Philippe Corcia

Summary

Country: France

Publications

  1. ncbi request reprint [Methods of the announcement of amyotrophic lateral sclerosis diagnosis in familial forms]
    P Corcia
    Centre SLA de Tours, CHU Bretonneau, Tours
    Rev Neurol (Paris) 162:4S122-4S126. 2006
  2. ncbi request reprint [Genetics of amyotrophic lateral sclerosis]
    Philippe Corcia
    CHRU de Tours, Centre SLA, Service de Neurologie et Neurophysiologie Clinique, 37044 Tours Cedex 1, France Université François Rabelais de Tours, UMR Inserm U930, 37000 Tours, France Electronic address
    Presse Med 43:555-62. 2014
  3. pmc Molecular imaging of microglial activation in amyotrophic lateral sclerosis
    Philippe Corcia
    ALS Center, Department of Neurology, CHRU Bretonneau, Tours, France
    PLoS ONE 7:e52941. 2012
  4. pmc Homozygous SMN2 deletion is a protective factor in the Swedish ALS population
    Philippe Corcia
    Centre SLA, CHRU de Tours, Tours, France
    Eur J Hum Genet 20:588-91. 2012
  5. doi request reprint Phenotype and genotype analysis in amyotrophic lateral sclerosis with TARDBP gene mutations
    P Corcia
    Centre SLA, CHU Tours, Tours, France
    Neurology 78:1519-26. 2012
  6. ncbi request reprint [Thoracic outlet syndrome: an unusual postoperative complication]
    P Corcia
    Service de Neurologie, CHRU Bretonneau, Tours, France
    Rev Neurol (Paris) 162:240-2. 2006
  7. doi request reprint Absence of the OPTN mutation in a patient with ALS and familial primary open angle glaucoma
    P Corcia
    Centre SLA, CHRU de Tours, Tours, France UMR INSERM U930, Universite Francois Rabelais de Tours, Tours, France
    J Neurol Sci 309:16-7. 2011
  8. doi request reprint The importance of the SMN genes in the genetics of sporadic ALS
    Philippe Corcia
    ALS Centre, CHU Tours, INSERM, Universite Francois Rabelais, 2 boulevard Tonnelle, Tours Cedex 1, France
    Amyotroph Lateral Scler 10:436-40. 2009
  9. doi request reprint [Genetics of motor neuron disorders]
    P Corcia
    Service de Neurologie et de Neurophysiologie Clinique, Hopital Bretonneau, CHRU de Tours, 37044 Tours cedex 9, France
    Rev Neurol (Paris) 164:115-30. 2008
  10. ncbi request reprint [Primary lateral sclerosis with breast cancer, a potential paraneoplastic neurological syndrome]
    P Corcia
    Clinique Neurologique, CHU Bretonneau, Tours
    Rev Neurol (Paris) 156:1020-2. 2000

Collaborators

Detail Information

Publications51

  1. ncbi request reprint [Methods of the announcement of amyotrophic lateral sclerosis diagnosis in familial forms]
    P Corcia
    Centre SLA de Tours, CHU Bretonneau, Tours
    Rev Neurol (Paris) 162:4S122-4S126. 2006
    ....
  2. ncbi request reprint [Genetics of amyotrophic lateral sclerosis]
    Philippe Corcia
    CHRU de Tours, Centre SLA, Service de Neurologie et Neurophysiologie Clinique, 37044 Tours Cedex 1, France Université François Rabelais de Tours, UMR Inserm U930, 37000 Tours, France Electronic address
    Presse Med 43:555-62. 2014
    ..This first implies that the mutation identified in the proband case is perfectly characterized as a pathogenic mutation...
  3. pmc Molecular imaging of microglial activation in amyotrophic lateral sclerosis
    Philippe Corcia
    ALS Center, Department of Neurology, CHRU Bretonneau, Tours, France
    PLoS ONE 7:e52941. 2012
    ..This finding might improve our understanding of the pathophysiology of ALS and might be a surrogate marker of efficacy of treatment on microglial activation...
  4. pmc Homozygous SMN2 deletion is a protective factor in the Swedish ALS population
    Philippe Corcia
    Centre SLA, CHRU de Tours, Tours, France
    Eur J Hum Genet 20:588-91. 2012
    ..We also suggest that SMN2 gene copy number might have different effects on ALS progression in disparate human populations...
  5. doi request reprint Phenotype and genotype analysis in amyotrophic lateral sclerosis with TARDBP gene mutations
    P Corcia
    Centre SLA, CHU Tours, Tours, France
    Neurology 78:1519-26. 2012
    ..To describe the phenotype and phenotype-genotype correlations in patients with amyotrophic lateral sclerosis (ALS) with TARDBP gene mutations...
  6. ncbi request reprint [Thoracic outlet syndrome: an unusual postoperative complication]
    P Corcia
    Service de Neurologie, CHRU Bretonneau, Tours, France
    Rev Neurol (Paris) 162:240-2. 2006
    ..Neurological and neurophysiological features were both consistent with a neurogenic thoracic outlet syndrome (NTOS)...
  7. doi request reprint Absence of the OPTN mutation in a patient with ALS and familial primary open angle glaucoma
    P Corcia
    Centre SLA, CHRU de Tours, Tours, France UMR INSERM U930, Universite Francois Rabelais de Tours, Tours, France
    J Neurol Sci 309:16-7. 2011
    ..The absence of OPTN gene mutation in a patient who suffered from two conditions linked to mutations of this gene does not support involvement of OPTN in ALS...
  8. doi request reprint The importance of the SMN genes in the genetics of sporadic ALS
    Philippe Corcia
    ALS Centre, CHU Tours, INSERM, Universite Francois Rabelais, 2 boulevard Tonnelle, Tours Cedex 1, France
    Amyotroph Lateral Scler 10:436-40. 2009
    ..The existence of abnormal SMN1 copy numbers in ALS provides additional evidence that gene copy number variants may contribute to neurodegeneration and might open new approaches to treatment...
  9. doi request reprint [Genetics of motor neuron disorders]
    P Corcia
    Service de Neurologie et de Neurophysiologie Clinique, Hopital Bretonneau, CHRU de Tours, 37044 Tours cedex 9, France
    Rev Neurol (Paris) 164:115-30. 2008
    ..We propose to detail causative and susceptibility genetic factors involved in MND and to discuss pathological mechanisms that may explain motor neuron death...
  10. ncbi request reprint [Primary lateral sclerosis with breast cancer, a potential paraneoplastic neurological syndrome]
    P Corcia
    Clinique Neurologique, CHU Bretonneau, Tours
    Rev Neurol (Paris) 156:1020-2. 2000
    ..So, in female patients with primary lateral sclerosis, a mammography should be recommended to search for breast cancer...
  11. ncbi request reprint Improvement of a CIDP associated with hepatitis C virus infection using antiviral therapy
    P Corcia
    Department of Neurology, CHRU Bretonneau, Tours, France
    Neurology 63:179-80. 2004
    ..Viral eradication was confirmed during the 4th week of treatment and was followed 3 weeks later by neurologic improvement. The patient resumed normal activity 1 year after the therapy was completed...
  12. ncbi request reprint SMN1 gene, but not SMN2, is a risk factor for sporadic ALS
    P Corcia
    INSERM U619, Faculte de Medecine, Tours, France
    Neurology 67:1147-50. 2006
    ..SMN1 gene deletions cause spinal muscular atrophy, and SMN2 gene deletions have been associated with sporadic lower motor neuron diseases...
  13. ncbi request reprint SMN1 gene study in three families in which ALS and spinal muscular atrophy co-exist
    P Corcia
    INSERM U316, Tours, France
    Neurology 59:1464-6. 2002
    ....
  14. ncbi request reprint [Acute motor axonal neuropathy, enterovirus and Amyotrophic lateral sclerosis: can there be a link?]
    P Corcia
    Clinique Neurologique, CHU Bretonneau, Tours
    Rev Neurol (Paris) 159:80-2. 2003
    ..This particular succession led to discuss a possible link between theses two disorders and consequently the involvement of enterovirus in the development of ALS...
  15. doi request reprint Association between divalent metal transport 1 encoding gene (SLC11A2) and disease duration in amyotrophic lateral sclerosis
    Helene Blasco
    UMR INSERM U930 CNRS 2448, Universite Francois Rabelais de Tours, Tours, France
    J Neurol Sci 303:124-7. 2011
    ..SLC11A2 gene encodes the divalent metal transport 1 (DMT1) mediating iron transport in cerebral endosomal compartments. The objective of the study was to analyze DMT1 as a possible risk or modulating factor in sporadic ALS (SALS)...
  16. doi request reprint The P413L chromogranin B variation in French patients with sporadic amyotrophic lateral sclerosis
    Helene Blasco
    UMR Inserm U930, Universite Francois Rabelais de Tours, France
    Amyotroph Lateral Scler 12:210-4. 2011
    ..4 vs. 62.0 years of age, respectively). Thus, our findings do not support the 413L variant of rs742710 as a risk factor for sporadic ALS in the French population...
  17. ncbi request reprint Untargeted 1H-NMR metabolomics in CSF: toward a diagnostic biomarker for motor neuron disease
    Helene Blasco
    From UMR Inserm U930 H B, L N D, C A, C V D, S M, P E, C R A, P C, Tours Université François Rabelais H B, L N D, C A, C V D, S M, P E, C R A, P C, Tours Laboratoire de Biochimie et Biologie Moléculaire H B, C A, P E, C R A, CHRU de Tours PPF ASB L N D, P E, Universite Francois Rabelais, Tours Fédération des Maladies du Système Nerveux P F P, P H G, Centre référent maladie rare SLA, Hopital de la Pitie Salpetriere, Paris Service de Neurologie C M, D D, CHRU de Lille and Centre SLA P C, Service de Neurologie, CHRU Bretonneau
    Neurology 82:1167-74. 2014
    ..To develop a CSF metabolomics signature for motor neuron disease (MND) using (1)H-NMR spectroscopy and to evaluate the predictive value of the profile in a separate cohort...
  18. doi request reprint Novel SOD1 mutation p.V31A identified with a slowly progressive form of amyotrophic lateral sclerosis
    Audrey Dangoumau
    UMR Inserm U930, Universite Francois Rabelais, Tours, PRES Centre Val de Loire Université, France
    Neurobiol Aging 35:266.e1-4. 2014
    ..In conclusion, we identified a novel SOD1 mutation in a patient with slow disease progression and supported the idea that different SOD1 mutations can lead to distinct ALS phenotypes. ..
  19. doi request reprint Mutations of the ANG gene in French patients with sporadic amyotrophic lateral sclerosis
    Agathe Paubel
    INSERM U930, Université François Rabelais Tours, CHRU de Tours, Faculte de Medecine, 10 boulevard Tonnelle, BP3223, 37032 Tours Cedex, France
    Arch Neurol 65:1333-6. 2008
    ..However, the cellular and molecular mechanisms that link ANG, a multidomain protein, to ALS are still unknown...
  20. ncbi request reprint Abnormal SMN1 gene copy number is a susceptibility factor for amyotrophic lateral sclerosis
    Philippe Corcia
    INSERM U316, Tours, France
    Ann Neurol 51:243-6. 2002
    ..An abnormal SMN1 gene locus may be a susceptibility factor for amyotrophic lateral sclerosis...
  21. doi request reprint Primary lateral sclerosis may occur within familial amyotrophic lateral sclerosis pedigrees
    Julien Praline
    ALS Centre, Tours, France
    Amyotroph Lateral Scler 11:154-6. 2010
    ..These observations strengthen the hypothesis that PLS may represent an ALS phenotype with a long evolution and strongly suggest the involvement of common genetic factors that can lead to upper and lower motor neuron death...
  22. doi request reprint Co-occurrence of progressive anarthria with an S393L TARDBP mutation and ALS within a family
    Julien Praline
    ALS Centre, Service de Neurologie et de Neurophysiologie Clinique, CHU Bretonneau, 2 boulevard Tonnelle, Tours Cedex 9, France
    Amyotroph Lateral Scler 13:155-7. 2012
    ..It has been previously reported in sporadic and familial amyotrophic lateral sclerosis. This case strengthens the hypothesis of a continuum between motor neuron disease and frontotemporal lobar degeneration among TDP-43 proteinopathies...
  23. ncbi request reprint Amyotrophic lateral sclerosis: a hormonal condition?
    Helene Blasco
    UMR Inserm U930, Universite Francois Rabelais de Tours, Tours, France
    Amyotroph Lateral Scler 13:585-8. 2012
    ..Given this complex relationship between gender and ALS, we developed a hypothesis about hormone involvement in ALS aetiology by suggesting protective effect of oestrogens and adverse effect of androgens...
  24. ncbi request reprint Malnutrition at the time of diagnosis is associated with a shorter disease duration in ALS
    Nadege Limousin
    Centre SLA, Service de Neurologie et de Neurophysiologie Clinique, CHRU, Tours, France
    J Neurol Sci 297:36-9. 2010
    ..The aim of our study was to determine whether clinical nutritional parameters that are used in daily practice are associated with prognosis and whether they can help guide therapeutic decisions...
  25. doi request reprint A rare motor neuron deleterious missense mutation in the DPYSL3 (CRMP4) gene is associated with ALS
    Helene Blasco
    UMR Inserm U930, Universite Francois Rabelais de Tours, Tours, France
    Hum Mutat 34:953-60. 2013
    ....
  26. ncbi request reprint Emergent EEG in clinical practice
    Julien Praline
    Service de Neurologie et de Neurophysiologie Clinique, Hopital Bretonneau, CHRU, 2 boulevard Tonnelle, 37044 Tours cedex 9, France
    Clin Neurophysiol 118:2149-55. 2007
    ..Our objective was to determine why clinicians order an emergency EEG, to assess to what extent it helps establish a correct diagnosis and to evaluate the result it has on subsequent patient management...
  27. ncbi request reprint CADASIL and ALS: a link?
    Julien Praline
    ALS Centre, Service de Neurologie et de Neurophysiologie Clinique, CHRU, Tours, France
    Amyotroph Lateral Scler 11:399-401. 2010
    ..The possible pathogenic role for a mutation in the Notch3 gene is discussed considering recent data on hypoxia in the pathophysiology of ALS...
  28. doi request reprint Initial evaluation in healthy humans of [18F]DPA-714, a potential PET biomarker for neuroinflammation
    Nicolas Arlicot
    Universite Francois Rabelais de Tours, UMR S930 and CNRS ERL 3106, Tours, France
    Nucl Med Biol 39:570-8. 2012
    ..We aimed to estimate the radiation dosimetry of the positron emission tomography (PET) TSPO radioligand [(18)F]DPA-714, and we evaluated in healthy volunteers its whole-body uptake and cerebral kinetics...
  29. doi request reprint Protein SUMOylation, an emerging pathway in amyotrophic lateral sclerosis
    Audrey Dangoumau
    UMR Inserm U930, Universite Francois Rabelais, Tours, France
    Int J Neurosci 123:366-74. 2013
    ..In this review, we summarize the functioning of the SUMO pathway in normal conditions and in response to stresses, its action on ALS-related proteins and discuss the need for further research on this pathway in ALS...
  30. ncbi request reprint [What are the applications of biomarkers in ALS today?]
    Helene Blasco
    CHRU de Tours, Laboratoire de Biochimie et Biologie Moleculaire, 37044 Tours, France Université François Rabelais, unité Inserm U930 neurogénétique et neurométabolomique, 37044 Tours, France Electronic address
    Presse Med 43:569-79. 2014
    ..The perspectives in biomarker research in ALS imply the combination of analytical methods, human abilities and harmonization of the strategies...
  31. ncbi request reprint Pure bulbar motor neuron involvement linked to an abnormal CAG repeat expansion in the androgen receptor gene
    Julien Praline
    ALSCentre, CHRUde Tours, Tours, France
    Amyotroph Lateral Scler 9:40-2. 2008
    ..This atypical phenotype led us to discuss the role of some genetic or environmental factors in SBMA...
  32. ncbi request reprint A clustering of conjugal amyotrophic lateral sclerosis in southeastern France
    Philippe Corcia
    Department of Neurology, University Hospital Bretonneau, Tours, France
    Arch Neurol 60:553-7. 2003
    ..The origin of amyotrophic lateral sclerosis (ALS) remains largely unknown but seems to be multifactorial. We believe that ALS clusters may help clinicians understand or analyze the role of environmental factors in ALS pathogenesis...
  33. doi request reprint Occurrence of eye movement disorders in motor neuron disease
    Emilie Beaufils
    MCentre SLA, Service de Neurologie et de Neurophysiologie Clinique CHRU de Tours, Tours, France
    Amyotroph Lateral Scler 13:84-6. 2012
    ..Motor neuron disease with eye movement disorders must not be considered as a distinct clinical entity and must not exclude a diagnosis of ALS...
  34. ncbi request reprint ALS and mercury intoxication: a relationship?
    Julien Praline
    Department of Neurology and Neurophysiology, CHRU, Tours, France
    Clin Neurol Neurosurg 109:880-3. 2007
    ..Although no autopsy was performed, we discuss the role of mercury intoxication in the occurrence of ALS in our case, considering the results of experimental studies on the toxicity of mercury for motor neuron...
  35. doi request reprint The high frequency of restless legs syndrome in patients with amyotrophic lateral sclerosis
    Nadege Limousin
    Centre SLA, Service de Neurologie et de Neurophysiologie Clinique, CHRU, Tours, France
    Amyotroph Lateral Scler 12:303-6. 2011
    ..023). In conclusion, RLS occurs frequently in ALS, and those affected should be identified and appropriately treated...
  36. pmc 1H-NMR-based metabolomic profiling of CSF in early amyotrophic lateral sclerosis
    Helene Blasco
    INSERM U930, CNRS 2448, Tours, France
    PLoS ONE 5:e13223. 2010
    ....
  37. ncbi request reprint Iron Metabolism Disturbance in a French Cohort of ALS Patients
    Charlotte Veyrat-Durebex
    Unité Mixte de Recherche U930, Institut National de la Sante et de la Recherche Medicale, Universite Francois Rabelais, Equipe neurogénétique et neurométabolomique, 10 boulevard Tonnelle, 37032 Tours, France Laboratoire de Biochimie et de Biologie Moléculaire, Hopital Bretonneau, Centre Hospitalier Régional Universitaire de Tours, 37044 Tours, France
    Biomed Res Int 2014:485723. 2014
    ..038). Conclusion. This is the first study showing a higher concentration of serum iron in ALS patients, strengthening the involvement of a deregulation of iron metabolism in ALS. ..
  38. ncbi request reprint Effect of the oligodendrocyte myelin glycoprotein (OMgp) on the expansion and neuronal differentiation of rat neural stem cells
    Isabelle Martin
    UMR Inserm U930, Universite Francois Rabelais de Tours, Tours, France
    Brain Res 1284:22-30. 2009
    ..Moreover, they suggest a possible implication for OMG gene in the etiology of neurofibromatosis type 1 forms characterized by a deletion of the NF1 gene locus containing OMG...
  39. ncbi request reprint Ictal bradycardia followed by cardiac asystole: a case report
    Karl Mondon
    Department of Neurology, Hopital Bretonneau, Tours, France
    Epileptic Disord 4:261-4. 2002
    ..The EEG during the ictal period was documented and analyzed. Clinical features and therapeutic considerations are discussed...
  40. ncbi request reprint [Environmental factors in ALS]
    Raul Juntas-Morales
    Hopital Gui de Chauliac, Service de Neurologie, Clinique du Motoneurone, INSERM 1051, 34925 Montpellier cedex 5, France
    Presse Med 43:549-54. 2014
    ..To date, there are insufficient scientific data to suggest that exposure to electromagnetic fields may increase the risk of having ALS. We are particularly missing longitudinal cohorts to demonstrate that risk...
  41. ncbi request reprint Peripheral myelin protein 22 gene duplication with atypical presentations: a new example of the wide spectrum of Charcot-Marie-Tooth 1A disease
    Stéphane Mathis
    Service de Neurologie, CHU Poitiers, Universite de Poitiers, 2 rue de la Miletrie, 86021 Poitiers, France Electronic address
    Neuromuscul Disord 24:524-8. 2014
    ....
  42. ncbi request reprint Breast cancer and motor neuron disease: clinical study of seven cases
    Elisabeth Sadot
    Service de Neurologie, Centre SLA, CHU de la Côte de Nacre, Caen, France
    Amyotroph Lateral Scler 8:288-91. 2007
    ..No anti-neuronal antibodies were found. Although there is no recognized pathophysiological link between breast cancer and UMN-predominant MND we suggest there may be comorbidity between the two diseases...
  43. ncbi request reprint Somatosensory evoked potentials in chronic inflammatory demyelinating polyradiculoneuropathy
    Hayet Salhi
    Department of Neurology Neurophysiology, Hospital of Tours, France and INSERM UMR930, Tours, France
    J Clin Neurophysiol 31:241-5. 2014
    ..Somatosensory evoked potentials (SEPs) offer complementary results to those of nerve conduction studies and contribute to the electrodiagnostic criteria of chronic inflammatory demyelinating polyradiculoneuropathy...
  44. pmc Amyotrophic lateral sclerosis and the clinical potential of dexpramipexole
    Philippe Corcia
    Centre SLA, CHRU de Tours, Tours, France UMR INSERM U930, Université François Rabelais de Tours PC, Tours, France
    Ther Clin Risk Manag 8:359-66. 2012
    ..Early phase trials in human ALS suggest that the drug can be taken safely by patients in doses that provide neuroprotection in preclinical models. A Phase III trial to test the efficacy of RPPX in ALS is underway...
  45. ncbi request reprint [Favorable outcome of acute porphyric neuropathy after treatment with heme arginate]
    E Diot
    CHRU de Tours, Groupement de Médecine Interne, INSERM U618 IFR135 Tours, France
    Rev Neurol (Paris) 163:1100-2. 2007
    ..Moreover, motor neuronal function improved while HA therapy was initiated 22 days after the clinical onset of weakness. This tempts us to propose HA therapy at any stage of acute porphyric neuropathy...
  46. ncbi request reprint [Cyclosporin-induced toxic neuromyopathy]
    A M Guennoc
    Clinique Neurologique, CHU Bretoneau, 37044 Tours
    Rev Neurol (Paris) 161:221-3. 2005
    ..Among neurological side effects, neuropathies or myopathies have been reported, specially inpatients given combinations of cyclosporine with co-enzyme A reductase inhibitors...
  47. ncbi request reprint [Demyelinating neuropathy and Sjögren's syndrome: a diagnostic pitfall]
    A M Guennoc
    Service de Neurologie et de Neurophysiologie Clinique, CHU Bretonneau, Tours, France
    Rev Neurol (Paris) 160:717-20. 2004
    ..Nevertheless some demyelinating neuropathies have been described in patients with SS. To date, the relationship between demyelinating neuropathies and SS remains imprecise...
  48. ncbi request reprint [Progressive anarthria: an individual entity]
    N Limousin
    Service de Neurologie et de Neurophysiologie Clinique, Hopital Bretonneau, CHRU de Tours, 2, boulevard Tonnelle, 37044 Tours Cedex, France
    Rev Neurol (Paris) 164:444-51. 2008
    ..The aim of this study was to analyze clinical and neuropsychological data and results of complementary tests in a series of patients presented with primary progressive anarthria...
  49. ncbi request reprint [Emergency EEG: actual indications and results]
    J Praline
    Service de Neurologie et de Neurophysiologie Clinique, Hopital Bretonneau, CHU, 2, boulevard Tonnelé, 37044 Tours Cedex, France
    Neurophysiol Clin 34:175-81. 2004
    ..We retrospectively confronted the recommendations with the actual requests for emergency EEG in our University hospital, in order to determine the contribution of the eEEG in the most frequent clinical situations encountered...
  50. doi request reprint Dyslipidemia is a protective factor in amyotrophic lateral sclerosis
    L Dupuis
    Fédération des Maladies du Système Nerveux, Centre référent maladie rare SLA, Hopital de la Pitie Salpetriere, 47 83, Boulevard de l Hopital, 75651 Paris, France
    Neurology 70:1004-9. 2008
    ..Inasmuch as lipids are the major source of energy for muscles, we determined the status of lipids in a population of patients with ALS and investigated whether lipid contents may have an impact on disease progression and survival...
  51. ncbi request reprint [Evaluation of sensory deficit of the inferior alveolar nerve after mandibular osteotomy]
    C Jarrosson
    Service de Chirurgie Maxillo Faciale et Stomatologie, CHU de Tours
    Rev Stomatol Chir Maxillofac 106:139-45. 2005
    ..The wide differences in results published to date led us to evaluate the incidence of sensorial disorders persisting for one year in a series of 40 patients...