Pierre Corvol

Summary

Country: France

Publications

  1. doi request reprint Can we live without a functional renin-angiotensin system?
    Pierre Corvol
    INSERM, and Collège de France, Paris, France
    Clin Exp Pharmacol Physiol 35:431-3. 2008
  2. doi request reprint [Effect of apelin in cardiovascular system and water metabolism]
    Pierre Corvol
    Inserm U833, College de France, 11 place Marcelin Berthelot, 75005 Paris, France
    Therapie 64:233-9. 2009
  3. ncbi request reprint Inhibition of angiogenesis: a new function for angiotensinogen and des(angiotensin I)angiotensinogen
    Pierre Corvol
    INSERM U36, College de France, 11, place Marcelin Berthelot, 75231 Paris Cedex 05, France
    Curr Hypertens Rep 5:149-54. 2003
  4. ncbi request reprint Gene and cell therapy in cardiovascular diseases: still a long way to go
    Pierre Corvol
    INSERM U36, College de France, 11 place Marcelin Berthelot, 75231 Paris, France
    Therapie 59:1-4. 2004
  5. ncbi request reprint Angiotensinogen impairs angiogenesis in the chick chorioallantoic membrane
    Marcus Brand
    Institut National de la Santé et de la Recherche Médicale Unité 36, Pathologie Vasculaire et Endocrinologie Renale, Chaire de Médecine Expérimentale, College de France, Paris, France
    J Mol Med (Berl) 85:451-60. 2007
  6. pmc Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness
    Ariane Galaup
    Institut National de la Sante et de la Recherche Medicale, Unit 36, 11 place Marcelin Berthelot, 75005 Paris, France
    Proc Natl Acad Sci U S A 103:18721-6. 2006
  7. pmc Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton
    Aurelie Cazes
    INSERM U36, College de France, Paris
    Circ Res 99:1207-15. 2006
  8. doi request reprint Loss-of-function point mutations associated with renal tubular dysgenesis provide insights about renin function and cellular trafficking
    Annie Michaud
    INSERM, U833, Paris, France
    Hum Mol Genet 20:301-11. 2011
  9. pmc Angiogenesis and diabetes: different responses to pro-angiogenic factors in the chorioallantoic membrane assay
    Giovana S Di Marco
    Institut National de la Santé et de la Recherche Médicale INSERM U833, College de France, Paris, France
    Mol Med 14:705-14. 2008
  10. ncbi request reprint Role of the renin-angiotensin system in primitive erythropoiesis in the chick embryo
    Katia Savary
    Institut National de la Santé et de la Recherche Médicale U36, College de France, Paris, France
    Blood 105:103-10. 2005

Detail Information

Publications69

  1. doi request reprint Can we live without a functional renin-angiotensin system?
    Pierre Corvol
    INSERM, and Collège de France, Paris, France
    Clin Exp Pharmacol Physiol 35:431-3. 2008
    ..In mice, nephrogenesis is completed 2 weeks after birth, whereas in humans it is completed before birth, at 38 weeks of gestation...
  2. doi request reprint [Effect of apelin in cardiovascular system and water metabolism]
    Pierre Corvol
    Inserm U833, College de France, 11 place Marcelin Berthelot, 75005 Paris, France
    Therapie 64:233-9. 2009
    ..Several effects of the apelin system counteract those of the renin angiotensin system. It may represent a new and promising therapeutic opportunity for the treatment of cardiovascular diseases...
  3. ncbi request reprint Inhibition of angiogenesis: a new function for angiotensinogen and des(angiotensin I)angiotensinogen
    Pierre Corvol
    INSERM U36, College de France, 11, place Marcelin Berthelot, 75231 Paris Cedex 05, France
    Curr Hypertens Rep 5:149-54. 2003
    ..These new data must be considered in light of the overall action of the renin-angiotensin system in angiogenesis...
  4. ncbi request reprint Gene and cell therapy in cardiovascular diseases: still a long way to go
    Pierre Corvol
    INSERM U36, College de France, 11 place Marcelin Berthelot, 75231 Paris, France
    Therapie 59:1-4. 2004
  5. ncbi request reprint Angiotensinogen impairs angiogenesis in the chick chorioallantoic membrane
    Marcus Brand
    Institut National de la Santé et de la Recherche Médicale Unité 36, Pathologie Vasculaire et Endocrinologie Renale, Chaire de Médecine Expérimentale, College de France, Paris, France
    J Mol Med (Berl) 85:451-60. 2007
    ..Angiotensinogen, therefore, impairs angiogenesis without altering the expression level of vascular growth factors through the induction of apoptosis and decreased endothelial cell proliferation...
  6. pmc Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness
    Ariane Galaup
    Institut National de la Sante et de la Recherche Medicale, Unit 36, 11 place Marcelin Berthelot, 75005 Paris, France
    Proc Natl Acad Sci U S A 103:18721-6. 2006
    ..Together, these results show that ANGPTL4, through its action on both vascular and tumor compartments, prevents the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness...
  7. pmc Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton
    Aurelie Cazes
    INSERM U36, College de France, Paris
    Circ Res 99:1207-15. 2006
    ..Altogether, these findings show that hypoxic endothelial cells accumulate ANGPTL4 in the ECM, which in turn negatively regulates their angiogenic capacities through an autocrine pathway...
  8. doi request reprint Loss-of-function point mutations associated with renal tubular dysgenesis provide insights about renin function and cellular trafficking
    Annie Michaud
    INSERM, U833, Paris, France
    Hum Mol Genet 20:301-11. 2011
    ..This is the first characterization of the mechanisms underlying loss of renin function in RTD...
  9. pmc Angiogenesis and diabetes: different responses to pro-angiogenic factors in the chorioallantoic membrane assay
    Giovana S Di Marco
    Institut National de la Santé et de la Recherche Médicale INSERM U833, College de France, Paris, France
    Mol Med 14:705-14. 2008
    ....
  10. ncbi request reprint Role of the renin-angiotensin system in primitive erythropoiesis in the chick embryo
    Katia Savary
    Institut National de la Santé et de la Recherche Médicale U36, College de France, Paris, France
    Blood 105:103-10. 2005
    ..Both treatments affected hematocrit by decreasing erythroblast proliferation. Thus, the RAS, and its effector peptide angiotensin II in particular, modulates primitive erythropoiesis...
  11. ncbi request reprint Angiotensinogen modulates renal vasculature growth
    Marcus Brand
    Institut National de la Santé et de la Recherche Médicale Unité 36, Pathologie Vasculaire et Endocrinologie Renale, College de France, Paris, France
    Hypertension 47:1067-74. 2006
    ..Altogether, these observations provide the first quantitative evidence that a high level of angiotensinogen expression can inhibit the growth of kidney artery walls in vivo...
  12. pmc Angiopoietin 2 alters pancreatic vascularization in diabetic conditions
    Sophie Calderari
    Inserm U833, College de France, Paris, France
    PLoS ONE 7:e29438. 2012
    ..We have grafted xenogenic (avian) embryonic pancreas in severe combined immuno-deficient (SCID) mouse and analyzed endocrine and endothelial development in hyperglycaemic compared to normoglycaemic conditions...
  13. ncbi request reprint Hyperglycemia-induced defects in angiogenesis in the chicken chorioallantoic membrane model
    Etienne Larger
    INSERM U36, Chaire de Médecine Expérimentale, College de France, Paris, France
    Diabetes 53:752-61. 2004
    ..Hyperglycemia can therefore impair angiogenesis without altering the expression level of vascular growth factors through induction of apoptosis and decreased proliferation of endothelial cells...
  14. pmc Akt down-regulates ERK1/2 nuclear localization and angiotensin II-induced cell proliferation through PEA-15
    Marianne Gervais
    Institut National de la Santé et de la Recherche Médicale U36, College de France, 75231 Paris, France
    Mol Biol Cell 17:3940-51. 2006
    ..Thus, Akt overactivation prevents the nuclear translocation of ERK1/2 and the AngII-induced proliferation through interaction with and stabilization of endogenous PEA-15...
  15. ncbi request reprint Implication of Ref-1 in the repression of renin gene transcription by intracellular calcium
    Sebastien Fuchs
    INSERM U36, College de France, Paris, France
    J Hypertens 21:327-35. 2003
    ..As the renin gene is negatively regulated by calcium in the same way as the parathormone (PTH) gene, we hypothesized that a similar molecular transcriptional mechanism could be involved...
  16. ncbi request reprint Migration-stimulating factor displays HEXXH-dependent catalytic activity important for promoting tumor cell migration
    Xavier Houard
    INSERM Unite 36, College de France, Paris, France
    Int J Cancer 116:378-84. 2005
    ..These results suggest that MSF may be involved in tumor progression...
  17. ncbi request reprint Critical overexpression of thrombospondin 1 in chronic leg ischaemia
    Judith Favier
    INSERM U36, College de France, Paris, France
    J Pathol 207:358-66. 2005
    ..The overproduction of this anti-angiogenic molecule was associated with a decrease in capillary density in the affected muscles. Thrombospondin 1 is thus a marker of chronic ischaemia and may affect angiogenesis in ischaemic tissues...
  18. ncbi request reprint Anti-angiogenic properties of myo-inositol trispyrophosphate in ovo and growth reduction of implanted glioma
    Gabin Sihn
    Laboratoire de Pathologie Vasculaire et Endocrinologie Rénale, INSERM U36, College de France, 11, place Marcelin Berthelot, 75005 Paris, France
    FEBS Lett 581:962-6. 2007
    ..These results point out the potential of ITPP for the development of a new class of anti-angiogenic and anti-cancer compounds...
  19. pmc Angiopoietin-like 4 is a proangiogenic factor produced during ischemia and in conventional renal cell carcinoma
    Sebastien Le Jan
    INSERM U36, College de France, Paris
    Am J Pathol 162:1521-8. 2003
    ..This study also suggests that ANGPTL4 may provide a link between metabolic disorders and hypoxia-induced angiogenesis...
  20. pmc Modulation of macrophage activation state protects tissue from necrosis during critical limb ischemia in thrombospondin-1-deficient mice
    Nicolas Bréchot
    INSERM, U833, Paris, France
    PLoS ONE 3:e3950. 2008
    ..TSP-1 is a matricellular protein that displays well-known angiostatic properties in cancer, and regulates inflammation in vivo and macrophages properties in vitro. We therefore sought to investigate its function in a mouse model of CLI...
  21. pmc Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice
    Sandrine Billet
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, INSERM U567, Paris, France
    J Clin Invest 117:1914-25. 2007
    ....
  22. ncbi request reprint Aminopeptidase N during the ontogeny of the chick
    Gabin Sihn
    Laboratoire de Pathologie Vasculaire et Endocinologie Rénale, INSERM U36, College de France, 11, place Marcelin Berthelot 75005 Paris, France
    Differentiation 74:119-28. 2006
    ..This study provides clues as to the possible role of APN in embryonic development...
  23. doi request reprint Angiotensinogen delays angiogenesis and tumor growth of hepatocarcinoma in transgenic mice
    Francois Vincent
    Chaire de Médecine Expérimentale, Inserm U833, College de France, Paris, France
    Cancer Res 69:2853-60. 2009
    ..Overexpression of human angiotensinogen decreases angiogenesis, and prevents tumor sinusoids from remodeling and arterialization, thus delaying tumor progression in vivo...
  24. ncbi request reprint Functionality of two new polymorphisms in the human renin gene enhancer region
    Sebastien Fuchs
    INSERM Unit 36, College de France, 11 place Marcelin Berthelot, 75005 Paris, France
    J Hypertens 20:2391-8. 2002
    ..The production of renin, which catalyses the rate-limiting step of the renin-angiotensin system, is strongly stimulated by a 225 bp enhancer element in the distal region of the promoter of the human gene (-5777 to -5552)...
  25. pmc Angiogenesis and vascular architecture in pheochromocytomas: distinctive traits in malignant tumors
    Judith Favier
    Collège de France and Institut National de la Santé et de la Recherche Médicale U36, Paris, France
    Am J Pathol 161:1235-46. 2002
    ..Altogether, our observations show that analysis of angiogenesis provides promising new criteria for the diagnosis of malignant pheochromocytomas...
  26. doi request reprint Soluble form of the (pro)renin receptor generated by intracellular cleavage by furin is secreted in plasma
    Christelle Cousin
    Institut National de la Santé et de la Recherche Médicale and Collège de France, Paris, France
    Hypertension 53:1077-82. 2009
    ..In conclusion, our results show that s(P)RR is generated intracellularly by furin cleavage, and that s(P)RR detected in plasma is able to bind renin...
  27. doi request reprint Link between adipose tissue angiogenesis and fat accumulation in severely obese subjects
    Amal Y Lemoine
    Institut National de la Santé et de la Recherche Médicale Unité 833, College de France, 75005 Paris, France
    J Clin Endocrinol Metab 97:E775-80. 2012
    ..The role of angiogenesis in the expandability of human adipose tissue is established. However, whether sc and omental WAT (scWAT and oWAT) angiogenesis could influence fat distribution and metabolic diseases is not known...
  28. pmc Reciprocal regulation of plasma apelin and vasopressin by osmotic stimuli
    Michel Azizi
    Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Universite Paris Descartes, Faculte de Medecine, and INSERM, CIC 9201, Paris, France
    J Am Soc Nephrol 19:1015-24. 2008
  29. pmc Angiogenesis associated with visceral and subcutaneous adipose tissue in severe human obesity
    Severine Ledoux
    Institut National de la Santé et de la Recherche Médicale U833, Chaire de Médecine Expérimentale, College de France, Paris, France
    Diabetes 57:3247-57. 2008
    ..Our aim was to compare the angiogenesis associated with subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) from the same obese patients in an in vivo model...
  30. ncbi request reprint Angiotensinogen and its cleaved derivatives inhibit angiogenesis
    Jerome Celerier
    Institut National de la Santé et de la Recherche Médicale Unité 36, Pathologie Vasculaire et Endocrinologie Renale, Chaire de Médecine Expérimentale, College de France, Paris, France
    Hypertension 39:224-8. 2002
    ..Our data demonstrated that these compounds exerted a clear and equipotent antiangiogenic effect, thus attributing a novel function to angiotensinogen and des(angiotensin I)angiotensinogen, for which no function was previously known...
  31. pmc Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform
    Celine Delaloy
    INSERM U36, College de France, 11 place Marcelin Berthelot, 75005 Paris, France
    Mol Cell Biol 23:9208-21. 2003
    ..Thus, control of human WNK1 gene expression of kinase-active or -deficient isoforms is mediated predominantly through the use of multiple transcription initiation sites and tissue-specific regulatory elements...
  32. ncbi request reprint Characterization of the expression of the hypoxia-induced genes neuritin, TXNIP and IGFBP3 in cancer
    Sebastien Le Jan
    INSERM, Unit 36, Paris, France
    FEBS Lett 580:3395-400. 2006
    ..We propose these hypoxia-induced genes could represent relevant prognostic tools and targets for therapeutic intervention in cancers...
  33. ncbi request reprint The hematopoietic system: a new niche for the renin-angiotensin system
    Christine Hubert
    College de France, Paris
    Nat Clin Pract Cardiovasc Med 3:80-5. 2006
    ..The clinical relevance and therapeutic applications of these findings offer a new area of clinical research. In this article, we review the evidence for a role for the renin system in the control of hematopoiesis at its different stages...
  34. ncbi request reprint Tyrosine kinase and mitogen-activated protein kinase/extracellularly regulated kinase differentially regulate intracellular calcium concentration responses to angiotensin II/III and bradykinin in rat cortical thick ascending limb
    Annette Hus-Citharel
    Institut National de la Santé et de la Recherche Médicale Unité 691, College de France, 75231 Paris Cedex 05, France
    Endocrinology 147:451-63. 2006
    ..In contrast, the stimulatory effect of Ang II/III on Na+ transport is more complex and involves PKC and MAPK/ERK pathways...
  35. pmc A role of the (pro)renin receptor in neuronal cell differentiation
    Aurelie Contrepas
    Institut National de la Sante et de la Recherche Medicale, Unit 833 and Collège de France, Experimental Medicine Unit, Paris, France
    Am J Physiol Regul Integr Comp Physiol 297:R250-7. 2009
    ..In conclusion, our results show that (P)RR is expressed in mouse brain and suggest that the XLMR and epilepsy phenotype might result from a dominant-negative effect of the Delta4-(P)RR protein...
  36. ncbi request reprint Akt is a major downstream target of PI3-kinase involved in angiotensin II-induced proliferation
    Céline Dugourd
    INSERM U36 College de France, 11, place Marcelin Berthelot, 75005 Paris, France
    Hypertension 41:882-90. 2003
    ..These results provide the first evidence of a specific and necessary role of Akt in Ang II-induced proliferation through a Gq protein-dependent calcium-independent pathway...
  37. ncbi request reprint Heterodimerization of endothelin-converting enzyme-1 isoforms regulates the subcellular distribution of this metalloprotease
    Laurent Muller
    INSERM U 36 Collège de France Paris, 75005 Paris, France
    J Biol Chem 278:545-55. 2003
    ..These data demonstrated that the targeting signals specific for ECE-1b constitute a regulatory domain per se that could modulate the localization and the activity of other isoforms...
  38. doi request reprint Spectrum of mutations in the renin-angiotensin system genes in autosomal recessive renal tubular dysgenesis
    Olivier Gribouval
    INSERM U983, Faculté de Médecine Paris Descartes, Universite Paris Descartes, Paris, France
    Hum Mutat 33:316-26. 2012
    ..The identification of the disease on the basis of precise clinical and histological analyses and the characterization of the genetic defects allow genetic counseling and early prenatal diagnosis...
  39. ncbi request reprint Vascular smooth muscle cells efficiently activate a new proteinase cascade involving plasminogen and fibronectin
    Xavier Houard
    INSERM Unite 36, College de France, 11 place Marcelin Berthelot, 75231 Paris Cedex 05, France
    J Cell Biochem 88:1188-201. 2003
    ..By hydrolyzing matrix protein plasmin activates a latent metalloproteinase that differs from MMP, fibronectin-proteinase. This metalloproteinase may participate to vascular wall remodeling, in concert with other proteinases...
  40. ncbi request reprint [Ontogenesis of the renin system. Implication of this system in hematopoiesis]
    Pierre Corvol
    INSERM U36, College de France, 11, place Marcelin Berthelot, 75231 Paris Cedex 05
    Bull Acad Natl Med 188:631-6; discussion 636-7. 2004
    ..In addition, this system is involved in hematopoiesis following experimental irradiation of mice: renin system antagonists improve hematopoiesis in this situation...
  41. ncbi request reprint [Angiotensin II receptor blockers: current status and future prospects]
    Pierre Corvol
    Hopital Europeen Georges Pompidou, Paris, France
    Drugs 62:53-64. 2002
    ....
  42. ncbi request reprint Aminopeptidase A, generating one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, plays a key role in central control of blood pressure
    Raphael Rozenfeld
    INSERM U 36, College de France, 11 place Marcelin Berthelot, 75005 Paris, France
    Proc West Pharmacol Soc 46:39-44. 2003
  43. ncbi request reprint Self-measurement and self-titration in hypertension: a pilot telemedicine study
    Guillaume Bobrie
    Department of Hypertension, Hopital Europeen Georges Pompidou, Paris, France
    Am J Hypertens 20:1314-20. 2007
    ..Home blood-pressure measurements (HBPM) improve compliance of patients and achievement of blood pressure (BP) targets. However, few studies have evaluated self-BP management by patients...
  44. ncbi request reprint Expression of endothelins in human cardiogenesis
    Marcus Brand
    College de France, INSERM U36, 11 place Marcelin Berthelot, 75231 Paris Cedex 05, France
    J Mol Med (Berl) 80:715-23. 2002
    ..The results of this study suggest an important role for the ET system in the formation of certain anatomical structures of the developing human heart...
  45. ncbi request reprint Renal tubular dysgenesis, a not uncommon autosomal recessive disorder leading to oligohydramnios: Role of the Renin-Angiotensin system
    Mireille Lacoste
    Institut National de la Sante et de la Recherche Medicale, Unité 574, College de France, Paris, France
    J Am Soc Nephrol 17:2253-63. 2006
    ..The identification of the disease on the basis of precise histologic analysis and the research of the genetic defect now allow genetic counseling and early prenatal diagnosis...
  46. pmc Expression of renin in large arteries outside the kidney revealed by human renin promoter/LacZ transgenic mouse
    Sebastien Fuchs
    INSERM Unit 36, College de France, Paris
    Am J Pathol 161:717-25. 2002
    ..Therefore, this strain is a suitable model to investigate renin gene pathophysiological regulations in vivo...
  47. ncbi request reprint Genetic determinants of nonmodulating hypertension
    Natapong Kosachunhanun
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Hypertension 42:901-8. 2003
    ..For this subclass of essential hypertension, it is likely that genotyping can be substituted for complex phenotyping for therapeutic and preventive decision making...
  48. ncbi request reprint Suppression of angiogenesis, tumor growth, and metastasis by adenovirus-mediated gene transfer of human angiotensinogen
    Celine Bouquet
    CNRS UMR8121 Univ Paris Sud Vectorologie et Transfert de Gènes, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France
    Mol Ther 14:175-82. 2006
    ..Its delivery by gene transfer represents a promising new strategy to block primary tumor growth and to prevent metastasis...
  49. ncbi request reprint Troponin T as a marker of differentiation revealed by proteomic analysis in renal arterioles
    Florence Pinet
    INSERM U508, Pasteur Institute, 1 rue du Professeur Calmette, 59019 Lille Cedex, France
    FASEB J 18:585-6. 2004
    ..Confocal microscopy showed that troponin T is specific of the smooth muscle phenotype and absent in the myoepithelioïd phenotype. Our data suggest that troponin T is only present in renal smooth muscle cells...
  50. doi request reprint Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis
    Judith C Sluimer
    Department of Pathology, Cardiovascular Research Institute Maastricht CARIM, University of Maastricht, Maastricht, The Netherlands
    J Am Coll Cardiol 51:1258-65. 2008
    ..We sought to examine the presence of hypoxia in human carotid atherosclerosis and its association with hypoxia-inducible transcription factor (HIF) and intraplaque angiogenesis...
  51. ncbi request reprint [VEGF, anti-vEGF and diseases]
    Pierre Corvol
    Medecine vasculaire, Hopital Europeen Georges Pompidou, 24, rue Leblanc, 75015 Paris
    Bull Acad Natl Med 192:289-300; discussion 300-2. 2008
    ..Vascular endothelial growth factor (VEGF) plays a major role, and VEGF inhibition is a promising therapeutic approach to some tumoral and ocular diseases...
  52. ncbi request reprint Male fertility is dependent on dipeptidase activity of testis ACE
    Sebastien Fuchs
    Nat Med 11:1140-2; author reply 1142-3. 2005
  53. ncbi request reprint Mice lacking endothelial ACE: normal blood pressure with elevated angiotensin II
    Justin M Cole
    Department of Pathology, Emory University, Atlanta, GA 30322, USA
    Hypertension 41:313-21. 2003
    ..The ACE 1/3 mice demonstrate the plasticity of the RAS and show that significant compensation is required to maintain normal, basal blood pressure in a mouse with an impaired local vascular and renal RAS...
  54. ncbi request reprint Mice lacking endothelial angiotensin-converting enzyme have a normal blood pressure
    Justin Cole
    Department of Pathology, Emory University, Atlanta, GA 30322, USA
    Circ Res 90:87-92. 2002
    ..3(-/-) mice are indistinguishable from littermate wild-type mice. These data show that, under basal conditions, the normal regulation of blood pressure and renal function is possible in a mouse devoid of endothelial ACE...
  55. ncbi request reprint Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas
    Anne Paule Gimenez-Roqueplo
    AP HP, Hopital Europeen Georges Pompidou, Département de Génétique Moléculaire, Paris
    Cancer Res 63:5615-21. 2003
    ..These data strongly suggest that SDHB gene is a tumor suppressor gene and that the identification of germ-line mutations in SDHB gene in patients with ASPs should be considered as a high-risk factor for malignancy or recurrence...
  56. ncbi request reprint Angiotensin-converting enzyme C-terminal catalytic domain is the main site of angiotensin I cleavage in vivo
    Sebastien Fuchs
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Hypertension 51:267-74. 2008
    ..Although mice lacking C-domain activity have normal physiology under laboratory conditions, they respond less well to the stress of dehydration...
  57. ncbi request reprint Angiotensin-converting enzyme 2 (ACE2) and ACE activities display tissue-specific sensitivity to undernutrition-programmed hypertension in the adult rat
    Guillaume Rivière
    The UPRES EA 2701, Laboratoire de Neuroendocrinologie du Developpement, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq cedex, France
    Hypertension 46:1169-74. 2005
    ..Our results indicate that ACE2 and ACE are coexpressed in numerous rat tissues and that their increased activity in the lung of FR30 rats may participate in hypertension programming...
  58. ncbi request reprint [The renin-angiotensin system in human brain and brain tumors: a function unrelated to blood pressure control?]
    Lucienne Juillerat-Jeanneret
    Institut Universitaire de Pathologie, CHUV, 25, Rue du Bugnon, CH1011 Lausanne, Suisse
    Bull Acad Natl Med 188:639-46; discussion 647-8. 2004
    ....
  59. ncbi request reprint Spotlight on Pierre Corvol, MD
    Emma Baines
    Circulation 113:f79-80. 2006
  60. pmc Characterization of the first non-insect invertebrate functional angiotensin-converting enzyme (ACE): leech TtACE resembles the N-domain of mammalian ACE
    Guillaume Rivière
    Laboratoire de Neuroendocrinologie du Developpement, UPRES EA 2701, Bat SN4 2e étage, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq cedex, France
    Biochem J 382:565-73. 2004
    ..Although the precise roles and endogenous substrates of TtACE remain to be identified, characterization of this ancestral peptidase will help to clarify its physiological roles in non-insect invertebrate species...
  61. pmc Brain renin-angiotensin system blockade by systemically active aminopeptidase A inhibitors: a potential treatment of salt-dependent hypertension
    Marie Claude Fournie-Zaluski
    Institut National de la Santé et de la Recherche Médicale U266, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8600, Departement de Pharmacochimie Moleculaire et Structurale, 4 avenue de l Observatoire, 75006 Paris, France
    Proc Natl Acad Sci U S A 101:7775-80. 2004
    ....
  62. ncbi request reprint Angiogenic activity of human chorionic gonadotropin through LH receptor activation on endothelial and epithelial cells of the endometrium
    Sarah Berndt
    Laboratory of Tumor and Development Biology, Centre de Recherche en cancérologie Expérimentale, Universite de Liege, Liege, Belgium
    FASEB J 20:2630-2. 2006
    ..VEGF and hCG also displayed additive activities. Altogether, these data demonstrate that peritrophoblastic angiostimulation may result from a paracrine dialogue between trophoblast, epithelial, and endothelial cells through hCG and VEGF...
  63. ncbi request reprint Effect of reduced angiotensin-converting enzyme gene expression and angiotensin-converting enzyme inhibition on angiotensin and bradykinin peptide levels in mice
    Duncan J Campbell
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
    Hypertension 43:854-9. 2004
    ..These studies demonstrate that ACE is the predominant pathway of angiotensin II formation in blood and tissues of mice and plays a major role in bradykinin (1-9) metabolism in blood and, to a lesser extent, in kidney and heart...
  64. ncbi request reprint Role of the N-terminal catalytic domain of angiotensin-converting enzyme investigated by targeted inactivation in mice
    Sebastien Fuchs
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 279:15946-53. 2004
    ..It also strongly suggests that the anemia present in ACE null mice is not due to the accumulation of the peptide N-acetyl-Ser-Asp-Lys-Pro...
  65. ncbi request reprint Inherited renal tubular dysgenesis: the first patients surviving the neonatal period
    Andrea Zingg-Schenk
    Nephrology Unit, University Children s Hospital, Steinwiesstrasse 75, 8032, Zurich, Switzerland
    Eur J Pediatr 167:311-6. 2008
    ..Genetic and functional analysis of the renin-angiotensin system contributes to correct diagnosis...
  66. ncbi request reprint Characterization of the first angiotensin-converting like enzyme in bacteria: Ancestor ACE is already active
    Guillaume Rivière
    Unité Neurosciences et Physiologie Adaptative, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq cedex, France
    Gene 399:81-90. 2007
    ..XcACE characterization demonstrates that ACE is an ancestral enzyme, provoking questions about its appearance and structure/activity specialisation during the course of evolution...
  67. pmc Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency
    Robert S Jackson
    Chemical Pathology Department, East Surrey Hospital, Surrey, United Kingdom
    J Clin Invest 112:1550-60. 2003
    ....
  68. ncbi request reprint Constitutive internalization of constitutively active agiotensin II AT(1A) receptor mutants is blocked by inverse agonists
    Stéphanie Miserey-Lenkei
    INSERM EPI 0103, Institut Cochin, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
    J Biol Chem 277:5891-901. 2002
    ..This mechanism is different from the down-regulation observed for CAMs of other G protein-coupled receptors and thus defines a new paradigm for the cellular regulation of CAMs...
  69. ncbi request reprint Steroidogenesis in aldosterone-producing adenoma revisited by transcriptome analysis
    Guillaume Assie
    Institut National de la Sante et de la Recherche Medicale, Unité 567, Centre National de la Recherche Scientifique 8104, Universite Paris 5, Institut Cochin, 24 rue du Fg Saint Jacques, 75014 Paris, France
    J Clin Endocrinol Metab 90:6638-49. 2005
    ..Primary aldosteronism (PAL) is the most frequent cause of secondary arterial hypertension. In PAL, aldosterone production is chronic, excessive, and autonomous...