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Species | D E CorpetSummaryCountry: France Publications
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Polyethylene-glycol, a potent suppressor of azoxymethane-induced colonic aberrant crypt foci in ratsD E Corpet
Sécurité des Aliments, INRA, Ecole Nationale Veterinaire de Toulouse, France
Carcinogenesis 20:915-8. 1999..0001). Two treated rats had no detectable ACF. PEG is 10 times more potent than other chemopreventive agents in this model. Since PEG is generally recognized as safe, its cancer-preventive features could be tested in humans...
Meat and cancer: haemoglobin and haemin in a low-calcium diet promote colorectal carcinogenesis at the aberrant crypt stage in ratsFabrice Pierre
Ecole Nationale Veterinaire Toulouse, UMR INRA ENVT Xénobiotiques, 23 Capelles, 31076 Toulouse, France
Carcinogenesis 24:1683-90. 2003..The results suggest that myoglobin in red meat could promote colon cancer. Diets high in calcium, or in oxidation-resistant fats, may prevent the possible cancer-promoting effect of red meat...
Red meat and colon cancer: should we become vegetarians, or can we make meat safer?Denis E Corpet
Universite de Toulouse, ENVT, INRA, UMR Toxalim, Capelles, France
Meat Sci 89:310-6. 2011..These additives, and others still under study, could provide an acceptable way to prevent colorectal cancer...- Consistent and fast inhibition of colon carcinogenesis by polyethylene glycol in mice and rats given various carcinogensD E Corpet
Sécurité des Aliments, Institut National de la Recherche Agronomique, Ecole Nationale Veterinaire de Toulouse, France
Cancer Res 60:3160-4. 2000..Moreover, PEG is one of the most potent inhibitors of colon tumor in the standard rat model. Since PEG has no known toxicity in humans, we think it should be tested as a chemopreventive agent in a clinical trial... - Dehydroalanine and lysinoalanine in thermolyzed casein do not promote colon cancer in the ratDenis E Corpet
Universite de Toulouse, INRA, ENVT, UMR1089 Xenobiotiques, F 31076 Toulouse, France
Food Chem Toxicol 46:3037-42. 2008..These results do not support the notion that lysinoalanine or dehydroalanine are a hazard with respect to colon carcinogenicity... - How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and menDenis E Corpet
UMR Xenobiotiques, Institut National Recherche Agronomique, Ecole Nationale Veterinaire Toulouse, BP 87614, 23 Capelles, 31076 Toulouse, France
Eur J Cancer 41:1911-22. 2005..However, rodent studies are useful to screen potential chemopreventive agents, and to study mechanisms of carcinogenesis and chemoprevention... - Most effective colon cancer chemopreventive agents in rats: a systematic review of aberrant crypt foci and tumor data, ranked by potencyDenis E Corpet
Institut National de la Recherche Agronomique, Ecole Nationale Veterinaire de Toulouse, 31076 Toulouse, France
Nutr Cancer 43:1-21. 2002..In conclusion, this review gathers most known chemopreventive agents, ranks the most promising agents against colon carcinogenesis in rats or mice, and further supports the use of ACF as a surrogate end point for tumors in rats... - Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model systemDenis E Corpet
UMR Xenobiotiques, Institut National Recherche Agronomique, Ecole Nationale Veterinaire Toulouse, 31076 Toulouse, France
Cancer Epidemiol Biomarkers Prev 12:391-400. 2003.... - Endogenous N-nitroso compounds, and their precursors, present in bacon, do not initiate or promote aberrant crypt foci in the colon of ratsG Parnaud
, Institut National de la Recherche Agronomique, , 31076 Toulouse, France
Nutr Cancer 38:74-80. 2000..01). Results suggest that NOC from dietary bacon would not enhance colon carcinogenesis in rats... - Insulin injections promote the growth of aberrant crypt foci in the colon of ratsD E Corpet
Institut National de la Recherche Agronomique, Ecole Nationale Veterinaire, Toulouse, France
Nutr Cancer 27:316-20. 1997..04). These data show that exogenous insulin can promote colon carcinogenesis in rats and suggest that life-style and diets leading to low blood insulin might protect humans against colorectal cancer... - Pluronic F68 block polymer, a very potent suppressor of carcinogenesis in the colon of rats and miceG Parnaud
, INRA, , 23 ch. des Capelles, Toulouse, 31076, France
Br J Cancer 84:90-3. 2001..0001). Next 3 studies confirmed this pluronic efficacy in rats and mice. This non-toxic laxative seems roughly 5 times more potent than PEG for chemoprevention... - Meat processing and colon carcinogenesis: cooked, nitrite-treated, and oxidized high-heme cured meat promotes mucin-depleted foci in ratsRaphaëlle L Santarelli
Universite de Toulouse, ENVT, INRA, UMR Xenobiotiques, France
Cancer Prev Res (Phila) 3:852-64. 2010..Nitrite treatment and oxidation increased this promoting effect, which was linked with increased fecal ATNC level. This study could lead to process modifications to make nonpromoting processed meat... - Polyethylene glycol, unique among laxatives, suppresses aberrant crypt foci, by elimination of cellsSylviane Tache
UMR Xenobiotiques, Institut National Recherche Agronomique, Ecole Nationale Veterinaire de Toulouse, Toulouse, France
Scand J Gastroenterol 41:730-6. 2006..In a search for the underling mechanisms, the hypothesis that fecal bulking and moisture decrease colon carcinogenesis was tested. We also investigated the PEG effects on crypt cells in vivo... - Ranking chemopreventive agents on rat colon carcinogenesisD E Corpet
, Institut National de la Recherche Agronomique, , 23 ch. Capelles, 31076 Toulouse, France
IARC Sci Publ 156:381-4. 2002 - Beef meat promotion of dimethylhydrazine-induced colorectal carcinogenesis biomarkers is suppressed by dietary calciumFabrice Pierre
UMR1089 Xenobiotiques, INRA ENVT, 23 ch Capelles, Toulouse, France
Br J Nutr 99:1000-6. 2008..They suggest that Ca can reduce colorectal cancer risk in meat-eaters. The results support the concept that toxicity associated with the excess of a useful nutrient may be prevented by another nutrient... - Chemoprevention of aberrant crypt foci in the colon of rats by dietary onionSylviane Tache
UMR1089 Xenobiotiques, INRA and ENVT, 23 ch Capelles, F 31076 Toulouse, France
Eur J Cancer 43:454-8. 2007..02). Phytochemicals diet and pluronic diet reduced ACF growth similarly. Data show that a 5% onion diet reduced carcinogenesis during initiation and promotion stages, and suggest this chemoprevention is due to known phytochemicals... - Beef meat and blood sausage promote the formation of azoxymethane-induced mucin-depleted foci and aberrant crypt foci in rat colonsFabrice Pierre
Ecole Nationale Veterinaire Toulouse, UMR INRA ENVT Xénobiotiques, 23 Capelles, 31076 Toulouse, France
J Nutr 134:2711-6. 2004..MDF promotion was correlated with high fecal water lipoperoxides and cytotoxicity (r = 0.65, P < 0.01). This is the first study to show the promotion of experimental carcinogenesis by dietary meat and the association with heme intake... - Cytostatic effect of polyethylene glycol on human colonic adenocarcinoma cellsG Parnaud
, Institut National de la Recherche Agronomique, Toulouse, France
Int J Cancer 92:63-9. 2001..This growth inhibition may be due to the high osmotic pressure induced by PEG in vitro. Because the osmotic pressure is high in feces of PEG-fed rats, it may explain the suppression of colon carcinogenesis by PEG... - Processed meat and colorectal cancer: a review of epidemiologic and experimental evidenceRaphaëlle L Santarelli
UMR1089 INRA ENVT Xénobiotiques, Universite de Toulouse, Ecole Nationale Veterinaire, Toulouse, France
Nutr Cancer 60:131-44. 2008..Nitrosation might increase the toxicity of heme in cured products. Solving this puzzle is a challenge that would permit to reduce cancer load by changing the processes rather than by banning processed meat... - New marker of colon cancer risk associated with heme intake: 1,4-dihydroxynonane mercapturic acidFabrice Pierre
, , Toulouse, France
Cancer Epidemiol Biomarkers Prev 15:2274-9. 2006..CONCLUSION: Urinary DHN-MA is a useful noninvasive biomarker for determining the risk of preneoplastic lesions associated with heme iron consumption and should be further investigated as a potential biomarker of colon cancer risk... - Polyethylene glycol and prevalence of colorectal adenomasEtienne Dorval
Gastroenterologie, Hopital Trousseau, CHRU de Tours
Gastroenterol Clin Biol 30:1196-9. 2006..French laxatives include Forlax (PEG4000), Movicol and Transipeg (PEG3350), and Idrocol (pluronic F68). This study tests the hypothesis that use of a PEG-based laxative might reduce the prevalence of colorectal tumors... - Impact of residual and therapeutic doses of ciprofloxacin in the human-flora-associated mice modelAgnes Perrin-Guyomard
Agence Francaise de Securite Sanitaire des Aliments, Laboratoire d Etudes et de Recherches sur les Médicaments Vétérinaires et les Désinfectants, BP 90203, 35302 Fougeres Cedex, France
Regul Toxicol Pharmacol 42:151-60. 2005..Under the experimental conditions of the study, the no-observed-effect level of ciprofloxacin was found to be less than 0.125 mg/kg b.w...