Research Topics
Species | Yesim DargaudSummaryCountry: France Publications
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Publications
Monitoring platelet dependent thrombin generation in miceYesim Dargaud
Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, and Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
Thromb Res 126:436-41. 2010..Thrombin generation was dose dependently diminished by low molecular weight heparin and increased by high concentrations of exogenous factor VIII i.e. the assay can detect both hypo- and hypercoagulability...- Evaluation of a standardized protocol for thrombin generation measurement using the calibrated automated thrombogram: an international multicentre studyYesim Dargaud
Unite d Hemostase Clinique, Hopital Edouard Herriot, Lyon, France
Thromb Res 130:929-34. 2012..In conclusion, our data demonstrated that the standardized TGT methodology evaluated in this study effectively reduces the variability of the assay to acceptable limits and may be used in clinical trials... - The potential role of synovial thrombomodulin in the pathophysiology of joint bleeds in haemophiliaY Dargaud
Unite d Hemostase Clinique, Hopital Edouard Herriot, Lyon, France
Haemophilia 18:818-23. 2012.... 
Haemophilia therapiesYesim Dargaud
Hopital Edouard Herriot, Comprehensive Haemophilia Treatment Centre, Lyon, France
Expert Opin Biol Ther 7:651-63. 2007....- Thrombin generation testing in haemophilia comprehensive care centresY Dargaud
Unite d Hemostase Clinique, Hopital Edouard Herriot, Lyon, France
Haemophilia 16:223-30. 2010..This study will review unmet laboratory needs in haemophilia and the potential applications of TGT in the management of haemophiliacs. Furthermore, technical and standardization issues of the method will be discussed... - Standardisation of thrombin generation test--which reference plasma for TGT? An international multicentre studyY Dargaud
Unite d Hemostase Clinique, Hopital Edouard Herriot, Lyon, France
Thromb Res 125:353-6. 2010..These results clearly demonstrate that the inter-centre variability of TGT can be significantly reduced by using a reference plasma normalization, and that certain RP have a better capacity to reduce this variability than others... - Use of calibrated automated thrombinography +/- thrombomodulin to recognise the prothrombotic phenotypeYesim Dargaud
Unite d Hemostase Clinique Laboratoire d Hemostase, Hopital Edouard Herriot, Lyon, France
Thromb Haemost 96:562-7. 2006..In conclusion, TG, measured with the CAT technique in the presence of TM is capable of detecting the prothrombotic phenotype with a high sensitivity of 0.93 (95% confidence limits 0.82-0.99)... - An unusual clinical presentation of factor XIII deficiency and issues relating to the monitoring of factor XIII replacement therapyYesim Dargaud
Clinical Haemostasis Unit, Edouard Herriot Hospital, France
Blood Coagul Fibrinolysis 19:447-52. 2008..We also showed that thromboelastometry could be a valuable tool for the monitoring of factor XIII replacement therapy... - Comparison of the capacities of two prothrombin complex concentrates to restore thrombin generation in plasma from orally anticoagulated patients: an in vitro studyY Dargaud
Laboratoire d Hemostase, Hopital Edouard Herriot, Lyon, and EA 4174, IFR 62, Universite Lyon 1, Lyon, France
J Thromb Haemost 6:962-8. 2008..As the final product generated by PCCs is thrombin, a thrombin generation (TG) test could theoretically be used for monitoring the hemostatic correction... - Inherited bleeding disorder due to familial type 2 platelet cyclo-oxygenase deficiencyYesim Dargaud
Laboratoire d Hemostase, pav E Hopital Edouard Herriot 5, place d Arsonval 69003 Lyon, France
Thromb Res 116:483-9. 2005..Thrombin generation test confirmed mild bleeding phenotype in patients with COX deficiency as they had normal thrombin generating capacity... - Evaluation of the overall haemostatic effect of recombinant factor VIIa by measuring thrombin generation and stability of fibrin clotsY Dargaud
Unite d Hemostase Clinique, Hopital Edouard Herriot, Lyon EA 4174, France
Haemophilia 17:957-61. 2011..Despite this overall correlation, a relatively large spreading around a general trend was observed, suggesting that the two assays bring complementary information on the haemostatic effect of rFVIIa... - Management of pregnant women with increased risk of venous thrombosisY Dargaud
Laboratoire d Hémostase et Unité d Hémostase Clinique, Hopital Edouard Herriot, Lyon, France
Int J Gynaecol Obstet 90:203-7. 2005..To evaluate the usefulness of score based management of pregnancies with high risk of venous thromboembolism (VTE)... - Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and BYesim Dargaud
Laboratoire d Hemostase, Hopital Edouard Herriot, Lyon, France
Thromb Haemost 93:475-80. 2005.... - Multiple arterial thromboses in a patient with primary antiphospholipid syndrome receiving a bromocriptine therapyY Dargaud
Service d Exploration Vasculaire, Hopital Edouard Herriot, Lyon, France
Lupus 13:957-60. 2004..It also emphasizes the need for a correct diagnosis of catastrophic antiphospholipid syndrome allowing to limit the prescription of aggressive therapies... - Two novel factor V null mutations associated with activated protein C resistance phenotype/genotype discrepancyYesim Dargaud
Laboratoire d Hemostase, Hopital Edouard Herriot, Lyon, France
Br J Haematol 123:342-5. 2003..Our results suggest the necessity to use both phenotypic and genotypic analyses in some cases to determine an accurate diagnosis... - New advances in the therapeutic and laboratory management of patients with haemophilia and inhibitorsY Dargaud
Clinical Haemostasis Unit, Hopital Edouard Herriot, Lyon, France
Haemophilia 14:20-7. 2008..Overall, it may be hoped that these new developments will lead to a marked improvement in the clinical management of haemophilia patients with inhibitors in the near future... - A risk score for the management of pregnant women with increased risk of venous thromboembolism: a multicentre prospective studyYesim Dargaud
Unite d Hemostase Clinique, Hopital Edouard Herriot, Universite Lyon 1, Lyon, France
Br J Haematol 145:825-35. 2009..The use of a risk score may provide a rational decision process to implement safe and effective antepartum thromboprophylaxis in pregnant women at high risk of VTE... - Use of the thrombin generation test to evaluate response to treatment with recombinant activated factor VIIYesim Dargaud
Clinical Hemostasis Unit, , Lyon, France
Semin Hematol 45:S72-3. 2008 - Prospective assessment of thrombin generation test for dose monitoring of bypassing therapy in hemophilia patients with inhibitors undergoing elective surgeryYesim Dargaud
Unite d Hemostase Clinique, Hopital Edouard Herriot, Lyon
Blood 116:5734-7. 2010..Our results also showed a correlation between in vivo clinical response to BPA and thrombin-generating capacity. These data suggest that TGT may represent a surrogate marker for monitoring bypassing therapies in surgical situations... - A case of Glanzmann's thrombasthenia successfully treated with recombinant factor viia during a surgical procedure: observations on the monitoring and the mechanism of action of this drugYesim Dargaud
Laboratoire d Hemostase, Hopital Edouard Herriot, Lyon, France
Haematologica 91:ECR20. 2006..After rFVIIa infusion, the fibrin network was tighter in comparison with the sample before rFVIIa injection. These results provide further ex vivo evidence on haemostatic efficacy of rFVIIa in Glanzmann's patients... - Whole-blood thrombin generation monitored with a calibrated automated thrombogram-based assayMarisa Ninivaggi
Synapse BV, CARIM, Maastricht University Medical Center, Maastricht, The Netherlands
Clin Chem 58:1252-9. 2012..The calibrated automated thrombogram (CAT) assay in plasma is a versatile tool to investigate patients with hypo- or hypercoagulable phenotypes. The objective was to make this method applicable for whole blood measurements... - Thrombin-generating capacity in patients with von Willebrand's diseaseLucia Rugeri
Unite d Hemostase Clinique, Hôpital Edouard Herriot Pavillon E 5, Place d Arsonval, 69003 Lyon, France
Haematologica 92:1639-46. 2007..The basis for this heterogeneous clinical expression of the deficit is still poorly understood. We investigated the relationship between thrombin generation and levels of factor VIII, VWF and clinical bleeding tendency... - Characterisation of 96 mutations in 128 unrelated severe haemophilia A patients from France. Description of 62 novel mutationsChristine Vinciguerra
Laboratoire d Hemostase, Hopital Edouard Herriot, 69437 Lyon Cedex 03, France
Thromb Haemost 95:593-9. 2006..Different approaches of molecular modelling were performed in addition to familial linkage analysis to determine the pathophysiological responsibility of these novel missense mutations... - Spontaneous proximal deep vein thrombosis in a patient with severe haemophilia AYesim Dargaud
, Pavilion E, , Lyon, France
Blood Coagul Fibrinolysis 14:407-9. 2003..This case illustrates the possibility for severe haemophilia patients to develop authentic spontaneous DVT without anti-haemophilic treatment and predisposing risk factors... - Major surgery in a severe haemophilia A patient with high titre inhibitor: use of the thrombin generation test in the therapeutic decisionY Dargaud
Centre Régional de Traitement de l Hémophilie, Hopital Edouard Herriot, Lyon, France
Haemophilia 11:552-8. 2005..In addition, it also suggests that TGT may have a major contribution in the decision-making process of the most adapted therapy for the treatment of such high-risk patients... - Study of the relationship between the suprascapular artery and the brachial plexusJ Dargaud
Laboratoire d Anatomie, Faculte de Medecine Lyon Grange Blanche, 8, avenue Rockefeller, 69373 Lyon, France
Surg Radiol Anat 24:108-12. 2002..The French version of this article is available in the form of electronic supplementary material and can be obtained by using the Springer LINK server located at http://dx.doi.org/10.1007/s00276-002-0026-5... - Activated factor X cleaves factor VIII at arginine 562, limiting its cofactor efficiencyJ L Plantier
Laboratoire d hémobiologie EA4174, Faculté RTH Laennec, Universite de Lyon, Universite Lyon 1, Lyon, France
J Thromb Haemost 8:286-93. 2010..Among the proteases that attack FVIII (activated factor X (FXa), activated protein C (APC) and plasmin), only APC cleaves within the FVIII A2 domain at R562 to fully abolish FVIII activity... - Reversal of the inhibitory effect of fondaparinux on thrombin generation by rFVIIa, aPCC and PCCH Desmurs-Clavel
Service de Medecine Interne, Hopital Edouard Herriot, Lyon, France
Thromb Res 123:796-8. 2009..A complete correction of thrombin generating capacity was found with low doses of Feiba while rFVIIa was responsible for a partial correction of the coagulation capacity... - Comparison of the clinical history of symptomatic isolated muscular calf vein thrombosis versus deep calf vein thrombosisJean Philippe Galanaud
Vascular Medicine Unit, Department of Internal Medicine, Montpellier University Hospital, Montpellier, France
J Vasc Surg 52:932-8, 938.e1-2. 2010..Despite their high prevalence, MCVT and DCVT have never been compared so far, which prevents possible modulation of distal DVT management according to the kind of distal DVT (MCVT or DCVT)... - Basic aspects of bypassing agentsC Negrier
Unite d Hemostase Clinique, Centre Régional de Traitement de l Hémophilie, Lyon, France
Haemophilia 12:48-52; discussion 52-3. 2006.... - Haemophilia and thrombophilia: an unexpected association!Y Dargaud
Centre Regional de Traitement des Hemophiles, Hopital Edouard Herriot, Lyon, France
Haemophilia 10:319-26. 2004.... - Platelet-dependent thrombography: a method for diagnostic laboratoriesYesim Dargaud
Department of Haematology, Addenbrooke's NHS Trust, Cambridge, UK
Br J Haematol 134:323-5. 2006..This method has potential application to the measurement of platelet-dependent thrombin generation in clinical diagnostic laboratories and hence the investigation of patients with apparent hypo- or hypercoagulable phenotypes... - Haemophilia patients exhibit prolonged coagulation time but normal lag time of thrombin generation test: are these results really discordant?Yesim Dargaud
Thromb Haemost 97:675-6. 2007 - Effect of standardization and normalization on imprecision of calibrated automated thrombography: an international multicentre studyYesim Dargaud
Department of Haematology, Addenbrooke s NHS Trust, Cambridge, UK
Br J Haematol 139:303-9. 2007..Standardization and normalization should be considered in future clinical studies which apply TG testing to clinical decision making...