxybate?
    Beatriz Abril
    Service de Neurologie, Hopital Gui de Chauliac, 34295 Montpellier, France
    Sleep Med 8:181-3. 2007
    ..We report a case of narcolepsy with a severe occurrence of typical RLS with GHB, symptoms never previously experienced by the subject and reversible after withdrawal...
  53. ncbi request reprint Olfactory dysfunction in narcolepsy with cataplexy
    Sophie Bayard
    Department of Neurology, Hopital Gui de Chauliac, CHU Montpellier, National Reference Network for Narcolepsy, INSERM U888, France
    Sleep Med 11:876-81. 2010
    ..Several lines of evidence suggest a role for hypocretin in olfactory function. Recent data have documented that NC is associated with olfactory dysfunction but smell testing has been performed only in small studies...
  54. ncbi request reprint [Restless legs syndrome: a genetic disease?]
    Valerie Cochen De Cock
    Unite des troubles du sommeil, Service de Neurologie, Hopital Gui de Chauliac, 34295 Montpellier Cedex 5, France
    Presse Med 39:579-86. 2010
    ..Proteins coded by some implicated genes are involved in the development of spinal motor neurons and spinal dorsal horns, and in brain iron homeostasis...
  55. ncbi request reprint [Physiopathology of idiopathic hypersomnia. Current studies and new orientations]
    M Billiard
    Service de Neurologie B, , 34295 Montpellier
    Rev Neurol (Paris) 157:S101-6. 2001
    ....
  56. doi request reprint The improvement of movement and speech during rapid eye movement sleep behaviour disorder in multiple system atrophy
    Valerie Cochen De Cock
    Unite des troubles du sommeil, Service de Neurologie, Hopital Gui de Chauliac, 2 av Emile Bertin Sans, 34000 Montpellier, France
    Brain 134:856-62. 2011
    ..The transient disappearance of parkinsonism here is all the more surprising since no treatment (even dopaminergic) provides a real benefit in this disabling disease...
  57. doi request reprint Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial
    Yves Dauvilliers
    Sleep Unit, Department of Neurology, Gui de Chauliac Hospital, University of Montpellier 1, Montpellier, France
    Lancet Neurol 12:1068-75. 2013
    ..We assessed the safety and efficacy of pitolisant (previously called BF2.649), a selective histamine H3 receptor inverse agonist that activates these neurons, in patients with narcolepsy...
  58. doi request reprint Recurrent hypersomnia: a review of 339 cases
    Michel Billiard
    Department of Neurology, Gui de Chauliac Hospital, 80 avenue Augustin Fliche, 34295 Montpellier Cedex 5, France
    Sleep Med Rev 15:247-57. 2011
    ....
  59. ncbi request reprint Successful management of cataplexy with intravenous immunoglobulins at narcolepsy onset
    Yves Dauvilliers
    Service de Neurologie B, Hopital Gui de Chauliac, Montpellier, France
    Ann Neurol 56:905-8. 2004
    ..Our findings point to the importance of early diagnosis of narcolepsy, which once treated quickly may modify its long-term outlook...
  60. ncbi request reprint A narcolepsy susceptibility locus maps to a 5 Mb region of chromosome 21q
    Yves Dauvilliers
    Service de Neurologie B, Hopital Gui de Chauliac, Montpellier, France
    Ann Neurol 56:382-8. 2004
    ..15 Mb region of 21q...
  61. pmc Autonomic response to periodic leg movements during sleep in narcolepsy-cataplexy
    Yves Dauvilliers
    Department of Neurology, National Reference Network for Orphan Diseases Narcolepsy and Idiopathic Hypersomnia, Hopital Gui de Chauliac, INSERM U888, Montpellier, France
    Sleep 34:219-23. 2011
    ..To test the hypothesis of autonomic nervous system dysfunction in patients with narcolepsy-cataplexy (NC) by assessing the physiologic activations associated with periodic limb movements during sleep (PLMS)...
  62. ncbi request reprint Kleine-Levin syndrome: an autoimmune hypothesis based on clinical and genetic analyses
    Y Dauvilliers
    Neurologie B, Hopital Gui de Chauliac, Montpellier, France
    Neurology 59:1739-45. 2002
    ..Pathophysiologic hypotheses include a hypothalamic dysfunction and abnormalities in the central serotonin and dopamine metabolism. Several clinical symptoms also suggest an underlying autoimmune process...
  63. ncbi request reprint [Immunological aspects of narcolepsy]
    B Carlander
    Service de Neurologie B, Hopital Gui de Chauliac, 34295 Montpellier
    Rev Neurol (Paris) 157:S97-100. 2001
    ....
  64. pmc Widespread hypermetabolism in symptomatic and asymptomatic episodes in kleine-levin syndrome
    Yves Dauvilliers
    Service de Neurologie, Hopital Gui de Chauliac, CHU Montpellier, Montpellier, France Centre de Référence Nationale Maladie Rare, Narcolepsie et Hypersomnie Idiopathique, Montpellier, France Inserm U1061, Montpellier, France
    PLoS ONE 9:e93813. 2014
    ..Here, we investigated relative changes in regional brain metabolism in Kleine-Levin syndrome (KLS) during symptomatic episodes and asymptomatic periods, as compared to healthy controls...
  65. doi request reprint Periodic leg movements during sleep in narcoleptic patients with or without restless legs syndrome
    Giuseppe Plazzi
    Department of Neurological Sciences, University of Bologna, Bologna, Italy
    J Sleep Res 21:155-62. 2012
    ..Even if RLS is only detected by targeted interview in NC, its frequency and impact on night-time sleep architecture and continuity suggest that this condition should be routinely searched for in NC...
  66. pmc Hypersomnia
    Yves Dauvilliers
    Service de Neurologie B, , INSERM E0361, Montpellier, France
    Dialogues Clin Neurosci 7:347-56. 2005
    ....
  67. ncbi request reprint Decision making in restless legs syndrome
    Sophie Bayard
    Department of Neurology, Gui de Chauliac Hospital, Montpellier 34295, France
    Mov Disord 25:2634-40. 2010
    ..From a clinical perspective, when using dopaminergic medication to treat RLS, patients with abnormal baseline behaviors should be closely monitored...
  68. ncbi request reprint [Genetics of human narcolepsy]
    Y Dauvilliers
    Service de Neurologie B, 80, avenue Augustin Fliche, , 34295 Montpellier, France
    Rev Neurol (Paris) 157:S92-6. 2001
    ..An autoimmune process is probable...
  69. doi request reprint Psychological health in central hypersomnias: the French Harmony study
    Y Dauvilliers
    Departement de Neurologie, Hopital Gui de Chauliac, 80 av Augustin Fliche, Cedex 5, Montpellier 34295, France
    J Neurol Neurosurg Psychiatry 80:636-41. 2009
    ....
  70. ncbi request reprint [Sleep disorders in children and adults]
    Yves Dauvilliers
    Service Neurologie B, Hopital Gui de Chauliac, 34295 Montpellier, 2 Unité INSERM 480, Lyon
    Rev Prat 53:1937-46. 2003
  71. ncbi request reprint MAO-A and COMT polymorphisms and gene effects in narcolepsy
    Y Dauvilliers
    Neurologie B, Hopital Gui de Chauliac, Montpellier France, France
    Mol Psychiatry 6:367-72. 2001
    ..In agreement with well-documented pharmacological results in canine narcolepsy, this study reports the first genetic evidence for the critical involvement of the dopaminergic and/or noradrenergic systems in human narcolepsy...
  72. ncbi request reprint Clinical aspects and pathophysiology of narcolepsy
    Yves Dauvilliers
    Service de Neurologie B, Hopital Gui de Chauliac, 80 avenue Augustin Fliche, 34295 Montpellier Cedex 5, France
    Clin Neurophysiol 114:2000-17. 2003
    ..However, other lines of research deserve to be pursued simultaneously, in view of comprehensive advancements in the understanding of narcolepsy...
  73. pmc Chiari malformation and sleep related breathing disorders
    Y Dauvilliers
    Service de Neurologie, Hopital Gui de Chauliac, INSERM U888 Montpellier, France
    J Neurol Neurosurg Psychiatry 78:1344-8. 2007
    ..To estimate the frequency, mechanisms and predictive factors of sleep apnoea syndrome (SAS) in a large group of children and adults with type I (CMI) and II (CMII) Chiari malformation (CM)...
  74. ncbi request reprint Genetics of normal and pathological sleep in humans
    Y Dauvilliers
    Service de Neurologie B, Gui de Chauliac Hospital, Montpellier, France
    Sleep Med Rev 9:91-100. 2005
    ..We review here the current progress in the genetics of normal and pathological sleep and suggest a few future perspectives...
  75. ncbi request reprint Sleep architecture, slow wave activity and sleep spindles in mild sleep disordered breathing
    B Ondze
    Service de Neurologie, Unité des Troubles du Sommeil et de l Eveil, Hôpital Gui de Chauliac B34295 Montpellier, Cedex 5, France
    Clin Neurophysiol 114:867-74. 2003
    ....
  76. doi request reprint Impact of genioplasty on mandibular growth during puberty
    Laure Frapier
    INSERM U888, University of Montpellier I, 2, avenue Emile Bertin Sans, 34000 Montpellier, France
    Int Orthod 8:342-59. 2010
    ..Our aim was to assess whether genioplasty performed at an earlier age can impact mandibular growth...
  77. doi request reprint [How to manage daytime sleepiness associated with Parkinson's disease]
    V Cochen de Cock
    Unite des troubles du sommeil, Service de Neurologie, CHU Gui de Chauliac, 80 avenue Augustin Fliche, 34295 Montpellier Cedex 5, France
    Rev Neurol (Paris) 166:793-9. 2010
    ..When the treatment of disturbed nighttime sleep and adjustments of the dopaminergic treatments are not sufficient to improve EDS, wake promoting treatments can be used. Their efficacy is variable but new hopeful drugs are coming soon...
  78. ncbi request reprint Sexual dimorphism of the catechol-O-methyltransferase gene in narcolepsy is associated with response to modafinil
    Y Dauvilliers
    Neurologie B, Hĵpital Gui de Chauliac, Montpellier, France
    Pharmacogenomics J 2:65-8. 2002
    ..Our results suggest that a sexual dimorphism in COMT activity affects the response to modafinil and probably to other dopaminergic stimulants...
  79. ncbi request reprint Sleep disorders and their impacts on healthy, dependent, and frail older adults
    V Cochen
    Unite du Sommeil, Service de Neurologie, CHU Rangueil, Toulouse, France
    J Nutr Health Aging 13:322-9. 2009
    ..Older adults can be classified into three groups based upon their overall level of disability: healthy, dependent, and frail. Frailty is an emerging concept that denotes older persons at increased risk for poor outcomes...
  80. ncbi request reprint EFNS guidelines on management of narcolepsy
    M Billiard
    School of Medicine, University of Montpellier, Montpellier, France
    Eur J Neurol 13:1035-48. 2006
    ..Our objective was to reinforce the use of those drugs evaluated in randomized placebo-controlled trials and to reach a consensus, as much as possible, on the use of other available medications...
  81. ncbi request reprint Very early onset AD with a de novo mutation in the presenilin 1 gene (Met 233 Leu)
    F Portet
    UNCD, Gui de Chauliac Hospital, Montpellier, France
    Neurology 61:1136-7. 2003
    ..The authors describe a 28-year-old woman with histopathologically confirmed early onset Alzheimer disease characterized by severe frontal lobe involvement associated with a de novo mutation in the presenilin 1 gene (PSEN1)...
  82. ncbi request reprint Genes for normal sleep and sleep disorders
    Mehdi Tafti
    Center for Integrative Genomics, University of Lausanne, 1015 Lausanne Dorigny, Switzerland
    Ann Med 37:580-9. 2005
    ..We review here the current progress in the genetics of normal and pathological sleep...
  83. ncbi request reprint A nationwide survey of excessive daytime sleepiness in Parkinson's disease in France
    Imad Ghorayeb
    Service d Explorations Fonctionnelles du Système Nerveux, Hopital Pellegrin, Bordeaux, France
    Mov Disord 22:1567-72. 2007
    ..EDS is common in ambulatory patients with PD and is a major risk factor for dozing and for SOS episodes behind the wheel in patients who drive...
  84. ncbi request reprint Normal CSF hypocretin-1 (orexin A) levels in dementia with Lewy bodies associated with excessive daytime sleepiness
    Christian R Baumann
    Neurology Department, University Hospital, Zurich, Switzerland
    Eur Neurol 52:73-6. 2004
    ..In DLB, excessive daytime sleepiness, hallucinations and REM sleep behavior may occur in the absence of a detectable hypocretin deficiency...
  85. doi request reprint An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patients
    Jian Sheng Lin
    INSERM U628, 69373 Lyon, France Faculté de Médecine, Universite Claude Bernard, 69373 Lyon, France
    Neurobiol Dis 30:74-83. 2008
    ..H(3)-receptor inverse agonists could constitute a novel effective treatment of EDS, particularly when associated with modafinil...
  86. ncbi request reprint Kleine-Levin syndrome in a 14-year-old girl: CSF hypocretin-1 measurements
    Claudio Podestá
    Department of Neurology FLENI, Sleep Laboratory, Buenos Aires, Argentina
    Sleep Med 7:649-51. 2006
    ..Together with previous data, this result is in favour of recurrent dysfunction at the hypothalamic level in Kleine-Levin syndrome...
  87. ncbi request reprint Pharmacogenomics in the treatment of narcolepsy
    Mehdi Tafti
    Biochemistry and Genetics Unit, Department of Psychiatry, Geneva University Hospitals, 2 Chemin du Petit Bel Air, CH 1225 Chene Bourg, Switzerland
    Pharmacogenomics 4:23-33. 2003
    ..Other pharmacogenetic targets include the orexinergic, noradrenergic and possibly the serotonergic pathways...
  88. ncbi request reprint Arousal reactions in sleepwalking and night terrors in adults: the role of respiratory events
    Fabrice Espa
    INSERM EMI 9930, Hôpital La Colombière, 34093 Montpellier Cedex 5 France
    Sleep 25:871-5. 2002
    ..The aim of the study was to determine the role of respiratory events, assessed by means of esophageal pressure monitoring, during arousals from slow wave sleep in adult patients with parasomnias...
  89. ncbi request reprint Energy cost of walking and gait instability in healthy 65- and 80-yr-olds
    Davide Malatesta
    Unite Propre de Recherche de l Enseignement Superier UPRES 701, Hopital Arnaud de Villeneuve, Montpellier, France
    J Appl Physiol 95:2248-56. 2003
    ..We thus concluded that other mechanisms, such as the energy expenditure associated with walking movements and related to mechanical work, or neuromuscular factors, are more likely involved in the higher cost of walking in elderly people...
  90. pmc Family history of insomnia in a population-based sample
    Simon Beaulieu-Bonneau
    Ecole de Psychologie, Universite Laval, Quebec, Canada
    Sleep 30:1739-45. 2007
    ....
  91. ncbi request reprint Narcolepsy and familial advanced sleep-phase syndrome: molecular genetics of sleep disorders
    Mehdi Tafti
    Center for Integrative Genomics CIG and Center for Investigation and Research in Sleep CIRS, University of Lausanne and Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Curr Opin Genet Dev 17:222-7. 2007
    ..Also, very recent studies using an animal model of familial advanced sleep-phase syndrome shed new light on the regulation of circadian rhythms...
  92. ncbi request reprint Follow-up of four narcolepsy patients treated with intravenous immunoglobulins
    Yves Dauvilliers
    Ann Neurol 60:153. 2006