Regis T Costello

Summary

Country: France

Publications

  1. ncbi request reprint [Treatment of essential thrombocythemia]
    R Costello
    Service d hématologie Professeur Gérard Sébahoun, Hopital Nord, Assistance Publique des Hopitaux de Marseille, Faculte de Medecine de Marseille, Universite de la Mediterranee, Chemin des Bourrelly, 13915 Marseille Cedex 20, France
    Rev Med Interne 26:947-55. 2005
  2. ncbi request reprint Gaucher disease and multiple myeloma
    Regis Costello
    Departement d Hematologie, Hopital Nord, Assistance Publique des Hopitaux de Marseille, Faculte de Medecine de Marseille, Universite de la Mediterranee, Marseille, France
    Leuk Lymphoma 47:1365-8. 2006
  3. pmc Differential expression of natural killer cell activating receptors in blood versus bone marrow in patients with monoclonal gammopathy
    Regis T Costello
    Laboratoire d Hematologie, Hopital Nord, Marseille, France
    Immunology 139:338-41. 2013
  4. doi request reprint [Pulmonary arterial hypertension and malignant hematologic disorders]
    R Costello
    Service d Hematologie, Hopital la Conception, 147, boulevard Baille, 13005 Marseille, France
    Rev Med Interne 31:621-5. 2010
  5. doi request reprint Peripheral T-cell lymphoma gene expression profiling and potential therapeutic exploitations
    Regis Costello
    Department of Haematology, Faculte de Medecine de Marseille, université de la Méditerranée Aix Marseille 2, Marseille, France
    Br J Haematol 150:21-7. 2010
  6. ncbi request reprint [Hematological aspects of Gaucher disease]
    R Costello
    Departement d Hematologie, Assistance Publique des Hopitaux de Marseille, Faculte de Medecine de Marseille, Universite de la Mediterrane, Hopital Nord, Chemin des Bourrelly, 13915 Marseille 20, France
    Rev Med Interne 28:S176-9. 2007
  7. ncbi request reprint Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia
    Regis T Costello
    Unité d Immunologie des Tumeurs Département d Hématologie, Institut Paoli Calmettes, Universite de la Mediterranee, Marseille, France
    Blood 99:3661-7. 2002
  8. ncbi request reprint NK cells: innate immunity against hematological malignancies?
    Regis T Costello
    Laboratoire Immunologie des Tumeurs, Centre de Lutte Contre le Cancer de Marseille, 232 Boulevard Sainte Marguerite, 13009 Marseille, France
    Trends Immunol 25:328-33. 2004
  9. ncbi request reprint Intensive sequential chemotherapy with hematopoietic growth factor support for non-Hodgkin lymphoma in patients infected with the human immunodeficiency virus
    Regis T Costello
    Departement d Hematologie, Institut Paoli Calmettes, Institut Paoli Calmettes Marseille, France
    Cancer 100:667-76. 2004
  10. ncbi request reprint Defective killing of dendritic cells by autologous natural killer cells from acute myeloid leukemia patients
    Cyril Fauriat
    Service d Hématologie Pr G Sébahoun, Hopital Nord, Chemin des Bourrelly, 13915 Marseille Cedex 20, France
    Blood 106:2186-8. 2005

Collaborators

Detail Information

Publications23

  1. ncbi request reprint [Treatment of essential thrombocythemia]
    R Costello
    Service d hématologie Professeur Gérard Sébahoun, Hopital Nord, Assistance Publique des Hopitaux de Marseille, Faculte de Medecine de Marseille, Universite de la Mediterranee, Chemin des Bourrelly, 13915 Marseille Cedex 20, France
    Rev Med Interne 26:947-55. 2005
    ..The potential toxicity of treatments, their leukemogenicity in particular, rises a decisional problem for young patients. We propose to review available data in order to propose the most rational treatment for each patient...
  2. ncbi request reprint Gaucher disease and multiple myeloma
    Regis Costello
    Departement d Hematologie, Hopital Nord, Assistance Publique des Hopitaux de Marseille, Faculte de Medecine de Marseille, Universite de la Mediterranee, Marseille, France
    Leuk Lymphoma 47:1365-8. 2006
    ..We then analyse relevant case reports and recent articles that provide convincing data regarding GD and MM association and suggest physiopathological links between the two disorders...
  3. pmc Differential expression of natural killer cell activating receptors in blood versus bone marrow in patients with monoclonal gammopathy
    Regis T Costello
    Laboratoire d Hematologie, Hopital Nord, Marseille, France
    Immunology 139:338-41. 2013
    ..Further studies regarding immune regulatory drugs in MG/MM will imperiously require the assessment of immune cell status not only in PB but also in BM to obtain more relevant data regarding anti-tumor efficacy...
  4. doi request reprint [Pulmonary arterial hypertension and malignant hematologic disorders]
    R Costello
    Service d Hematologie, Hopital la Conception, 147, boulevard Baille, 13005 Marseille, France
    Rev Med Interne 31:621-5. 2010
    ....
  5. doi request reprint Peripheral T-cell lymphoma gene expression profiling and potential therapeutic exploitations
    Regis Costello
    Department of Haematology, Faculte de Medecine de Marseille, université de la Méditerranée Aix Marseille 2, Marseille, France
    Br J Haematol 150:21-7. 2010
    ..In conclusion, gene expression profiling is beginning to change the pathological classification, the prognosis profiles and the therapeutic approach in T-cell lymphomas...
  6. ncbi request reprint [Hematological aspects of Gaucher disease]
    R Costello
    Departement d Hematologie, Assistance Publique des Hopitaux de Marseille, Faculte de Medecine de Marseille, Universite de la Mediterrane, Hopital Nord, Chemin des Bourrelly, 13915 Marseille 20, France
    Rev Med Interne 28:S176-9. 2007
    ..Gaucher disease is the most frequent lysosomal storage disease, and corresponds to an inherited deficiency of glucocerebrosidase. Due to excessive accumulation of glucocerebroside in bone marrow, cytopenia and bone lesions occur...
  7. ncbi request reprint Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia
    Regis T Costello
    Unité d Immunologie des Tumeurs Département d Hématologie, Institut Paoli Calmettes, Universite de la Mediterranee, Marseille, France
    Blood 99:3661-7. 2002
    ..In few cases, however, this failure appears to involve a mechanism of tumor escape based on down-regulation of ligands relevant for NCR-mediated target cell recognition...
  8. ncbi request reprint NK cells: innate immunity against hematological malignancies?
    Regis T Costello
    Laboratoire Immunologie des Tumeurs, Centre de Lutte Contre le Cancer de Marseille, 232 Boulevard Sainte Marguerite, 13009 Marseille, France
    Trends Immunol 25:328-33. 2004
    ....
  9. ncbi request reprint Intensive sequential chemotherapy with hematopoietic growth factor support for non-Hodgkin lymphoma in patients infected with the human immunodeficiency virus
    Regis T Costello
    Departement d Hematologie, Institut Paoli Calmettes, Institut Paoli Calmettes Marseille, France
    Cancer 100:667-76. 2004
    ..Optimal treatment of human immunodeficiency virus (HIV)-associated non-Hodgkin lymphoma (NHL) has yet to be defined, because chemotherapy could exacerbate immunodeficiency, with subsequent adverse effects for patients...
  10. ncbi request reprint Defective killing of dendritic cells by autologous natural killer cells from acute myeloid leukemia patients
    Cyril Fauriat
    Service d Hématologie Pr G Sébahoun, Hopital Nord, Chemin des Bourrelly, 13915 Marseille Cedex 20, France
    Blood 106:2186-8. 2005
    ..This may lead to specific T-lymphocyte tolerization by spontaneous or ex vivo expanded iDCs expressing leukemia-derived antigens...
  11. ncbi request reprint LIGHT costimulates CD40 triggering and induces immunoglobulin secretion; a novel key partner in T cell-dependent B cell terminal differentiation
    Thomas Duhen
    Centre Lutte Contre le Cancer, Laboratoire d Immunologie des Tumeurs, Universite de la Mediterranee, Marseille, France
    Eur J Immunol 34:3534-41. 2004
    ....
  12. ncbi request reprint Natural killer cell-triggering receptors in patients with acute leukaemia
    Cyril Fauriat
    Institut Paoli Calmettes, Faculté de Médecine de Marseille and Université de la Méditerranée, Marseille, France
    Leuk Lymphoma 44:1683-9. 2003
    ....
  13. ncbi request reprint Deficient expression of NCR in NK cells from acute myeloid leukemia: Evolution during leukemia treatment and impact of leukemia cells in NCRdull phenotype induction
    Cyril Fauriat
    Laboratoire d Immunologie des Tumeurs, Institut National de la Santé et de la Recherche Médicale INSERM Unite Mixté de Recherche UMR 599, Marseille, France
    Blood 109:323-30. 2007
    ..The prognostic value of NCR expression is discussed, and pathophysiologic implication of the NCR phenotype will be further investigated in a larger study...
  14. ncbi request reprint [New insights into cytotoxic effector cells]
    J Rey
    Laboratoire d Immunologie des Tumeurs, Departement d Hematologie, Institut Paoli Calmettes, 232 Boulevard Sainte Marguerite, 13009 Marseille
    Bull Cancer 92:935-43. 2005
    ..The data recently acquired concerning the effector cytotoxic cells contribute to a better understanding of the interactions between the immune system and tumour cells. This may provide rational basis for combined immunotherapy protocols...
  15. ncbi request reprint New approaches in the immunotherapy of haematological malignancies
    Regis T Costello
    Département d Hématologie and Laboratoire d Immunologie des Tumeurs, Institut Paoli Calmettes, Universite de la Mediterranee, Marseille, France
    Eur J Haematol 70:333-45. 2003
    ..e. the reversal of immune escape mechanisms either via the correction of deficient phases of the immune response or by the amplification of physiological mechanisms...
  16. ncbi request reprint Non-Hodgkin's lymphoma after kidney transplantation: a single institution study
    Jean El Cheikh
    Departement d Hematologie, Institut Paoli Calmettes et Service de Néphrologie, Hopital de la Conception, Marseille, France
    Leuk Res 30:118-9. 2006
    ..Restoration of a functional immune system may contribute to decrease the rate of lymphoma recurrence, in line with the absence of lymphoma relapse in our six patients, who are all still alive and in complete remission...
  17. ncbi request reprint Immunobiology of haematological malignant disorders: the basis for novel immunotherapy protocols
    Regis T Costello
    Institut Paoli Calmettes, Universite de la Mediterranee, Marseille, France
    Lancet Oncol 5:47-55. 2004
    ..Last, we discuss non-HLA-restricted immunity, which does not require the recognition of specific antigens and relies on particular cell populations such as natural killer cells...
  18. pmc Expression of natural killer cell activating receptors in patients with chronic lymphocytic leukaemia
    Regis T Costello
    APHM, Hopital Nord, Laboratoire d Hématologie Aix Marseille Université, TAGC unité INSERM U928 APHM, Hopital la Conception, Service d Hematologie, Marseille, France
    Immunology 135:151-7. 2012
    ....
  19. ncbi request reprint The co-expression of 2B4 (CD244) and CD160 delineates a subpopulation of human CD8+ T cells with a potent CD160-mediated cytolytic effector function
    Jérôme Rey
    Laboratoire d Immunologie des Tumeurs, Institut Paoli Calmettes, Marseille, France
    Eur J Immunol 36:2359-66. 2006
    ..We conclude that the co-expression of 2B4 and CD160 defines a CD8+ T lymphocyte subpopulation with high CTL activity...
  20. doi request reprint A role for HVEM, but not lymphotoxin-beta receptor, in LIGHT-induced tumor cell death and chemokine production
    Christine Pasero
    INSERM UMR891, Centre de Recherche en Cancerologie de Marseille, Université de Méditerranée, Institut de Cancérologie et d Immunologie de Marseille, Marseille, France
    Eur J Immunol 39:2502-14. 2009
    ..In conclusion, we describe a novel, as yet unknown killing effect of LIGHT through HVEM on a lymphoid malignancy, and combined with induction of chemokine release this may represent an additional tool to boost cancer immunotherapy...
  21. doi request reprint Rank ligand stimulation induces a partial but functional maturation of human monocyte-derived dendritic cells
    Jean Marc Schiano de Colella
    Laboratoire d Immunologie des Tumeurs, Institut Paoli Calmettes, Universite de la Mediterranee, Marseille, France
    Eur Cytokine Netw 19:81-8. 2008
    ..Our results show that ligation of RANK on DC cell surfaces is not only a survival stimulus, but also induces a partial and specific mature DC phenotype, the physiological significance of which is under investigation...
  22. ncbi request reprint LIGHT, a new TNF superfamily member, is essential for memory T helper cell-mediated activation of dendritic cells
    Yannis Morel
    Laboratory of Tumor Immunology, Institute Paoli Calmettes, Marseille, France
    Eur J Immunol 33:3213-9. 2003
    ..LIGHT and CD40L can also regulate IL-12 production by CCR7+ DC capable of migration to lymph nodes. These data suggest that both LIGHT and CD40L may be involved in the maintenance or reactivation of secondary Th1 responses...
  23. ncbi request reprint [Is pure red cell aplasia a new extra digestive manifestation of celiac disease?]
    A L Couderc
    Service de Medecine Interne, Hopital Nord, Assistance Publique Hôpitaux de Marseille APHM, Universite de la Mediterranee, Chemin des Bourrely, 13915 Marseille, Cedex 20, France
    Rev Med Interne 27:336-9. 2006
    ..Celiac disease is an autoimmune enteropathy that appears on a predisposed genetic background. Its clinical presentation has been extended those last years by varied extradigestive manifestations...