Alain Dautant

Summary

Country: France

Publications

  1. pmc Crystal structure of the Mg·ADP-inhibited state of the yeast F1c10-ATP synthase
    Alain Dautant
    Universite Bordeaux 2, CNRS, Institut de Biochimie et Génétique Cellulaires, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    J Biol Chem 285:29502-10. 2010
  2. pmc Intersubunit ionic interactions stabilize the nucleoside diphosphate kinase of Mycobacterium tuberculosis
    Florian Georgescauld
    IBGC, University Bordeaux, Bordeaux, France
    PLoS ONE 8:e57867. 2013
  3. ncbi request reprint The modulation in subunits e and g amounts of yeast ATP synthase modifies mitochondrial cristae morphology
    Geneviève Arselin
    Institut de Biochimie et Genetique Cellulaires du CNRS, Universite Victor Segalen, Bordeaux 2, 1, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    J Biol Chem 279:40392-9. 2004
  4. doi request reprint Supramolecular organization of the yeast F1Fo-ATP synthase
    Daniel Thomas
    CNRS, Interactions Cellulaires et Moleculaires, UMR 6026, Universite Rennes 1, Campus de Beaulieu, Batiment 13, F 35042 Rennes Cedex, France
    Biol Cell 100:591-601. 2008
  5. doi request reprint ATP synthase oligomerization: from the enzyme models to the mitochondrial morphology
    Johan Habersetzer
    University of Bordeaux, IBGC, UMR 5095, F 33000 Bordeaux, France
    Int J Biochem Cell Biol 45:99-105. 2013
  6. ncbi request reprint The structure of the Escherichia coli nucleoside diphosphate kinase reveals a new quaternary architecture for this enzyme family
    Lucile Moynié
    Institut de Biochimie et Génétique Cellulaires, UMR 5095 CNRS Université Victor Segalen Bordeaux 2, 33077 Bordeaux Cedex, France
    Proteins 67:755-65. 2007
  7. ncbi request reprint Topological and functional study of subunit h of the F1Fo ATP synthase complex in yeast Saccharomyces cerevisiae
    Remi Fronzes
    Institut de Biochimie et Génétique Cellulaires du Centre National de la Recherche Scientifique, UMR5095, Universite Victor Segalen Bordeaux 2, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Biochemistry 42:12038-49. 2003
  8. ncbi request reprint Failure to assemble the alpha 3 beta 3 subcomplex of the ATP synthase leads to accumulation of the alpha and beta subunits within inclusion bodies and the loss of mitochondrial cristae in Saccharomyces cerevisiae
    Linnka Lefebvre-Legendre
    Institut de Biochimie et Génétique Cellulaires du Centre National de la Recherche Scientifique, Universite Victor Segalen, 1 rue Camille Saint Saens, Bordeaux 33077 Cedex, France
    J Biol Chem 280:18386-92. 2005
  9. pmc Functional significance of four successive glycine residues in the pyrophosphate binding loop of fungal 6-oxopurine phosphoribosyltransferases
    Lucile Moynié
    IBGC, Universite de Bordeaux, UMR 5095, F 33000 Bordeaux, France
    Protein Sci 21:1185-96. 2012
  10. doi request reprint Rotor architecture in the yeast and bovine F1-c-ring complexes of F-ATP synthase
    Marie France Giraud
    Univ de Bordeaux, IBGC, UMR 5095, F 33000 Bordeaux, France
    J Struct Biol 177:490-7. 2012

Collaborators

  • Marie France Giraud
  • Ioan Lascu
  • Pascal Sirand-Pugnet
  • Isabelle Sagot
  • Daniel Thomas
  • Jean Velours
  • Tudor Borza
  • Anja Persson
  • Lucile Moynié
  • Florian Georgescauld
  • Daniel Brèthes
  • Geneviève Arselin
  • Benedicte Salin
  • Johann Habersetzer
  • Johan Habersetzer
  • Laure Beven
  • Jacques Schaeffer
  • Bertrand Daignan-Fornier
  • Jean Claude Talbot
  • Stéphanie Escusa
  • Linnka Lefebvre-Legendre
  • Jacques Vaillier
  • Remi Fronzes
  • Pernile Harris
  • Isabelle Larrieu
  • Claire Stines-Chaumeil
  • Iulia Mocan
  • Laura Cervoni
  • Widade Ziani
  • Patrick Paumard
  • Claire Charenton
  • Annick Breton
  • Guillaume Bouyssou
  • Alain Blanchard
  • Fabien Labroussaa
  • Anna Sköllermo
  • Fanny Boissier
  • Abdelhamid Maali
  • Bernard Pucci
  • Ange Polidori
  • Touria Cohen-Bouhacina
  • Aurélie Massoni
  • Damien Laporte
  • Helian Boucherie
  • Jean Paul di Rago
  • Sharon H Ackerman
  • Bénédicte Coulary-Salin
  • Katell Bathany
  • Jean Marie Schmitter
  • Stephane Chaignepain

Detail Information

Publications18

  1. pmc Crystal structure of the Mg·ADP-inhibited state of the yeast F1c10-ATP synthase
    Alain Dautant
    Universite Bordeaux 2, CNRS, Institut de Biochimie et Génétique Cellulaires, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    J Biol Chem 285:29502-10. 2010
    ..On the rotor ring, the essential cGlu(59) carboxylate group is surrounded by hydrophobic residues and is not involved in hydrogen bonding...
  2. pmc Intersubunit ionic interactions stabilize the nucleoside diphosphate kinase of Mycobacterium tuberculosis
    Florian Georgescauld
    IBGC, University Bordeaux, Bordeaux, France
    PLoS ONE 8:e57867. 2013
    ..Indeed, guanidinium and many other salts stabilized the hexamer with a half maximum effect of about 0.1 M, increasing protein thermostability. The crystal structure of the D93N mutant has been solved...
  3. ncbi request reprint The modulation in subunits e and g amounts of yeast ATP synthase modifies mitochondrial cristae morphology
    Geneviève Arselin
    Institut de Biochimie et Genetique Cellulaires du CNRS, Universite Victor Segalen, Bordeaux 2, 1, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    J Biol Chem 279:40392-9. 2004
    ..When doxycycline is removed after five generations, cristae are mainly observed. The data demonstrate that the inner structure of mitochondria depends upon the ability of ATP synthase to make supramolecular structures...
  4. doi request reprint Supramolecular organization of the yeast F1Fo-ATP synthase
    Daniel Thomas
    CNRS, Interactions Cellulaires et Moleculaires, UMR 6026, Universite Rennes 1, Campus de Beaulieu, Batiment 13, F 35042 Rennes Cedex, France
    Biol Cell 100:591-601. 2008
    ..For a large range of organisms, it has been shown that mitochondrial ATP synthase adopts oligomeric structures. Moreover, several studies have suggested that a link exists between ATP synthase and mitochondrial morphology...
  5. doi request reprint ATP synthase oligomerization: from the enzyme models to the mitochondrial morphology
    Johan Habersetzer
    University of Bordeaux, IBGC, UMR 5095, F 33000 Bordeaux, France
    Int J Biochem Cell Biol 45:99-105. 2013
    ..This review also discusses the physiological role of this oligomerization process and its potential implications in mammal pathology. This article is part of a Directed Issue entitled: Bioenergetic Dysfunction, adaptation and therapy...
  6. ncbi request reprint The structure of the Escherichia coli nucleoside diphosphate kinase reveals a new quaternary architecture for this enzyme family
    Lucile Moynié
    Institut de Biochimie et Génétique Cellulaires, UMR 5095 CNRS Université Victor Segalen Bordeaux 2, 33077 Bordeaux Cedex, France
    Proteins 67:755-65. 2007
    ..The evolutionary conservation of the interface residues indicates that this new quaternary structure seems to be the most frequent assembly mode in bacterial tetrameric NDP kinases...
  7. ncbi request reprint Topological and functional study of subunit h of the F1Fo ATP synthase complex in yeast Saccharomyces cerevisiae
    Remi Fronzes
    Institut de Biochimie et Génétique Cellulaires du Centre National de la Recherche Scientifique, UMR5095, Universite Victor Segalen Bordeaux 2, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Biochemistry 42:12038-49. 2003
    ..Finally, functional characterization of mitochondria from mutants expressing different C-terminal shortened subunit h suggested that its C-terminal part is not essential for the assembly of a functional F1Fo ATP synthase...
  8. ncbi request reprint Failure to assemble the alpha 3 beta 3 subcomplex of the ATP synthase leads to accumulation of the alpha and beta subunits within inclusion bodies and the loss of mitochondrial cristae in Saccharomyces cerevisiae
    Linnka Lefebvre-Legendre
    Institut de Biochimie et Génétique Cellulaires du Centre National de la Recherche Scientifique, Universite Victor Segalen, 1 rue Camille Saint Saens, Bordeaux 33077 Cedex, France
    J Biol Chem 280:18386-92. 2005
    ..These observations are in accord with other studies in the literature that have pointed to a central role for the ATP synthase in biogenesis of the mitochondrial inner membrane...
  9. pmc Functional significance of four successive glycine residues in the pyrophosphate binding loop of fungal 6-oxopurine phosphoribosyltransferases
    Lucile Moynié
    IBGC, Universite de Bordeaux, UMR 5095, F 33000 Bordeaux, France
    Protein Sci 21:1185-96. 2012
    ..Mutations affecting the enzyme activity or the previously characterized feedback inhibition by GMP are located at the nucleotide binding site and the dimer interface...
  10. doi request reprint Rotor architecture in the yeast and bovine F1-c-ring complexes of F-ATP synthase
    Marie France Giraud
    Univ de Bordeaux, IBGC, UMR 5095, F 33000 Bordeaux, France
    J Struct Biol 177:490-7. 2012
    ..yF(1)c(10)(II) provides a model of a more efficient generator. yF(1)c(10)(II) and bovine bF(1)c(8) structures share a common rotor architecture with the inertia center of the F(1)-stator close to the rotor axis...
  11. doi request reprint Mitochondrial F1F0-ATP synthase and organellar internal architecture
    Jean Velours
    Universite Bordeaux 2, CNRS, Institut de Biochimie et Génétique Cellulaires, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Int J Biochem Cell Biol 41:1783-9. 2009
    ..This paper reviews the ATP synthase components whose modifications lead to anomalous mitochondrial morphology and also provides a schema showing the formation of the so-called onion-like structures...
  12. ncbi request reprint Skp1-Cullin-F-box-dependent degradation of Aah1p requires its interaction with the F-box protein Saf1p
    Stéphanie Escusa
    Universite Bordeaux 2, CNRS Institut de Biochimie et Génétique Cellulaires, CNRS UMR 5095, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    J Biol Chem 282:20097-103. 2007
    ..All together, our data strongly argue for Saf1p being a bona fide Skp1-Cullin-F-box subunit...
  13. pmc Evidence of the proximity of ATP synthase subunits 6 (a) in the inner mitochondrial membrane and in the supramolecular forms of Saccharomyces cerevisiae ATP synthase
    Jean Velours
    CNRS, Institut de Biochimie et Génétique Cellulaires, UMR 5095, Pessac, France
    J Biol Chem 286:35477-84. 2011
    ....
  14. ncbi request reprint Hydrogenated and fluorinated surfactants derived from Tris(hydroxymethyl)-acrylamidomethane allow the purification of a highly active yeast F1-F0 ATP-synthase with an enhanced stability
    Jean Claude Talbot
    CNRS, Institut de Biochimie et Génétique Cellulaires, Universite Bordeaux 2, 1 rue Camille Saint Saens, 33077, Bordeaux Cedex, France
    J Bioenerg Biomembr 41:349-60. 2009
    ..Relipidated enzymes prepared with fluorinated surfactants remained highly sensitive towards inhibitors, even after 6 weeks...
  15. ncbi request reprint Crystal structures of S120G mutant and wild type of human nucleoside diphosphate kinase A in complex with ADP
    Marie France Giraud
    Institut de Biochimie et Génétique Cellulaires, UMR 5095 CNRS Université Victor Segalen Bordeaux 2, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    J Bioenerg Biomembr 38:261-4. 2006
    ..This suggests that the S120G mutation may affect an other protein property than NDP kinase activity...
  16. pmc Specific evolution of F1-like ATPases in mycoplasmas
    Laure Beven
    University Bordeaux, UMR 1332 de Biologie du Fruit et Pathologie, Villenave D Ornon, France
    PLoS ONE 7:e38793. 2012
    ..We propose a model, in which the F(1)-like structure is associated with a hypothetical X(0) sector located in the membrane of mycoplasma cells...
  17. pmc Structure of Mycobacterium tuberculosis nucleoside diphosphate kinase R80N mutant in complex with citrate
    Florian Georgescauld
    Institut de Biochimie et de Génétique Cellulaires, UMR 5095, CNRS, 1 rue Camille Saint Saens, 33077 Bordeaux, France
    Acta Crystallogr F Struct Biol Commun 70:40-3. 2014
    ..Structural analysis shows that the citrate is present at the location of the nucleotide phosphate groups. ..
  18. ncbi request reprint The GxxxG motif of the transmembrane domain of subunit e is involved in the dimerization/oligomerization of the yeast ATP synthase complex in the mitochondrial membrane
    Geneviève Arselin
    Institut de Biochimie et Genetique Cellulaires du CNRS, Universite Victor Segalen, Bordeaux, France
    Eur J Biochem 270:1875-84. 2003
    ....