Luc Cynober

Summary

Country: France

Publications

  1. ncbi request reprint [Nutritional support at the hospital: diagnosis of malnutrition and its associated risks for better prevention and treatment]
    Luc Cynober
    Service inter hospitalier de Biochimie, Hôpital Cochin Hôtel Dieu, 27, rue du Faubourg Saint Jacques, 75679 Paris Cedex 14
    Bull Acad Natl Med 195:645-56; discussion 656-60. 2011
  2. doi request reprint A proposal for an upper limit of leucine safe intake in healthy adults
    Luc Cynober
    Clinical Chemistry Laboratory, Cochin and Hôtel Dieu Hospitals, AP HP, Paris, France
    J Nutr 142:2249S-2250S. 2012
  3. doi request reprint How nutritional risk is assessed and managed in European hospitals: a survey of 21,007 patients findings from the 2007-2008 cross-sectional nutritionDay survey
    Karin Schindler
    Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Clin Nutr 29:552-9. 2010
  4. doi request reprint The 2009 ESPEN Sir David Cuthbertson. Citrulline: a new major signaling molecule or just another player in the pharmaconutrition game?
    Luc Cynober
    Laboratory of Biological Nutrition, EA 2498, Universite Paris Descartes, France
    Clin Nutr 29:545-51. 2010
  5. doi request reprint Effects of a diabetes-specific enteral nutrition on nutritional and immune status of diabetic, obese, and endotoxemic rats: interest of a graded arginine supply
    Charlotte Breuillard
    Laboratoire de Biologie de la Nutrition, Faculte de Pharmacie, Universite Paris Descartes, Service de Biochimie, Hôpitaux Universitaires Paris Centre, Paris, France
    Crit Care Med 40:2423-30. 2012
  6. ncbi request reprint Does the ornithine-alpha-ketoglutarate ratio influence ornithine alpha-ketoglutarate metabolism in healthy rats?
    Cécile Loï
    Laboratoire de Biologie de la Nutrition, EA 2498, Faculte de Pharmacie, Universite Paris Descartes, 75270 Paris Cedex 06, France
    Metabolism 56:105-14. 2007
  7. ncbi request reprint In vivo induction of insulin secretion by ornithine alpha-ketoglutarate: involvement of nitric oxide and glutamine
    Christina Schneid
    INSERM U 341, Hotel Dieu Hospital, Paris and the Laboratoire de Biologie de la Nutrition, Paris 5 University EA 2498, Paris, France
    Metabolism 52:344-50. 2003
  8. doi request reprint Impairment of arginine metabolism in rats after massive intestinal resection: effect of parenteral nutrition supplemented with citrulline compared with arginine
    Sylwia Osowska
    Laboratoire de Biologie de la Nutrition, EA 2498, Faculté de Pharmacie Université Paris Descartes, 4 avenue de l Observatoire, 75270 Paris Cedex 06, France
    Clin Sci (Lond) 115:159-66. 2008
  9. doi request reprint Arginine-supplemented enteral nutrition in critically ill diabetic and obese rats: a dose-ranging study evaluating nutritional status and macrophage function
    Sandra Bonhomme
    Laboratory of Biological Nutrition, EA 4466, Faculty of Pharmacy, Paris Descartes University, Paris, France
    Nutrition 29:305-12. 2013
  10. ncbi request reprint Protective effects of regulatory amino acids on ischemia-reperfusion injury in the isolated perfused rat liver
    Heidi Schuster
    Laboratoire de Biologie de la Nutrition, EA2498, Faculte de Pharmacie, Universite Paris 5, Paris, France
    Scand J Gastroenterol 41:1342-9. 2006

Collaborators

Detail Information

Publications59

  1. ncbi request reprint [Nutritional support at the hospital: diagnosis of malnutrition and its associated risks for better prevention and treatment]
    Luc Cynober
    Service inter hospitalier de Biochimie, Hôpital Cochin Hôtel Dieu, 27, rue du Faubourg Saint Jacques, 75679 Paris Cedex 14
    Bull Acad Natl Med 195:645-56; discussion 656-60. 2011
    ....
  2. doi request reprint A proposal for an upper limit of leucine safe intake in healthy adults
    Luc Cynober
    Clinical Chemistry Laboratory, Cochin and Hôtel Dieu Hospitals, AP HP, Paris, France
    J Nutr 142:2249S-2250S. 2012
    ....
  3. doi request reprint How nutritional risk is assessed and managed in European hospitals: a survey of 21,007 patients findings from the 2007-2008 cross-sectional nutritionDay survey
    Karin Schindler
    Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Clin Nutr 29:552-9. 2010
    ..Recognition and treatment of undernutrition in hospitalized patients are not often a priority in clinical practice...
  4. doi request reprint The 2009 ESPEN Sir David Cuthbertson. Citrulline: a new major signaling molecule or just another player in the pharmaconutrition game?
    Luc Cynober
    Laboratory of Biological Nutrition, EA 2498, Universite Paris Descartes, France
    Clin Nutr 29:545-51. 2010
    ..CIT could also be a safe way to deliver ARG to endothelial and immune cells, and can certainly prevent excessive uncontrolled nitric oxide production...
  5. doi request reprint Effects of a diabetes-specific enteral nutrition on nutritional and immune status of diabetic, obese, and endotoxemic rats: interest of a graded arginine supply
    Charlotte Breuillard
    Laboratoire de Biologie de la Nutrition, Faculte de Pharmacie, Universite Paris Descartes, Service de Biochimie, Hôpitaux Universitaires Paris Centre, Paris, France
    Crit Care Med 40:2423-30. 2012
    ..As a large intake of arginine may be deleterious, this amino acid was given in graded fashion...
  6. ncbi request reprint Does the ornithine-alpha-ketoglutarate ratio influence ornithine alpha-ketoglutarate metabolism in healthy rats?
    Cécile Loï
    Laboratoire de Biologie de la Nutrition, EA 2498, Faculte de Pharmacie, Universite Paris Descartes, 75270 Paris Cedex 06, France
    Metabolism 56:105-14. 2007
    ....
  7. ncbi request reprint In vivo induction of insulin secretion by ornithine alpha-ketoglutarate: involvement of nitric oxide and glutamine
    Christina Schneid
    INSERM U 341, Hotel Dieu Hospital, Paris and the Laboratoire de Biologie de la Nutrition, Paris 5 University EA 2498, Paris, France
    Metabolism 52:344-50. 2003
    ..Thus OKG acts directly with glucose on islets to induce insulin secretion via mechanisms involving NO and glutamine synthesis. In addition, our results suggest that OKG and glucose act via separate pathways...
  8. doi request reprint Impairment of arginine metabolism in rats after massive intestinal resection: effect of parenteral nutrition supplemented with citrulline compared with arginine
    Sylwia Osowska
    Laboratoire de Biologie de la Nutrition, EA 2498, Faculté de Pharmacie Université Paris Descartes, 4 avenue de l Observatoire, 75270 Paris Cedex 06, France
    Clin Sci (Lond) 115:159-66. 2008
    ..These results suggest that citrulline should be considered as a potential supplement for total parenteral nutrition of short bowel syndrome patients...
  9. doi request reprint Arginine-supplemented enteral nutrition in critically ill diabetic and obese rats: a dose-ranging study evaluating nutritional status and macrophage function
    Sandra Bonhomme
    Laboratory of Biological Nutrition, EA 4466, Faculty of Pharmacy, Paris Descartes University, Paris, France
    Nutrition 29:305-12. 2013
    ..However, studies have raised concerns about possible adverse effects of such diets in intensive-care patients. We therefore analyzed the metabolic and immunologic effects of an arginine-enriched diet in stressed diabetic-obese rats...
  10. ncbi request reprint Protective effects of regulatory amino acids on ischemia-reperfusion injury in the isolated perfused rat liver
    Heidi Schuster
    Laboratoire de Biologie de la Nutrition, EA2498, Faculte de Pharmacie, Universite Paris 5, Paris, France
    Scand J Gastroenterol 41:1342-9. 2006
    ..The aim of this study was to evaluate the protective effect of these AAs on warm ischaemia-reperfusion (I/R) injury in the isolated perfused rat liver...
  11. doi request reprint Endotoxemia affects citrulline, arginine and glutamine bioavailability
    Fatimazahra Elwafi
    Laboratoire de Pharmacie Galenique, UPRES EA 4466, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris Descartes, Paris, France
    Eur J Clin Invest 42:282-9. 2012
    ..However, the effects of septic shock on aminoacid (AAs) bioavailability are poorly documented. The aim of this study was to compare the bioavailability of citrulline, arginine and glutamine during endotoxemia...
  12. doi request reprint In vivo bioluminescent imaging of a new model of infectious complications in head-injury rats
    Christophe Moinard
    Laboratoire de Biologie de la Nutrition EA 4466, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
    J Neurotrauma 29:335-42. 2012
    ..Combined with the in vivo monitoring of the infection by bioluminescence, this model offers a valuable tool to evaluate specific strategies for HI patients...
  13. doi request reprint Evidence for impairment of hepatic energy homeostasis in head-injured rat
    Christophe Moinard
    Laboratoire de Biologie de la Nutrition EA 2498, Faculte de Pharmacie, Universite Paris Descartes, Paris, France
    J Neurotrauma 25:124-9. 2008
    ..These findings demonstrate that TBI is responsible for an impairment of liver energy homeostasis. Moreover, these alterations are related neither to anorexia nor to decreased mitochondrial oxidative capacity...
  14. doi request reprint Overexpression of ornithine aminotransferase: consequences on amino acid homeostasis
    Gabrielle Ventura
    Laboratoire de Biologie de la Nutrition EA2498, Faculte de Pharmacie, Universite Paris Descartes, 4 avenue de l Observatoire, 75270 Paris Cedex 06, France
    Br J Nutr 101:843-51. 2009
    ..We conclude that OAT overexpression has only limited metabolic effects, probably due to the reversible nature of the enzyme. Moreover, these metabolic modifications had no effect on phenotype...
  15. doi request reprint Metabolic response and nutritional support in traumatic brain injury: evidence for resistance to renutrition
    Christine Charrueau
    Laboratoire de Pharmacie Galenique, EA2498, Universite Paris Descartes, Faculte des Sciences Pharmaceutiques et Biologiques, Paris, France
    J Neurotrauma 26:1911-20. 2009
    ..It also demonstrates that using standard enteral nutrition cannot reverse this phenomenon. Thus, developing new nutritional strategies to cover TBI patients' specific nutritional requirements appears mandatory...
  16. ncbi request reprint Arginine-enriched diet limits plasma and muscle glutamine depletion in head-injured rats
    Christophe Moinard
    Laboratoire de Biologie de la Nutrition, EA2498, Faculte de Pharmacie, Universite Rene Descartes, Paris, France
    Nutrition 22:1039-44. 2006
    ..This study investigated the ability of an enteral formula enriched with ARG to restore the GLN pools in an experimental model of head injury...
  17. doi request reprint Increasing plasma glutamine in postoperative patients fed an arginine-rich immune-enhancing diet--a pharmacokinetic randomized controlled study
    Cécile Loï
    Laboratoire de Biologie de la Nutrition, Faculte de Pharmacie, Universite Paris Descartes, France
    Crit Care Med 37:501-9. 2009
    ..To analyze plasma GLN and related amino acid (AA) kinetics in response to an ARG-enriched IED in ICU surgical patients...
  18. ncbi request reprint Effects of ornithine alpha-ketoglutarate on protein metabolism in Yoshida sarcoma-bearing rats
    Frédéric Segaud
    Laboratoire de Biologie de la Nutrition EA 2498, Faculte de Pharmacie, Universite Paris Descartes, 4 avenue de l Observatoire, 75270 Paris, Cedex 06, France
    Clin Nutr 26:624-30. 2007
    ....
  19. ncbi request reprint Dose dependency of the effect of ornithine alpha-ketoglutarate on tissue glutamine concentrations and hypercatabolic response in endotoxaemic rats
    Pascal Pernet
    Service de Biochimie A, Hopital Saint Antoine, Paris, France
    Br J Nutr 92:627-34. 2004
    ..05). In conclusion, OKG exerted a dose-dependent effect on tissue Gln concentration and N balance, but only the highest dosage counteracted myofibrillar hypercatabolism and caused a positive N balance...
  20. ncbi request reprint Citrulline and the gut
    Emmanuel Curis
    Laboratoire de Biomathématiques, Faculte de Pharmacie, Universite Paris Descartes, Paris, France
    Curr Opin Clin Nutr Metab Care 10:620-6. 2007
    ..This review discusses these two aspects of citrulline, as well as the recent developments in the understanding of its metabolism...
  21. doi request reprint Plasma citrulline is a biomarker of enterocyte mass and an indicator of parenteral nutrition in HIV-infected patients
    Pascal Crenn
    Departement de Medecine, Hopital Raymond Poincare, AP HP, Universite de Versailles Saint Quentin en Yvelines, Garches, France
    Am J Clin Nutr 90:587-94. 2009
    ..Plasma citrulline is a biomarker of enterocyte mass and function in humans...
  22. doi request reprint Leucine and citrulline modulate muscle function in malnourished aged rats
    Cécile Faure
    Département de Biologie Expérimentale, Métabolique et Clinique EA 4466, Faculte de Pharmacie, Universite Paris Descartes, 75 270, Paris Cedex 06, France
    Amino Acids 42:1425-33. 2012
    ..05, respectively) but only leucine improved maximal tetanic isometric force (+101%, P < 0.05). In conclusion, this is the first study to demonstrate the ability of two amino acids (leucine and citrulline) to modulate muscle function...
  23. doi request reprint Arginine reduces bacterial invasion in rats with head injury: an in vivo evaluation by bioluminescence
    Christophe Moinard
    Laboratory Biologie de la Nutrition EA 4466, Faculté des Sciences Pharmaceutiques et Biologiques de l Université Paris Descartes, Paris, France
    Crit Care Med 40:278-80. 2012
    ..However, this claim is not supported by any experimental or clinical data. We set out to determine whether an enteral supply of arginine would modulate bacterial invasion in rats with head injury...
  24. ncbi request reprint Effect of an immune-enhancing diet on lymphocyte in head-injured rats: what is the role of arginine?
    Djamel Hamani
    Universite Paris Descartes, Faculte de Pharmacie, Laboratoire de Biologie de la Nutrition EA2498, 4 avenue de l Observatoire, 75270, Paris Cedex 06, France
    Intensive Care Med 33:1076-84. 2007
    ..The aim of this study was to determine the role of arginine in the immunomodulatory effects of an IED (Crucial) in head-injured rats...
  25. ncbi request reprint Pretreatment of starved rats with ornithine alpha-ketoglutarate: effects on hepatic mRNA levels and plasma concentrations of three liver-secreted proteins
    Frédéric Segaud
    Laboratoire de Biologie de la Nutrition EA 2498, Faculte de Pharmacie, Paris, France
    Nutrition 21:732-9. 2005
    ..This study investigated in vivo the ability of OKG to modulate hepatic gene expression of three liver-secreted proteins: albumin, transthyretin, and retinol binding protein...
  26. ncbi request reprint Ornithine alpha-ketoglutarate metabolism in the healthy rat in the postabsorptive state
    Cécile Loï
    Faculte de Pharmacie, Laboratoire de Biologie de la Nutrition, EA 2498, Paris Descartes University, 75270 Paris Cedex 6, France
    Metabolism 54:1108-14. 2005
    ....
  27. doi request reprint Interactions between ω3 polyunsaturated fatty acids and arginine on nutritional and immunological aspects in severe inflammation
    Djamel Hamani
    Laboratoire de Biologie de la Nutrition EA2498, Faculte de Pharmacie, Universite Paris Descartes, 4 avenue de l Observatoire, 75270 Paris, Cedex 06, France
    Clin Nutr 29:654-62. 2010
    ..The aim of this study was to examine the role of arginine (Arg) and ω3 polyunsaturated fatty acids (ω3 PUFAs) in the effect of an IED (Crucial(®)) in a validated rat model of inflammation induced by turpentine (TI)...
  28. doi request reprint Effect of intestinal resections on arginine metabolism: practical implications for nutrition support
    Pascal Crenn
    Laboratoire de Biologie de Nutrition, EA 2498, Universite Paris Descartes, Faculte de Pharmacie, Paris, France
    Curr Opin Clin Nutr Metab Care 13:65-9. 2010
    ..The present review relates recent developments in the understanding of arginine and citrulline metabolism and complementation after intestinal resection...
  29. ncbi request reprint Arginine and glutamine availability and macrophage functions in the obese insulin-resistant Zucker rat
    Marie Céline Blanc
    Laboratoire de Biologie de la Nutrition, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris 5 Rene Descartes, Paris, France
    J Cell Physiol 202:153-9. 2005
    ....
  30. doi request reprint Effects of leucine and citrulline versus non-essential amino acids on muscle protein synthesis in fasted rat: a common activation pathway?
    Servane Le Plenier
    Département Biologie Expérimentale, Métabolique et Clinique, Faculte de Pharmacie, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
    Amino Acids 43:1171-8. 2012
    ..LEU, CIT and NEAA may have different actions on MPS in this model as they share different mTORC1 regulation capacities...
  31. doi request reprint Arginine or citrulline associated with a statin stimulates nitric oxide production in bovine aortic endothelial cells
    Marie Clotilde Berthe
    Laboratoire de Biologie de la Nutrition, EA2498, Universite Paris Descartes, France
    Eur J Pharmacol 670:566-70. 2011
    ..These results form a strong rationale to evaluate the potential utilization of these in atherosclerosis prevention and treatment...
  32. doi request reprint An oligomeric diet limits the response to injury in traumatic brain-injured rats
    Christophe Moinard
    Laboratoire de Biologie de la Nutrition, EA 4466, Universite Paris Descartes, Faculte des Sciences Pharmaceutiques et Biologiques, Sorbonne Paris Cité, Paris, France
    J Neurotrauma 30:975-80. 2013
    ..05) and soleus muscle. These results show that the use of an oligomeric diet may limit response to injury after brain injury and could be a simple nutritional strategy in this setting...
  33. doi request reprint High plasma citrulline and arginine levels ensured by sustained-release citrulline supplementation in rats
    Marie Clotilde Berthe
    Laboratoire de Biologie de la Nutrition, EA2498, Universite Paris Descartes, Paris, France
    Nutrition 27:1168-71. 2011
    ..However, citrulline is very rapidly metabolized. We therefore developed a sustained-release form of citrulline and evaluated its metabolic behavior in rats...
  34. ncbi request reprint Ornithine alpha-ketoglutarate supplementation influences motor activity in healthy rats
    Christophe Moinard
    Laboratoire de Biologie de la Nutrition EA 2498, Faculte de Pharmacie, 4, avenue de l Observatoire, Paris, Cedex 06 75270, France
    Clin Nutr 23:485-90. 2004
    ..Ornithine alpha-ketoglutarate (OKG) improves nutritional status in malnourished patients. Published and unpublished data suggest OKG may have effects on the central nervous system that may contribute to its action...
  35. pmc Features, causes and consequences of splanchnic sequestration of amino acid in old rats
    Marion Jourdan
    Laboratory of Biological Nutrition EA 4466, Paris Descartes University, Paris, France
    PLoS ONE 6:e27002. 2011
    ..SSAA mechanisms are unknown but may involve an increased net utilization of ingested AA in the splanchnic area...
  36. doi request reprint Colonic luminal ammonia and portal blood L-glutamine and L-arginine concentrations: a possible link between colon mucosa and liver ureagenesis
    Mamy Eklou-Lawson
    INRA, CNRH IdF, AgroParisTech, UMR 914 Nutrition Physiology and Ingestive Behavior, 16 rue Claude Bernard, 75005, Paris, France
    Amino Acids 37:751-60. 2009
    ....
  37. doi request reprint Citrulline enhances myofibrillar constituents expression of skeletal muscle and induces a switch in muscle energy metabolism in malnourished aged rats
    Cécile Faure
    Département de Biologie Expérimentale, Métabolique et Clinique EA 4466, Faculte de Pharmacie, Universite Paris Descartes, Paris, France
    Proteomics 13:2191-201. 2013
    ..AL and R, p < 0.05). In conclusion, Cit supplementation increases expression of the main myofibrillar proteins and seems to induce a switch in muscle energy metabolism, from aerobia toward anaerobia. ..
  38. ncbi request reprint Therapeutic use of branched-chain amino acids in burn, trauma, and sepsis
    Jean Pascal De Bandt
    Laboratoire de Biochimie A, Hopital Hotel Dieu, Paris, France
    J Nutr 136:308S-13S. 2006
    ..Thus, we should abandon the concept of BCAA-supplemented nutrition for a more promising leucine-supplemented nutrition that requires further evaluation...
  39. doi request reprint Impact of protein pulse feeding on lean mass in malnourished and at-risk hospitalized elderly patients: a randomized controlled trial
    Olivier Bouillanne
    Service de Gérontologie 2, AP HP, Hôpital Emile Roux, France
    Clin Nutr 32:186-92. 2013
    ..This study aimed to evaluate the efficacy of a new nutritional strategy, termed protein pulse feeding...
  40. ncbi request reprint Geriatric Nutritional Risk Index: a new index for evaluating at-risk elderly medical patients
    Olivier Bouillanne
    Services de Gérontologie 2 and Biologie de la Nutrition EA2498, Universite Paris 5, Paris, France
    Am J Clin Nutr 82:777-83. 2005
    ..However, this index remains limited for elderly patients because of difficulties in establishing their normal weight...
  41. doi request reprint Consequences of age-related splanchnic sequestration of leucine on interorgan glutamine metabolism in old rats
    Marion Jourdan
    Laboratory of Biological Nutrition, EA 4466, Paris Descartes University, Paris, France
    J Appl Physiol 115:229-34. 2013
    ..Our results demonstrate the existence of an age-related change of interorgan Gln metabolism, which may be, in part, driven by SSLeu. ..
  42. ncbi request reprint Lessons from pharmacokinetics in the design of new nutrition formulas for critically ill patients
    Luc Cynober
    Biochemistry Laboratory, Hotel Dieu Hospital, AP HP, Laboratory of Biological Nutrition EA 2498, Pharmacy School, Paris 5 University, Paris, France
    Nestle Nutr Workshop Ser Clin Perform Programme 8:265-72; discussion 272-7. 2003
  43. ncbi request reprint Isolated perfused liver model: the rat and guinea pig compared
    Samira Chaib
    Laboratoire de Biologie de la Nutrition EA 2498, Faculte de Pharmacie, Laboratoire de Biochimie A, Hôpital Hotel Dieu AP HP, Paris, France
    Nutrition 20:458-64. 2004
    ..We compared the model of isolated perfused guinea pig liver with the classic model of isolated perfused rat liver, especially with respect to amino acid metabolism...
  44. ncbi request reprint Taurine status and response to intravenous taurine supplementation in adults with short-bowel syndrome undergoing long-term parenteral nutrition: a pilot study
    Stephane M Schneider
    AP HP Saint Lazare Hospital, Gastroenterology and Nutrition Support Unit, Paris, France
    Br J Nutr 96:365-70. 2006
    ....
  45. ncbi request reprint Citrulline: a new player in the control of nitrogen homeostasis
    Christophe Moinard
    Laboratoire de Biologie de la Nutrition, EA 2498, Faculte de Pharmacie, Universite Paris Descartes, and Laboratoire Biochimie, Hotel Dieu, AP HP, Paris 75004, France
    J Nutr 137:1621S-1625S. 2007
    ....
  46. ncbi request reprint Pharmacokinetics of arginine and related amino acids
    Luc Cynober
    Clinical Chemistry Laboratory, Hotel Dieu Hospital, and Laboratory of Biological Nutrition EA 2498, Faculty of Pharmacy, University Paris 5 René Descartes, Paris 75006, France
    J Nutr 137:1646S-1649S. 2007
    ..To date, there have been no pharmacokinetic studies on the long-term administration of these AAs in healthy subjects despite the need to determine the safe upper limit of daily intake...
  47. doi request reprint Performance of glycogen phosphorylase isoenzyme BB is weak in the detection of patients with non-ST-elevation acute coronary syndrome
    Christophe Meune
    Cardiology Department, Universite Paris Descartes, Groupe Hospitalier Cochin Broca Hôtel Dieu, APHP, Paris, France
    Clin Biochem 44:1343-5. 2011
    ..To examine the diagnostic performance of glycogen-phosphorylase-isoenzyme-BB (GPBB) combined with cardiac troponin I (cTnI) in acute coronary syndrome (ACS)...
  48. ncbi request reprint Plasma citrulline: A marker of enterocyte mass in villous atrophy-associated small bowel disease
    Pascal Crenn
    Department of Hepagastroenterology and Nutrion Support, Hopital Lariboisiere, Paris, France
    Gastroenterology 124:1210-9. 2003
    ..Our objective was to evaluate citrulline as a marker of severity and extent of villous atrophy in patients without intestinal resection...
  49. ncbi request reprint Introduction to the 5th Amino Acid Assessment Workshop
    Luc Cynober
    Clinical Chemistry Laboratory, Hôtel Dieu Hospital AP HP and Laboratory of Biological Nutrition EA 2498, Pharmacy Faculty, Paris Descartes University, Paris, France
    J Nutr 136:1633S-1635S. 2006
    ..The fourth AAAW focused on branched-chain AAs. The articles in this supplement issue of the journal summarize the fifth workshop in the series, which focused on sulfur amino acids...
  50. ncbi request reprint General discussion at 2nd Amino Acid Assessment Workshop (2nd AAAW)
    Luc Cynober
    Nutrition Department, Pharmacy School, Paris 5 University and Biochem Lab, Hotel Dieu Hospital, Paris, France
    J Nutr 133:2101S-2107S. 2003
  51. doi request reprint Leucine and citrulline: two major regulators of protein turnover
    Luc Cynober
    Clinical Chemistry Laboratory, Cochin and Hôtel Dieu Hospitals, AP HP, Paris Descartes University, Paris, France
    World Rev Nutr Diet 105:97-105. 2013
    ..Therefore, beyond a strong rationale, large clinical studies are required before any reliable recommendations can be issued on the use of leucine- or citrulline-enriched diets in ICU patients...
  52. doi request reprint Analytical evaluation of a high-sensitivity troponin T assay and its clinical assessment in acute coronary syndrome
    Camille Chenevier-Gobeaux
    Clinical Chemistry Laboratory, Cochin and Hôtel Dieu Hospitals, Assistance Publique des Hopitaux de Paris, Paris, France
    Ann Clin Biochem 48:452-8. 2011
    ..The recently developed, highly sensitive cardiac troponin T (hs-cTnT) immunoassay improves the detection of acute myocardial infarction (AMI). However, this assay requires further analytical and clinical evaluation...
  53. doi request reprint Formulation and evaluation of ATP-containing liposomes including lactosylated ASGPr ligand
    Karona Tep
    Laboratoire de Pharmacie Galenique, Universite Paris Descartes, Faculte des Sciences Pharmaceutiques et Biologiques, Paris Cedex, France
    J Liposome Res 19:287-300. 2009
    ..05). Nevertheless, regarding the adenosine triphosphate (ATP) assay, a slight increase was obtained with liposome loaded with ATP incorporating Lac-10-chol after 24 hours (P < 0.05)...
  54. doi request reprint TMPRSS2-ERG fusion transcripts in matched urine and needle rinse material after biopsy for the detection of prostate cancer
    Phuong Nhi Bories
    Laboratoire de Biochimie, Groupe Hospitalier Cochin Broca Hôtel Dieu, Hopital Cochin, 27 rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    Clin Chem 59:245-51. 2013
    ..We combined urine and prostate biopsy rinse material (BRM) assays to improve the fusion gene detection rate...
  55. ncbi request reprint L-cysteine encapsulation in liposomes: effect of phospholipids nature on entrapment efficiency and stability
    Nabil El Kateb
    Faculte des Sciences Pharmaceutiques et Biologiques, Laboratoire de Pharmacie Galenique, Paris, France
    J Microencapsul 25:399-413. 2008
    ..2 and 73.0% +/- 1.7 remained encapsulated after 24h at 25 degrees C and 4 degrees C, respectively. In conclusion, HSPC offering both stronger rigidity and lesser propensity for peroxidation led to optimize L-CySH liposomal stability...
  56. ncbi request reprint Effects of ornithine alpha-ketoglutarate on insulin secretion in rat pancreatic islets: implication of nitric oxide synthase and glutamine synthetase pathways
    Christina Schneid
    INSERM U 341, Service de Diabetologie, Hopital Hotel Dieu, Paris, France
    Br J Nutr 89:249-57. 2003
    ..A better understanding of OKG insulino-secretory properties and its mechanisms of action are a prerequisite for its use in insulin-compromised situations...
  57. ncbi request reprint Glucose transport in fibroblasts is unaffected by polyamines
    Alain Hernvann
    Laboratoire de Biochimie A, Hopital Cochin, APHP, Paris, France
    Nutrition 24:100-2. 2008
    ..Because polyamines are known to stimulate d-glucose uptake in brush-border membrane vesicles, we investigated whether or not they stimulated sugar uptake in confluent cultured fibroblasts...
  58. ncbi request reprint Immune-enhancing diets for stressed patients with a special emphasis on arginine content: analysis of the analysis
    Luc Cynober
    Biochemistry Laboratory, Hôtel Dieu Hospital AP HO, and Nutrition Laboratory, University Paris 5, Paris, France
    Curr Opin Clin Nutr Metab Care 6:189-93. 2003
    ..An American consensus and a meta-analysis provide divergent conclusions. The main goal of the present review is to analyze these documents...
  59. doi request reprint Midregional pro-atrial natriuretic peptide for the diagnosis of cardiac-related dyspnea according to renal function in the emergency department: a comparison with B-type natriuretic peptide (BNP) and N-terminal proBNP
    Camille Chenevier-Gobeaux
    Department of Clinical Chemistry, Hôpital Cochin Hôtel Dieu, Assistance Publique Hopitaux de Paris, Paris, France
    Clin Chem 56:1708-17. 2010
    ..We evaluated the impact of renal function on MR-proANP concentrations and compared our results to those of BNP and NT-proBNP...