R Dantzer

Summary

Country: France

Publications

  1. ncbi The rank assessed in a food competition test influences subsequent reactivity to immune and social challenges in mice
    Elodie Merlot
    Neurobiologie Integrative, INRA, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux, France
    Brain Behav Immun 18:468-75. 2004
  2. ncbi Immune alterations induced by social defeat do not alter the course of an on-going BCG infection in mice
    Elodie Merlot
    Neurobiologie Integrative, INRA INSERM, Institut Francois Magendie, Bordeaux, France
    Neuroimmunomodulation 11:414-8. 2004
  3. ncbi Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity
    Robert Dantzer
    Neurobiologie Integrative, INRA, CNRS, Institut Francois Magendie, Universite Bordeaux 2, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Eur J Pharmacol 500:399-411. 2004
  4. ncbi Cytokine production by spleen cells after social defeat in mice: activation of T cells and reduced inhibition by glucocorticoids
    Elodie Merlot
    Neurobiologie Integrative, INRA INSERM, Institut FrançMagendie, Bordeaux, France
    Stress 7:55-61. 2004
  5. ncbi Chronic administration of tianeptine balances lipopolysaccharide-induced expression of cytokines in the spleen and hypothalamus of rats
    Nathalie Castanon
    , , , 33077 Bordeaux Cedex, France
    Psychoneuroendocrinology 29:778-90. 2004
  6. ncbi Neural and humoral pathways of communication from the immune system to the brain: parallel or convergent?
    R Dantzer
    INRA INSERM U394, Bordeaux, France
    Auton Neurosci 85:60-5. 2000
  7. ncbi Cytokines and depression: fortuitous or causative association?
    R Dantzer
    INRA INSERM U394, Bordeaux, France
    Mol Psychiatry 4:328-32. 1999
  8. ncbi Vasopressin, gonadal steroids and social recognition
    R Dantzer
    INSERM U394, Bordeaux, France
    Prog Brain Res 119:409-14. 1998
  9. ncbi Somatization: a psychoneuroimmune perspective
    Robert Dantzer
    Neurobiologie Integrative, CNRS INRA Université de Bordeaux 2, Institut Francois Magendie, 33077 Bordeaux Cedex, France
    Psychoneuroendocrinology 30:947-52. 2005
  10. ncbi Cytokines and sickness behavior
    R Dantzer
    Neurobiologie Integrative, INSERM, Bordeaux, France
    Ann N Y Acad Sci 840:586-90. 1998

Collaborators

Detail Information

Publications98

  1. ncbi The rank assessed in a food competition test influences subsequent reactivity to immune and social challenges in mice
    Elodie Merlot
    Neurobiologie Integrative, INRA, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux, France
    Brain Behav Immun 18:468-75. 2004
    ..Therefore, social interactions emerging in a stable social group may be involved in the individual differences observed in endocrine activity and in immune system reactivity...
  2. ncbi Immune alterations induced by social defeat do not alter the course of an on-going BCG infection in mice
    Elodie Merlot
    Neurobiologie Integrative, INRA INSERM, Institut Francois Magendie, Bordeaux, France
    Neuroimmunomodulation 11:414-8. 2004
    ..Accordingly, social defeat was unable to influence the mycobacterial growth in vivo. These results support the hypothesis postulating that stress does not affect antigen-specific response when it is applied after priming...
  3. ncbi Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity
    Robert Dantzer
    Neurobiologie Integrative, INRA, CNRS, Institut Francois Magendie, Universite Bordeaux 2, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Eur J Pharmacol 500:399-411. 2004
    ....
  4. ncbi Cytokine production by spleen cells after social defeat in mice: activation of T cells and reduced inhibition by glucocorticoids
    Elodie Merlot
    Neurobiologie Integrative, INRA INSERM, Institut FrançMagendie, Bordeaux, France
    Stress 7:55-61. 2004
    ..Wounded and non-wounded mice presented similar responses to stress. This study shows that social disruption stress enhances the reactivity of cells from both the acquired and innate immune systems...
  5. ncbi Chronic administration of tianeptine balances lipopolysaccharide-induced expression of cytokines in the spleen and hypothalamus of rats
    Nathalie Castanon
    , , , 33077 Bordeaux Cedex, France
    Psychoneuroendocrinology 29:778-90. 2004
    ..These results open new vistas in the pharmacological activity of tianeptine and provide further insights on the possible mechanisms of action involved in its neuroprotective properties...
  6. ncbi Neural and humoral pathways of communication from the immune system to the brain: parallel or convergent?
    R Dantzer
    INRA INSERM U394, Bordeaux, France
    Auton Neurosci 85:60-5. 2000
    ..Activation of neurons by cytokines can be direct or indirect, via prostaglandins. The way the neural pathway of transmission interacts with the humoral pathway remains to be elucidated...
  7. ncbi Cytokines and depression: fortuitous or causative association?
    R Dantzer
    INRA INSERM U394, Bordeaux, France
    Mol Psychiatry 4:328-32. 1999
    ....
  8. ncbi Vasopressin, gonadal steroids and social recognition
    R Dantzer
    INSERM U394, Bordeaux, France
    Prog Brain Res 119:409-14. 1998
    ..These findings are discussed in relation to the role of vasopressin in learning and memory...
  9. ncbi Somatization: a psychoneuroimmune perspective
    Robert Dantzer
    Neurobiologie Integrative, CNRS INRA Université de Bordeaux 2, Institut Francois Magendie, 33077 Bordeaux Cedex, France
    Psychoneuroendocrinology 30:947-52. 2005
    ..All these new findings have the potential to contribute to a renewed biopsychological approach to somatization and somatoform disorders...
  10. ncbi Cytokines and sickness behavior
    R Dantzer
    Neurobiologie Integrative, INSERM, Bordeaux, France
    Ann N Y Acad Sci 840:586-90. 1998
    ..All these findings point to the role of neural afferents for transmitting the immune message from the periphery to the brain...
  11. ncbi Cytokine-induced sickness behavior: mechanisms and implications
    R Dantzer
    INRA INSERM U394, Bordeaux, France
    Ann N Y Acad Sci 933:222-34. 2001
    ..However, the mechanisms that are involved in plasticity of the sickness motivational state are not yet understood...
  12. ncbi Cytokine, sickness behavior, and depression
    Robert Dantzer
    Laboratory of Integrative Neurobiology, CNRS, INRA, University of Bordeaux 2, 33077 Bordeaux Cedex, France
    Neurol Clin 24:441-60. 2006
    ..In addition, a dynamic view of the cellular interactions that occur at the brain sites of cytokine production and action is missing, together with a clarification of the mechanisms that favor the transition toward pathology...
  13. ncbi Cytokines and depression: an update
    Robert Dantzer
    INRA-INSERM U394, Institut Francois Magendie Integrative Neurobiology, Rue Camille Saint-Saens, 33077 Bordeaux Cedex, France
    Brain Behav Immun 16:501-2. 2002
  14. ncbi Innate immunity at the forefront of psychoneuroimmunology
    Robert Dantzer
    Integrative Neurobiology, Bordeaux, France
    Brain Behav Immun 18:1-6. 2004
    ..In this presidential address, I present the main methodological and conceptual developments that have allowed such progress...
  15. ncbi [Relationships between the brain and the immune system]
    Robert Dantzer
    INRA INSERM U394, rue Camille Saint Saens, 33077 Bordeaux, France
    J Soc Biol 197:81-8. 2003
    ..These locally produced cytokines diffuse throughout the brain parenchyma to act on target brain areas so as to organise the central components of the host response to infection (fever, neuroendocrine activation, and sickness behavior)...
  16. ncbi Interleukin-4 and interleukin-10 regulate IL1-beta induced mouse primary astrocyte activation: a comparative study
    F Pousset
    INSERM U 394, Bordeaux, France
    Glia 26:12-21. 1999
    ..Therefore, we conclude that IL-10 and dexamethasone have rapid immunosuppressive effects on the astrocyte response to IL-1beta stimulation, whereas IL-4, which has a delayed action, acts as an immune inducer...
  17. ncbi Endogenous brain IL-1 mediates LPS-induced anorexia and hypothalamic cytokine expression
    S Laye
    Institut National de la Recherche Agronomique Institut National de la Santé et de la Recherche Médicale Unité 394, Neurobiologie Integrative, 33077 Bordeaux, France
    Am J Physiol Regul Integr Comp Physiol 279:R93-8. 2000
    ..These findings indicate that endogenous brain IL-1 plays a pivotal role in the development of the hypothalamic cytokine response to a systemic inflammatory stimulus...
  18. ncbi Role of interleukin-1beta and tumour necrosis factor-alpha in lipopolysaccharide-induced sickness behaviour: a study with interleukin-1 type I receptor-deficient mice
    R M Bluthe
    INRA INSERM U394, Institut Francois Magendie, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France Université Bordeaux I, 33400 Talence, France
    Eur J Neurosci 12:4447-56. 2000
    ....
  19. ncbi The vagus nerve mediates behavioural depression, but not fever, in response to peripheral immune signals; a functional anatomical analysis
    J P Konsman
    INSERM U394, Neurobiologie Integrative, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Eur J Neurosci 12:4434-46. 2000
    ....
  20. ncbi Central injection of IL-10 antagonizes the behavioural effects of lipopolysaccharide in rats
    R M Bluthe
    INRA INSERM U394, Institut Francois Magendie, Bordeaux, France
    Psychoneuroendocrinology 24:301-11. 1999
    ..c.v. IL-10 (300 ng/rat). Rats lost body weight after i.c.v. LPS, and this effect was attenuated by i.c.v. IL-10. These results indicate that IL-10 is able to modulate the production and/or action of central proinflammatory cytokines...
  21. ncbi Molecular basis of sickness behavior
    R Dantzer
    INSERM U394, Bordeaux, France
    Ann N Y Acad Sci 856:132-8. 1998
    ..Evidence exists that different components of sickness behavior are mediated by different cytokines and that the relative importance of these cytokines is not the same in the peripheral and central cytokine compartments...
  22. ncbi Cholecystokinin receptors do not mediate the behavioral effects of lipopolysaccharide in mice
    R M Bluthe
    INRA INSERM U 394, Domaine de Carreire, Bordeaux, France
    Physiol Behav 62:385-9. 1997
    ....
  23. ncbi Chronic treatment with the atypical antidepressant tianeptine attenuates sickness behavior induced by peripheral but not central lipopolysaccharide and interleukin-1beta in the rat
    N Castanon
    INRA INSERM U394, Neurobiologie Integrative, Institut Francois Magendie, Bordeau, France
    Psychopharmacology (Berl) 154:50-60. 2001
    ..In this last case, however, the effect of antidepressants has been only studied on the effect of peripherally administered cytokines...
  24. ncbi Blockade of brain type II interleukin-1 receptors potentiates IL1beta-induced anorexia in mice
    S Cremona
    INSERM U394, Neurobiologie Integrative, Bordeaux, France
    Neurosci Lett 246:101-4. 1998
    ..The effects of IL1beta were abrogated in the positive control group treated with IL1ra (2 microg, i.c.v). These results suggest that brain IL1RII down-regulate the effects of IL1beta on its cell targets in the brain...
  25. ncbi Dexamethasone up-regulates type II IL-1 receptor in mouse primary activated astrocytes
    F Pousset
    INSERM U.394, Institut F. Magendie, Bordeaux, France
    J Neurochem 76:901-9. 2001
    ..These findings support the concept that glucocorticoids have important regulatory effect on the response of astrocytes to IL-1...
  26. ncbi Characterization of interleukin-1 receptor antagonist isoform expression in the brain of lipopolysaccharide-treated rats
    K Palin
    INSERM U 394, rue C Saint Saëns, 33077 Bordeaux Cedex, France
    Neuroscience 103:161-9. 2001
    ..These results demonstrate for the first time that brain cells are able to produce interleukin-1 receptor antagonist isoforms in response to a peripheral immune challenge with a predominance of the secreted over intracellular forms...
  27. ncbi Expression of type I and type II interleukin-1 receptors in mouse brain
    P Parnet
    INRA INSERM, Laboratory of Integrative Neurobiology, Bordeaux, France
    Brain Res Mol Brain Res 27:63-70. 1994
    ..These data show that mouse brain expresses both type I and type II IL-1 receptor mRNA and proteins and offer further support to the idea that type I IL-1 receptors are synthesized and expressed by neurons...
  28. ncbi Association between immune activation and early depressive symptoms in cancer patients treated with interleukin-2-based therapy
    L Capuron
    INSERM U 394, Neurobiologie Integrative, Institut Francois Magendie, 33077, Bordeaux Cedex, France
    Psychoneuroendocrinology 26:797-808. 2001
    ..These results support the hypothesis of close relationship between depressive symptoms and the activation of the cytokine network...
  29. ncbi Central injection of interleukin-13 potentiates LPS-induced sickness behavior in rats
    R M Bluthe
    Integrative Neurobiology Laboratory, INRA INSERM U394, Institut Fracois Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Neuroreport 12:3979-83. 2001
    ..Administration of IL-13 (300 ng) 12 h prior to LPS (150 microg/kg) did not block the depressing effects of LPS on social exploration. These results indicate that IL-13 acts as a proinflammatory cytokine in the brain...
  30. ncbi Central mediation of the effects of interleukin-1 on social exploration and body weight in mice
    R M Bluthe
    INRA INSERM U394, Bordeaux, France
    Psychoneuroendocrinology 22:1-11. 1997
    ..i.c.v. IL-1ra (3.6 micrograms/mouse) also attenuated the effects of i.p. IL-1 beta (500 ng/mouse) on social behavior and change in body weight, suggesting that the effects of peripheral IL-1 beta are centrally mediated...
  31. ncbi Hypersensitivity of lurcher mutant mice to the depressing effects of lipopolysaccharide and interleukin-1 on behaviour
    R M Bluthe
    INRA INSERM U394, Bordeaux, France
    Neuroreport 8:1119-22. 1997
    ..This difference may be due to the higher reactivity of brain macrophages and glial cells to LPS and IL-1 in Lurcher mice than in wild type...
  32. ncbi Early depressive symptoms in cancer patients receiving interleukin 2 and/or interferon alfa-2b therapy
    L Capuron
    Institut National de la Santé et de la Recherche Médicale U 394, Neurobiologie Integrative, Institut Francois Magendie, and Institut Bergonié, Comprehensive Cancer Center, Bordeaux, France
    J Clin Oncol 18:2143-51. 2000
    ..The objective of the present study was to evaluate the depressive and anxiety symptoms induced by IL-2 and/or INFalpha-2b in cancer patients during the first days of cytokine immunotherapy...
  33. ncbi A role of IL-1 in MPTP-induced changes in striatal dopaminergic and serotoninergic transporter binding: clues from interleukin-1 type I receptor-deficient mice
    Guillaume Hebert
    INSERM U394, Neurobiologie Integrative, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Brain Res Mol Brain Res 136:267-70. 2005
    ..These data point to a possible role of IL-1RI in the early MPTP-induced structural or functional remodeling of the nigrostriatal dopamine system...
  34. ncbi Rat microglial cells secrete predominantly the precursor of interleukin-1beta in response to lipopolysaccharide
    N Chauvet
    INRA-INSERM U.394, , 33077 Bordeaux Cedex, France
    Eur J Neurosci 14:609-17. 2001
    ..Microglial cells share with macrophages the ability to release large amounts of pro-IL-1beta of which the extracellular role remains to be determined...
  35. ncbi Diffusion and action of intracerebroventricularly injected interleukin-1 in the CNS
    J P Konsman
    INSERM U394, Neurobiologie Integrative, Institut Francois Magendie, rue Camille Saint Saens, 33077, Cedex, Bordeaux, France
    Neuroscience 101:957-67. 2000
    ....
  36. ncbi IL-10 and IL-4 regulate type-I and type-II IL-1 receptors expression on IL-1 beta-activated mouse primary astrocytes
    F Pousset
    INRA-INSERM U394, Institut F. Magendie, Bordeaux, France
    J Neurochem 79:726-36. 2001
    ..Collectively, these results establish the existence of receptor cross-talk between pro- and anti-inflammatory cytokines on a critical type of cell that regulates inflammatory events in the brain...
  37. ncbi Role of IL-6 in cytokine-induced sickness behavior: a study with IL-6 deficient mice
    R M Bluthe
    INRA INSERM U394, Institut Francois Magendie, Rue Camille St Saëns, 33077 Cedex, Bordeaux, France
    Physiol Behav 70:367-73. 2000
    ..c.v.). These results show that IL-6 released at the periphery and /or in the central nervous system plays a role in the behavioral response to LPS and IL-1...
  38. ncbi Suppression of restraint-induced plasma cytokines in mice pretreated with LPS
    E Merlot
    INSERM U394, , , Bordeaux, France
    Stress 5:131-5. 2002
    ..They also suggest that LPS may induce a long lasting suppression of plasma cytokines through mechanisms that remain to be elucidated...
  39. ncbi Conditioned taste aversion with lipopolysaccharide and peptidoglycan does not activate cytokine gene expression in the spleen and hypothalamus of mice
    Cecile Mormede
    INRA INSERM U394 Neurobiologie Intégrative, Institut Francois Magendie, rue Camille Saint Saens, 3307 Bordeaux Cedex, France
    Brain Behav Immun 18:186-200. 2004
    ..This modulation of the NFkappaB and MAPK signalling pathways is interpreted in terms of a possible conditioned sensitisation of the immune system...
  40. ncbi Cellular distribution of interleukin-1alpha-immunoreactivity after MPTP intoxication in mice
    Guillaume Hebert
    INSERM U394, Neurobiologie Integrative, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Brain Res Mol Brain Res 138:156-63. 2005
    ..In the striatum, IL-1alpha-ir was also detected in a non-astrocytic perivascular component, with a distribution similar to GAP-43-ir. IL-1alpha could thus directly or indirectly influence striatal reorganization after MPTP...
  41. ncbi Chronic mild stress in mice decreases peripheral cytokine and increases central cytokine expression independently of IL-10 regulation of the cytokine network
    Cecile Mormede
    INRA INSERM U394, Neurobiologie Integrative, Institut Francois Magendie, Bordeaux, France
    Neuroimmunomodulation 10:359-66. 2002
    ..The production and action of pro-inflammatory cytokines are down-regulated by anti-inflammatory cytokines such as IL-10. This makes IL-10-deficient mice a potentially useful model to assess the effects of stress on cytokine production...
  42. ncbi Uncoupling of interleukin-6 from its signalling pathway by dietary n-3-polyunsaturated fatty acid deprivation alters sickness behaviour in mice
    Rozenn Mingam
    Psychoneuroimmunologie, Nutrition et Genetique, PsyNuGen, INRA 1286, CNRS 5226, Universite Bordeaux 2, Bordeaux, France
    Eur J Neurosci 28:1877-86. 2008
    ..The relative deficiency of Western diets in n-3 PUFA could impact on behavioural aspects of the host response to infection...
  43. ncbi Inactivation of the cerebral NFkappaB pathway inhibits interleukin-1beta-induced sickness behavior and c-Fos expression in various brain nuclei
    Agnes Nadjar
    UMR INRA I 244 CNRS Université Victor Segalen Bordeaux II, Institut Francois Magendie, rue Léo Saignat Bordeaux, Cedex, France
    Neuropsychopharmacology 30:1492-9. 2005
    ....
  44. ncbi Timing and specificity of the cognitive changes induced by interleukin-2 and interferon-alpha treatments in cancer patients
    L Capuron
    INSERM U394, Neurobiologie Integrative, Institut Francois Magendie, Bordeaux, France
    Psychosom Med 63:376-86. 2001
    ....
  45. ncbi Cytokine-induced sickness behavior: where do we stand?
    R Dantzer
    INRA INSERM U394, Bordeaux Cedex, 33077, France
    Brain Behav Immun 15:7-24. 2001
    ..There is clinical and experimental evidence that activation of the brain cytokine system is associated with depression, although the exact relationship between sickness behavior and depression is still elusive...
  46. ncbi Chronic treatment with the antidepressant tianeptine attenuates lipopolysaccharide-induced Fos expression in the rat paraventricular nucleus and HPA axis activation
    Nathalie Castanon
    INRA INSERM U394, Neurobiologie Integrative, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Psychoneuroendocrinology 28:19-34. 2003
    ..These results open new vistas on the pharmacological activity of tianeptine and provide further insights on the action mechanisms of antidepressants in clinics...
  47. ncbi Nuclear factor kappaB nuclear translocation as a crucial marker of brain response to interleukin-1. A study in rat and interleukin-1 type I deficient mouse
    Agnes Nadjar
    INRA INSERM U 394, Institut F Magendie, Bordeaux, France
    J Neurochem 87:1024-36. 2003
    ..The study of the consequences of the impairment of NFkappaB pathway activation in in vivo experimentation should bring important clues about the precise role of this transcription factor...
  48. ncbi Expression and regulation of interleukin-1 receptors in the brain. Role in cytokines-induced sickness behavior
    Patricia Parnet
    Laboratory of Integrative Neurobiology, INRA INSERM U394, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    J Neuroimmunol 125:5-14. 2002
    ..Finally, modulation of IL-1 action on its receptor by various opposing factors including glucocorticoids and anti-inflammatory cytokines is discussed...
  49. ncbi Effects of insulin-like growth factor-I on cytokine-induced sickness behavior in mice
    Rose Marie Bluthé
    Integrative Neurobiology, CNRS INRA University Victor Segalen, Bordeaux, France
    Brain Behav Immun 20:57-63. 2006
    ..These findings indicate that IGF-I is more potent in attenuating sickness behavior induced by TNFalpha than that caused by IL-1beta, which is consistent with the relative specificity of the TNFalpha/IGF-I interactions in the brain...
  50. ncbi Importance of fighting in the immune effects of social defeat
    Elodie Merlot
    Neurobiologie Integrative, INRA INSERM, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux, France
    Physiol Behav 80:351-7. 2003
    ..The increased immune reactivity observed in the fight-associated procedure could result from either a stronger psychological stress or a direct immune activation through the wounds...
  51. ncbi Dual effect of central injection of recombinant rat interleukin-4 on lipopolysaccharide-induced sickness behavior in rats
    Rose Marie Bluthé
    Integrative Neurobiology Laboratory, INRA INSERM U394, Institut Francois Magendie, rue Camille Saint Saens, 33077, Bordeaux Cedex, France
    Neuropsychopharmacology 26:86-93. 2002
    ..These results indicate that the regulation of cytokine-induced sickness behavior by IL-4 can be either inhibitory or stimulatory depending on the sequencing of IL-4 and LPS treatments...
  52. ncbi Time-course of the expression of inflammatory cytokines and matrix metalloproteinases in the striatum and mesencephalon of mice injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a dopaminergic neurotoxin
    Guillaume Hebert
    INSERM U 394 Neurobiologie Intégrative, Institut Francois Magendie, Bordeaux, France
    Neurosci Lett 349:191-5. 2003
    ....
  53. ncbi Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior
    Maite Moreau
    INRA, UMR 1286 PsyNuGen, Bâtiment UFR Pharmacie, Case courrier 34, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, CNRS, UMR 5226, IFR8, F 33076 Bordeaux, France
    Brain Behav Immun 22:1087-95. 2008
    ....
  54. ncbi In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1 beta in the murine brain
    Rozenn Mingam
    PsyNuGen, INRA, UMR1286, CNRS, UMR5226, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33077 Bordeaux, France
    Brain Behav Immun 22:234-44. 2008
    ..These results show that P2X7R plays a key role in the brain cytokine response to immune stimuli, which certainly applies also to cytokine-dependent alterations in brain functions including sickness behavior...
  55. ncbi How the immune and nervous systems interact during disease-associated anorexia
    J P Konsman
    INSERM Unit 394, François Magendie Institute, Bordeaux, France
    Nutrition 17:664-8. 2001
    ..The mechanisms by which interleukin-1beta gains access to the brain and the potential role of neuropeptide-Y-containing neurons in the arcuate hypothalamus in mediating anorexia during disease are discussed...
  56. ncbi Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy
    L Capuron
    INSERM INRA, Integrative Neurobiology, Institut Francois Magendie, 33077 Bordeaux, France
    Mol Psychiatry 7:468-73. 2002
    ..These findings indicate that the development of depressive symptoms in patients undergoing cytokine therapy could be mediated by a reduced availability of the serotonin relevant amino acid precursor, tryptophan...
  57. ncbi Signaling pathways of interleukin-1 actions in the brain: anatomical distribution of phospho-ERK1/2 in the brain of rat treated systemically with interleukin-1beta
    A Nadjar
    INRA UMR1244, CNRS FRE2723, rue C Saint Saëns, Institut Francois Magendie, Universite Victor Segalen Bordeaux 2, 33077 Bordeaux Cedex, France
    Neuroscience 134:921-32. 2005
    ....
  58. ncbi Conditioned place aversion with interleukin-1beta in mice is not associated with activation of the cytokine network
    Cecile Mormede
    INRA INSERM U394 Neurobiologie Intégrative, Institut Francois Magendie, rue Camille Saint Saens, 33077, Bordeaux Cedex, France
    Brain Behav Immun 17:110-20. 2003
    ..These data do not support the possibility of conditioned alterations in the cytokine network...
  59. ncbi Interleukin-1beta mediates the memory impairment associated with a delayed type hypersensitivity response to bacillus Calmette-Guérin in the rat hippocampus
    Karine Palin
    INRA UMR 1244 Université V Segalen Bordeaux 2, FRE CNRS Institut François Magendie, rue Camille Saint Saens, 33077 Bordeaux, France
    Brain Behav Immun 18:223-30. 2004
    ..These results show that overexpression of IL-1beta in the brain during the course of a chronic inflammation has deleterious consequences on cognitive processes, that are reversed by blockade of IL-1 receptors...
  60. ncbi Cytokine-induced sickness behaviour: mechanisms and implications
    Jan Pieter Konsman
    Laboratory of Integrative Neurobiology, INRA-INSERM U 394, Rue Camille Saint-Saens, Bordeaux, France
    Trends Neurosci 25:154-9. 2002
    ..The cellular and molecular components of this previously unsuspected system are being progressively identified. These advances are opening new avenues for understanding brain disorders, including depression...
  61. ncbi Influence of the course of brain inflammation on the endogenous IL-1beta/IL-1Ra balance in the model of brain delayed-type hypersensitivity response to bacillus Calmette-Guérin in Lewis rats
    Karine Palin
    INRA UMR 1244, Université V Segalen Bordeaux 2, FRE CNRS Institut François Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    J Neuroimmunol 149:22-30. 2004
    ..Besides showing that the course of inflammation alters the brain IL-1beta/IL-1Ra ratio, these findings point to the importance of monitoring plasma IL-1beta/IL-1Ra ratio to predict the course of brain inflammation...
  62. ncbi The enzyme indoleamine 2,3-dioxygenase is induced in the mouse brain in response to peripheral administration of lipopolysaccharide and superantigen
    J Lestage
    INRA INSERM U394, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Brain Behav Immun 16:596-601. 2002
    ..These results support the involvement of peripheral IFN-gamma in the control of L-tryptophan catabolism in the brain...
  63. ncbi Molecular identification of two types of interleukin-1 receptors in the murine pituitary gland
    P Parnet
    INRA INSERM, Unité de Recherches de Neurobiologie des Comportements, U 176, Bordeaux, France
    J Neuroendocrinol 5:213-9. 1993
    ..These data identify two different forms of the IL-1 receptor in both normal and transformed pituitary cells and establish that these receptors are similar at the molecular level to those first identified on T and B lymphocytes...
  64. ncbi Pentoxifylline and insulin-like growth factor-I (IGF-I) abrogate kainic acid-induced cognitive impairment in mice
    Rose Marie Bluthé
    Integrative Neurobiology, CNRS INRA University Victor Segalen, Bordeaux, France
    J Neuroimmunol 169:50-8. 2005
    ..These findings indicate that endogenous TNFalpha is probably involved in the detrimental effects of kainate on cognition and that exogenous IGF-I can oppose these effects, probably by antagonizing TNFalpha-induced neurotoxicity...
  65. ncbi Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration
    Caroline Andre
    INRA, UMR 1286 PsyNuGen, Universite Victor Segalen Bordeaux 2, CNRS, UMR 5226, IFR8, F 33076 Bordeaux, France
    J Neuroimmunol 200:90-9. 2008
    ..This study suggests that different mechanisms regulate the activation of IDO by lipopolysaccharide in various brain structures...
  66. ncbi Bacille Calmette-Guérin inoculation induces chronic activation of peripheral and brain indoleamine 2,3-dioxygenase in mice
    Maite Moreau
    Laboratory of Neurobiologie Integrative, Formation de Recherche en Evolution 2723 Centre National de la Recherche Scientifique Unite Mixte de Recherche 1244 Institut National de Recherche Agronomique, Institut Francois Magendie, Bordeaux, France
    J Infect Dis 192:537-44. 2005
    ..We aimed to develop an experimental model of chronic IDO activation based on bacille Calmette-Guérin (BCG) infection that elicits a robust increase in levels of interferon (IFN)- gamma, a key cytokine in the activation of IDO...
  67. ncbi Mood alterations during interferon-alfa therapy in patients with chronic hepatitis C: evidence for an overlap between manic/hypomanic and depressive symptoms
    Aymery Constant
    Department of Health Psychology EA 3662, University of Bordeaux 2, France
    J Clin Psychiatry 66:1050-7. 2005
    ..The impact of such findings on therapeutic management should be investigated...
  68. ncbi Anti-NR1 N-terminal-domain vaccination unmasks the crucial action of tPA on NMDA-receptor-mediated toxicity and spatial memory
    Karim Benchenane
    INSERM, INSERM Avenir tPA in the working brain, Universite de Caen Basse Normandie, Cyceron, 14074 Caen Cedex, France
    J Cell Sci 120:578-85. 2007
    ..Interesting therapeutic possibilities for several brain pathologies that involve excitotoxicity may now be envisaged...
  69. ncbi Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior
    Francois Frenois
    Integrative Immunology and Behavior Program, University of Illinois at Urbana Champaign, 212 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, IL 61801, USA
    Psychoneuroendocrinology 32:516-31. 2007
    ....
  70. ncbi TNFalpha-induced sickness behavior in mice with functional 55 kD TNF receptors is blocked by central IGF-I
    Karine Palin
    Department of Animal Sciences, Integrative Immunology and Behavior Program, Laboratory of Integrative Immunophysiology, University of Illinois at Urbana Champaign, IL, USA
    J Neuroimmunol 187:55-60. 2007
    ..c.v., 300 ng/mouse). These results establish that sickness behavior induced by central TNFalpha via the TNF-R1 (p55) is directly opposed by IGF-I in the brain...
  71. ncbi Twenty years of research on cytokine-induced sickness behavior
    Robert Dantzer
    Integrative Immunology and Behavior Program, Laboratory of Integrative Immunophysiology, Department of Animal Sciences, University of Illinois at Urbana Champaign, IL 61801, USA
    Brain Behav Immun 21:153-60. 2007
    ..The time is ripe to begin to move these fundamental discoveries in mice to man and some of the pharmacological tools are already available to antagonize the detrimental actions of cytokines...
  72. ncbi Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFalpha-induced resistance to IGF-I in myoblasts
    Klemen Strle
    Laboratories of Integrative Immunophysiology, College of Medicine, University of Illinois, Urbana, IL 61801, United States
    J Neuroimmunol 188:48-55. 2007
    ..Instead, IL-10 acts to prevent TNFalpha-induced phosphorylation of JNK. These findings demonstrate that IL-10 serves a previously unrecognized protective role in muscle progenitors by overcoming TNFalpha-induced resistance to IGF-I...
  73. ncbi Chronic psychosocial stress down-regulates central cytokines mRNA
    Alessandro Bartolomucci
    Dipartimento di Biologia Evolutiva e Funzionale, Universita di Parma, Parco Area delle Scienze 11 A, 43100, Parma, Italy
    Brain Res Bull 62:173-8. 2003
    ..These findings may open new perspectives for understanding the pathophysiological basis of chronic stress-induced disorders...
  74. ncbi C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts
    Klemen Strle
    Laboratories of Immunophysiology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA
    Endocrinology 147:4363-73. 2006
    ..These results establish that the resistance of muscle progenitor cells to IGF-I, which is caused by inflammatory stimuli, is mediated by the JNK stress kinase pathway...
  75. ncbi Cytokine-induced sickness behavior
    Keith W Kelley
    Department of Animal Sciences, Laboratory of Immunophysiology, University of Illinois, 207 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana 61801, USA
    Brain Behav Immun 17:S112-8. 2003
    ..Advances that have been made during the past decade should now be extended to clinical studies in an attempt to alleviate sickness symptoms and improve quality of life for cancer patients...
  76. ncbi Inhibition of vagally mediated immune-to-brain signaling by vanadyl sulfate speeds recovery from sickness
    Daniel R Johnson
    Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 102:15184-9. 2005
    ..Taken together, these data indicate that VS improves recovery from LPS-induced sickness by blocking vagally mediated immune-to-brain signaling and by up-regulating brain expression of IL-1beta antagonists...
  77. ncbi A biological substrate for somatoform disorders: importance of pathophysiology
    Joel E Dimsdale
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Psychosom Med 69:850-4. 2007
    ..Studies on communication pathways from the immune system to the brain provide exciting new information on the pathophysiology of inflammation-associated symptoms...
  78. ncbi IL-1beta-mediated innate immunity is amplified in the db/db mouse model of type 2 diabetes
    Jason C O'Connor
    Department of Animal Sciences, University of Illinois at Urbana Champain, Urbana, IL 61801, USA
    J Immunol 174:4991-7. 2005
    ..Taken together, these results indicate that IL-1beta-mediated innate immunity is augmented in db/db mice both at the periphery and in the brain, and the mechanism is due to diabetes-associated loss of IL-1beta counterregulation...
  79. ncbi From inflammation to sickness and depression: when the immune system subjugates the brain
    Robert Dantzer
    Integrative Immunology and Behavior, Department of Animal Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana Champaign, Illinois 61801, USA
    Nat Rev Neurosci 9:46-56. 2008
    ..Inflammation is therefore an important biological event that might increase the risk of major depressive episodes, much like the more traditional psychosocial factors...
  80. ncbi Proinflammatory cytokine impairment of insulin-like growth factor I-induced protein synthesis in skeletal muscle myoblasts requires ceramide
    Klemen Strle
    University of Illinois, Laboratory of Immunophysiology, 207 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, Illinois 61801, USA
    Endocrinology 145:4592-602. 2004
    ....
  81. ncbi Cytokines and depression: the need for a new paradigm
    Lucile Capuron
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA 30322, USA
    Brain Behav Immun 17:S119-24. 2003
    ..This paper discusses ways in which these emerging data may lead to advances in the recognition and management of non-specific neurobehavioral symptoms associated with the development and progression of cancer...
  82. ncbi Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism? A cytokine-immunologic model of cancer symptoms
    Charles S Cleeland
    Department of Symptom Research, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer 97:2919-25. 2003
    ..These symptoms include pain, wasting, fatigue, cognitive impairment, anxiety, and depression, many of which co-occur. There is growing recognition that at least some of these symptoms may share common biologic mechanisms...
  83. ncbi Social factors and individual vulnerability to chronic stress exposure
    Alessandro Bartolomucci
    Dipartimento di Biologia Evolutiva e Funzionale, Universita di Parma, Parma, Italy
    Neurosci Biobehav Rev 29:67-81. 2005
    ....
  84. ncbi The taste of sickness: lipopolysaccharide-induced finickiness in rats
    Arnaud Aubert
    EA 3248, Psychobiologie des Emotions, Faculte des Sciences, DESCO, Parc de Grandmont, F 37200 Tours, France
    Physiol Behav 84:437-44. 2005
    ..These LPS-induced changes are interpreted as an increase in finickiness and are discussed in regard to their potential role in the adaptation of individuals to sickness...
  85. ncbi Prototypical anti-inflammatory cytokine IL-10 prevents loss of IGF-I-induced myogenin protein expression caused by IL-1beta
    Klemen Strle
    Laboratory of Integrative Immunophysiology, Integrative Immunology and Behavior Program, Department of Animal Sciences, College of Agricultural, Consumer and Enviromental Sciences, University of Illinois, Urbana, IL 61801, USA
    Am J Physiol Endocrinol Metab 294:E709-18. 2008
    ..Collectively, these data demonstrate that IL-10 acts in a novel, nonclassical, protective manner in nonhematopoietic cells to inhibit the IL-1beta receptor-induced JNK kinase pathway, resulting in prevention of IGF-I resistance...
  86. ncbi Autistic children: a neuroimmune perspective
    Robert Dantzer
    Integrative Immunology and Behavior Program, University of Illinois at Urbana-Champaign, 212 ERML, 1201 W Gregory Drive, Urbana, IL 61801, USA
    Brain Behav Immun 22:804-5. 2008
  87. ncbi NFkappaB activates in vivo the synthesis of inducible Cox-2 in the brain
    Agnes Nadjar
    Institut F Magendie, Unité de Neurobiologie Intégrative, Bordeaux Cedex, France
    J Cereb Blood Flow Metab 25:1047-59. 2005
    ..These findings strongly support the hypothesis that IL-1beta-induced NFkappaB activation plays a major role in transmission of immune signals from the periphery to the brain...
  88. ncbi [Neuro-immune interactions in psychopathology with the example of interferon-alpha-induced depression]
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30033, USA
    J Soc Biol 197:151-6. 2003
    ..In addition, some behavioral and biological markers of the vulnerability for IFN-alpha-induced depression were identified. These findings provide important information concerning the relationship between cytokines and depression...
  89. ncbi IL-10 promotes survival of microglia without activating Akt
    Klemen Strle
    Laboratory of Immunophysiology, Department of Animal Sciences, University of Illinois, 207 ERML, 1201 W. Gregory Dr, Urbana, IL 61801, USA
    J Neuroimmunol 122:9-19. 2002
    ..These data establish that IL-10 activates Stat3 and inhibits the mitochondrial pathway of cell death without activating the Akt cell survival pathway...
  90. ncbi Age-associated loss of bone marrow hematopoietic cells is reversed by GH and accompanies thymic reconstitution
    Richard A French
    Laboratory of Immunophysiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
    Endocrinology 143:690-9. 2002
    ....
  91. ncbi IL-1beta impairs insulin-like growth factor i-induced differentiation and downstream activation signals of the insulin-like growth factor i receptor in myoblasts
    Suzanne R Broussard
    Laboratories of Immunophysiology, 207 Edward R Madigan Laboratory, University of Illinois at Urbana Champaign, 1201 West Gregory Drive, Urbana, IL 61801, USA
    J Immunol 172:7713-20. 2004
    ..Collectively, the results are consistent with the notion that very low concentrations of IL-1beta significantly impair myogenesis, but they are unable to do so in the absence of the growth factor IGF-I...
  92. ncbi IL-1beta suppresses prolonged Akt activation and expression of E2F-1 and cyclin A in breast cancer cells
    Wen Hong Shen
    Laboratory of Immunophysiology, University of Illinois, Urbana, IL 61801, USA
    J Immunol 172:7272-81. 2004
    ..In this manner, Akt serves as a critical bridge that links proximal receptor signaling events to more distal cell cycle machinery...
  93. ncbi A cytokine-based neuroimmunologic mechanism of cancer-related symptoms
    Bang-Ning Lee
    Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
    Neuroimmunomodulation 11:279-92. 2004
    ..These concepts open exciting new avenues for translational research in the pathophysiology and treatment of cancer-related symptoms...
  94. ncbi Tumor necrosis factor alpha inhibits insulin-like growth factor I-induced hematopoietic cell survival and proliferation
    Wen Hong Shen
    University of Illinois, Laboratory of Immunophysiology, Department of Animal Sciences, 207 Edward R. Madigan Laboratory, 1201 West Gregory Drive, Urbana, Illinois 61801, USA
    Endocrinology 145:3101-5. 2004
    ..These results support the general concept that proinflammatory cytokines impair the actions of hormones on hematopoietic cells, leading to IGF-I receptor resistance...
  95. ncbi Baseline mood and psychosocial characteristics of patients developing depressive symptoms during interleukin-2 and/or interferon-alpha cancer therapy
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Behav Immun 18:205-13. 2004
    ....
  96. ncbi Proinflammatory cytokines block growth of breast cancer cells by impairing signals from a growth factor receptor
    Wen-Hong Shen
    Laboratory of Immunophysiology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA
    Cancer Res 62:4746-56. 2002
    ..These data also highlight growth factor receptor adaptor molecules, such as insulin receptor substrate-1, rather than the receptors themselves as targets for antitumor therapeutic strategies...
  97. ncbi Insulin-like growth factor-I enhances the biological activity of brain-derived neurotrophic factor on cerebrocortical neurons
    Robert H McCusker
    250 Edward R Madigan Laboratory, Urbana, IL 61801 3873, USA
    J Neuroimmunol 179:186-90. 2006
    ..IGF-I enhanced expression of BDNF receptors (Trk-B) and increased the ability of BDNF to induce ERK1/2 phosphorylation. This IGF-I-induced increase in BDNF responsiveness describes a new interaction between these peptides in the brain...
  98. ncbi Identification and treatment of symptoms associated with inflammation in medically ill patients
    Robert Dantzer
    Integrative Immunology and Behavior Program, 212 ERML, 1201 W Gregory Drive, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Psychoneuroendocrinology 33:18-29. 2008
    ..This resulted in a number of recommendations that should improve the recognition and management of inflammation-associated symptoms in medically ill patients...