Yesim Dargaud

Summary

Country: France

Publications

  1. ncbi request reprint Use of calibrated automated thrombinography +/- thrombomodulin to recognise the prothrombotic phenotype
    Yesim Dargaud
    Unite d Hemostase Clinique Laboratoire d Hemostase, Hopital Edouard Herriot, Lyon, France
    Thromb Haemost 96:562-7. 2006
  2. doi request reprint Monitoring platelet dependent thrombin generation in mice
    Yesim Dargaud
    Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, and Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Thromb Res 126:436-41. 2010
  3. doi request reprint Bleeding risk in warfarinized patients with a therapeutic international normalized ratio: the effect of low factor IX levels
    Y Dargaud
    Unite d Hemostase Clinique, Hopital Edouard Herriot, Universite Lyon 1, Lyon, France
    J Thromb Haemost 11:1043-52. 2013
  4. doi request reprint Evaluation of a standardized protocol for thrombin generation measurement using the calibrated automated thrombogram: an international multicentre study
    Yesim Dargaud
    Unite d Hemostase Clinique, Hopital Edouard Herriot, Lyon, France
    Thromb Res 130:929-34. 2012
  5. doi request reprint The potential role of synovial thrombomodulin in the pathophysiology of joint bleeds in haemophilia
    Y Dargaud
    Unite d Hemostase Clinique, Hopital Edouard Herriot, Lyon, France
    Haemophilia 18:818-23. 2012
  6. ncbi request reprint Haemophilia therapies
    Yesim Dargaud
    Hopital Edouard Herriot, Comprehensive Haemophilia Treatment Centre, Lyon, France
    Expert Opin Biol Ther 7:651-63. 2007
  7. doi request reprint Standardisation of thrombin generation test--which reference plasma for TGT? An international multicentre study
    Y Dargaud
    Unite d Hemostase Clinique, Hopital Edouard Herriot, Lyon, France
    Thromb Res 125:353-6. 2010
  8. doi request reprint Thrombin generation testing in haemophilia comprehensive care centres
    Y Dargaud
    Unite d Hemostase Clinique, Hopital Edouard Herriot, Lyon, France
    Haemophilia 16:223-30. 2010
  9. doi request reprint Comparison of the capacities of two prothrombin complex concentrates to restore thrombin generation in plasma from orally anticoagulated patients: an in vitro study
    Y Dargaud
    Laboratoire d Hemostase, Hopital Edouard Herriot, Lyon, and EA 4174, IFR 62, Universite Lyon 1, Lyon, France
    J Thromb Haemost 6:962-8. 2008
  10. doi request reprint New advances in the therapeutic and laboratory management of patients with haemophilia and inhibitors
    Y Dargaud
    Clinical Haemostasis Unit, Hopital Edouard Herriot, Lyon, France
    Haemophilia 14:20-7. 2008

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Use of calibrated automated thrombinography +/- thrombomodulin to recognise the prothrombotic phenotype
    Yesim Dargaud
    Unite d Hemostase Clinique Laboratoire d Hemostase, Hopital Edouard Herriot, Lyon, France
    Thromb Haemost 96:562-7. 2006
    ..In conclusion, TG, measured with the CAT technique in the presence of TM is capable of detecting the prothrombotic phenotype with a high sensitivity of 0.93 (95% confidence limits 0.82-0.99)...
  2. doi request reprint Monitoring platelet dependent thrombin generation in mice
    Yesim Dargaud
    Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, and Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Thromb Res 126:436-41. 2010
    ..Thrombin generation was dose dependently diminished by low molecular weight heparin and increased by high concentrations of exogenous factor VIII i.e. the assay can detect both hypo- and hypercoagulability...
  3. doi request reprint Bleeding risk in warfarinized patients with a therapeutic international normalized ratio: the effect of low factor IX levels
    Y Dargaud
    Unite d Hemostase Clinique, Hopital Edouard Herriot, Universite Lyon 1, Lyon, France
    J Thromb Haemost 11:1043-52. 2013
    ..We hypothesized the INR might underestimate the level of anticoagulation in a subject with a lower factor (F) IX level than average...
  4. doi request reprint Evaluation of a standardized protocol for thrombin generation measurement using the calibrated automated thrombogram: an international multicentre study
    Yesim Dargaud
    Unite d Hemostase Clinique, Hopital Edouard Herriot, Lyon, France
    Thromb Res 130:929-34. 2012
    ..In conclusion, our data demonstrated that the standardized TGT methodology evaluated in this study effectively reduces the variability of the assay to acceptable limits and may be used in clinical trials...
  5. doi request reprint The potential role of synovial thrombomodulin in the pathophysiology of joint bleeds in haemophilia
    Y Dargaud
    Unite d Hemostase Clinique, Hopital Edouard Herriot, Lyon, France
    Haemophilia 18:818-23. 2012
    ....
  6. ncbi request reprint Haemophilia therapies
    Yesim Dargaud
    Hopital Edouard Herriot, Comprehensive Haemophilia Treatment Centre, Lyon, France
    Expert Opin Biol Ther 7:651-63. 2007
    ....
  7. doi request reprint Standardisation of thrombin generation test--which reference plasma for TGT? An international multicentre study
    Y Dargaud
    Unite d Hemostase Clinique, Hopital Edouard Herriot, Lyon, France
    Thromb Res 125:353-6. 2010
    ..These results clearly demonstrate that the inter-centre variability of TGT can be significantly reduced by using a reference plasma normalization, and that certain RP have a better capacity to reduce this variability than others...
  8. doi request reprint Thrombin generation testing in haemophilia comprehensive care centres
    Y Dargaud
    Unite d Hemostase Clinique, Hopital Edouard Herriot, Lyon, France
    Haemophilia 16:223-30. 2010
    ..This study will review unmet laboratory needs in haemophilia and the potential applications of TGT in the management of haemophiliacs. Furthermore, technical and standardization issues of the method will be discussed...
  9. doi request reprint Comparison of the capacities of two prothrombin complex concentrates to restore thrombin generation in plasma from orally anticoagulated patients: an in vitro study
    Y Dargaud
    Laboratoire d Hemostase, Hopital Edouard Herriot, Lyon, and EA 4174, IFR 62, Universite Lyon 1, Lyon, France
    J Thromb Haemost 6:962-8. 2008
    ..As the final product generated by PCCs is thrombin, a thrombin generation (TG) test could theoretically be used for monitoring the hemostatic correction...
  10. doi request reprint New advances in the therapeutic and laboratory management of patients with haemophilia and inhibitors
    Y Dargaud
    Clinical Haemostasis Unit, Hopital Edouard Herriot, Lyon, France
    Haemophilia 14:20-7. 2008
    ..Overall, it may be hoped that these new developments will lead to a marked improvement in the clinical management of haemophilia patients with inhibitors in the near future...
  11. doi request reprint An unusual clinical presentation of factor XIII deficiency and issues relating to the monitoring of factor XIII replacement therapy
    Yesim Dargaud
    Clinical Haemostasis Unit, Edouard Herriot Hospital, France
    Blood Coagul Fibrinolysis 19:447-52. 2008
    ..We also showed that thromboelastometry could be a valuable tool for the monitoring of factor XIII replacement therapy...
  12. doi request reprint Evaluation of the overall haemostatic effect of recombinant factor VIIa by measuring thrombin generation and stability of fibrin clots
    Y Dargaud
    Unite d Hemostase Clinique, Hopital Edouard Herriot, Lyon EA 4174, France
    Haemophilia 17:957-61. 2011
    ..Despite this overall correlation, a relatively large spreading around a general trend was observed, suggesting that the two assays bring complementary information on the haemostatic effect of rFVIIa...
  13. doi request reprint A risk score for the management of pregnant women with increased risk of venous thromboembolism: a multicentre prospective study
    Yesim Dargaud
    Unite d Hemostase Clinique, Hopital Edouard Herriot, Universite Lyon 1, Lyon, France
    Br J Haematol 145:825-35. 2009
    ..The use of a risk score may provide a rational decision process to implement safe and effective antepartum thromboprophylaxis in pregnant women at high risk of VTE...
  14. ncbi request reprint Two novel factor V null mutations associated with activated protein C resistance phenotype/genotype discrepancy
    Yesim Dargaud
    Laboratoire d Hemostase, Hopital Edouard Herriot, Lyon, France
    Br J Haematol 123:342-5. 2003
    ..Our results suggest the necessity to use both phenotypic and genotypic analyses in some cases to determine an accurate diagnosis...
  15. ncbi request reprint Multiple arterial thromboses in a patient with primary antiphospholipid syndrome receiving a bromocriptine therapy
    Y Dargaud
    Service d Exploration Vasculaire, Hopital Edouard Herriot, Lyon, France
    Lupus 13:957-60. 2004
    ..It also emphasizes the need for a correct diagnosis of catastrophic antiphospholipid syndrome allowing to limit the prescription of aggressive therapies...
  16. ncbi request reprint Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B
    Yesim Dargaud
    Laboratoire d Hemostase, Hopital Edouard Herriot, Lyon, France
    Thromb Haemost 93:475-80. 2005
    ....
  17. ncbi request reprint Management of pregnant women with increased risk of venous thrombosis
    Y Dargaud
    Laboratoire d Hémostase et Unité d Hémostase Clinique, Hopital Edouard Herriot, Lyon, France
    Int J Gynaecol Obstet 90:203-7. 2005
    ..To evaluate the usefulness of score based management of pregnancies with high risk of venous thromboembolism (VTE)...
  18. ncbi request reprint Inherited bleeding disorder due to familial type 2 platelet cyclo-oxygenase deficiency
    Yesim Dargaud
    Laboratoire d Hemostase, pav E Hopital Edouard Herriot 5, place d Arsonval 69003 Lyon, France
    Thromb Res 116:483-9. 2005
    ..Thrombin generation test confirmed mild bleeding phenotype in patients with COX deficiency as they had normal thrombin generating capacity...
  19. doi request reprint Use of the thrombin generation test to evaluate response to treatment with recombinant activated factor VII
    Yesim Dargaud
    Clinical Hemostasis Unit, Hopital Edouard Herriot, Lyon, France
    Semin Hematol 45:S72-3. 2008
  20. doi request reprint Prospective assessment of thrombin generation test for dose monitoring of bypassing therapy in hemophilia patients with inhibitors undergoing elective surgery
    Yesim Dargaud
    Unite d Hemostase Clinique, Hopital Edouard Herriot, Lyon
    Blood 116:5734-7. 2010
    ..Our results also showed a correlation between in vivo clinical response to BPA and thrombin-generating capacity. These data suggest that TGT may represent a surrogate marker for monitoring bypassing therapies in surgical situations...
  21. ncbi request reprint A case of Glanzmann's thrombasthenia successfully treated with recombinant factor viia during a surgical procedure: observations on the monitoring and the mechanism of action of this drug
    Yesim Dargaud
    Laboratoire d Hemostase, Hopital Edouard Herriot, Lyon, France
    Haematologica 91:ECR20. 2006
    ..After rFVIIa infusion, the fibrin network was tighter in comparison with the sample before rFVIIa injection. These results provide further ex vivo evidence on haemostatic efficacy of rFVIIa in Glanzmann's patients...
  22. ncbi request reprint Spontaneous proximal deep vein thrombosis in a patient with severe haemophilia A
    Yesim Dargaud
    Centre Régional de Traitement de l Hémophilie, Pavilion E, Hopital Edouard Herriot, Lyon, France
    Blood Coagul Fibrinolysis 14:407-9. 2003
    ..This case illustrates the possibility for severe haemophilia patients to develop authentic spontaneous DVT without anti-haemophilic treatment and predisposing risk factors...
  23. doi request reprint Whole-blood thrombin generation monitored with a calibrated automated thrombogram-based assay
    Marisa Ninivaggi
    Synapse BV, CARIM, Maastricht University Medical Center, Maastricht, The Netherlands
    Clin Chem 58:1252-9. 2012
    ..The calibrated automated thrombogram (CAT) assay in plasma is a versatile tool to investigate patients with hypo- or hypercoagulable phenotypes. The objective was to make this method applicable for whole blood measurements...
  24. ncbi request reprint Thrombin-generating capacity in patients with von Willebrand's disease
    Lucia Rugeri
    Unite d Hemostase Clinique, Hôpital Edouard Herriot Pavillon E 5, Place d Arsonval, 69003 Lyon, France
    Haematologica 92:1639-46. 2007
    ..The basis for this heterogeneous clinical expression of the deficit is still poorly understood. We investigated the relationship between thrombin generation and levels of factor VIII, VWF and clinical bleeding tendency...
  25. ncbi request reprint Characterisation of 96 mutations in 128 unrelated severe haemophilia A patients from France. Description of 62 novel mutations
    Christine Vinciguerra
    Laboratoire d Hemostase, Hopital Edouard Herriot, 69437 Lyon Cedex 03, France
    Thromb Haemost 95:593-9. 2006
    ..Different approaches of molecular modelling were performed in addition to familial linkage analysis to determine the pathophysiological responsibility of these novel missense mutations...
  26. ncbi request reprint Major surgery in a severe haemophilia A patient with high titre inhibitor: use of the thrombin generation test in the therapeutic decision
    Y Dargaud
    Centre Régional de Traitement de l Hémophilie, Hopital Edouard Herriot, Lyon, France
    Haemophilia 11:552-8. 2005
    ..In addition, it also suggests that TGT may have a major contribution in the decision-making process of the most adapted therapy for the treatment of such high-risk patients...
  27. doi request reprint Reversal of the inhibitory effect of fondaparinux on thrombin generation by rFVIIa, aPCC and PCC
    H Desmurs-Clavel
    Service de Medecine Interne, Hopital Edouard Herriot, Lyon, France
    Thromb Res 123:796-8. 2009
    ..A complete correction of thrombin generating capacity was found with low doses of Feiba while rFVIIa was responsible for a partial correction of the coagulation capacity...
  28. ncbi request reprint Study of the relationship between the suprascapular artery and the brachial plexus
    J Dargaud
    Laboratoire d Anatomie, Faculte de Medecine Lyon Grange Blanche, 8, avenue Rockefeller, 69373 Lyon, France
    Surg Radiol Anat 24:108-12. 2002
    ..The French version of this article is available in the form of electronic supplementary material and can be obtained by using the Springer LINK server located at http://dx.doi.org/10.1007/s00276-002-0026-5...
  29. doi request reprint Activated factor X cleaves factor VIII at arginine 562, limiting its cofactor efficiency
    J L Plantier
    Laboratoire d hémobiologie EA4174, Faculté RTH Laennec, Universite de Lyon, Universite Lyon 1, Lyon, France
    J Thromb Haemost 8:286-93. 2010
    ..Among the proteases that attack FVIII (activated factor X (FXa), activated protein C (APC) and plasmin), only APC cleaves within the FVIII A2 domain at R562 to fully abolish FVIII activity...
  30. doi request reprint Comparison of the clinical history of symptomatic isolated muscular calf vein thrombosis versus deep calf vein thrombosis
    Jean Philippe Galanaud
    Vascular Medicine Unit, Department of Internal Medicine, Montpellier University Hospital, Montpellier, France
    J Vasc Surg 52:932-8, 938.e1-2. 2010
    ..Despite their high prevalence, MCVT and DCVT have never been compared so far, which prevents possible modulation of distal DVT management according to the kind of distal DVT (MCVT or DCVT)...
  31. ncbi request reprint Haemophilia and thrombophilia: an unexpected association!
    Y Dargaud
    Centre Regional de Traitement des Hemophiles, Hopital Edouard Herriot, Lyon, France
    Haemophilia 10:319-26. 2004
    ....
  32. ncbi request reprint Basic aspects of bypassing agents
    C Negrier
    Unite d Hemostase Clinique, Centre Régional de Traitement de l Hémophilie, Lyon, France
    Haemophilia 12:48-52; discussion 52-3. 2006
    ....
  33. ncbi request reprint Haemophilia patients exhibit prolonged coagulation time but normal lag time of thrombin generation test: are these results really discordant?
    Yesim Dargaud
    Thromb Haemost 97:675-6. 2007
  34. ncbi request reprint Platelet-dependent thrombography: a method for diagnostic laboratories
    Yesim Dargaud
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    Br J Haematol 134:323-5. 2006
    ..This method has potential application to the measurement of platelet-dependent thrombin generation in clinical diagnostic laboratories and hence the investigation of patients with apparent hypo- or hypercoagulable phenotypes...
  35. ncbi request reprint Effect of standardization and normalization on imprecision of calibrated automated thrombography: an international multicentre study
    Yesim Dargaud
    Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
    Br J Haematol 139:303-9. 2007
    ..Standardization and normalization should be considered in future clinical studies which apply TG testing to clinical decision making...