Genomes and Genes
- 16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cellsG D'Angelo
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California School of Medicine, San Francisco 94143, USA
Mol Endocrinol 13:692-704. 1999..Taken together, these findings show that 16K hPRL inhibits the VEGF-induced Ras activation; this antagonism represents a novel and potentially important mechanism for the control of angiogenesis...
- Hypoxia-induced transcriptional activation of vascular endothelial growth factor is inhibited by serumG D'Angelo
Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UPR 411, 660 route des Lucioles, Sophia Antipolis, Valbonne, 06560, France
Biochem Biophys Res Commun 267:334-8. 2000..It is concluded that growth-promoting cytokines regulate hypoxic gene induction in smooth muscle cells...
- Cyclosporin A prevents the hypoxic adaptation by activating hypoxia-inducible factor-1alpha Pro-564 hydroxylationGisela D'Angelo
Institut de Pharmacologie Moleculaire et Cellulaire du CNRS, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
J Biol Chem 278:15406-11. 2003..We conclude that CsA destabilizes HIF-1alpha by promoting hydroxylation of Pro-564 in the ODD domain. Such a mechanism may prevent hypoxic adaptation during CsA-induced nephrotoxicity and contribute to the adverse effects of this drug...
- Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenationGisela D'Angelo
Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
J Biol Chem 278:38183-7. 2003..The results suggest that a hypoxic upregulation of PHD (presumably PHD-2) acts as a feedback mechanism to stop hypoxic responses in reoxygenated cells. We propose that proline hydroxylation might play a role in hypoxic preconditioning...