D E Corpet

Summary

Country: France

Publications

  1. ncbi request reprint Polyethylene-glycol, a potent suppressor of azoxymethane-induced colonic aberrant crypt foci in rats
    D E Corpet
    Sécurité des Aliments, INRA, Ecole Nationale Veterinaire de Toulouse, France
    Carcinogenesis 20:915-8. 1999
  2. pmc Meat and cancer: haemoglobin and haemin in a low-calcium diet promote colorectal carcinogenesis at the aberrant crypt stage in rats
    Fabrice Pierre
    Ecole Nationale Veterinaire Toulouse, UMR INRA ENVT Xénobiotiques, 23 Capelles, 31076 Toulouse, France
    Carcinogenesis 24:1683-90. 2003
  3. doi request reprint Red meat and colon cancer: should we become vegetarians, or can we make meat safer?
    Denis E Corpet
    Universite de Toulouse, ENVT, INRA, UMR Toxalim, Capelles, France
    Meat Sci 89:310-6. 2011
  4. pmc Heme-induced biomarkers associated with red meat promotion of colon cancer are not modulated by the intake of nitrite
    Fatima Z Chenni
    Department of Biology, Université Djillali Liabés, Sidi Bel Abbes, Algeria
    Nutr Cancer 65:227-33. 2013
  5. ncbi request reprint Consistent and fast inhibition of colon carcinogenesis by polyethylene glycol in mice and rats given various carcinogens
    D E Corpet
    Sécurité des Aliments, Institut National de la Recherche Agronomique, Ecole Nationale Veterinaire de Toulouse, France
    Cancer Res 60:3160-4. 2000
  6. doi request reprint Dehydroalanine and lysinoalanine in thermolyzed casein do not promote colon cancer in the rat
    Denis E Corpet
    Universite de Toulouse, INRA, ENVT, UMR1089 Xenobiotiques, F 31076 Toulouse, France
    Food Chem Toxicol 46:3037-42. 2008
  7. pmc Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system
    Denis E Corpet
    UMR Xenobiotiques, Institut National Recherche Agronomique, Ecole Nationale Veterinaire Toulouse, 31076 Toulouse, France
    Cancer Epidemiol Biomarkers Prev 12:391-400. 2003
  8. pmc Most effective colon cancer chemopreventive agents in rats: a systematic review of aberrant crypt foci and tumor data, ranked by potency
    Denis E Corpet
    Institut National de la Recherche Agronomique, Ecole Nationale Veterinaire de Toulouse, 31076 Toulouse, France
    Nutr Cancer 43:1-21. 2002
  9. ncbi request reprint How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men
    Denis E Corpet
    UMR Xenobiotiques, Institut National Recherche Agronomique, Ecole Nationale Veterinaire Toulouse, BP 87614, 23 Capelles, 31076 Toulouse, France
    Eur J Cancer 41:1911-22. 2005
  10. pmc Endogenous N-nitroso compounds, and their precursors, present in bacon, do not initiate or promote aberrant crypt foci in the colon of rats
    G Parnaud
    , Institut National de la Recherche Agronomique, , 31076 Toulouse, France
    Nutr Cancer 38:74-80. 2000

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Polyethylene-glycol, a potent suppressor of azoxymethane-induced colonic aberrant crypt foci in rats
    D E Corpet
    Sécurité des Aliments, INRA, Ecole Nationale Veterinaire de Toulouse, France
    Carcinogenesis 20:915-8. 1999
    ..0001). Two treated rats had no detectable ACF. PEG is 10 times more potent than other chemopreventive agents in this model. Since PEG is generally recognized as safe, its cancer-preventive features could be tested in humans...
  2. pmc Meat and cancer: haemoglobin and haemin in a low-calcium diet promote colorectal carcinogenesis at the aberrant crypt stage in rats
    Fabrice Pierre
    Ecole Nationale Veterinaire Toulouse, UMR INRA ENVT Xénobiotiques, 23 Capelles, 31076 Toulouse, France
    Carcinogenesis 24:1683-90. 2003
    ..The results suggest that myoglobin in red meat could promote colon cancer. Diets high in calcium, or in oxidation-resistant fats, may prevent the possible cancer-promoting effect of red meat...
  3. doi request reprint Red meat and colon cancer: should we become vegetarians, or can we make meat safer?
    Denis E Corpet
    Universite de Toulouse, ENVT, INRA, UMR Toxalim, Capelles, France
    Meat Sci 89:310-6. 2011
    ..These additives, and others still under study, could provide an acceptable way to prevent colorectal cancer...
  4. pmc Heme-induced biomarkers associated with red meat promotion of colon cancer are not modulated by the intake of nitrite
    Fatima Z Chenni
    Department of Biology, Université Djillali Liabés, Sidi Bel Abbes, Algeria
    Nutr Cancer 65:227-33. 2013
    ..We thus suggest that the rat model could be relevant for study the effect of red meat on colon carcinogenesis, in spite of the lack of nitrite in the saliva of rats...
  5. ncbi request reprint Consistent and fast inhibition of colon carcinogenesis by polyethylene glycol in mice and rats given various carcinogens
    D E Corpet
    Sécurité des Aliments, Institut National de la Recherche Agronomique, Ecole Nationale Veterinaire de Toulouse, France
    Cancer Res 60:3160-4. 2000
    ..Moreover, PEG is one of the most potent inhibitors of colon tumor in the standard rat model. Since PEG has no known toxicity in humans, we think it should be tested as a chemopreventive agent in a clinical trial...
  6. doi request reprint Dehydroalanine and lysinoalanine in thermolyzed casein do not promote colon cancer in the rat
    Denis E Corpet
    Universite de Toulouse, INRA, ENVT, UMR1089 Xenobiotiques, F 31076 Toulouse, France
    Food Chem Toxicol 46:3037-42. 2008
    ..These results do not support the notion that lysinoalanine or dehydroalanine are a hazard with respect to colon carcinogenicity...
  7. pmc Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system
    Denis E Corpet
    UMR Xenobiotiques, Institut National Recherche Agronomique, Ecole Nationale Veterinaire Toulouse, 31076 Toulouse, France
    Cancer Epidemiol Biomarkers Prev 12:391-400. 2003
    ....
  8. pmc Most effective colon cancer chemopreventive agents in rats: a systematic review of aberrant crypt foci and tumor data, ranked by potency
    Denis E Corpet
    Institut National de la Recherche Agronomique, Ecole Nationale Veterinaire de Toulouse, 31076 Toulouse, France
    Nutr Cancer 43:1-21. 2002
    ..In conclusion, this review gathers most known chemopreventive agents, ranks the most promising agents against colon carcinogenesis in rats or mice, and further supports the use of ACF as a surrogate end point for tumors in rats...
  9. ncbi request reprint How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men
    Denis E Corpet
    UMR Xenobiotiques, Institut National Recherche Agronomique, Ecole Nationale Veterinaire Toulouse, BP 87614, 23 Capelles, 31076 Toulouse, France
    Eur J Cancer 41:1911-22. 2005
    ..However, rodent studies are useful to screen potential chemopreventive agents, and to study mechanisms of carcinogenesis and chemoprevention...
  10. pmc Endogenous N-nitroso compounds, and their precursors, present in bacon, do not initiate or promote aberrant crypt foci in the colon of rats
    G Parnaud
    , Institut National de la Recherche Agronomique, , 31076 Toulouse, France
    Nutr Cancer 38:74-80. 2000
    ..01). Results suggest that NOC from dietary bacon would not enhance colon carcinogenesis in rats...
  11. pmc Insulin injections promote the growth of aberrant crypt foci in the colon of rats
    D E Corpet
    Institut National de la Recherche Agronomique, Ecole Nationale Veterinaire, Toulouse, France
    Nutr Cancer 27:316-20. 1997
    ..04). These data show that exogenous insulin can promote colon carcinogenesis in rats and suggest that life-style and diets leading to low blood insulin might protect humans against colorectal cancer...
  12. pmc Pluronic F68 block polymer, a very potent suppressor of carcinogenesis in the colon of rats and mice
    G Parnaud
    , INRA, , 23 ch. des Capelles, Toulouse, 31076, France
    Br J Cancer 84:90-3. 2001
    ..0001). Next 3 studies confirmed this pluronic efficacy in rats and mice. This non-toxic laxative seems roughly 5 times more potent than PEG for chemoprevention...
  13. pmc Meat processing and colon carcinogenesis: cooked, nitrite-treated, and oxidized high-heme cured meat promotes mucin-depleted foci in rats
    Raphaëlle L Santarelli
    Universite de Toulouse, ENVT, INRA, UMR Xenobiotiques, France
    Cancer Prev Res (Phila) 3:852-64. 2010
    ..Nitrite treatment and oxidation increased this promoting effect, which was linked with increased fecal ATNC level. This study could lead to process modifications to make nonpromoting processed meat...
  14. ncbi request reprint Ranking chemopreventive agents on rat colon carcinogenesis
    D E Corpet
    UMR Xenobiotiques, Institut National de la Recherche Agronomique, Ecole Nationale Veterinaire de Toulouse, 23 ch Capelles, 31076 Toulouse, France
    IARC Sci Publ 156:381-4. 2002
  15. pmc Polyethylene glycol, unique among laxatives, suppresses aberrant crypt foci, by elimination of cells
    Sylviane Tache
    UMR Xenobiotiques, Institut National Recherche Agronomique, Ecole Nationale Veterinaire de Toulouse, Toulouse, France
    Scand J Gastroenterol 41:730-6. 2006
    ..In a search for the underling mechanisms, the hypothesis that fecal bulking and moisture decrease colon carcinogenesis was tested. We also investigated the PEG effects on crypt cells in vivo...
  16. ncbi request reprint Beef meat and blood sausage promote the formation of azoxymethane-induced mucin-depleted foci and aberrant crypt foci in rat colons
    Fabrice Pierre
    Ecole Nationale Veterinaire Toulouse, UMR INRA ENVT Xénobiotiques, 23 Capelles, 31076 Toulouse, France
    J Nutr 134:2711-6. 2004
    ..MDF promotion was correlated with high fecal water lipoperoxides and cytotoxicity (r = 0.65, P < 0.01). This is the first study to show the promotion of experimental carcinogenesis by dietary meat and the association with heme intake...
  17. pmc Beef meat promotion of dimethylhydrazine-induced colorectal carcinogenesis biomarkers is suppressed by dietary calcium
    Fabrice Pierre
    UMR1089 Xenobiotiques, INRA ENVT, 23 ch Capelles, Toulouse, France
    Br J Nutr 99:1000-6. 2008
    ..They suggest that Ca can reduce colorectal cancer risk in meat-eaters. The results support the concept that toxicity associated with the excess of a useful nutrient may be prevented by another nutrient...
  18. ncbi request reprint Chemoprevention of aberrant crypt foci in the colon of rats by dietary onion
    Sylviane Tache
    UMR1089 Xenobiotiques, INRA and ENVT, 23 ch Capelles, F 31076 Toulouse, France
    Eur J Cancer 43:454-8. 2007
    ..02). Phytochemicals diet and pluronic diet reduced ACF growth similarly. Data show that a 5% onion diet reduced carcinogenesis during initiation and promotion stages, and suggest this chemoprevention is due to known phytochemicals...
  19. ncbi request reprint Cytostatic effect of polyethylene glycol on human colonic adenocarcinoma cells
    G Parnaud
    , Institut National de la Recherche Agronomique, Toulouse, France
    Int J Cancer 92:63-9. 2001
    ..This growth inhibition may be due to the high osmotic pressure induced by PEG in vitro. Because the osmotic pressure is high in feces of PEG-fed rats, it may explain the suppression of colon carcinogenesis by PEG...
  20. pmc Processed meat and colorectal cancer: a review of epidemiologic and experimental evidence
    Raphaëlle L Santarelli
    UMR1089 INRA ENVT Xénobiotiques, Universite de Toulouse, Ecole Nationale Veterinaire, Toulouse, France
    Nutr Cancer 60:131-44. 2008
    ..Nitrosation might increase the toxicity of heme in cured products. Solving this puzzle is a challenge that would permit to reduce cancer load by changing the processes rather than by banning processed meat...
  21. ncbi request reprint New marker of colon cancer risk associated with heme intake: 1,4-dihydroxynonane mercapturic acid
    Fabrice Pierre
    Ecole Nationale Veterinaire Toulouse, UMR INRA ENVT 1089 Xénobiotiques, Toulouse, France
    Cancer Epidemiol Biomarkers Prev 15:2274-9. 2006
    ....
  22. ncbi request reprint Polyethylene glycol and prevalence of colorectal adenomas
    Etienne Dorval
    Gastroenterologie, Hopital Trousseau, CHRU de Tours
    Gastroenterol Clin Biol 30:1196-9. 2006
    ..French laxatives include Forlax (PEG4000), Movicol and Transipeg (PEG3350), and Idrocol (pluronic F68). This study tests the hypothesis that use of a PEG-based laxative might reduce the prevalence of colorectal tumors...
  23. ncbi request reprint Impact of residual and therapeutic doses of ciprofloxacin in the human-flora-associated mice model
    Agnes Perrin-Guyomard
    Agence Francaise de Securite Sanitaire des Aliments, Laboratoire d Etudes et de Recherches sur les Médicaments Vétérinaires et les Désinfectants, BP 90203, 35302 Fougeres Cedex, France
    Regul Toxicol Pharmacol 42:151-60. 2005
    ..Under the experimental conditions of the study, the no-observed-effect level of ciprofloxacin was found to be less than 0.125 mg/kg b.w...