- Mechanisms of meningeal invasion by a bacterial extracellular pathogen, the example of Neisseria meningitidisOlivier Join-Lambert
INSERM, Unité 570, 156 rue de Vaugirard, 75015 Paris, France
Prog Neurobiol 91:130-9. 2010..meningitidis is also able to recruit the polarity complex Par3/Par6/aPKC that re-routes endothelial cell adhesion molecules of interendothelial junctions, opening a paracellular route for bacteria to cross the endothelial barrier...
- Meningococcal type IV pili recruit the polarity complex to cross the brain endotheliumMathieu Coureuil
Universite Paris Descartes, Faculte de Medecine, Inserm U 570, 75015 Paris, France
Science 325:83-7. 2009....
- Meningococcus Hijacks a β2-adrenoceptor/β-Arrestin pathway to cross brain microvasculature endotheliumMathieu Coureuil
Universite Paris Descartes, Faculte de Medecine, 75006 Paris, France
Cell 143:1149-60. 2010..The identification of the mechanism used for hijacking host cell signaling machineries opens perspectives for treatment and prevention of meningococcal infection...
- Two strikingly different signaling pathways are induced by meningococcal type IV pili on endothelial and epithelial cellsHervé Lecuyer
Universite Paris Descartes, Sorbonne Paris Cité, Faculte de Medecine, INSERM U1002, and Assistance Publique Hopitaux de Paris, Hopital Necker Enfants Malades, Paris, France
Infect Immun 80:175-86. 2012..These data demonstrate that even though pilus-mediated signaling induces an apparently similar cortical plaque, in epithelial and endothelial cell lineages, the signaling pathways are strikingly different in both models...
- The meningococcal minor pilin PilX is responsible for type IV pilus conformational changes associated with signaling to endothelial cellsTerry Brissac
Faculte de Medecine, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
Infect Immun 80:3297-306. 2012..These data support a model in which surface-exposed motifs of PilX use forces generated by pilus retraction to promote conformational changes required for TFP-mediated signaling...
- Chronic meningococcemia cutaneous lesions involve meningococcal perivascular invasion through the remodeling of endothelial barriersNicolas Dupin
Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
Clin Infect Dis 54:1162-5. 2012..Both in vivo and in vitro data suggest that, in these lesions, meningococci gain access from the capillary lumen to the peripheral extravascular compartment, in the absence of vascular dislocation, through a paraendothelial route...