- Development of the Crohn's disease digestive damage score, the Lémann scoreBenjamin Pariente
Department of Hepatogastroenterology, Hopital Saint Louis, Paris, France
Inflamm Bowel Dis 17:1415-22. 2011..This instrument could be used to assess the effect of various medical therapies on the progression of bowel damage...
- Is there still a room for azathioprine monotherapy in inflammatory bowel disease?Anne Bourrier
184, rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, France
Curr Drug Targets 14:1471-9. 2013..It is thus advised to initiate azathioprine monotherapy in these intermediate cases, and to continue azathioprine if anatomical remission is achieved. ..
- Early administration of azathioprine vs conventional management of Crohn's Disease: a randomized controlled trialJacques Cosnes
Hôpital St Antoine and Université Pierre et Marie Curie, Paris, France Electronic address
Gastroenterology 145:758-65.e2; quiz e14-5. 2013..We compared the efficacy of early treatment (within 6 months after diagnosis) with azathioprine versus conventional management of patients at high risk for disabling disease...
- Misleading pustular plaques of the lower limbs during Crohn's disease: two case reportsDavid Farhi
AP HP, Hopital Tenon, Department of Dermatology, Paris F 75020, France
J Med Case Reports 1:109. 2007..Cutaneous Crohn's disease is characterized by skin non-caseating epithelioid granulomatas with giant cells, remote from the gastrointestinal tract. We report herein two new cases...
- Crohn's disease phenotype, prognosis, and long-term complications: what to expect?Jacques Cosnes
Service de Gastroenterologie et Nutrition, Hôpital St Antoine et Université Pierre et Marie Curie, Paris
Acta Gastroenterol Belg 71:303-7. 2008....
- Incidence of autoimmune diseases in celiac disease: protective effect of the gluten-free dietJacques Cosnes
Service de Gastroenterologie et Nutrition, Hôpital St Antoine and Université Pierre and Marie Curie, Paris, France
Clin Gastroenterol Hepatol 6:753-8. 2008..Celiac disease may be associated with autoimmune diseases. The aims of the present study were to determine in celiac patients which factors modulate the risk of autoimmune disease and to evaluate the effect of the gluten-free diet...
- [Inflammatory bowel disease: from sulfasalazine to biologics]J Cosnes
Service de Gastroenterologie et Nutrition, Hopital Saint Antoine, UPMC, Paris VI, 75571 Paris, France
Gastroenterol Clin Biol 33:692-701. 2009..Moreover development of new therapeutic agents may permit to avoid surgery in patients who do not respond to therapy...
- Can we modulate the clinical course of inflammatory bowel diseases by our current treatment strategies?Jacques Cosnes
Service de Gastroenterologie et Nutrition, Hôpital St Antoine et Université Pierre et Marie Curie Paris VI, Paris, France
Dig Dis 27:516-21. 2009..There is the need in the next few years to better define these subgroups and to compare different strategies within each group through randomized interventional studies...
- Epidemiology and natural history of inflammatory bowel diseasesJacques Cosnes
Service de Gastroenterologie et Nutrition, Hôpital St Antoine and Pierre et Marie Curie University Paris VI, Paris, France
Gastroenterology 140:1785-94. 2011..It has been proposed that only aggressive therapeutic approaches, based on treatment of early recurrent lesions in asymptomatic individuals, have a significant impact on progression of these chronic diseases...
- Smoking, physical activity, nutrition and lifestyle: environmental factors and their impact on IBDJacques Cosnes
Service de Gastroenterologie et Nutrition, Hopital St Antoine, Paris, France
Dig Dis 28:411-7. 2010..In total, adhering to four simple lifestyle factors - never smoking, physical activity, prudent diet and body mass index <25 - may have a strong impact both on the prevention of major chronic diseases and on the course of IBD...
- Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort studyLaurent Beaugerie
Department of Gastroenterology, Assistance Publique Hopitaux de Paris AP HP, Hopital Saint Antoine, Universite Pierre et Marie Curie Paris VI, Paris, France
Lancet 374:1617-25. 2009..Reports of an increased risk of lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease are controversial. We assessed this risk in a prospective observational cohort study...
- Usefulness of co-treatment with immunomodulators in patients with inflammatory bowel disease treated with scheduled infliximab maintenance therapyHarry Sokol
Gastroenterology and Nutrition Department, Saint Antoine Hospital, AP HP, 184 rue du Faubourg Saint Antoine, Paris, France
Gut 59:1363-8. 2010..The aim of this study was to assess whether IS co-treatment is useful in patients with inflammatory bowel disease (IBD) on scheduled IFX infusions...
- Predictive factors of response to cyclosporine in steroid-refractory ulcerative colitisWulfran Cacheux
Department of Gastroenterology, Assistance Publique des Hopitaux de Paris AP HP, Saint Antoine Hospital, Paris, France
Am J Gastroenterol 103:637-42. 2008..However, the individual's response to cyclosporine is poorly predictable. The aim of this study was to identify predictive factors of the response to cyclosporine in steroid-refractory UC...
- Risk factors for neoplasia in inflammatory bowel disease patients with pancolitisVivianne Bergeron
Service de Gastroenterologie et Nutrition, Hôpital Saint Antoine et Université Pierre et Marie Curie PARIS VI, Paris, France
Am J Gastroenterol 105:2405-11. 2010....
- Genotype/phenotype analyses for 53 Crohn's disease associated genetic polymorphismsCamille Jung
Universite Paris Diderot, UMR843, Paris, France
PLoS ONE 7:e52223. 2012..However, the impact of these associations in clinical practice remains to be defined. The aim of the study was to analyse the relationship between genotypes and phenotypes for the main 53 CD-associated polymorphisms...
- [Refractory proctitis]Philippe Seksik
Service de Gastroenterologie et Nutrition, Hopital Saint Antoine, Paris, France
Gastroenterol Clin Biol 31:393-7. 2007
- Disease activity and cancer risk in inflammatory bowel disease associated with primary sclerosing cholangitisHarry Sokol
Gastroenterology and Nutrition Department, Hospital Saint Antoine 184, rue du Faubourg Saint Antoine, Cedex 12, Paris 75571, France
World J Gastroenterol 14:3497-503. 2008..To investigate the phenotype of inflammatory bowel disease associated with primary sclerosing cholangitis (PSC-IBD)...
- Intestinal perforation in Crohn's disease. Factors predictive of surgical resectionHélène Brihier
Service de Gastroentérologie et Nutrition et Service de Chirurgie, Hopital Saint Antoine, Paris
Gastroenterol Clin Biol 29:1105-11. 2005..New medical therapeutic options challenge the usual surgical management of Crohn's disease patients with intestinal perforation...
- Predictive factors of response of perianal Crohn's disease to azathioprine or 6-mercaptopurineThierry Lecomte
Service de Gastroenterologie et Nutrition, Hopital Saint Antoine, Paris, France
Dis Colon Rectum 46:1469-75. 2003..This study was designed to evaluate the predictive factors of response of perianal Crohn's disease to azathioprine or 6-mercaptopurine...
- Long-term outcome of patients with Crohn's disease who respond to azathioprineMarine Camus
Department of Gastroenterology, Saint Antoine Hospital, Assistance Publique Hôpitaux de Paris and Paris VI University, Paris, France
Clin Gastroenterol Hepatol 11:389-94. 2013..Little is known about the long-term outcomes of patients with Crohn's disease (CD) who have a complete response to therapy with azathioprine. We assessed the long-term effects of azathioprine in responders...
- Incidence of nodular regenerative hyperplasia in inflammatory bowel disease patients treated with azathioprinePhilippe Seksik
Pierre and Marie Curie University, Faculte de Medecine, AP HP, Department of Gastroenterology and Nutrition, Hopital Saint Antoine, Paris, France
Inflamm Bowel Dis 17:565-72. 2011..The objective of this study was to evaluate the prevalence of NRH and its predictive factors in IBD patients treated with AZA...
- Significance of erythema nodosum and pyoderma gangrenosum in inflammatory bowel diseases: a cohort study of 2402 patientsDavid Farhi
Department of Dermatology, Hopital Tenon, AP HP, Paris, France
Medicine (Baltimore) 87:281-93. 2008..07). In conclusion, neither erythema nodosum nor pyoderma gangrenosum was significantly associated with the severity criteria in IBD; however, their occurrence may reflect a peculiar phenotype among affected patients...
- Predictive factors of eczema-like eruptions among patients without cutaneous psoriasis receiving infliximab: a cohort study of 92 patientsAbdolrasool Esmailzadeh
Department of Dermatology Allergology, Tenon Hospital, Paris, France
Dermatology 219:263-7. 2009..Anti-tumor-necrosis-factor-alpha agents are limited by their side effects. Eczema is one of the most frequent adverse reactions affecting quality of life...
- Pregnancy outcome in patients with inflammatory bowel disease treated with thiopurines: cohort from the CESAME StudyJessica Coelho
Department of Digestive Diseases, Lariboisiere Hospital, Paris, France
Gut 60:198-203. 2011..The aim of this study was to evaluate the pregnancy outcome of women with IBD who have been exposed to thiopurines...
- Prior appendectomy and the phenotype and course of Crohn's diseaseJacques Cosnes
Service de Gastroenterologie et Nutrition, Hopital St Antoine, 184 rue du Faubourg St Antoine, 75571 Paris Cedex 12, France
World J Gastroenterol 12:1235-42. 2006..To determine whether prior appendectomy modifies the phenotype and severity of Crohn's disease...
- Overexpression of microRNAs-155 and 21 targeting mismatch repair proteins in inflammatory bowel diseasesMagali Svrcek
INSERM UMR S 938 Centre de Recherche Saint Antoine, Equipe Instabilité des Microsatellites et Cancers, Equipe Labellisée Ligue contre le Cancer, Paris, France
Carcinogenesis 34:828-34. 2013..The detection and monitoring of miR-155 field defect may, therefore, have implications for the prevention and treatment of MSI IBD CRCs...
- Epstein-Barr virus viral load in Crohn's disease: effect of immunosuppressive therapyDidier Reijasse
Department of Gastroenterology, Saint Antoine University, Paris, France
Inflamm Bowel Dis 10:85-90. 2004..The aim of this work was to determine EBV-VL in patients with Crohn's disease (CD), both according to disease activity and use of immunosuppressive therapy, including infliximab...
- Risk factors associated with small bowel adenocarcinoma in Crohn's disease: a case-control studyGaël Piton
Service de Gastroenterologie et Nutrition, Centre Hospitalier Universitaire de Besancon, France
Am J Gastroenterol 103:1730-6. 2008..It is well established that Crohn's disease (CD) is associated with an increased risk of small bowel adenocarcinoma (SBA). The data concerning SBA risk factors in CD are scanty. The aim of this study was to identify them...
- Gender differences in the response of colitis to smokingJacques Cosnes
Hopital Saint Antoine, 184 rue du Faubourg St Antoine, 75571 Paris Cedex 12, France
Clin Gastroenterol Hepatol 2:41-8. 2004..The aim of this study was to examine in parallel the effect of smoking on ulcerative colitis and Crohn's colitis and assess the effect of gender on the response of colitis to smoking...
- Presentation and long-term follow-up of refractory celiac disease: comparison of type I with type IIGeorgia Malamut
Universite Paris Descartes, Paris, France
Gastroenterology 136:81-90. 2009..We compared the clinical and biological characteristics of RCD I and RCD II at diagnosis, the risk of developing an overt lymphoma, and the predictive factors of survival...
- Effects of light smoking consumption on the clinical course of Crohn's diseasePhilippe Seksik
Gastroenterology and Nutrition Department, Hôpital Saint Antoine and Université Pierre et Marie Curie, Paris VI, AP HP, Paris, France
Inflamm Bowel Dis 15:734-41. 2009..Cigarette smoking is associated with a more severe Crohn's disease (CD) course. However, the effect of light consumption is not known. Our aim was to characterize the effect of a light tobacco consumption on the course of CD...
- Predictors of Crohn's diseaseLaurent Beaugerie
Department of Gastroenterology, Saint Antoine Hospital, and Pierre et Marie Curie University, Paris, France
Gastroenterology 130:650-6. 2006..Early intensive therapy in Crohn's disease should be considered only in patients with disabling disease. The aim of our study was to identify at diagnosis factors predictive of a subsequent 5-year disabling course...
- Acute cryptosporidiosis as a cause of sudden recurrence of digestive symptoms in patients with Crohn's diseaseOrianne Colussi
Department of Gastroenterology and Nutrition, AP HP, Hôpital Saint Antoine F 75012 and UPMC Univ Paris 06 F 75005, Paris, France
J Crohns Colitis 4:669-70. 2010....
- Long-term evolution of disease behavior of Crohn's diseaseJacques Cosnes
Service d hépatogastroentérologie et nutrition, Hopital Rothschild, Paris, France
Inflamm Bowel Dis 8:244-50. 2002..Our aim was to assess the long-term evolution of the disease behavior of CD and to determine the predictive factors and prognostic implications of this evolution...
- [Undiagnosed celiac disease in childhood]Jacques Cosnes
Service de Gastroenterologie et Nutrition, Hopital Rothschild, Paris, France
Gastroenterol Clin Biol 26:616-23. 2002..This study was designed to assess the proportion of adult patients with celiac disease who had had undiagnosed symptoms during childhood and to determine the consequences of such diagnostic delay...
- Current smoking differentially affects blood mononuclear cells from patients with Crohn's disease and ulcerative colitis: relevance to its adverse role in the diseaseVivianne Bergeron
INSERM ERL U1057, UMR 7203, Paris, France
Inflamm Bowel Dis 18:1101-11. 2012..To investigate this paradox, we evaluated the effect of cigarette smoke in the function of blood mononuclear cells from healthy subjects and patients with CD or UC in flare up...
- Natural history of Crohn's disease: comparison between childhood- and adult-onset diseaseBenedicte Pigneur
gastroentérologie et nutrition pédiatrique, Hopital d Enfants Armand Trousseau, AP HP, Paris, France
Inflamm Bowel Dis 16:953-61. 2010..Childhood-onset Crohn's disease (CD) might reflect a more severe form of disease. To test this hypothesis we analyzed the long-term natural history of CD in an adult cohort of patients with childhood-onset compared to adult-onset CD...
- Outcome of infants with celiac diseaseJean Jacques Baudon
Departement de Pediatrie, Hopital Saint Antoine, Paris
Gastroenterol Clin Biol 29:1097-102. 2005..Determine the proportion of infants whose celiac disease (CD) was confirmed in childhood and evaluate their prognosis in adulthood...
- Methylation tolerance due to an O6-methylguanine DNA methyltransferase (MGMT) field defect in the colonic mucosa: an initiating step in the development of mismatch repair-deficient colorectal cancersMagali Svrcek
Equipe Instabilité des Microsatellites et Cancers, Hopital Saint Antoine, Paris Cedex, France
Gut 59:1516-26. 2010..It was therefore hypothesised that an MGMT field defect may constitute a preneoplastic event for the development of MMR-deficient tumours displaying microsatellite instability (MSI)...
- Multidrug resistance gene-1 polymorphisms and resistance to cyclosporine A in patients with steroid resistant ulcerative colitisFady Daniel
Department of Gastroenterology, Assistance Publique des Hopitaux de Paris AP HP, Hopital Europeen Georges Pompidou, Paris, France
Inflamm Bowel Dis 13:19-23. 2007..This study aimed to establish whether multidrug resistance gene (MDR)1 polymorphisms would be associated with CsA failure...
- Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseasesHenri Duboc
INSERM ERL U 1057, UMR7203, Paris, France
Gut 62:531-9. 2013..As dysbiosis has been reported in inflammatory bowel diseases (IBD), we aim to investigate the impact of IBD-associated dysbiosis on BA metabolism and its influence on the epithelial cell inflammation response...
- Erythema nodosum-like eruption as a manifestation of azathioprine hypersensitivity in patients with inflammatory bowel diseaseAnne Laure de Fonclare
Department of Dermatology, Hopital Tenon, Universite Pierre et Marie Curie, Paris, France
Arch Dermatol 143:744-8. 2007..Clinical manifestations of hypersensitivity to azathioprine may mimic symptoms of the initial disease. We report 5 cases of peculiar skin hypersensitivity reactions to azathioprine in patients with inflammatory bowel disease...
- Tobacco and IBD: relevance in the understanding of disease mechanisms and clinical practiceJacques Cosnes
Service de Gastroenterologie et Nutrition, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, France
Best Pract Res Clin Gastroenterol 18:481-96. 2004..A large amount of supportive information, use of nicotine-replacement therapies and antidepressants, and individual counselling might aid the patient in quitting...
- The enteropathy associated with common variable immunodeficiency: the delineated frontiers with celiac diseaseGeorgia Malamut
Universite Paris Descartes, France
Am J Gastroenterol 105:2262-75. 2010..We aimed to assess the clinical and histopathological features of the enteropathy associated with CVID...
- Azathioprine withdrawal in patients with Crohn's disease maintained on prolonged remission: a high risk of relapseXavier Treton
Hopital Beaujon, Pôle des Maladies de l Appareil Digestif, France
Clin Gastroenterol Hepatol 7:80-5. 2009....
- [Mycophenolate mofetil in refractory Crohn's disease after failure of treatments by azathioprine or methotrexate]Samira Hafraoui
Services d Hépato gastroentérologie, Hôpital Cl Huriez, Lille, Paris, France
Gastroenterol Clin Biol 26:17-22. 2002..Failure or intolerance of treatments by azathioprine (AZA) or methotrexate (MTX) is an important problem in the maintenance treatment of refractory CD. Results of the alternative use of mycophenolate mofetil (MMF) are conflicting...
- [Medical treatment of chronic radiation enteritis]Didier Reijasse
service d hépato gastroentérologie et nutrition, Hopital Rothschild, Paris, France
Gastroenterol Clin Biol 26:686-95. 2002
- Complications and surgery in the inflammatory bowel diseases biological eraHarry Sokol
Service de Gastroenterologie et Nutrition, Hopital St Antoine, et Université Paris VI, Paris, France
Curr Opin Gastroenterol 30:378-84. 2014..This article reviews the existing data on the long-term efficacy of biologics, that is, anti-TNF agents, for preventing complications and surgery in patients with IBD...
- Specific clinical and biological features characterize inflammatory bowel disease associated colorectal cancers showing microsatellite instabilityMagali Svrcek
Assistance Publique Hopitaux de Paris AP HP, Hopital Saint Antoine, Service d Anatomie Pathologique, Paris, France
J Clin Oncol 25:4231-8. 2007..We investigated a large series of IBD-N for associations between MSI and several biologic and clinical parameters related to tumors, patients, and their treatment...
- A nutritional support team in the pediatric intensive care unit: changes and factors impeding appropriate nutritionCecile Lambe
Réanimation Pédiatrique, Hopital Necker Enfants Malades, APHP, Universite Rene Descartes, Paris, France
Clin Nutr 26:355-63. 2007....