Harriet Corvol

Summary

Country: France

Publications

  1. doi request reprint [Challenges of personalized medicine for cystic fibrosis]
    H Corvol
    Service de pneumologie pédiatrique, Centre de Ressources et de Compétences pour la Mucoviscidose, Centre de reference des maladies respiratoires rares, Hopital Trousseau, AP HP, 26, avenue du Dr Netter, 75012 Paris, France Unité Inserm U938, Centre de Recherche Saint Antoine, 34, Rue Crozatier, 75012 Paris, France Université Pierre et Marie Curie Paris 6, 4, place Jussieu, 75005 Paris, France Electronic address
    Arch Pediatr 22:778-86. 2015
  2. doi request reprint [Why use long-term macrolide therapy in pediatric pulmonology?]
    H Corvol
    Service de pneumologie pédiatrique, Hopital Trousseau, AP HP, Centre de Ressources et de Compétences pour la Mucoviscidose, Centre de reference des maladies respiratoires rares, Universite Pierre et Marie Curie Paris 6, unité Inserm U938, 26, avenue du Dr Netter, 75012 Paris, France Electronic address
    Arch Pediatr 21:314-21. 2014
  3. pmc New insights into pediatric idiopathic pulmonary hemosiderosis: the French RespiRare(®) cohort
    Jessica Taytard
    Pediatric Pulmonary Department, AP HP, Hopital Trousseau, Universite Pierre et Marie Curie PARIS6, Inserm U938, 26, avenue du Docteur Arnold Netter, 75012 Paris, France
    Orphanet J Rare Dis 8:161. 2013
  4. doi request reprint Ancestral haplotype 8.1 and lung disease severity in European cystic fibrosis patients
    Harriet Corvol
    AP HP, Hopital Trousseau, Pediatric Pulmonary Department, Inserm U938, Paris, France
    J Cyst Fibros 11:63-7. 2012
  5. pmc Longitudinal survey of Staphylococcus aureus in cystic fibrosis patients using a multiple-locus variable-number of tandem-repeats analysis method
    Hoang Vu-Thien
    Universite Paris Sud 11, CNRS, UMR 8621, Institut de Genetique et Microbiologie, Orsay 91405, France
    BMC Microbiol 10:24. 2010
  6. pmc Genetic ancestry modifies pharmacogenetic gene-gene interaction for asthma
    Harriet Corvol
    Department of Biopharmaceutical Sciences, University of California, San Francisco, California, USA
    Pharmacogenet Genomics 19:489-96. 2009
  7. doi request reprint Genetic variations in inflammatory mediators influence lung disease progression in cystic fibrosis
    Harriet Corvol
    AP HP, Hopital Trousseau, Pediatric Pulmonary Department, Paris, France
    Pediatr Pulmonol 43:1224-32. 2008
  8. doi request reprint Pharmacogenetic response to albuterol among asthmatics
    Harriet Corvol
    UCSF Lung Biology Center, University of California, San Francisco, CA 94143 2911, USA
    Pharmacogenomics 9:505-10. 2008
  9. pmc Glucocorticoid receptor gene polymorphisms associated with progression of lung disease in young patients with cystic fibrosis
    Harriet Corvol
    Universite Pierre et Marie Curie PARIS6, Paris, 75571 France
    Respir Res 8:88. 2007
  10. pmc AGER -429T/C is associated with an increased lung disease severity in cystic fibrosis
    Julie Beucher
    AP HP, Hopital Trousseau, Pediatric Pulmonary Department, Inserm U938, Paris, France
    PLoS ONE 7:e41913. 2012

Collaborators

Detail Information

Publications32

  1. doi request reprint [Challenges of personalized medicine for cystic fibrosis]
    H Corvol
    Service de pneumologie pédiatrique, Centre de Ressources et de Compétences pour la Mucoviscidose, Centre de reference des maladies respiratoires rares, Hopital Trousseau, AP HP, 26, avenue du Dr Netter, 75012 Paris, France Unité Inserm U938, Centre de Recherche Saint Antoine, 34, Rue Crozatier, 75012 Paris, France Université Pierre et Marie Curie Paris 6, 4, place Jussieu, 75005 Paris, France Electronic address
    Arch Pediatr 22:778-86. 2015
    ..The various challenges of personalized medicine applied to cystic fibrosis issues are discussed in this paper. ..
  2. doi request reprint [Why use long-term macrolide therapy in pediatric pulmonology?]
    H Corvol
    Service de pneumologie pédiatrique, Hopital Trousseau, AP HP, Centre de Ressources et de Compétences pour la Mucoviscidose, Centre de reference des maladies respiratoires rares, Universite Pierre et Marie Curie Paris 6, unité Inserm U938, 26, avenue du Dr Netter, 75012 Paris, France Electronic address
    Arch Pediatr 21:314-21. 2014
    ..It also provides new insights on the potential effects of macrolides on diffuse parenchymal lung diseases. ..
  3. pmc New insights into pediatric idiopathic pulmonary hemosiderosis: the French RespiRare(®) cohort
    Jessica Taytard
    Pediatric Pulmonary Department, AP HP, Hopital Trousseau, Universite Pierre et Marie Curie PARIS6, Inserm U938, 26, avenue du Docteur Arnold Netter, 75012 Paris, France
    Orphanet J Rare Dis 8:161. 2013
    ..We present the French pediatric cohort of IPH collected through the French Reference Center for Rare Lung Diseases (RespiRare®, http://www.respirare.fr)...
  4. doi request reprint Ancestral haplotype 8.1 and lung disease severity in European cystic fibrosis patients
    Harriet Corvol
    AP HP, Hopital Trousseau, Pediatric Pulmonary Department, Inserm U938, Paris, France
    J Cyst Fibros 11:63-7. 2012
    ..As inflammation is a key component inducing CF lung damage, we investigated whether the 8.1AH represents a lung function modifier in CF...
  5. pmc Longitudinal survey of Staphylococcus aureus in cystic fibrosis patients using a multiple-locus variable-number of tandem-repeats analysis method
    Hoang Vu-Thien
    Universite Paris Sud 11, CNRS, UMR 8621, Institut de Genetique et Microbiologie, Orsay 91405, France
    BMC Microbiol 10:24. 2010
    ..Multiple-locus variable-number tandem repeat analysis (MLVA/VNTR) was used to survey S. aureus clinical isolates in a French paediatric CF centre...
  6. pmc Genetic ancestry modifies pharmacogenetic gene-gene interaction for asthma
    Harriet Corvol
    Department of Biopharmaceutical Sciences, University of California, San Francisco, California, USA
    Pharmacogenet Genomics 19:489-96. 2009
    ..Therefore, we reasoned that interactions between the IL6 and IL6R genes might be associated with bronchodilator drug responsiveness to albuterol in asthmatic patients...
  7. doi request reprint Genetic variations in inflammatory mediators influence lung disease progression in cystic fibrosis
    Harriet Corvol
    AP HP, Hopital Trousseau, Pediatric Pulmonary Department, Paris, France
    Pediatr Pulmonol 43:1224-32. 2008
    ..These findings support the concept that TGFB1 gene variants appear to be important genetic modifiers of lung disease progression in CF...
  8. doi request reprint Pharmacogenetic response to albuterol among asthmatics
    Harriet Corvol
    UCSF Lung Biology Center, University of California, San Francisco, CA 94143 2911, USA
    Pharmacogenomics 9:505-10. 2008
    ..Herein, we focus on pharmacogenetic associations between genetic variants in the beta(2)-adrenergic receptor gene and bronchodilator response to albuterol among subjects with asthma...
  9. pmc Glucocorticoid receptor gene polymorphisms associated with progression of lung disease in young patients with cystic fibrosis
    Harriet Corvol
    Universite Pierre et Marie Curie PARIS6, Paris, 75571 France
    Respir Res 8:88. 2007
    ....
  10. pmc AGER -429T/C is associated with an increased lung disease severity in cystic fibrosis
    Julie Beucher
    AP HP, Hopital Trousseau, Pediatric Pulmonary Department, Inserm U938, Paris, France
    PLoS ONE 7:e41913. 2012
    ..The functional promoter AGER -429C variant is associated with an increased RAGE expression that can lead to an increased lung inflammation and a more severe lung disease...
  11. ncbi request reprint Influence of interleukin-10 on Aspergillus fumigatus infection in patients with cystic fibrosis
    Jacques Brouard
    Inserm E213, Armand Trousseau Hospital, Paris, and the Department of Pediatrics, Georges Clemenceau Hospital, Caen, France
    J Infect Dis 191:1988-91. 2005
    ..fumigatus. These results suggest that polymorphisms in the promoter region of the IL-10 gene may influence the host response to A. fumigatus in the context of CF...
  12. ncbi request reprint Distinct cytokine production by lung and blood neutrophils from children with cystic fibrosis
    Harriet Corvol
    Departement de Pneumologie Pediatrique Institut National de la Santé et de la Recherche Médicale E213, Hopital Armand Trousseau, 75012 Paris, France
    Am J Physiol Lung Cell Mol Physiol 284:L997-1003. 2003
    ..They provide support to the hypothesis that not only the CF genotype but also the local environment may modify the functional properties of the neutrophils...
  13. pmc Neutrophils in cystic fibrosis display a distinct gene expression pattern
    Minou Adib-Conquy
    Unit Cytokines and Inflammation, Institut Pasteur, Paris, France
    Mol Med 14:36-44. 2008
    ..Altogether, this study clearly demonstrates that blood PMNs from CF patients display a profound modification of gene expression profile associated with the disease, suggesting a state of activation of these cells...
  14. doi request reprint Macrolides: new therapeutic perspectives in lung diseases
    Loic Guillot
    Inserm U938, Paris F 75012, France
    Int J Biochem Cell Biol 43:1241-6. 2011
    ..It also discusses novel findings which suggest that macrolides may contribute to alveolar surfactant homeostasis...
  15. pmc Interstitial lung diseases in children
    Annick Clement
    Pediatric Pulmonary Department, Reference Center for Rare Lung Diseases, AP HP, Hopital Trousseau, INSERM UMR S 938, Universite Pierre et Marie Curie Paris 6, Paris, F 75012 France
    Orphanet J Rare Dis 5:22. 2010
    ..An overall favorable response to corticosteroid therapy is observed in around 50% of cases, often associated with sequelae such as limited exercise tolerance or the need for long-term oxygen therapy...
  16. doi request reprint Lung sarcoidosis in children: update on disease expression and management
    Nadia Nathan
    Pediatric Pulmonary Department, AP HP, Hopital Trousseau, Paris, France Université Pierre et Marie Curie Paris6, Paris, France UMR S U933, INSERM, Paris, France
    Thorax 70:537-42. 2015
    ..Sarcoidosis is a rare lung disease in children. The aim of the present study was to provide update information on disease presentation and progression, patient management and prognosis factors in a cohort of children with lung sarcoidosis...
  17. doi request reprint Lung disease modifier genes in cystic fibrosis
    Loic Guillot
    INSERM, UMR_S 938, CDR Saint Antonie, Paris, France Sorbonne Universités, UPMC Univ Paris 06, UMR_S 938, CDR Saint Antonie, Paris, France Electronic address
    Int J Biochem Cell Biol 52:83-93. 2014
    ..e. the candidate gene approach; (2) a "without a priori" approach, analyzing the whole genome by linkage and genome-wide association studies (GWAS), or the whole exome by exome sequencing...
  18. pmc A national internet-linked based database for pediatric interstitial lung diseases: the French network
    Nadia Nathan
    AP HP, Hopital Trousseau, Pediatric Pulmonary Department, Paris, France
    Orphanet J Rare Dis 7:40. 2012
    ..After the launch of the French Reference Centre for Rare Lung Diseases (RespiRare®), we created a national network and a web-linked database to collect data on pediatric ILD...
  19. pmc Multiple-locus variable-number tandem-repeat analysis for longitudinal survey of sources of Pseudomonas aeruginosa infection in cystic fibrosis patients
    Hoang Vu-Thien
    Bacteriologie, Hopital Armand Trousseau, INSERM URM S 719, Paris, France
    J Clin Microbiol 45:3175-83. 2007
    ..aeruginosa infection. The resulting data and strain genetic profiles can be queried on http://bacterial-genotyping.igmors.u-psud.fr...
  20. doi request reprint Lessons from a French collaborative case-control study in cystic fibrosis patients during the 2009 A/H1N1 influenza pandemy
    Julie Bucher
    Hopital Necker Enfants Malades, Paris, France
    BMC Infect Dis 16:55. 2016
    ..However, the real morbidity of the influenza virus in CF needs to be further investigated because previous studies were only observational...
  21. doi request reprint Normal and Cystic Fibrosis Human Bronchial Epithelial Cells Infected with Pseudomonas aeruginosa Exhibit Distinct Gene Activation Patterns
    Viviane Balloy
    INSERM, UMR_S 938, CdR Saint Antoine, Paris, France Sorbonne Universités, UPMC Univ Paris 06, UMR_S 938, CdR Saint Antoine, Paris, France
    PLoS ONE 10:e0140979. 2015
    ..aeruginosa infection. Compared to noninfected cells, infected cells showed changes in gene activity, which were most marked 6 h postinfection and usually consisted in upregulation...
  22. doi request reprint New insights about miRNAs in cystic fibrosis
    Florence Sonneville
    INSERM UMR_S938, CdR Saint Antoine, Paris, France Sorbonne Universités, UPMC University Paris 06, Paris, France
    Am J Pathol 185:897-908. 2015
    ..The identification of miRNAs involved in CF disease progression opens up new avenues toward treatments targeting selected clinical components of CF, independently from the CFTR mutation...
  23. doi request reprint Anoctamin 1 dysregulation alters bronchial epithelial repair in cystic fibrosis
    Manon Ruffin
    INSERM, U938, 34 rue Crozatier, 75012 Paris, France UPMC, University of Paris 06, 4 place Jussieu, 75005 Paris, France
    Biochim Biophys Acta 1832:2340-51. 2013
    ..In summary, our study demonstrates involvement of ANO1 decreased activity and expression in abnormal CF airway epithelial repair and suggests that ANO1 correction may improve this process. ..
  24. pmc Reference percentiles for FEV(1) and BMI in European children and adults with cystic fibrosis
    Pierre Yves Boelle
    AP HP, Hôpital Trousseau Pediatric Pulmonary Department, Hopital St Antoine Public Health Department, Paris, France
    Orphanet J Rare Dis 7:64. 2012
    ..Here, we used a large database of European CF patients to compute CF specific reference equations for FEV(1) and BMI, derived CF-specific percentile charts and compared these European data to their nearest international equivalents...
  25. doi request reprint Translating the genetics of cystic fibrosis to personalized medicine
    Harriet Corvol
    INSERM, UMR_S 938, CdR Saint Antoine, Paris, France Sorbonne Universités, UPMC University Paris 06, UMR_S 938, CdR Saint Antoine, Paris, France Pneumologie pédiatrique, APHP, Hopital Trousseau, Paris, France
    Transl Res 168:40-9. 2016
    ..The various current and future challenges of personalized medicine as they apply to the issues faced in CF are discussed in this review. ..
  26. doi request reprint Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis
    Harriet Corvol
    Assistance Publique Hopitaux de Paris AP HP, Hopital Trousseau, Pediatric Pulmonary Department Institut National de la Santé et la Recherche Médicale INSERM U938, Paris 75012, France
    Nat Commun 6:8382. 2015
    ..The fifth locus, on chr11p12-p13 (EHF/APIP; P=1.9 × 10(-10)), was previously shown to be associated with lung disease. These results provide new insights into potential targets for modulating lung disease severity in CF. ..
  27. doi request reprint HRCT and MRI of the lung in children with cystic fibrosis: comparison of different scoring systems
    Chiara Sileo
    AP HP, Hopital Trousseau, Pediatric Radiology Department, Paris, France Université Pierre et Marie Curie Paris 6, Paris, France
    J Cyst Fibros 13:198-204. 2014
    ....
  28. doi request reprint Lung alveolar epithelium and interstitial lung disease
    Harriet Corvol
    INSERM, UMR S U938, Paris, France
    Int J Biochem Cell Biol 41:1643-51. 2009
    ..The mechanisms underlying disease progression are discussed, with a main focus on the apoptotic pathway, the endoplasmic reticulum stress response and the developmental pathway...
  29. pmc Flagellin concentrations in expectorations from cystic fibrosis patients
    Viviane Balloy
    Unité de Défense Innée et Inflammation, Institut Pasteur, Paris, France
    BMC Pulm Med 14:100. 2014
    ..The aim was to measure flagellin concentrations in the expectorations of CF patients and to examine whether there are correlations with the level of respiratory insufficiency and inflammation...
  30. doi request reprint Moving beyond genetics: is FAM13A a major biological contributor in lung physiology and chronic lung diseases?
    Harriet Corvol
    INSERM, UMR_S 938, CdR Saint Antoine, Paris, France Sorbonne Universités, UPMC Univ Paris 06, UMR_S 938, CdR Saint Antoine, Paris, France Pneumologie pédiatrique, APHP, Hopital Trousseau, Paris, France
    J Med Genet 51:646-9. 2014
    ..Further interpretations of FAM13A variants may help in the understanding of CLD mechanisms and reveal opportunity for intervention. ..
  31. doi request reprint Evaluation of the trachea and intrathoracic airways by the acoustic reflection method in children with cystic fibrosis
    Nicolas Leboulanger
    UPMC University Paris 06, France
    Respir Physiol Neurobiol 181:74-8. 2012
    ..37, p=0.04). The tracheal cross-sectional area measured by the ARM is normal in children with CF but the increase in Raw during FE suggests an increase in intrathoracic airway distensibility...
  32. ncbi request reprint Circulating and airway neutrophils in cystic fibrosis display different TLR expression and responsiveness to interleukin-10
    Anne France Petit-Bertron
    Unit Cytokines and Inflammation, Institut Pasteur, 28 rue Dr Roux, 75015 Paris, France
    Cytokine 41:54-60. 2008
    ....