Gisela D'Angelo

Summary

Country: France

Publications

  1. ncbi 16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells
    G D'Angelo
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California School of Medicine, San Francisco 94143, USA
    Mol Endocrinol 13:692-704. 1999
  2. ncbi Hypoxia-induced transcriptional activation of vascular endothelial growth factor is inhibited by serum
    G D'Angelo
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UPR 411, 660 route des Lucioles, Sophia Antipolis, Valbonne, 06560, France
    Biochem Biophys Res Commun 267:334-8. 2000
  3. ncbi Cyclosporin A prevents the hypoxic adaptation by activating hypoxia-inducible factor-1alpha Pro-564 hydroxylation
    Gisela D'Angelo
    Institut de Pharmacologie Moleculaire et Cellulaire du CNRS, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 278:15406-11. 2003
  4. ncbi Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation
    Gisela D'Angelo
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 278:38183-7. 2003

Detail Information

Publications4

  1. ncbi 16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells
    G D'Angelo
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California School of Medicine, San Francisco 94143, USA
    Mol Endocrinol 13:692-704. 1999
    ..Taken together, these findings show that 16K hPRL inhibits the VEGF-induced Ras activation; this antagonism represents a novel and potentially important mechanism for the control of angiogenesis...
  2. ncbi Hypoxia-induced transcriptional activation of vascular endothelial growth factor is inhibited by serum
    G D'Angelo
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UPR 411, 660 route des Lucioles, Sophia Antipolis, Valbonne, 06560, France
    Biochem Biophys Res Commun 267:334-8. 2000
    ..It is concluded that growth-promoting cytokines regulate hypoxic gene induction in smooth muscle cells...
  3. ncbi Cyclosporin A prevents the hypoxic adaptation by activating hypoxia-inducible factor-1alpha Pro-564 hydroxylation
    Gisela D'Angelo
    Institut de Pharmacologie Moleculaire et Cellulaire du CNRS, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 278:15406-11. 2003
    ..We conclude that CsA destabilizes HIF-1alpha by promoting hydroxylation of Pro-564 in the ODD domain. Such a mechanism may prevent hypoxic adaptation during CsA-induced nephrotoxicity and contribute to the adverse effects of this drug...
  4. ncbi Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation
    Gisela D'Angelo
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 278:38183-7. 2003
    ..The results suggest that a hypoxic upregulation of PHD (presumably PHD-2) acts as a feedback mechanism to stop hypoxic responses in reoxygenated cells. We propose that proline hydroxylation might play a role in hypoxic preconditioning...