- [Effect of oxidized indoles on monoamine oxidase activity in the rat brain mitochondria]M Crumeyrolle
Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow
Vopr Med Khim 48:201-3. 2002..Isatin acted as a rather selective monoamine oxidase B inhibitor, whereas 5-hydroxyoxindole was more selective monoamine oxidase A inhibitor, but it was less potent than that of 5-hydroxyisatin, a synthetic analogue of isatin...
- In situ imaging of specific binding of [3H]isatin in rat brainMichele Crumeyrolle-Arias
Laboratoire CRRET CNRS FRE2412, Universite Paris 12, Creteil, France
J Neurochem 84:618-20. 2003..The distribution became cortex, cerebellum, hypothalamus > hippocampus > brain stem > thalamus approximately striatum...
- Inhibition of brain mitochondrial monoamine oxidases by the endogenous compound 5-hydroxyoxindoleMichele Crumeyrolle-Arias
Laboratoire CRRET FRE CNRS 2412, Universite Paris 12 Val de Marne, 94010 Creteil, France
Biochem Pharmacol 67:977-9. 2004..5 microM), but it was the only highly selective MAO-A inhibitor among the all compounds studied (IC50 MAO-A:IC50 MAO-B = 0.044). Thus, the in vitro data suggest that MAO-A may represent potential target for 5-hydroxyoxindole...