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Genomes and Genes | Cristine Alves da CostaSummaryCountry: France Publications
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Publications
Recent advances on alpha-synuclein cell biology: functions and dysfunctionsC Alves Da Costa
IPMC du CNRS, UMR6097, 660 route des Lucioles, Sophia Antipolis, 06560, Valbonne, France
Curr Mol Med 3:17-24. 2003....
Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6E Giaime
Institut de Neuromédecine Moléculaire IN2M and Institut de Pharmacologie Moléculaire et Cellulaire, UMR6097 CNRS UNSA, Equipe labellisée Fondation pour la Recherche Médicale, 06560, Sophia Antipolis, Valbonne, France
Cell Death Differ 17:158-69. 2010..Therefore, we show here that DJ-1 loss of function could be due to impaired caspase-6 proteolysis and we document the fact that various DJ-1 mutations could lead to PD pathology through distinct molecular mechanisms...
Apoptosis in Parkinson's disease: is p53 the missing link between genetic and sporadic Parkinsonism?Cristine Alves da Costa
Institut de Pharmacologie Moléculaire et Cellulaire IPMC and Institut de NeuroMédecine Moléculaire IN2M, UMR6097 CNRS UNSA, team Fondation pour la Recherche Médicale, 660 route des Lucioles, 06560, Valbonne, France
Cell Signal 23:963-8. 2011....- Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's diseaseCristine Alves da Costa
Institut de Pharmacologie Moleculaire et Cellulaire, UMR6097 CNRS UNSA, Equipe labellisée Fondation pour la Recherche Médicale, 660 route des Lucioles, 06560, Valbonne, France
Nat Cell Biol 11:1370-5. 2009..This study reveals a ubiquitin ligase-independent function of parkin in the control of transcription and a functional link between parkin and p53 that is altered by AR-JP mutations... - Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's diseaseCristine Alves da Costa
Institute of Molecular and Cellular Pharmacology, Coeducational Unit of Research 6097, National Center of Scientific Research Nice Sophia Antipolis University, 06560 Valbonne, France
J Neurosci 26:6377-85. 2006..Thus our study shows that AICDs control p53 at a transcriptional level, in vitro and in vivo, and that FAD mutations increase p53 expression and activity in cells and human brains... - DJ-1: a newcomer in Parkinson's disease pathologyCristine Alves da Costa
IPMC, UMR6097 CNRS UNSA, Equipe labellisée Fondation pour la Recherche Médicale, 660 route des Lucioles, 06560, Valbonne, France
Curr Mol Med 7:650-7. 2007..All these points along with the description of recent data showing the interaction of DJ-1 with other PD-associated proteins will be given... - 6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregationCristine Alves da Costa
IPMC du CNRS, UMR6097, Equipe Labellisée FRM, 660 route des Lucioles, 06560 Valbonne, France
J Biol Chem 281:9824-31. 2006..The drastically distinct effects of 6OH-DOPA and MPP(+) on alpha-synuclein function are discussed with respect to Parkinson disease pathology and animal models mimicking this pathology... - Recent insights on the pro-apoptotic phenotype elicited by presenilin 2 and its caspase and presenilinase-derived fragmentsCristine Alves da Costa
Institut de Pharmacologie Moléculaire et Cellulaire of Centre Nationale de la Recherche Scientifique, UMR6097 CNRS UNSA, Sophia Antipolis, France
Curr Alzheimer Res 2:507-14. 2005..The distinct apoptotic phenotypes elicited by the two parent proteins presenilins 1 and 2 and their functional cross talk will be briefly discussed... - p53-dependent control of transactivation of the Pen2 promoter by presenilinsJulie Dunys
Institut de Pharmacologie Moléculaire et Cellulaire of Centre National de la Recherche Scientifique and Institut de NeuroMédecine Moléculaire, Equipe labellisée Fondation pour la Recherche Médicale, Valbonne, France
J Cell Sci 122:4003-8. 2009..Interestingly, PEN-2 expression was also reduced in p53-deficient mouse brain. Overall, our study describes a p53-dependent regulation of PEN-2 expression by other members of the gamma-secretase complex, namely presenilins... - The gamma/epsilon-secretase-derived APP intracellular domain fragments regulate p53Frederic Checler
Institut de Pharmacologie Moleculaire et Cellulaire, UMR6097CNRS UNSA, Valbonne 06560, France
Curr Alzheimer Res 4:423-6. 2007..Our studies demonstrate that AICDs control p53 at a transcriptional level, in vitro and in vivo and unravel a still unknown function for presenilins... - Caspase-3-derived C-terminal product of synphilin-1 displays antiapoptotic function via modulation of the p53-dependent cell death pathwayEmilie Giaime
, CNRS, , , 660 route des Lucioles, 06560, Valbonne, France
J Biol Chem 281:11515-22. 2006..Altogether, our study is the first demonstration that synphilin-1 harbors a protective function that is controlled by the C-terminal fragment generated by its proteolysis by caspase-3... - Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's diseaseCristine Alves da Costa
Institut de Pharmacologie Moléculaire et Cellulaire of Centre National de la Recherche Scientifique, UMR6097, 06560 Valbonne, France
J Biol Chem 278:37330-5. 2003..In this context, the cross-talk between these two parent proteins is discussed... - p53-Dependent Aph-1 and Pen-2 anti-apoptotic phenotype requires the integrity of the gamma-secretase complex but is independent of its activityJulie Dunys
Institut de Pharmacologie Moleculaire et Cellulaire, UMR 6097 CNRS UNSA, Equipe labellisée, Fondation pour la Recherche Médicale, 660 route des Lucioles, 06560 Valbonne, France
J Biol Chem 282:10516-25. 2007..Our work also demonstrates that this phenotype is strictly dependent on the molecular integrity of the gamma-secretase complex but remains independent of the gamma-secretase catalytic activity... - The C-terminal products of cellular prion protein processing, C1 and C2, exert distinct influence on p53-dependent staurosporine-induced caspase-3 activationClaire Sunyach
Institut de Pharmacologie Moleculaire et Cellulaire du CNRS, UMR6097, université Nice Sophia Antipolis, Equipe labellisée Fondation pour la Recherche Médicale, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
J Biol Chem 282:1956-63. 2007..Therefore, the nature of the proteolytic cleavage taking place on PrP(c) yielded C-terminal catabolites with distinct function and could be seen as a switch mechanism controlling the function of the PrP(c) in cell survival... - Neprilysin activity and expression are controlled by nicastrinR Pardossi-Piquard
Institut de Pharmacologie Moléculaire et Cellulaire du Centre National de la Recherche Scientifique, Equipe labellisée Fondation pour la Recherche Médicale, Valbonne, France
J Neurochem 97:1052-6. 2006..This delayed effect on neprilysin expression correlates well with our demonstration of an indirect gamma-secretase-dependent modulation of neprilysin at its transcriptional level... - Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPalpha secretion: control by the proteasomeP Marambaud
Institut de Pharmacologie Moleculaire et Cellulaire, du CNRS, UPR411, 660 route des Lucioles, Sophia Antipolis, Valbonne, 06560, France
Biochem Biophys Res Commun 252:134-8. 1998..This protection against proteasomal degradation directly modulates the APPalpha secretion response elicited by wt- and FAD-linked PS2 expression in human HEK293 cells...