Luc Cynober

Summary

Country: France

Publications

  1. ncbi Pharmacokinetics of arginine and related amino acids
    Luc Cynober
    Clinical Chemistry Laboratory, Hotel Dieu Hospital, and Laboratory of Biological Nutrition EA 2498, Faculty of Pharmacy, University Paris 5 René Descartes, Paris 75006, France
    J Nutr 137:1646S-1649S. 2007
  2. ncbi Plasma citrulline: A marker of enterocyte mass in villous atrophy-associated small bowel disease
    Pascal Crenn
    Department of Hepagastroenterology and Nutrion Support, Hopital Lariboisiere, Paris, France
    Gastroenterology 124:1210-9. 2003
  3. ncbi Glutamine in the intensive care unit
    Luc Cynober
    aDepartment of Clinical Chemistry, Hôpitaux Universitaires Paris Centre, AP HP bLaboratory of Nutrition Biology EA 4466, Department of Experimental, Metabolic and Clinical Biology, Faculty of Pharmacy, Paris Descartes University, Sorbonne Paris Cité, Paris, France
    Curr Opin Clin Nutr Metab Care 17:98-104. 2014
  4. doi Fat mass protects hospitalized elderly persons against morbidity and mortality
    Olivier Bouillanne
    Hôpital Emile Roux, Assistance Publique Hopitaux de Paris, Limeil Brevannes, France
    Am J Clin Nutr 90:505-10. 2009
  5. ncbi Citrulline as a biomarker of intestinal failure due to enterocyte mass reduction
    Pascal Crenn
    Departement de Medecine, Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris, Universite de Versailles Saint Quentin en Yvelines, Garches, France
    Clin Nutr 27:328-39. 2008
  6. ncbi Tolerance and efficacy of a new enteral formula specifically designed for elderly persons: an experimental study in the aged rat
    Agathe Raynaud-Simon
    Geriatrics Department, Bichat University Hospital, Paris Cedex 18, France
    J Gerontol A Biol Sci Med Sci 63:669-77. 2008
  7. doi Plasma citrulline is a biomarker of enterocyte mass and an indicator of parenteral nutrition in HIV-infected patients
    Pascal Crenn
    Departement de Medecine, Hopital Raymond Poincare, AP HP, Universite de Versailles Saint Quentin en Yvelines, Garches, France
    Am J Clin Nutr 90:587-94. 2009
  8. doi Evidence that albumin is not a suitable marker of body composition-related nutritional status in elderly patients
    Olivier Bouillanne
    Service de Gérontologie 2, Hôpital Emile Roux, Assistance Publique Hopitaux de Paris, Limeil Brevannes, France
    Nutrition 27:165-9. 2011
  9. doi The 2009 ESPEN Sir David Cuthbertson. Citrulline: a new major signaling molecule or just another player in the pharmaconutrition game?
    Luc Cynober
    Laboratory of Biological Nutrition, EA 2498, Universite Paris Descartes, France
    Clin Nutr 29:545-51. 2010
  10. doi Effect of intestinal resections on arginine metabolism: practical implications for nutrition support
    Pascal Crenn
    Laboratoire de Biologie de Nutrition, EA 2498, Universite Paris Descartes, Faculte de Pharmacie, Paris, France
    Curr Opin Clin Nutr Metab Care 13:65-9. 2010

Collaborators

Detail Information

Publications58

  1. ncbi Pharmacokinetics of arginine and related amino acids
    Luc Cynober
    Clinical Chemistry Laboratory, Hotel Dieu Hospital, and Laboratory of Biological Nutrition EA 2498, Faculty of Pharmacy, University Paris 5 René Descartes, Paris 75006, France
    J Nutr 137:1646S-1649S. 2007
    ..To date, there have been no pharmacokinetic studies on the long-term administration of these AAs in healthy subjects despite the need to determine the safe upper limit of daily intake...
  2. ncbi Plasma citrulline: A marker of enterocyte mass in villous atrophy-associated small bowel disease
    Pascal Crenn
    Department of Hepagastroenterology and Nutrion Support, Hopital Lariboisiere, Paris, France
    Gastroenterology 124:1210-9. 2003
    ..Our objective was to evaluate citrulline as a marker of severity and extent of villous atrophy in patients without intestinal resection...
  3. ncbi Glutamine in the intensive care unit
    Luc Cynober
    aDepartment of Clinical Chemistry, Hôpitaux Universitaires Paris Centre, AP HP bLaboratory of Nutrition Biology EA 4466, Department of Experimental, Metabolic and Clinical Biology, Faculty of Pharmacy, Paris Descartes University, Sorbonne Paris Cité, Paris, France
    Curr Opin Clin Nutr Metab Care 17:98-104. 2014
    ..To analyze the recent literature (2011-2013) on glutamine supplementation of parenteral and enteral nutrition in critically ill patients. Potential confounding factors that may explain conflicting results are suggested...
  4. doi Fat mass protects hospitalized elderly persons against morbidity and mortality
    Olivier Bouillanne
    Hôpital Emile Roux, Assistance Publique Hopitaux de Paris, Limeil Brevannes, France
    Am J Clin Nutr 90:505-10. 2009
    ..However, these studies did not perform direct, separate, and reliable measurements of fat and lean mass by using a reference technique...
  5. ncbi Citrulline as a biomarker of intestinal failure due to enterocyte mass reduction
    Pascal Crenn
    Departement de Medecine, Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris, Universite de Versailles Saint Quentin en Yvelines, Garches, France
    Clin Nutr 27:328-39. 2008
    ..For this reason plasma or serum citrulline concentration has been proposed as a biomarker of remnant small bowel mass and function. This article reviews this concept and its metabolic basis...
  6. ncbi Tolerance and efficacy of a new enteral formula specifically designed for elderly persons: an experimental study in the aged rat
    Agathe Raynaud-Simon
    Geriatrics Department, Bichat University Hospital, Paris Cedex 18, France
    J Gerontol A Biol Sci Med Sci 63:669-77. 2008
    ..Threonine and isoleucine content in the soleus and gastrocnemius were higher in ESF-fed rats than SI-fed ones. ESF improved intestinal transit. Thus, in old rats, the ESF favored nutritional status more than a standard formula...
  7. doi Plasma citrulline is a biomarker of enterocyte mass and an indicator of parenteral nutrition in HIV-infected patients
    Pascal Crenn
    Departement de Medecine, Hopital Raymond Poincare, AP HP, Universite de Versailles Saint Quentin en Yvelines, Garches, France
    Am J Clin Nutr 90:587-94. 2009
    ..Plasma citrulline is a biomarker of enterocyte mass and function in humans...
  8. doi Evidence that albumin is not a suitable marker of body composition-related nutritional status in elderly patients
    Olivier Bouillanne
    Service de Gérontologie 2, Hôpital Emile Roux, Assistance Publique Hopitaux de Paris, Limeil Brevannes, France
    Nutrition 27:165-9. 2011
    ..Our objective was to clarify whether serum albumin in geriatric patients is a marker of body composition-related nutritional status, risk of morbidity/mortality, neither, or both...
  9. doi The 2009 ESPEN Sir David Cuthbertson. Citrulline: a new major signaling molecule or just another player in the pharmaconutrition game?
    Luc Cynober
    Laboratory of Biological Nutrition, EA 2498, Universite Paris Descartes, France
    Clin Nutr 29:545-51. 2010
    ..CIT could also be a safe way to deliver ARG to endothelial and immune cells, and can certainly prevent excessive uncontrolled nitric oxide production...
  10. doi Effect of intestinal resections on arginine metabolism: practical implications for nutrition support
    Pascal Crenn
    Laboratoire de Biologie de Nutrition, EA 2498, Universite Paris Descartes, Faculte de Pharmacie, Paris, France
    Curr Opin Clin Nutr Metab Care 13:65-9. 2010
    ..The present review relates recent developments in the understanding of arginine and citrulline metabolism and complementation after intestinal resection...
  11. doi Midregional pro-atrial natriuretic peptide for the diagnosis of cardiac-related dyspnea according to renal function in the emergency department: a comparison with B-type natriuretic peptide (BNP) and N-terminal proBNP
    Camille Chenevier-Gobeaux
    Department of Clinical Chemistry, Hôpital Cochin Hôtel Dieu, Assistance Publique Hopitaux de Paris, Paris, France
    Clin Chem 56:1708-17. 2010
    ..We evaluated the impact of renal function on MR-proANP concentrations and compared our results to those of BNP and NT-proBNP...
  12. ncbi L-arginine plus atorvastatin for prevention of atheroma formation in genetically hypercholesterolaemic rabbits
    Carole Rasmusen
    Laboratory of Biological Nutrition EA 2498, Faculty of Pharmacy, Paris Descartes University, 4 avenue de l Observatoire, 75270 Paris Cedex 06, France
    Br J Nutr 97:1083-9. 2007
    ..This is a relatively novel therapeutic approach associating a macronutrient and a drug...
  13. doi Arginine-supplemented enteral nutrition in critically ill diabetic and obese rats: a dose-ranging study evaluating nutritional status and macrophage function
    Sandra Bonhomme
    Laboratory of Biological Nutrition, EA 4466, Faculty of Pharmacy, Paris Descartes University, Paris, France
    Nutrition 29:305-12. 2013
    ..However, studies have raised concerns about possible adverse effects of such diets in intensive-care patients. We therefore analyzed the metabolic and immunologic effects of an arginine-enriched diet in stressed diabetic-obese rats...
  14. doi Leucine and citrulline: two major regulators of protein turnover
    Luc Cynober
    Clinical Chemistry Laboratory, Cochin and Hôtel Dieu Hospitals, AP HP, Paris Descartes University, Paris, France
    World Rev Nutr Diet 105:97-105. 2013
    ..Therefore, beyond a strong rationale, large clinical studies are required before any reliable recommendations can be issued on the use of leucine- or citrulline-enriched diets in ICU patients...
  15. ncbi In vivo induction of insulin secretion by ornithine alpha-ketoglutarate: involvement of nitric oxide and glutamine
    Christina Schneid
    INSERM U 341, Hotel Dieu Hospital, Paris and the Laboratoire de Biologie de la Nutrition, Paris 5 University EA 2498, Paris, France
    Metabolism 52:344-50. 2003
    ..Thus OKG acts directly with glucose on islets to induce insulin secretion via mechanisms involving NO and glutamine synthesis. In addition, our results suggest that OKG and glucose act via separate pathways...
  16. doi A proposal for an upper limit of leucine safe intake in healthy adults
    Luc Cynober
    Clinical Chemistry Laboratory, Cochin and Hôtel Dieu Hospitals, AP HP, Paris, France
    J Nutr 142:2249S-2250S. 2012
    ....
  17. ncbi Introduction to the 5th Amino Acid Assessment Workshop
    Luc Cynober
    Clinical Chemistry Laboratory, Hôtel Dieu Hospital AP HP and Laboratory of Biological Nutrition EA 2498, Pharmacy Faculty, Paris Descartes University, Paris, France
    J Nutr 136:1633S-1635S. 2006
    ..The fourth AAAW focused on branched-chain AAs. The articles in this supplement issue of the journal summarize the fifth workshop in the series, which focused on sulfur amino acids...
  18. ncbi Ornithine alpha-ketoglutarate metabolism in the healthy rat in the postabsorptive state
    Cécile Loï
    Faculte de Pharmacie, Laboratoire de Biologie de la Nutrition, EA 2498, Paris Descartes University, 75270 Paris Cedex 6, France
    Metabolism 54:1108-14. 2005
    ....
  19. ncbi The feeding route (enteral or parenteral) affects the plasma response of the dipetide Ala-Gln and the amino acids glutamine, citrulline and arginine, with the administration of Ala-Gln in preoperative patients
    Gerdien C Melis
    Department of Surgery, VU University Medical Centre, Amsterdam, The Netherlands
    Br J Nutr 94:19-26. 2005
    ..Interestingly, in spite of the high availability of citrulline with enteral administration of the dipeptide, only parenteral infusion of Ala-Gln increased plasma arginine concentration...
  20. ncbi Does the ornithine-alpha-ketoglutarate ratio influence ornithine alpha-ketoglutarate metabolism in healthy rats?
    Cécile Loï
    Laboratoire de Biologie de la Nutrition, EA 2498, Faculte de Pharmacie, Universite Paris Descartes, 75270 Paris Cedex 06, France
    Metabolism 56:105-14. 2007
    ....
  21. ncbi Impairment of lymphocyte function in head-injured rats: effects of standard and immune-enhancing diets for enteral nutrition
    Linda Belabed
    Laboratoire de Biologie de la Nutrition EA2498, 4 avenue de l Observatoire, 75270 Paris Cedex 06, France
    Clin Nutr 25:832-41. 2006
    ..The aim of the study was to investigate the consequences of HI on lymphocyte function and to determine the effects of an enteral IED comparatively to a standard enteral nutrition...
  22. ncbi Taurine status and response to intravenous taurine supplementation in adults with short-bowel syndrome undergoing long-term parenteral nutrition: a pilot study
    Stephane M Schneider
    AP HP Saint Lazare Hospital, Gastroenterology and Nutrition Support Unit, Paris, France
    Br J Nutr 96:365-70. 2006
    ....
  23. ncbi Arginine-enriched diet limits plasma and muscle glutamine depletion in head-injured rats
    Christophe Moinard
    Laboratoire de Biologie de la Nutrition, EA2498, Faculte de Pharmacie, Universite Rene Descartes, Paris, France
    Nutrition 22:1039-44. 2006
    ..This study investigated the ability of an enteral formula enriched with ARG to restore the GLN pools in an experimental model of head injury...
  24. ncbi Arginine does not exacerbate markers of inflammation in cocultures of human enterocytes and leukocytes
    Alexandr Parlesak
    Department of Physiology of Nutrition, Hohenheim University, D 70593 Stuttgart, Germany
    J Nutr 137:106-11. 2007
    ..Because it also does not seem to affect the integrity of enterocyte layers, a detrimental role of arginine during septic-like conditions seems unlikely...
  25. ncbi Citrulline and the gut
    Emmanuel Curis
    Laboratoire de Biomathématiques, Faculte de Pharmacie, Universite Paris Descartes, Paris, France
    Curr Opin Clin Nutr Metab Care 10:620-6. 2007
    ..This review discusses these two aspects of citrulline, as well as the recent developments in the understanding of its metabolism...
  26. ncbi Dose dependency of the effect of ornithine alpha-ketoglutarate on tissue glutamine concentrations and hypercatabolic response in endotoxaemic rats
    Pascal Pernet
    Service de Biochimie A, Hopital Saint Antoine, Paris, France
    Br J Nutr 92:627-34. 2004
    ..05). In conclusion, OKG exerted a dose-dependent effect on tissue Gln concentration and N balance, but only the highest dosage counteracted myofibrillar hypercatabolism and caused a positive N balance...
  27. ncbi Impairment of arginine metabolism in rats after massive intestinal resection: effect of parenteral nutrition supplemented with citrulline compared with arginine
    Sylwia Osowska
    Laboratoire de Biologie de la Nutrition, EA 2498, Faculté de Pharmacie Université Paris Descartes, 4 avenue de l Observatoire, 75270 Paris Cedex 06, France
    Clin Sci (Lond) 115:159-66. 2008
    ..These results suggest that citrulline should be considered as a potential supplement for total parenteral nutrition of short bowel syndrome patients...
  28. ncbi About immune-enhancing diets in critically ill patients
    Luc Cynober
    Crit Care Med 35:329-30; author reply 330. 2007
  29. ncbi General discussion at 2nd Amino Acid Assessment Workshop (2nd AAAW)
    Luc Cynober
    Nutrition Department, Pharmacy School, Paris 5 University and Biochem Lab, Hotel Dieu Hospital, Paris, France
    J Nutr 133:2101S-2107S. 2003
  30. doi Evidence for impairment of hepatic energy homeostasis in head-injured rat
    Christophe Moinard
    Laboratoire de Biologie de la Nutrition EA 2498, Faculte de Pharmacie, Universite Paris Descartes, Paris, France
    J Neurotrauma 25:124-9. 2008
    ..These findings demonstrate that TBI is responsible for an impairment of liver energy homeostasis. Moreover, these alterations are related neither to anorexia nor to decreased mitochondrial oxidative capacity...
  31. ncbi Sex-differential expression of ornithine aminotransferase in the mouse kidney
    Olivier Levillain
    Universite Claude Bernard Lyon I, Faculté de Médecine Lyon RTH Laënnec, Laboratoire de Physiopathologie Métabolique et Rénale, Institut National de la Santé et de la Recherche Médicale INSERM U 499, Lyon, France
    Am J Physiol Renal Physiol 292:F1016-27. 2007
    ..Expression of medium-chain acyl-CoA synthetase protein confirmed this finding. We report sexual dimorphism of Oat expression in the mouse kidney and show that Oat is naturally downregulated in the presence of testosterone...
  32. doi We must improve our understanding of the basic mechanisms of the different phases of sepsis
    Luc Cynober
    Clin Nutr 27:311-2. 2008
  33. ncbi Effect of an immune-enhancing diet on lymphocyte in head-injured rats: what is the role of arginine?
    Djamel Hamani
    Universite Paris Descartes, Faculte de Pharmacie, Laboratoire de Biologie de la Nutrition EA2498, 4 avenue de l Observatoire, 75270, Paris Cedex 06, France
    Intensive Care Med 33:1076-84. 2007
    ..The aim of this study was to determine the role of arginine in the immunomodulatory effects of an IED (Crucial) in head-injured rats...
  34. ncbi Citrulline: a new player in the control of nitrogen homeostasis
    Christophe Moinard
    Laboratoire de Biologie de la Nutrition, EA 2498, Faculte de Pharmacie, Universite Paris Descartes, and Laboratoire Biochimie, Hotel Dieu, AP HP, Paris 75004, France
    J Nutr 137:1621S-1625S. 2007
    ....
  35. ncbi Effects of ornithine alpha-ketoglutarate on protein metabolism in Yoshida sarcoma-bearing rats
    Frédéric Segaud
    Laboratoire de Biologie de la Nutrition EA 2498, Faculte de Pharmacie, Universite Paris Descartes, 4 avenue de l Observatoire, 75270 Paris, Cedex 06, France
    Clin Nutr 26:624-30. 2007
    ....
  36. ncbi Protective effects of regulatory amino acids on ischemia-reperfusion injury in the isolated perfused rat liver
    Heidi Schuster
    Laboratoire de Biologie de la Nutrition, EA2498, Faculte de Pharmacie, Universite Paris 5, Paris, France
    Scand J Gastroenterol 41:1342-9. 2006
    ..The aim of this study was to evaluate the protective effect of these AAs on warm ischaemia-reperfusion (I/R) injury in the isolated perfused rat liver...
  37. ncbi Pre- and postoperative aminoacidemia in breast cancer: a study vs. matched healthy subjects
    Régine Minet-Quinard
    Laboratoire de Biochimie, Biologie Moléculaire et Nutrition, Faculte de Pharmacie, Clermont Ferrand, France
    Cancer Invest 22:203-10. 2004
    ..Among the various patterns reported for breast cancer, we confirm one of those described by Cascino in 1995, and we show that these levels revert to normal after tumor surgical removal...
  38. ncbi General Discussion at the 3rd Amino Acid Assessment Workshop (3rd AAAW)
    Luc Cynober
    Nutrition Department, Pharmacy School, Paris 5 University and Biochem Lab, Hotel Dieu Hospital, Paris, France and Laboratory of Human Nutrition, Massachusetts Institute of Technology, Cambridge MA 02139
    J Nutr 134:1667S-72S. 2004
  39. ncbi Isolated perfused liver model: the rat and guinea pig compared
    Samira Chaib
    Laboratoire de Biologie de la Nutrition EA 2498, Faculte de Pharmacie, Laboratoire de Biochimie A, Hôpital Hotel Dieu AP HP, Paris, France
    Nutrition 20:458-64. 2004
    ..We compared the model of isolated perfused guinea pig liver with the classic model of isolated perfused rat liver, especially with respect to amino acid metabolism...
  40. ncbi Asymmetrical dimethylarginine and multiple organ failure
    Luc Cynober
    Clin Nutr 22:505; author reply 505-6. 2003
  41. ncbi Lessons from pharmacokinetics in the design of new nutrition formulas for critically ill patients
    Luc Cynober
    Biochemistry Laboratory, Hotel Dieu Hospital, AP HP, Laboratory of Biological Nutrition EA 2498, Pharmacy School, Paris 5 University, Paris, France
    Nestle Nutr Workshop Ser Clin Perform Programme 8:265-72; discussion 272-7. 2003
  42. ncbi Immune-enhancing diets for stressed patients with a special emphasis on arginine content: analysis of the analysis
    Luc Cynober
    Biochemistry Laboratory, Hôtel Dieu Hospital AP HO, and Nutrition Laboratory, University Paris 5, Paris, France
    Curr Opin Clin Nutr Metab Care 6:189-93. 2003
    ..An American consensus and a meta-analysis provide divergent conclusions. The main goal of the present review is to analyze these documents...
  43. ncbi Effects of ornithine alpha-ketoglutarate on insulin secretion in rat pancreatic islets: implication of nitric oxide synthase and glutamine synthetase pathways
    Christina Schneid
    INSERM U 341, Service de Diabetologie, Hopital Hotel Dieu, Paris, France
    Br J Nutr 89:249-57. 2003
    ..A better understanding of OKG insulino-secretory properties and its mechanisms of action are a prerequisite for its use in insulin-compromised situations...
  44. ncbi Evidence that glutamine modulates respiratory burst in stressed rat polymorphonuclear cells through its metabolism into arginine
    Christophe Moinard
    Laboratoire de Biochimie, Biologie Moléculaire et Nutrition EA 2416 and Centre de Recherche en Nutrition Humaine, Faculte de Pharmacie, Clermont Ferrand, France
    Br J Nutr 88:689-95. 2002
    ..In vivo inhibition of GLN synthase did not modify the effect of ARG on ROS production. In conclusion, GLN and ARG modulate ROS production in neutrophils from stressed rats by the same pathway involving polyamine and NO* synthesis...
  45. ncbi Qualitative manipulation of amino acid supply during total parenteral nutrition in surgical patients
    Marie Pierre Bérard
    Laboratoire de Biologie de la Nutrition, Universite de Paris V, France
    JPEN J Parenter Enteral Nutr 26:136-43. 2002
    ..An appropriate mixture would limit plasma amino acid imbalances and improve nitrogen retention. This therapy must now be tested in a larger population of patients...
  46. ncbi Ornithine alpha-ketoglutarate supplementation influences motor activity in healthy rats
    Christophe Moinard
    Laboratoire de Biologie de la Nutrition EA 2498, Faculte de Pharmacie, 4, avenue de l Observatoire, Paris, Cedex 06 75270, France
    Clin Nutr 23:485-90. 2004
    ..Ornithine alpha-ketoglutarate (OKG) improves nutritional status in malnourished patients. Published and unpublished data suggest OKG may have effects on the central nervous system that may contribute to its action...
  47. ncbi C-reactive protein and body mass index predict outcome in end-stage respiratory failure
    Noël J M Cano
    Departement de Nutrition, Clinique Residence du Parc, Rue Gaston Berger, 13010 Marseille, France
    Chest 126:540-6. 2004
    ..To determine the predictive factors of morbidity and mortality in patients with end-stage respiratory disease...
  48. ncbi Arginine and glutamine availability and macrophage functions in the obese insulin-resistant Zucker rat
    Marie Céline Blanc
    Laboratoire de Biologie de la Nutrition, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris 5 Rene Descartes, Paris, France
    J Cell Physiol 202:153-9. 2005
    ....
  49. ncbi Does dietary ornithine alpha-ketoglutarate supplementation protect the liver against ischemia-reperfusion injury?
    Heidi Schuster
    Laboratoire de Biologie de la Nutrition, EA2498, Faculte de Pharmacie, Universite Paris 5, 4 avenue de l Observatoire, 75270 Paris Cedex 06, France
    Clin Nutr 24:375-84. 2005
    ..This action can tentatively be attributed to the role of OKG as a glutamine precursor rather than to the synthesis of arginine and nitric oxide...
  50. ncbi Evaluation of a glycine-rich amino acid solution for parenteral nutrition in endotoxemic rats
    Cécile Loï
    Laboratoire de Biologie de la Nutrition, Faculte de Pharmacie, Paris 5, France
    Crit Care Med 33:2344-9. 2005
    ..The aim of this study was to compare the nutritional effects of a glycine-rich amino acid solution for parenteral nutrition (AFD) with a standard one (Vintene) (glycine, 15 vs. 9 g/L) in endotoxemic rats...
  51. ncbi Geriatric Nutritional Risk Index: a new index for evaluating at-risk elderly medical patients
    Olivier Bouillanne
    Services de Gérontologie 2 and Biologie de la Nutrition EA2498, Universite Paris 5, Paris, France
    Am J Clin Nutr 82:777-83. 2005
    ..However, this index remains limited for elderly patients because of difficulties in establishing their normal weight...
  52. ncbi Pretreatment of starved rats with ornithine alpha-ketoglutarate: effects on hepatic mRNA levels and plasma concentrations of three liver-secreted proteins
    Frédéric Segaud
    Laboratoire de Biologie de la Nutrition EA 2498, Faculte de Pharmacie, Paris, France
    Nutrition 21:732-9. 2005
    ..This study investigated in vivo the ability of OKG to modulate hepatic gene expression of three liver-secreted proteins: albumin, transthyretin, and retinol binding protein...
  53. ncbi Polyamines: metabolism and implications in human diseases
    Christophe Moinard
    Laboratoire de Biologie de la Nutrition EA 2498, Faculte de Pharmacie, 4, avenue de l Observatoire, 75270 Paris Cedex 06, France
    Clin Nutr 24:184-97. 2005
    ..This paper summarises the knowledge about polyamines metabolism and point out the importance of these molecules as a target for the development of therapeutic tools and nutritional strategy...
  54. ncbi Characterization of the alteration of nutritional state in brain injury induced by fluid percussion in rats
    Christophe Moinard
    Laboratoire de Biologie de la Nutrition EA 2498, Faculte de Pharmacie, 4 avenue de l Observatoire, 75270 Paris Cedex 06, France
    Intensive Care Med 31:281-8. 2005
    ..This study characterized the hypercatabolism level and nutritional status of TBI rats...
  55. ncbi Aortic banding in rat as a model to investigate malnutrition associated with heart failure
    Cécile Héliès-Toussaint
    INRA UR 1154 LMFC, Faculte de Pharmacie, 5, rue J B Clement, F 92290 Châtenay Malabry France
    Am J Physiol Regul Integr Comp Physiol 288:R1325-31. 2005
    ..These rats with heart failure displayed a multiorgan failure and malnutrition, which reflected the clinical situation of human chronic heart failure...
  56. ncbi Effect of aging on liver functions-an experimental study in a perfused rat liver model
    Marion Jourdan
    Laboratory of Biological Nutrition EA 2498, 4 avenue de l Observatoire 75270 Paris cedex 06, France
    Exp Gerontol 39:1341-6. 2004
    ..Bile flow was also recorded. As ICG is removed exclusively by the liver without bioconversion, its clearance reflects hepatic functional mass...
  57. ncbi Ornithine alpha-ketoglutarate as a potent precursor of arginine and nitric oxide: a new job for an old friend
    Luc Cynober
    Biochemistry Laboratory, Hôtel Dieu Hospital AP HP and Laboratory of Biological Nutrition EA 2498, School of Pharmacy, Paris 5 University
    J Nutr 134:2858S-2862S; discussion 2895S. 2004
    ..The use of genetically modified animals (i.e., knockout for NOS expression) is required to confirm this hypothesis...
  58. ncbi Effects of ornithine 2-oxoglutarate on neutrophils in stressed rats: evidence for the involvement of nitric oxide and polyamines
    Christophe Moinard
    Laboratoire de Biochimie, Biologie Moléculaire et Nutrition EA 2416 and Centre de Recherche en Nutrition Humaine, Faculte de Pharmacie, 63001 Clermont Ferrand, France
    Clin Sci (Lond) 102:287-95. 2002
    ..These data suggest that OKG (or its metabolites) and arginine are channelled differently in PMNs. This hypothesis deserves further study...