Research Topics
| N Costedoat-ChalumeauSummaryCountry: France Publications
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Publications
Questions about dexamethasone use for the prevention of anti-SSA related congenital heart blockN Costedoat-Chalumeau
Centre Hospitalier, Universitaire Pitié Salpêtrière, Paris, France
Ann Rheum Dis 62:1010-2. 2003..Mothers with anti-SSA/Ro antibodies who have had a previous fetus with congenital heart block (CHB) have a risk of recurrence estimated to be up to 16%...
[Pleading to maintain hydroxychloroquine throughout Lupus pregnancies]N Costedoat-Chalumeau
Service de Medecine Interne, CHU Pitie Salpetriere, 47 83, Boulevard de l Hopital, 75651 Paris Cedex 13, France
Rev Med Interne 26:467-9. 2005..Further studies with prospective follow-up of children exposed in utero to HCQ remain however needed to provide a definitive answer...
Anti-SSA/Ro and anti-SSB/La antibody-mediated congenital heart blockN Costedoat-Chalumeau
Service de Medecine Interne, Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
Lupus 14:660-4. 2005..Curative treatment of CHB is based on fluorinated steroids (dexamethasone or betamethasone) that do cross the placenta in an active form. Guidelines are available but further studies are needed to optimize treatment...
Anti-SSA/Ro antibodies and the heart: more than complete congenital heart block? A review of electrocardiographic and myocardial abnormalities and of treatment optionsNathalie Costedoat-Chalumeau
Service de Medecine Interne, Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
Arthritis Res Ther 7:69-73. 2005..Treatment of CHB is not well established and needs to be assessed carefully. The risks and benefits of prenatal fluorinated steroids are discussed...
Safety of hydroxychloroquine in pregnant patients with connective tissue diseases. Review of the literatureNathalie Costedoat-Chalumeau
Service de Medecine Interne, Centre Hospitalier Universitaire Pitie Salpetriere, 47 83 boulevard de l Hopital, 75651 Paris Cedex 13, France
Autoimmun Rev 4:111-5. 2005..However, the amount of HCQ received by children through lactation seems very low. In conclusion, HCQ should probably be maintained throughout pregnancy in patients with SLE and it does not seem necessary to advise against breastfeeding...
[Obstetrical management of patients at risk of neonatal lupus syndrome: review of the literature]N Costedoat-Chalumeau
Service de Medecine Interne, CHU Pitie Salpetriere, 47 83, Boulevard de l Hopital, 75651 Paris Cedex 13
J Gynecol Obstet Biol Reprod (Paris) 35:146-56. 2006..Electrocardiogram should be performed in the first days of life for all children to detect incomplete CHB. Therapy for CHB detected in utero is based on fluorinated steroids, especially betamethasone. Its efficiency is variable...
Cardiomyopathy related to antimalarial therapy with illustrative case reportNathalie Costedoat-Chalumeau
Service de Medecine Interne, Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
Cardiology 107:73-80. 2007....
Outcome of pregnancies in patients with anti-SSA/Ro antibodies: a study of 165 pregnancies, with special focus on electrocardiographic variations in the children and comparison with a control groupNathalie Costedoat-Chalumeau
Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
Arthritis Rheum 50:3187-94. 2004..To assess the pathologic nature of these manifestations, this study focused on electrocardiographic (EKG) variations in these children, comparing them with findings in a control group...
Safety of hydroxychloroquine in pregnant patients with connective tissue diseases: a study of one hundred thirty-three cases compared with a control groupNathalie Costedoat-Chalumeau
Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
Arthritis Rheum 48:3207-11. 2003..We now report our experience with 133 pregnancies in women being treated with HCQ, resulting in 117 live births. Results in the HCQ group are compared with those in a control group...
[Neonatal lupus syndrome: review of the literature]N Costedoat-Chalumeau
Service de Medecine Interne, Centre Hospitalier Universitaire Pitie Salpetriere, 47 83, Boulevard de l Hopital, 75651 Paris Cedex 13, France
Rev Med Interne 24:659-71. 2003..FUTURE PROSPECTS AND PROJECTS: The efficiency of prophylactic treatment of CHB is not established. Therapy for CHB detected in utero is not standardized and involves fluorinated steroids (especially betamethasone)...
[Vitamin D and autoimmunity. Second part: Clinical aspects]Y Schoindre
Service de Medecine Interne, Université Versailles Saint Quentin en Yvelines, Hopital Foch, 40, rue Worth, 92151 Suresnes Cedex, France
Rev Med Interne 33:87-93. 2012....
Heart conduction disorders related to antimalarials toxicity: an analysis of electrocardiograms in 85 patients treated with hydroxychloroquine for connective tissue diseasesN Costedoat-Chalumeau
AP HP Service de Médecine Interne, Centre de Reference National Pour les Lupus et le Syndrome des Antiphospholipides, Centre Hospitalier Universitaire Pitie Salpetriere, Paris Cedex 13, France
Rheumatology (Oxford) 46:808-10. 2007..Since no data were available for HCQ, we studied electrocardiograms (ECGs) in 85 unselected patients with CTD treated with HCQ as the sole antimalarial...
[Pregnancy and antiphospholipid syndrome]N Costedoat-Chalumeau
Service de Medecine Interne, Centre de Référence National pour le Lupus Systémique et le Syndrome des Antiphospholipides, Hopital Pitie Salpetriere, AP HP, Universite Pierre et Marie Curie Paris 6, 47 83, Boulevard de l Hopital, 75651 Paris Cedex 13, France
Rev Med Interne 33:209-16. 2012..Treatment optimization and multidisciplinary antenatal care improve the prognosis of pregnancies in women with obstetric APS, leading to a favorable outcome most of the time...
The association of systemic lupus erythematosus and myasthenia gravis: a series of 17 cases, with a special focus on hydroxychloroquine use and a review of the literatureM Jallouli
Centre Hospitalier Universitaire Pitie Salpetriere, Universite Paris 6, AP HP, Paris, France
J Neurol 259:1290-7. 2012..Hydroxychloroquine treatment appears to be safe in this setting...
[Catastrophic antiphospholipid syndrome]N Costedoat-Chalumeau
Service de Medecine Interne, Centre de Référence National pour le Lupus Systémique et le Syndrome des Antiphospholipides, faculté Paris 6, Hopital Pitie Salpetriere, 47 83, Boulevard de l Hopital, 75013 Paris, France
Rev Med Interne 33:194-9. 2012..The prevention of CAPS is based upon the adequate management of the perioperative period when surgery cannot be avoided, the prompt treatment of infections and the education of patients with antiphospholipid syndrome...
AL cardiac amyloidosis and arterial thromboembolic eventsP Hausfater
Emergency Department, Pitie Salpetriere University Hospital Centre, 75651 Paris Cedex 13, France
Scand J Rheumatol 34:315-9. 2005..To study the prevalence and characteristics of arterial thromboembolic events (ATEE) in the course of AL amyloidosis...
[Critical review of the new recommendations on screening for hydroxychloroquine retinopathy]N Costedoat-Chalumeau
Service de Medecine Interne, Centre de Reference National Pour les Lupus et le Syndrome des Antiphospholipides, CHU Pitie Salpetriere, AP HP, Universite Paris VI, 47 83, Boulevard de l Hopital, 75651 Paris Cedex 13, France
Rev Med Interne 33:265-7. 2012..A baseline examination is advised as a reference and then, annual screening should be initiated no later than 5 years after starting hydroxychloroquine therapy...
Potentiation of vitamin K antagonists by high-dose intravenous methylprednisoloneN Costedoat-Chalumeau
Groupe Hospitalier Universitaire Pitié Salpêtrière, Paris, France
Ann Intern Med 132:631-5. 2000..Oral anticoagulants and pulse high-dose intravenous methylprednisolone are often administered concomitantly, but no data on potential interactions are available...
Posterior reversible encephalopathy syndrome during systemic lupus erythematosus: four new cases and review of the literatureG Leroux
Department of Internal Medicine, Centre Hospitalier Universitaire Pitie Salpetriere, 83 Boulevard de l hopital, 75013 Paris, France
Lupus 17:139-47. 2008..The hypertension and other worsening factors should be treated. Finally, the evolution of this clinical and radiological spectacular syndrome is generally rapidly favorable...
[Management of antiphospholipid syndrome]D Saadoun
Service de Medecine Interne, centre de référence national pour le lupus et le syndrome des antiphospholipides, CHU Pitie Salpetriere, AP HP, Universite Pierre et Marie Curie Paris 6, 47 83, Boulevard de l Hopital, 75651 Paris Cedex 13, France
Rev Med Interne 33:217-22. 2012..5. The possible occurrence of relapse despite anticoagulation in the therapeutic target may lead to the addition of aspirin. The development of new anti-thrombotic agents might change the management of APS in the coming years...
[Liver disease and pregnancy]C Delluc
Centre de Référence National pour le Lupus Systémique et le Syndrome des Antiphospholipides, Service de Medecine Interne, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47 83, Boulevard de l Hopital, 75651 Paris Cedex 13, France
Rev Med Interne 30:508-15. 2009..Management of liver disease can be different during pregnancy. The knowledge of liver dysfunction during pregnancy is of help for a better management of the mother in order to avoid maternal and fetal mortality and morbidity...
[Hydroxychloroquine and systemic lupus: a reappraisal]N Costedoat-Chalumeau
Université de Pierre et Marie Curie Paris 6, Centre de Reference National Pour les Lupus et le Syndrome des Antiphospholipides, centre hospitalier universitaire de la Pitié Salpêtrière, Paris, France
Rev Med Interne 29:735-7. 2008..Hydroxychloroquine (HCQ) is still too often considered as a second-line treatment in systemic lupus erythematosus (SLE) patients...
[Central serous chorioretinopathy and systemic diseases report of 2 cases associated with corticotherapy]A Bouyon
, , 47-83, , 75651 Paris Cedex 13, France
Rev Med Interne 27:487-91. 2006..CONCLUSION: Similarly to cataract or glaucoma, central serous chorioretinopathy belongs to the potential ocular side-effect of steroid treatment, and thus deserves to be known by internists...
[Vitamin D and autoimmunity. First part: Fundamental aspects]Y Schoindre
Service de Medecine Interne, Université Versailles Saint Quentin en Yvelines, Hopital Foch, 40, rue Worth, 92151 Suresnes Cedex, France
Rev Med Interne 33:80-6. 2012..The authors present their actions on myeloid dendritic cells, T cells, B cells, as well as on the synthesis of antimicrobial peptides and autophagy, and the potential beneficial effects in autoimmune and inflammatory diseases...
[Spleen and liver nodules]J Cohen-Bittan
, , 47-83, , 75651 Paris Cedex 13, France
Rev Med Interne 28:420-1. 2007
Tumor antigen markers for the detection of solid cancers in inflammatory myopathiesZahir Amoura
Service de Medecine Interne, Hopital Pitie Salpetriere, 47 83 Bd de l Hopital, 75013 Paris, France
Cancer Epidemiol Biomarkers Prev 14:1279-82. 2005....
Cardiovascular involvement, an overlooked feature of Erdheim-Chester disease: report of 6 new cases and a literature reviewJulien Haroche
Service de Medecine Interne, Hopital Pitie Salpetriere, Paris, France
Medicine (Baltimore) 83:371-92. 2004..Data concerning follow-up were available for 58 (80.6%) patients. Of these, 35 (60.3%) patients died, confirming the severe prognosis of ECD. Cardiovascular complications were responsible for the death of 11 of the 35 patients (31.4%)...
Cryoglobulinemia vasculitisPatrice Cacoub
Service de Medecine Interne, hôpital La Pitié Salpêtrière, Paris, France
Curr Opin Rheumatol 14:29-35. 2002....
Thrombotic thrombocytopenic purpura with severe ADAMTS-13 deficiency in two patients with primary antiphospholipid syndromeZahir Amoura
Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
Arthritis Rheum 50:3260-4. 2004..Our findings suggest that primary APS must be added to the list of autoimmune disorders that can be complicated by TTP...
Changes in enoxaparin pharmacokinetics during pregnancy and implications for antithrombotic therapeutic strategyC Lebaudy
Pharmacology Department, Pitie Salpetriere Hospital, AP HP, Paris, France
Clin Pharmacol Ther 84:370-7. 2008..We recommend the administration of doses normalized for body weight changes so as to counteract enoxaparin pharmacokinetic changes that accompany various stages of pregnancy...
[A vertebroplasty with dyspnea]G Leroux
, , 75651 Paris Cedex 13, France
Rev Med Interne 28:492-4. 2007
[Scurvy]A Bouyon
, , 47-83, , 75651 Paris Cedex 13, France
Rev Med Interne 25:934-5. 2004
[Edematous syndrome revealing an exudative lymphocytic gastritis: efficacy of omeprazole]P Cacoub
Service de Medecine Interne, Hopital de la Pitie Salpetriere, Paris
Gastroenterol Clin Biol 24:963-4. 2000..Inflammatory involvement of the gastric mucosa probably caused protein losing in this patient. Recognition of this exsudative gastropathy is important because long term remission is obtained with omeprazole...
Impact of antiphosholipid biology in maternal Down syndrome screeningChristine Brochet
UF d Oncobiochimie et Biochimie Prénatale, GH Pitié Salpétrière, AP HP, Paris, France
Prenat Diagn 29:481-8. 2009..Because AFP is involved in the calculation of the risk of trisomy 21 (T21), we studied the effect of AFP variations in the presence of aPL during T21 screening...
Factors influencing the efficacy of two injections of a pandemic 2009 influenza A (H1N1) nonadjuvanted vaccine in systemic lupus erythematosusA Mathian
Centre de Reference National Pour les Lupus et le Syndrome des Antiphospholipides, Groupement Hospitalier Pitié Salpêtrière, AP HP, Universite Pierre et Marie Curie, université Paris 06, and INSERM UMR S 945, Paris, France
Arthritis Rheum 63:3502-11. 2011..To assess the factors influencing the efficacy of 2 injections of a pandemic 2009 influenza A (H1N1) vaccine in patients with systemic lupus erythematosus (SLE)...
Very low blood hydroxychloroquine concentration as an objective marker of poor adherence to treatment of systemic lupus erythematosusNathalie Costedoat-Chalumeau
AP HP, Service de Medecine Interne, Centre de Référence National pour le Lupus Systémique et le Syndrome des Antiphospholipides, CHU Pitie Salpetriere, 47 83 boulevard de l Hopital, 75651 Paris Cedex 13, France
Ann Rheum Dis 66:821-4. 2007..Poor adherence to treatment is difficult to diagnose accurately. Hydroxychloroquine (HCQ) has a long elimination half-life and its concentration in whole blood can be measured easily...
Clinical features and outcomes in 348 patients with polyarteritis nodosa: a systematic retrospective study of patients diagnosed between 1963 and 2005 and entered into the French Vasculitis Study Group DatabaseChristian Pagnoux
Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
Arthritis Rheum 62:616-26. 2010..This study was undertaken to describe the main characteristics of and long-term outcomes in patients with well-characterized PAN diagnoses...
[Sarcomania has its limits!]A Birenbaum
, , 47-83, , 75651 Paris Cedex 13, France
Rev Med Interne 25:S231-3. 2004
Low blood concentration of hydroxychloroquine is a marker for and predictor of disease exacerbations in patients with systemic lupus erythematosusNathalie Costedoat-Chalumeau
Assistance Publique Hopitaux de Paris, Centre Hospitalier Universitaire Pitie Salpetriere, Universite Paris VI Pierre et Marie Curie, Paris, France
Arthritis Rheum 54:3284-90. 2006..To study the possible relationship between whole-blood hydroxychloroquine (HCQ) concentrations and clinical efficacy of HCQ in patients with systemic lupus erythematosus (SLE)...
Takayasu arteritis in France: a single-center retrospective study of 82 cases comparing white, North African, and black patientsLaurent Arnaud
Service de Medecine Interne, Hopital Pitie Salpetriere, AP HP, Universite Paris 6, Paris, France
Medicine (Baltimore) 89:1-17. 2010..North African patients have a higher occurrence of ischemic stroke and poorer survival than white patients...
Potentiation of fluindione or warfarin by dexamethasone in multiple myeloma and AL amyloidosisJeremie Sellam
Service de Medecine Interne, Centre Hospitalier Universitaire Pitie Salpetriere, Universite Paris VI Pierre et Marie Curie, Centre de Reference National Pour les Lupus et le Syndrome des Antiphospholipides, Paris, France
Joint Bone Spine 74:446-52. 2007....
Hydroxychloroquine blood assay as a marker of nonadherence in patients with systemic lupus erythematosus: comment on the article by Koneru et alNathalie Costedoat-Chalumeau
Arthritis Rheum 59:153; author reply 153-4. 2008
Relationship between blood hydroxychloroquine and desethylchloroquine concentrations and cigarette smoking in treated patients with connective tissue diseasesGaëlle Leroux
Ann Rheum Dis 66:1547-8. 2007
Corrected QT interval in anti-SSA-positive adults with connective tissue disease: comment on the article by Lazzerini et alNathalie Costedoat-Chalumeau
Arthritis Rheum 52:676-7; author reply 677-8. 2005
Evidence of transplacental passage of hydroxychloroquine in humansNathalie Costedoat-Chalumeau
, Paris, France
Arthritis Rheum 46:1123-4. 2002
Hemophagocytic syndrome in a pregnant patient with systemic lupus erythematosus, complicated with preeclampsia and cerebral hemorrhageLaurent Perard
Ann Hematol 86:541-4. 2007
Hydroxychloroquine in systemic lupus erythematosusNathalie Costedoat-Chalumeau
Lancet 369:1257-8. 2007
Drug-induced hemophagocytosisOlivier Lambotte
Am J Med 112:592-3. 2002
[We don't beat around the bush anymore]]F Badet
, Centre Hospitalier Lyon-Sud, , France
Rev Med Interne 26:S197-9. 2005
[Cystadenoma of the liver with high levels of ACE and CA 19-9 in the cyst]Christophe Tresallet
Service de Chirurgie Generale, digestive et endocrinienne, Hopital de la Pitie, 47 83 boulevard de l Hopital, 75651 Paris Cedex 13
Gastroenterol Clin Biol 27:413-5. 2003..Definitive histological evaluation is the only means to discriminate malignant from benign cysts. We report a case of cystadenoma of the liver with very high cystic levels and normal serum levels of CEA and CA 19-9...
