Alain Combes

Summary

Country: France

Publications

  1. ncbi Tissue Doppler imaging estimation of pulmonary artery occlusion pressure in ICU patients
    Alain Combes
    Réanimation Médicale, Institut de Cardiologie, AP HP, Hopital Pitie Salpetriere, 47 Boulevard de l Hopital, 75013 Paris, France
    Intensive Care Med 30:75-81. 2004
  2. ncbi Impact of methicillin resistance on outcome of Staphylococcus aureus ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, 75651 Paris Cedex 13, France
    Am J Respir Crit Care Med 170:786-92. 2004
  3. ncbi Estimation of left ventricular systolic function by single transpulmonary thermodilution
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47, Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Intensive Care Med 30:1377-83. 2004
  4. ncbi Clinical and autopsy diagnoses in the intensive care unit: a prospective study
    Alain Combes
    Services de Réanimation Médicale, Hopital Bichat, Assistance Publique Hopitaux de Paris, Paris, France
    Arch Intern Med 164:389-92. 2004
  5. ncbi The impact of methicillin resistance on the outcome of poststernotomy mediastinitis due to Staphylococcus aureus
    Alain Combes
    Service de Reanimation Medicale, Institut de Cardiologie, Hôpital PitiéSalpêtrière, Paris, France
    Clin Infect Dis 38:822-9. 2004
  6. ncbi Chronic exposure to interleukin 1beta induces a delayed and reversible alteration in excitation-contraction coupling of cultured cardiomyocytes
    Alain Combes
    Service de Reanimation Medicale, Pr Gibert, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Pflugers Arch 445:246-56. 2002
  7. ncbi Incidence and outcome of polymicrobial ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Hopital Bichat, AP HP, Paris, France
    Chest 121:1618-23. 2002
  8. ncbi Early predictors for infection recurrence and death in patients with ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris 6, France
    Crit Care Med 35:146-54. 2007
  9. ncbi Impact of piperacillin resistance on the outcome of Pseudomonas ventilator-associated pneumonia
    Alain Combes
    Groupe Hospitalier Pitie Salpetriere, Assistance Publique, Hôpitaux de Paris Université Pierre et Marie Curie, Paris 6, Service de Reanimation Medicale, Institut de Cardiologie, Paris, France
    Intensive Care Med 32:1970-8. 2006
  10. ncbi Outcomes, long-term quality of life, and psychologic assessment of fulminant myocarditis patients rescued by mechanical circulatory support
    Mariana Mirabel
    Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Crit Care Med 39:1029-35. 2011

Detail Information

Publications61

  1. ncbi Tissue Doppler imaging estimation of pulmonary artery occlusion pressure in ICU patients
    Alain Combes
    Réanimation Médicale, Institut de Cardiologie, AP HP, Hopital Pitie Salpetriere, 47 Boulevard de l Hopital, 75013 Paris, France
    Intensive Care Med 30:75-81. 2004
    ..This study assessed whether the E/E' ratio provides an accurate estimation of pulmonary artery occlusion pressure (PAOP) in mechanically ventilated ICU patients...
  2. ncbi Impact of methicillin resistance on outcome of Staphylococcus aureus ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, 75651 Paris Cedex 13, France
    Am J Respir Crit Care Med 170:786-92. 2004
    ....
  3. ncbi Estimation of left ventricular systolic function by single transpulmonary thermodilution
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47, Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Intensive Care Med 30:1377-83. 2004
    ..The global cardiac systolic function may be decreased despite preserved left ventricular function in this situation.)..
  4. ncbi Clinical and autopsy diagnoses in the intensive care unit: a prospective study
    Alain Combes
    Services de Réanimation Médicale, Hopital Bichat, Assistance Publique Hopitaux de Paris, Paris, France
    Arch Intern Med 164:389-92. 2004
    ..Autopsy rates have declined worldwide, but recent retrospective intensive care unit (ICU) data indicate major discrepancies between more than 25% of clinical and autopsy diagnoses...
  5. ncbi The impact of methicillin resistance on the outcome of poststernotomy mediastinitis due to Staphylococcus aureus
    Alain Combes
    Service de Reanimation Medicale, Institut de Cardiologie, Hôpital PitiéSalpêtrière, Paris, France
    Clin Infect Dis 38:822-9. 2004
    ..Methicillin resistance did not significantly affect ICU mortality among patients with poststernotomy mediastinitis who benefited from optimal treatments...
  6. ncbi Chronic exposure to interleukin 1beta induces a delayed and reversible alteration in excitation-contraction coupling of cultured cardiomyocytes
    Alain Combes
    Service de Reanimation Medicale, Pr Gibert, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Pflugers Arch 445:246-56. 2002
    ..Alterations in contractile function did not occur through NO-mediated pathways. These results support the hypothesis that IL-1beta may play an important role in contractile dysfunction through alterations in calcium homeostasis...
  7. ncbi Incidence and outcome of polymicrobial ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Hopital Bichat, AP HP, Paris, France
    Chest 121:1618-23. 2002
    ..To determine the epidemiology and outcome of polymicrobial ventilator-associated pneumonia (VAP)...
  8. ncbi Early predictors for infection recurrence and death in patients with ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris 6, France
    Crit Care Med 35:146-54. 2007
    ..The objective of this study was to describe resolution of VAP variables and to determine early predictors of VAP recurrence and death...
  9. ncbi Impact of piperacillin resistance on the outcome of Pseudomonas ventilator-associated pneumonia
    Alain Combes
    Groupe Hospitalier Pitie Salpetriere, Assistance Publique, Hôpitaux de Paris Université Pierre et Marie Curie, Paris 6, Service de Reanimation Medicale, Institut de Cardiologie, Paris, France
    Intensive Care Med 32:1970-8. 2006
    ....
  10. ncbi Outcomes, long-term quality of life, and psychologic assessment of fulminant myocarditis patients rescued by mechanical circulatory support
    Mariana Mirabel
    Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Crit Care Med 39:1029-35. 2011
    ....
  11. ncbi Role of serial routine microbiologic culture results in the initial management of ventilator-associated pneumonia
    Jan Hayon
    , and Service de Microbiologie, , , Paris, France
    Am J Respir Crit Care Med 165:41-6. 2002
    ..Based on these data, the contribution of routine microbiologic specimens in guiding initial antimicrobial therapy decisions for patients with suspected VAP appears limited...
  12. ncbi Mortality among patients admitted to intensive care units during weekday day shifts compared with "off" hours
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Crit Care Med 35:3-11. 2007
    ....
  13. ncbi Use of quantitative cultures and reduced duration of antibiotic regimens for patients with ventilator-associated pneumonia to decrease resistance in the intensive care unit
    Jean Chastre
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, 75651 Paris Cedex 13, France
    Clin Infect Dis 43:S75-81. 2006
    ....
  14. ncbi Impact of antibiotic-resistant bacteria on the outcome of ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Pr Gibert, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Semin Respir Crit Care Med 27:23-8. 2006
    ....
  15. ncbi Is tracheostomy associated with better outcomes for patients requiring long-term mechanical ventilation?
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Crit Care Med 35:802-7. 2007
    ..To evaluate the effect of tracheostomy on intensive care unit (ICU) and in-hospital mortality for patients requiring prolonged (> 3 days) mechanical ventilation (MV)...
  16. ncbi Does invasive diagnosis of nosocomial pneumonia during off-hours delay treatment?
    Charles Edouard Luyt
    Universite Pierre et Marie Curie, Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47 Boulevard de l Hopital, 75651, Paris Cedex 13, France
    Intensive Care Med 33:734-7. 2007
    ..m. to 8:29 a.m. the next day for night shifts, from Saturday 1:00 p.m. to Monday 8:29 a.m. for weekends, and from 8:30 a.m. to 8:29 a.m. the following morning for public holidays)...
  17. ncbi Early percutaneous tracheotomy versus prolonged intubation of mechanically ventilated patients after cardiac surgery: a randomized trial
    Jean Louis Trouillet
    Institut de Cardiologie, Hopital de la Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Institut National de la Sante et de la Recherche Medicale, Paris, France
    Ann Intern Med 154:373-83. 2011
    ..Whether early percutaneous tracheotomy in patients who require prolonged mechanical ventilation can shorten mechanical ventilation duration and lower mortality remains controversial...
  18. ncbi Usefulness of procalcitonin for the diagnosis of ventilator-associated pneumonia
    Charles Edouard Luyt
    Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Universite Paris 6, 75651, Paris Cedex 13, France
    Intensive Care Med 34:1434-40. 2008
    ..To assess the predictive capacity for the diagnosis of ventilator-associated pneumonia (VAP) of serum procalcitonin levels before and on the day it is suspected...
  19. ncbi Factors predicting ventilator-associated pneumonia recurrence
    Alain Combes
    , , , Paris, France
    Crit Care Med 31:1102-7. 2003
    ..CONCLUSIONS: Factors of ventilator-associated pneumonia recurrence evaluated on D8 of a 14-day course of antibiotics are linked to the severity of lung injury and persistence of fever, but not to first-episode pathogen(s)...
  20. ncbi Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial
    Lila Bouadma
    Service de Reanimation Medicale, Universite Paris 7 Denis Diderot, Hopital Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Paris, France
    Lancet 375:463-74. 2010
    ..We aimed to establish the effectiveness of an algorithm based on the biomarker procalcitonin to reduce antibiotic exposure in this setting...
  21. ncbi New diagnostic and prognostic markers of ventilator-associated pneumonia
    Jean Chastre
    Medical Intensive Care Unit, Pitie Salpetriere Hospital, Pierre and Marie Curie University, Paris, France
    Curr Opin Crit Care 12:446-51. 2006
    ..The purpose of this review is to analyze the potential advantages and drawbacks of using biomarkers of bacterial infection for the diagnosis and prognosis of ventilator-associated pneumonia...
  22. ncbi Outcomes and long-term quality-of-life of patients supported by extracorporeal membrane oxygenation for refractory cardiogenic shock
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris 6, Paris, France
    Crit Care Med 36:1404-11. 2008
    ..To assess the outcomes and long-term quality-of-life of patients supported by extracorporeal membrane oxygenation (ECMO) for refractory cardiogenic shock...
  23. ncbi Controversies in ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Semin Respir Crit Care Med 31:47-54. 2010
    ....
  24. ncbi Impact of extracorporeal membrane oxygenation and continuous venovenous hemodiafiltration on the pharmacokinetics of oseltamivir carboxylate in critically ill patients with pandemic (H1N1) influenza
    Florian Lemaître
    Pharmacy Department, Pitie Salpetriere Hospital, Assistance Publique des Hopitaux de Paris, AP HP, Paris, France
    Ther Drug Monit 34:171-5. 2012
    ..This study was designed to evaluate the impact of ECMO and CVVHDF on the pharmacokinetics of oseltamivir carboxylate (OC) in critically ill patients with pandemic (H1N1) influenza treated with oseltamivir...
  25. ncbi Predictors of successful extracorporeal membrane oxygenation (ECMO) weaning after assistance for refractory cardiogenic shock
    Nadia Aissaoui
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris 6, Paris, France
    Intensive Care Med 37:1738-45. 2011
    ..This study evaluated a weaning strategy following support for refractory cardiogenic shock to identify clinical, hemodynamic, and Doppler echocardiography parameters associated with successful ECMO removal...
  26. ncbi Prolonged mechanical ventilation after cardiac surgery: outcome and predictors
    Jean Louis Trouillet
    Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Paris 6 Pierre et Marie Curie, Paris, France
    J Thorac Cardiovasc Surg 138:948-53. 2009
    ..Our objective was to identify patients still requiring mechanical ventilation 3 days after the operation and those successfully weaned by day 10 to avoid needless and potentially hazardous interventions, such as tracheostomy...
  27. ncbi Diagnostic techniques and procedures for establishing the microbial etiology of ventilator-associated pneumonia for clinical trials: the pros for quantitative cultures
    Jean Chastre
    Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Clin Infect Dis 51:S88-92. 2010
    ....
  28. ncbi Procalcitonin kinetics as a prognostic marker of ventilator-associated pneumonia
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, 47, Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Am J Respir Crit Care Med 171:48-53. 2005
    ..Multivariate analyses retained serum procalcitonin levels on Days 1, 3, and 7 as strong predictors of unfavorable outcome. Based on these data, procalcitonin could be a prognostic marker of outcome during VAP...
  29. ncbi Nosocomial infections in adult cardiogenic shock patients supported by venoarterial extracorporeal membrane oxygenation
    Matthieu Schmidt
    Service de Reanimation Medicale, Institut de Cardiologie
    Clin Infect Dis 55:1633-41. 2012
    ..Cardiogenic shock patients who received the latest generation VA-ECMO still had a high risk of developing NIs, particularly VAP. Strategies aimed at preventing these infections may improve the outcomes of these critically ill patients...
  30. ncbi Two-dimensional strain rate and Doppler tissue myocardial velocities: analysis by echocardiography of hemodynamic and functional changes of the failed left ventricle during different degrees of extracorporeal life support
    Nadia Aissaoui
    Universite Rene Descartes Paris V, Paris, France
    J Am Soc Echocardiogr 25:632-40. 2012
    ....
  31. ncbi Biomarkers to optimize antibiotic therapy for pneumonia due to multidrug-resistant pathogens
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, France
    Clin Chest Med 32:431-8. 2011
    ..5 ng/mL or has decreased by 80% or more compared with the peak concentration, antibiotics can be stopped. With this strategy, extreme vigilance must be maintained after terminating antimicrobial therapy to detect a recurrent infection...
  32. ncbi Paracorporeal pulsatile biventricular assist device versus extracorporal membrane oxygenation-extracorporal life support in adult fulminant myocarditis
    Olivier N Pages
    Institut de Cardiologie, Service de Chirurgie Thoracique et Cardiovasculaire, Universite Pierre et Marie Curie Paris 6, AP HP, Groupe Pitié Salpêtrière, Paris, France
    J Thorac Cardiovasc Surg 137:194-7. 2009
    ..Whether these patients can be as efficiently supported with femorofemoral extracorporeal membrane oxygenation remains unclear...
  33. ncbi Acute poststernotomy mediastinitis managed with debridement and closed-drainage aspiration: factors associated with death in the intensive care unit
    Jean Louis Trouillet
    Service de Reanimation Medicale, Hôpital La Pitié Salpêtrière Assistance Publique Hôpitaux de Paris, France
    J Thorac Cardiovasc Surg 129:518-24. 2005
    ..The purpose of the study is to describe an intensive care unit's experience in the treatment of poststernotomy mediastinitis and to identify factors associated with intensive care unit death...
  34. ncbi Adverse effect on a referral intensive care unit's performance of accepting patients transferred from another intensive care unit
    Alain Combes
    , , Paris, France
    Crit Care Med 33:705-10. 2005
    ..Future benchmarking and profiling systems should evaluate and adequately account for the ICU-transfer factor to provide healthcare payers and consumers with more accurate and valid information on the true performance of referral centers...
  35. ncbi Viral infections in the ICU
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Paris, and Université Paris 6 Pierre et Marie Curie, France
    Curr Opin Crit Care 14:605-8. 2008
    ..The present study reviews the precise role of viruses as causes of pneumonia in mechanically ventilated patients...
  36. ncbi Gender impact on the outcomes of critically ill patients with nosocomial infections
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Crit Care Med 37:2506-11. 2009
    ..Highly controversial data exist regarding gender-related differences in outcomes of severe nosocomial infections, reflecting potential confounders related to case-mixes or heterogeneity of populations evaluated...
  37. ncbi Impact of tracheotomy on sedative administration, sedation level, and comfort of mechanically ventilated intensive care unit patients
    Ania Nieszkowska
    , , Paris, France
    Crit Care Med 33:2527-33. 2005
    ..CONCLUSION: On the basis of these observations, we conclude that tracheotomized mechanically ventilated ICU patients required less intravenous sedative administration, spent less time heavily sedated, and achieved more autonomy earlier...
  38. ncbi The invasive (quantitative) diagnosis of ventilator-associated pneumonia
    Jean Chastre
    Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, 43 87 bd de l Hôpital, 75651 Paris Cedex 13, France
    Respir Care 50:797-807; discussion 807-12. 2005
    ..Bronchoalveolar lavage may also provide useful clues for the diagnosis of other forms of respiratory failure, such as pulmonary hemorrhage or other types of infections, especially in immunocompromised patients...
  39. ncbi Herpes simplex virus lung infection in patients undergoing prolonged mechanical ventilation
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Université de Paris Pierre et Marie Curie, Assistance Publique Hopitaux de Paris, Paris Cedex 13, France
    Am J Respir Crit Care Med 175:935-42. 2007
    ....
  40. ncbi Value of the serum procalcitonin level to guide antimicrobial therapy for patients with ventilator-associated pneumonia
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Semin Respir Crit Care Med 32:181-7. 2011
    ..Accordingly, for VAP patients, procalcitonin may be used to stop antibiotics as early as day 3 after their initiation, if its concentration is <0.5 ng/mL or has decreased by ≥80%, compared with the first peak concentration...
  41. ncbi Usefulness of cardiac biomarkers to predict cardiac recovery in patients on extracorporeal membrane oxygenation support for refractory cardiogenic shock
    Charles Edouard Luyt
    Service de Reanimation, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France Université Paris 6 Pierre et Marie Curie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France Electronic address
    J Crit Care 27:524.e7-524.e14. 2012
    ....
  42. ncbi Virus-induced acute respiratory distress syndrome: epidemiology, management and outcome
    Charles Edouard Luyt
    Assistance Publique Hopitaux de Paris, Universite Paris 6 Pierre et Marie Curie, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Service de Reanimation Medicale, 75651 Paris Cedex 13, France
    Presse Med 40:e561-8. 2011
    ..Ganciclovir can be considered for patients with ARDS and histology- or cytology-proven CMV pneumonia...
  43. ncbi Aerosolized antibiotics to treat ventilator-associated pneumonia
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, 47 83 boulevard de l Hopital, Paris Cedex 13, France
    Curr Opin Infect Dis 22:154-8. 2009
    ..This review summarizes the recent data on antibiotic aerosolization to treat ventilator-associated pneumonia...
  44. ncbi Long-term outcomes of pandemic 2009 influenza A(H1N1)-associated severe ARDS
    Charles Edouard Luyt
    Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hôpitaux de Paris et Université Paris 6 Pierre et Marie Curie, Paris, France
    Chest 142:583-92. 2012
    ..The objective of this study was to compare the 1-year outcomes of survivors of A(H1N1)-associated ARDS, according to use or no use of extracorporeal lung assist (ECLA), using its need as an ARDS severity surrogate...
  45. ncbi Emergency circulatory support in refractory cardiogenic shock patients in remote institutions: a pilot study (the cardiac-RESCUE program)
    Sylvain Beurtheret
    Department of Cardiovascular Surgery, Pitie Salpetriere University Hospital, Paris Curie University, Paris, France
    Eur Heart J 34:112-20. 2013
    ..In this otherwise lethal situation, our pilot experience suggests that over one-third of such patients can survive to hospital discharge...
  46. ncbi Extracorporeal membrane oxygenation for 2009 influenza A (H1N1) acute respiratory distress syndrome: single-centre experience with 1-year follow-up
    Sylvain Beurtheret
    Division of Cardiac Surgery, Pitie Salpetriere Hospital, University Pierre et Marie Curie, Paris, France
    Eur J Cardiothorac Surg 41:691-5. 2012
    ..The use of extracorporeal membrane oxygenation (ECMO) could be advocated as therapeutic solution. We present our experience with ECMO utilized in patients with influenza A (H1N1)-associated respiratory failure...
  47. ncbi Continuous venovenous haemodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: a multicentre randomised trial
    Christophe Vinsonneau
    Department of Intensive Care, Cochin Port Royal University Hospital, Rene Descartes University, Paris, France
    Lancet 368:379-85. 2006
    ..In this study, we compare the effect of intermittent haemodialysis and continuous venovenous haemodiafiltration on survival rates in critically ill patients with acute renal failure as part of multiple-organ dysfunction syndrome...
  48. ncbi Early use of the pulmonary artery catheter and outcomes in patients with shock and acute respiratory distress syndrome: a randomized controlled trial
    Christian Richard
    Service de Reanimation Medicale, Hopital de Bicetre, Le Kremlin Bicetre, France
    JAMA 290:2713-20. 2003
    ..Many physicians believe that the pulmonary artery catheter (PAC) is useful for the diagnosis and treatment of cardiopulmonary disturbances; however, observational studies suggest that its use may be harmful...
  49. ncbi Extracorporeal membrane oxygenation for respiratory failure in adults
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Curr Opin Crit Care 18:99-104. 2012
    ..This article reviews case series and trials that evaluated extracorporeal membrane oxygenation (ECMO) for respiratory failure and describes patient and circuit management in the modern era of ECMO support...
  50. ncbi Extracorporeal membrane oxygenation for 2009 influenza A (H1N1)-associated acute respiratory distress syndrome
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Semin Respir Crit Care Med 32:188-94. 2011
    ..However, whether the 25 to 50% mortality observed in the reported ECMO series was affected by the recourse to this technique could not be established...
  51. ncbi The long and difficult road to better evaluation of outcomes of prolonged mechanical ventilation: not yet a highway to heaven
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
    Crit Care 11:120. 2007
    ..However, predictors of mortality and long-term functional outcomes that are reliable and accurate at the level of the individual patient remain to be identified...
  52. ncbi [Impact of ECMO on drugs pharmacokinetics]
    Nesrine Hasni
    Service Pharmacie, Groupe Hospitalier Pitie Salpetriere, AP HP, Paris, France
    Therapie 66:405-12. 2011
    ..However, more research is needed to identify dosage strategies for this patient population...
  53. ncbi Diffusion tensor imaging to predict long-term outcome after cardiac arrest: a bicentric pilot study
    Charles Edouard Luyt
    Service de Reanimation, School of Medicine, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Université Paris Pierre et Marie Curie, Paris, France
    Anesthesiology 117:1311-21. 2012
    ..The authors' objective was to determine whether an assessment with diffusion tensor imaging, a brain magnetic resonance imaging sequence, increases the accuracy of 1 yr functional outcome prediction in cardiac arrest survivors...
  54. ncbi What is the niche for extracorporeal membrane oxygenation in severe acute respiratory distress syndrome?
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris 6, Paris, France
    Curr Opin Crit Care 18:527-32. 2012
    ..This article reviews the results of case series and trials which evaluated venovenous extracorporeal membrane oxygenation (VV-ECMO) for severe respiratory failure. Potential indications of the technique in this setting are discussed...
  55. ncbi Circulatory support for fulminant myocarditis: consideration for implantation, weaning and explantation
    Pascal Leprince
    Service de Chirurgie Thoracique et Cardiovasculaire, Groupe Pitié Salpêtrière, Institut de Cardiologie, 47 83 boulevard de l Hopital, 75013 Paris, France
    Eur J Cardiothorac Surg 24:399-403. 2003
    ..Fulminant myocarditis (FM) is an uncommon but life-threatening condition for which a mechanical circulatory support (MCS) device can be life-saving. However, device selection, weaning and explantation procedures remain poorly defined...
  56. ncbi Fatal disseminated Acanthamoeba lenticulata infection in a heart transplant patient
    Stephane Barete
    Department of Dermatology and Allergy, Hopital Tenon, Assistance Publique Hopitaux de Paris, France
    Emerg Infect Dis 13:736-8. 2007
    ..The diagnosis was based on skin histopathologic results and confirmed by isolation of the ameba from involved skin and molecular analysis of a partial 18S rRNA gene sequence (DF3)...
  57. ncbi Methicillin-resistant Staphylococcus aureus prolongs intensive care unit stay in ventilator-associated pneumonia, despite initially appropriate antibiotic therapy
    Andrew F Shorr
    Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC, USA
    Crit Care Med 34:700-6. 2006
    ..Confronting the adverse impact of MRSA will require efforts that address more than the initial antibiotic prescription...
  58. ncbi Morbidity, mortality, and quality-of-life outcomes of patients requiring >or=14 days of mechanical ventilation
    Alain Combes
    , , , France
    Crit Care Med 31:1373-81. 2003
    ..Future studies should focus on physical or psychosocial rehabilitation that could lead to improved management of patients after their ICU stay...
  59. ncbi Reproducibility of protected specimen brush and bronchoalveolar lavage conserved at 4 degrees C for 48 hours
    Xavier Forceville
    Service de Reanimation Polyvalente, Centre Hospitalier de Meaux, Saint Faron, 6 8 rue Saint Fiacre, 77104 Meaux, France
    Intensive Care Med 28:857-63. 2002
    ..Nevertheless, they are only validated for immediate laboratory processing. This study was therefore conducted to determine whether 48 h conservation at a mere 4 degrees C enables good culture reproducibility for both PSB and BAL...
  60. ncbi Backrest elevation for the prevention of ventilator-associated pneumonia: back to the real world?
    Alain Combes
    Crit Care Med 34:559-61. 2006
  61. ncbi Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study
    Xavier Forceville
    Service de Reanimation Polyvalente, Centre Hospitalier de Meaux, Hôpital Saint Faron, 6 8 rue Saint Fiacre, 77104 Meaux, France
    Crit Care 11:R73. 2007
    ..We investigated the effects of a continuous administration of high doses of selenium in septic shock patients...