Alain Combes

Summary

Country: France

Publications

  1. ncbi request reprint Tissue Doppler imaging estimation of pulmonary artery occlusion pressure in ICU patients
    Alain Combes
    Réanimation Médicale, Institut de Cardiologie, AP HP, Hopital Pitie Salpetriere, 47 Boulevard de l Hopital, 75013 Paris, France
    Intensive Care Med 30:75-81. 2004
  2. ncbi request reprint The impact of methicillin resistance on the outcome of poststernotomy mediastinitis due to Staphylococcus aureus
    Alain Combes
    Service de Reanimation Medicale, Institut de Cardiologie, Hôpital PitiéSalpêtrière, Paris, France
    Clin Infect Dis 38:822-9. 2004
  3. ncbi request reprint Incidence and outcome of polymicrobial ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Hopital Bichat, AP HP, Paris, France
    Chest 121:1618-23. 2002
  4. ncbi request reprint Chronic exposure to interleukin 1beta induces a delayed and reversible alteration in excitation-contraction coupling of cultured cardiomyocytes
    Alain Combes
    Service de Reanimation Medicale, Pr Gibert, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Pflugers Arch 445:246-56. 2002
  5. ncbi request reprint Clinical and autopsy diagnoses in the intensive care unit: a prospective study
    Alain Combes
    Services de Réanimation Médicale, Hopital Bichat, Assistance Publique Hopitaux de Paris, Paris, France
    Arch Intern Med 164:389-92. 2004
  6. ncbi request reprint Estimation of left ventricular systolic function by single transpulmonary thermodilution
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47, Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Intensive Care Med 30:1377-83. 2004
  7. ncbi request reprint Impact of methicillin resistance on outcome of Staphylococcus aureus ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, 75651 Paris Cedex 13, France
    Am J Respir Crit Care Med 170:786-92. 2004
  8. ncbi request reprint Early predictors for infection recurrence and death in patients with ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris 6, France
    Crit Care Med 35:146-54. 2007
  9. ncbi request reprint Morbidity, mortality, and quality-of-life outcomes of patients requiring >or=14 days of mechanical ventilation
    Alain Combes
    Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, France
    Crit Care Med 31:1373-81. 2003
  10. doi request reprint Outcomes, long-term quality of life, and psychologic assessment of fulminant myocarditis patients rescued by mechanical circulatory support
    Mariana Mirabel
    Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Crit Care Med 39:1029-35. 2011

Detail Information

Publications71

  1. ncbi request reprint Tissue Doppler imaging estimation of pulmonary artery occlusion pressure in ICU patients
    Alain Combes
    Réanimation Médicale, Institut de Cardiologie, AP HP, Hopital Pitie Salpetriere, 47 Boulevard de l Hopital, 75013 Paris, France
    Intensive Care Med 30:75-81. 2004
    ..This study assessed whether the E/E' ratio provides an accurate estimation of pulmonary artery occlusion pressure (PAOP) in mechanically ventilated ICU patients...
  2. ncbi request reprint The impact of methicillin resistance on the outcome of poststernotomy mediastinitis due to Staphylococcus aureus
    Alain Combes
    Service de Reanimation Medicale, Institut de Cardiologie, Hôpital PitiéSalpêtrière, Paris, France
    Clin Infect Dis 38:822-9. 2004
    ..Methicillin resistance did not significantly affect ICU mortality among patients with poststernotomy mediastinitis who benefited from optimal treatments...
  3. ncbi request reprint Incidence and outcome of polymicrobial ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Hopital Bichat, AP HP, Paris, France
    Chest 121:1618-23. 2002
    ..To determine the epidemiology and outcome of polymicrobial ventilator-associated pneumonia (VAP)...
  4. ncbi request reprint Chronic exposure to interleukin 1beta induces a delayed and reversible alteration in excitation-contraction coupling of cultured cardiomyocytes
    Alain Combes
    Service de Reanimation Medicale, Pr Gibert, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Pflugers Arch 445:246-56. 2002
    ..Alterations in contractile function did not occur through NO-mediated pathways. These results support the hypothesis that IL-1beta may play an important role in contractile dysfunction through alterations in calcium homeostasis...
  5. ncbi request reprint Clinical and autopsy diagnoses in the intensive care unit: a prospective study
    Alain Combes
    Services de Réanimation Médicale, Hopital Bichat, Assistance Publique Hopitaux de Paris, Paris, France
    Arch Intern Med 164:389-92. 2004
    ..Autopsy rates have declined worldwide, but recent retrospective intensive care unit (ICU) data indicate major discrepancies between more than 25% of clinical and autopsy diagnoses...
  6. ncbi request reprint Estimation of left ventricular systolic function by single transpulmonary thermodilution
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47, Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Intensive Care Med 30:1377-83. 2004
    ..The global cardiac systolic function may be decreased despite preserved left ventricular function in this situation.)..
  7. ncbi request reprint Impact of methicillin resistance on outcome of Staphylococcus aureus ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, 75651 Paris Cedex 13, France
    Am J Respir Crit Care Med 170:786-92. 2004
    ....
  8. ncbi request reprint Early predictors for infection recurrence and death in patients with ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris 6, France
    Crit Care Med 35:146-54. 2007
    ..The objective of this study was to describe resolution of VAP variables and to determine early predictors of VAP recurrence and death...
  9. ncbi request reprint Morbidity, mortality, and quality-of-life outcomes of patients requiring >or=14 days of mechanical ventilation
    Alain Combes
    Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, France
    Crit Care Med 31:1373-81. 2003
    ..To determine the outcome and health-related quality of life of patients requiring >or=14 days of mechanical ventilation in the intensive care unit (ICU)...
  10. doi request reprint Outcomes, long-term quality of life, and psychologic assessment of fulminant myocarditis patients rescued by mechanical circulatory support
    Mariana Mirabel
    Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Crit Care Med 39:1029-35. 2011
    ....
  11. ncbi request reprint Role of serial routine microbiologic culture results in the initial management of ventilator-associated pneumonia
    Jan Hayon
    Service de Reanimation Medicale, and Service de Microbiologie, Hôpital Bichat Cl Bernard, Assistance Publique Hopitaux de Paris, Paris, France
    Am J Respir Crit Care Med 165:41-6. 2002
    ..Based on these data, the contribution of routine microbiologic specimens in guiding initial antimicrobial therapy decisions for patients with suspected VAP appears limited...
  12. ncbi request reprint Impact of piperacillin resistance on the outcome of Pseudomonas ventilator-associated pneumonia
    Alain Combes
    Groupe Hospitalier Pitie Salpetriere, Assistance Publique, Hôpitaux de Paris Université Pierre et Marie Curie, Paris 6, Service de Reanimation Medicale, Institut de Cardiologie, Paris, France
    Intensive Care Med 32:1970-8. 2006
    ....
  13. ncbi request reprint The PRESERVE mortality risk score and analysis of long-term outcomes after extracorporeal membrane oxygenation for severe acute respiratory distress syndrome
    Matthieu Schmidt
    Medical Surgical Intensive Care Unit, iCAN, Institute of Cardiometabolism and Nutrition, Service de Reanimation Medicale, Groupe Hôpital de la Pitié Salpêtrière, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris 6, 47, Bd de l Hopital, 75651, Paris Cedex 13, France
    Intensive Care Med 39:1704-13. 2013
    ..We also assessed long-term survivors' health-related quality of life (HRQL), respiratory symptoms, and anxiety, depression and post-traumatic stress disorder (PTSD) frequencies...
  14. ncbi request reprint Factors predicting ventilator-associated pneumonia recurrence
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Hopital Bichat, Paris, France
    Crit Care Med 31:1102-7. 2003
    ..To determine the factors associated with ventilator-associated pneumonia recurrence in patients alive after 8 days of treatment for a first episode...
  15. ncbi request reprint Mortality among patients admitted to intensive care units during weekday day shifts compared with "off" hours
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Crit Care Med 35:3-11. 2007
    ....
  16. pmc Nosocomial infections in adult cardiogenic shock patients supported by venoarterial extracorporeal membrane oxygenation
    Matthieu Schmidt
    Service de Reanimation Medicale, Institut de Cardiologie, Paris Cedex 13, France
    Clin Infect Dis 55:1633-41. 2012
    ..Incidence and impact on adult patients' outcomes of nosocomial infections (NIs) occurring during venoarterial extracorporeal membrane oxygenation (VA-ECMO) support for refractory cardiogenic shock have rarely been described...
  17. ncbi request reprint Use of quantitative cultures and reduced duration of antibiotic regimens for patients with ventilator-associated pneumonia to decrease resistance in the intensive care unit
    Jean Chastre
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, 75651 Paris Cedex 13, France
    Clin Infect Dis 43:S75-81. 2006
    ....
  18. doi request reprint Venoarterial extracorporeal membrane oxygenation support for refractory cardiovascular dysfunction during severe bacterial septic shock
    Nicolas Bréchot
    Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Crit Care Med 41:1616-26. 2013
    ....
  19. doi request reprint Early percutaneous tracheotomy versus prolonged intubation of mechanically ventilated patients after cardiac surgery: a randomized trial
    Jean Louis Trouillet
    Institut de Cardiologie, Hopital de la Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Institut National de la Sante et de la Recherche Medicale, Paris, France
    Ann Intern Med 154:373-83. 2011
    ..Whether early percutaneous tracheotomy in patients who require prolonged mechanical ventilation can shorten mechanical ventilation duration and lower mortality remains controversial...
  20. doi request reprint Usefulness of procalcitonin for the diagnosis of ventilator-associated pneumonia
    Charles Edouard Luyt
    Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Universite Paris 6, 75651, Paris Cedex 13, France
    Intensive Care Med 34:1434-40. 2008
    ..To assess the predictive capacity for the diagnosis of ventilator-associated pneumonia (VAP) of serum procalcitonin levels before and on the day it is suspected...
  21. ncbi request reprint Impact of antibiotic-resistant bacteria on the outcome of ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Pr Gibert, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Semin Respir Crit Care Med 27:23-8. 2006
    ....
  22. ncbi request reprint Is tracheostomy associated with better outcomes for patients requiring long-term mechanical ventilation?
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Crit Care Med 35:802-7. 2007
    ..To evaluate the effect of tracheostomy on intensive care unit (ICU) and in-hospital mortality for patients requiring prolonged (> 3 days) mechanical ventilation (MV)...
  23. doi request reprint Controversies in ventilator-associated pneumonia
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Semin Respir Crit Care Med 31:47-54. 2010
    ....
  24. doi request reprint Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial
    Lila Bouadma
    Service de Reanimation Medicale, Universite Paris 7 Denis Diderot, Hopital Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Paris, France
    Lancet 375:463-74. 2010
    ..We aimed to establish the effectiveness of an algorithm based on the biomarker procalcitonin to reduce antibiotic exposure in this setting...
  25. ncbi request reprint Does invasive diagnosis of nosocomial pneumonia during off-hours delay treatment?
    Charles Edouard Luyt
    Universite Pierre et Marie Curie, Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47 Boulevard de l Hopital, 75651, Paris Cedex 13, France
    Intensive Care Med 33:734-7. 2007
    ..m. to 8:29 a.m. the next day for night shifts, from Saturday 1:00 p.m. to Monday 8:29 a.m. for weekends, and from 8:30 a.m. to 8:29 a.m. the following morning for public holidays)...
  26. doi request reprint Outcomes and long-term quality-of-life of patients supported by extracorporeal membrane oxygenation for refractory cardiogenic shock
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris 6, Paris, France
    Crit Care Med 36:1404-11. 2008
    ..To assess the outcomes and long-term quality-of-life of patients supported by extracorporeal membrane oxygenation (ECMO) for refractory cardiogenic shock...
  27. ncbi request reprint Adverse effect on a referral intensive care unit's performance of accepting patients transferred from another intensive care unit
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Paris, France
    Crit Care Med 33:705-10. 2005
    ..To determine whether observed and predicted mortality for intensive care unit (ICU) transfer admissions is different from non-ICU transfer admissions and how that might affect ICU performance evaluation...
  28. doi request reprint Usefulness of cardiac biomarkers to predict cardiac recovery in patients on extracorporeal membrane oxygenation support for refractory cardiogenic shock
    Charles Edouard Luyt
    Service de Reanimation, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
    J Crit Care 27:524.e7-14. 2012
    ....
  29. doi request reprint Impact of extracorporeal membrane oxygenation and continuous venovenous hemodiafiltration on the pharmacokinetics of oseltamivir carboxylate in critically ill patients with pandemic (H1N1) influenza
    Florian Lemaître
    Pharmacy Department, Pitie Salpetriere Hospital, Assistance Publique des Hopitaux de Paris, AP HP, Paris, France
    Ther Drug Monit 34:171-5. 2012
    ..This study was designed to evaluate the impact of ECMO and CVVHDF on the pharmacokinetics of oseltamivir carboxylate (OC) in critically ill patients with pandemic (H1N1) influenza treated with oseltamivir...
  30. doi request reprint Predictors of successful extracorporeal membrane oxygenation (ECMO) weaning after assistance for refractory cardiogenic shock
    Nadia Aissaoui
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris 6, Paris, France
    Intensive Care Med 37:1738-45. 2011
    ..This study evaluated a weaning strategy following support for refractory cardiogenic shock to identify clinical, hemodynamic, and Doppler echocardiography parameters associated with successful ECMO removal...
  31. doi request reprint Prolonged mechanical ventilation after cardiac surgery: outcome and predictors
    Jean Louis Trouillet
    Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Paris 6 Pierre et Marie Curie, Paris, France
    J Thorac Cardiovasc Surg 138:948-53. 2009
    ..Our objective was to identify patients still requiring mechanical ventilation 3 days after the operation and those successfully weaned by day 10 to avoid needless and potentially hazardous interventions, such as tracheostomy...
  32. doi request reprint Diagnostic techniques and procedures for establishing the microbial etiology of ventilator-associated pneumonia for clinical trials: the pros for quantitative cultures
    Jean Chastre
    Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Clin Infect Dis 51:S88-92. 2010
    ....
  33. doi request reprint Blood oxygenation and decarboxylation determinants during venovenous ECMO for respiratory failure in adults
    Matthieu Schmidt
    Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Institute of Cardiometabolism and Nutrition, Assistance Publique Hôpitaux de Paris Université Pierre et Marie Curie, Paris 6, France
    Intensive Care Med 39:838-46. 2013
    ....
  34. ncbi request reprint New diagnostic and prognostic markers of ventilator-associated pneumonia
    Jean Chastre
    Medical Intensive Care Unit, Pitie Salpetriere Hospital, Pierre and Marie Curie University, Paris, France
    Curr Opin Crit Care 12:446-51. 2006
    ..The purpose of this review is to analyze the potential advantages and drawbacks of using biomarkers of bacterial infection for the diagnosis and prognosis of ventilator-associated pneumonia...
  35. doi request reprint Emergency circulatory support in refractory cardiogenic shock patients in remote institutions: a pilot study (the cardiac-RESCUE program)
    Sylvain Beurtheret
    Department of Cardiovascular Surgery, Pitie Salpetriere University Hospital, Paris Curie University, Paris, France
    Eur Heart J 34:112-20. 2013
    ..The cardiac-RESCUE program was designed to test the feasibility of providing circulatory support distant from specialized ECMO centres, for RCS patients in remote locations...
  36. doi request reprint Extracorporeal membrane oxygenation for pandemic influenza A(H1N1)-induced acute respiratory distress syndrome: a cohort study and propensity-matched analysis
    Tai Pham
    Service de Reanimation Medicale, Groupe Hospitalier Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
    Am J Respir Crit Care Med 187:276-85. 2013
    ..Many patients with severe acute respiratory distress syndrome (ARDS) caused by influenza A(H1N1) infection receive extracorporeal membrane oxygenation (ECMO) as a rescue therapy...
  37. doi request reprint Two-dimensional strain rate and Doppler tissue myocardial velocities: analysis by echocardiography of hemodynamic and functional changes of the failed left ventricle during different degrees of extracorporeal life support
    Nadia Aissaoui
    Universite Rene Descartes Paris V, Paris, France
    J Am Soc Echocardiogr 25:632-40. 2012
    ....
  38. doi request reprint Biomarkers to optimize antibiotic therapy for pneumonia due to multidrug-resistant pathogens
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, France
    Clin Chest Med 32:431-8. 2011
    ..5 ng/mL or has decreased by 80% or more compared with the peak concentration, antibiotics can be stopped. With this strategy, extreme vigilance must be maintained after terminating antimicrobial therapy to detect a recurrent infection...
  39. doi request reprint Paracorporeal pulsatile biventricular assist device versus extracorporal membrane oxygenation-extracorporal life support in adult fulminant myocarditis
    Olivier N Pages
    Institut de Cardiologie, Service de Chirurgie Thoracique et Cardiovasculaire, Universite Pierre et Marie Curie Paris 6, AP HP, Groupe Pitié Salpêtrière, Paris, France
    J Thorac Cardiovasc Surg 137:194-7. 2009
    ..Whether these patients can be as efficiently supported with femorofemoral extracorporeal membrane oxygenation remains unclear...
  40. doi request reprint Viral infections in the ICU
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Paris, and Université Paris 6 Pierre et Marie Curie, France
    Curr Opin Crit Care 14:605-8. 2008
    ..The present study reviews the precise role of viruses as causes of pneumonia in mechanically ventilated patients...
  41. ncbi request reprint Acute lung injury after mechanical circulatory support implantation in patients on extracorporeal life support: an unrecognized problem
    David Boulate
    Assistance Publique Hopitaux de Paris, Department of Cardiac and Thoracic Surgery, Cardiologic Institute, hôpital La Pitié Salpêtrière, Paris, France
    Eur J Cardiothorac Surg 44:544-9; discussion 549-50. 2013
    ..The aim of our study was to analyse the frequency, impact on mortality and characteristics of patients presenting ALI after MCS implantation in the bridge-to-bridge (BTB) strategy...
  42. doi request reprint Delivering antibiotics to the lungs of patients with ventilator-associated pneumonia: an update
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47 83, Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Expert Rev Anti Infect Ther 11:511-21. 2013
    ....
  43. ncbi request reprint Acute poststernotomy mediastinitis managed with debridement and closed-drainage aspiration: factors associated with death in the intensive care unit
    Jean Louis Trouillet
    Service de Reanimation Medicale, Hôpital La Pitié Salpêtrière Assistance Publique Hôpitaux de Paris, France
    J Thorac Cardiovasc Surg 129:518-24. 2005
    ..The purpose of the study is to describe an intensive care unit's experience in the treatment of poststernotomy mediastinitis and to identify factors associated with intensive care unit death...
  44. ncbi request reprint Procalcitonin kinetics as a prognostic marker of ventilator-associated pneumonia
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, 47, Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Am J Respir Crit Care Med 171:48-53. 2005
    ..Multivariate analyses retained serum procalcitonin levels on Days 1, 3, and 7 as strong predictors of unfavorable outcome. Based on these data, procalcitonin could be a prognostic marker of outcome during VAP...
  45. doi request reprint Gender impact on the outcomes of critically ill patients with nosocomial infections
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Crit Care Med 37:2506-11. 2009
    ..Highly controversial data exist regarding gender-related differences in outcomes of severe nosocomial infections, reflecting potential confounders related to case-mixes or heterogeneity of populations evaluated...
  46. ncbi request reprint Early use of the pulmonary artery catheter and outcomes in patients with shock and acute respiratory distress syndrome: a randomized controlled trial
    Christian Richard
    Service de Reanimation Medicale, Hopital de Bicetre, Le Kremlin Bicetre, France
    JAMA 290:2713-20. 2003
    ..Many physicians believe that the pulmonary artery catheter (PAC) is useful for the diagnosis and treatment of cardiopulmonary disturbances; however, observational studies suggest that its use may be harmful...
  47. ncbi request reprint Impact of tracheotomy on sedative administration, sedation level, and comfort of mechanically ventilated intensive care unit patients
    Ania Nieszkowska
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Paris, France
    Crit Care Med 33:2527-33. 2005
    ..To assess the impact of tracheotomy on sedative administration, sedation level, and autonomy of mechanically-ventilated intensive care unit (ICU) patients...
  48. doi request reprint Value of the serum procalcitonin level to guide antimicrobial therapy for patients with ventilator-associated pneumonia
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Semin Respir Crit Care Med 32:181-7. 2011
    ..Accordingly, for VAP patients, procalcitonin may be used to stop antibiotics as early as day 3 after their initiation, if its concentration is <0.5 ng/mL or has decreased by ≥80%, compared with the first peak concentration...
  49. ncbi request reprint Herpes simplex virus lung infection in patients undergoing prolonged mechanical ventilation
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Université de Paris Pierre et Marie Curie, Assistance Publique Hopitaux de Paris, Paris Cedex 13, France
    Am J Respir Crit Care Med 175:935-42. 2007
    ....
  50. ncbi request reprint The invasive (quantitative) diagnosis of ventilator-associated pneumonia
    Jean Chastre
    Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, 43 87 bd de l Hôpital, 75651 Paris Cedex 13, France
    Respir Care 50:797-807; discussion 807-12. 2005
    ..Bronchoalveolar lavage may also provide useful clues for the diagnosis of other forms of respiratory failure, such as pulmonary hemorrhage or other types of infections, especially in immunocompromised patients...
  51. doi request reprint Virus-induced acute respiratory distress syndrome: epidemiology, management and outcome
    Charles Edouard Luyt
    Assistance Publique Hopitaux de Paris, Universite Paris 6 Pierre et Marie Curie, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Service de Reanimation Medicale, 75651 Paris Cedex 13, France
    Presse Med 40:e561-8. 2011
    ..Ganciclovir can be considered for patients with ARDS and histology- or cytology-proven CMV pneumonia...
  52. doi request reprint Aerosolized antibiotics to treat ventilator-associated pneumonia
    Charles Edouard Luyt
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, 47 83 boulevard de l Hopital, Paris Cedex 13, France
    Curr Opin Infect Dis 22:154-8. 2009
    ..This review summarizes the recent data on antibiotic aerosolization to treat ventilator-associated pneumonia...
  53. doi request reprint Imipenem, meropenem, or doripenem to treat patients with Pseudomonas aeruginosa ventilator-associated pneumonia
    Charles Edouard Luyt
    Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
    Antimicrob Agents Chemother 58:1372-80. 2014
    ..15) and mortality rates (47%, 25%, and 22%, respectively; P=0.07). Carbapenem resistance emerged similarly among patients treated with any carbapenem. No carbapenem was superior to another for preventing carbapenem resistance emergence...
  54. doi request reprint [Acute myocarditis]
    Alain Combes
    Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Service de Reanimation Medicale, 75651 Paris Cedex 13, France
    Presse Med 41:621-7. 2012
    ..For highly unstable patients, a Mobile Cardiac Assistance Unit, that rapidly travels to primary care hospitals with a portable ECMO system and hooks it up before refractory multiorgan failure takes hold, is the preferred option...
  55. ncbi request reprint Long-term outcomes of pandemic 2009 influenza A(H1N1)-associated severe ARDS
    Charles Edouard Luyt
    Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hôpitaux de Paris et Université Paris 6 Pierre et Marie Curie, Paris, France
    Chest 142:583-92. 2012
    ..The objective of this study was to compare the 1-year outcomes of survivors of A(H1N1)-associated ARDS, according to use or no use of extracorporeal lung assist (ECLA), using its need as an ARDS severity surrogate...
  56. doi request reprint Extracorporeal membrane oxygenation for 2009 influenza A (H1N1) acute respiratory distress syndrome: single-centre experience with 1-year follow-up
    Sylvain Beurtheret
    Division of Cardiac Surgery, Pitie Salpetriere Hospital, University Pierre et Marie Curie, Paris, France
    Eur J Cardiothorac Surg 41:691-5. 2012
    ..The use of extracorporeal membrane oxygenation (ECMO) could be advocated as therapeutic solution. We present our experience with ECMO utilized in patients with influenza A (H1N1)-associated respiratory failure...
  57. ncbi request reprint Continuous venovenous haemodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: a multicentre randomised trial
    Christophe Vinsonneau
    Department of Intensive Care, Cochin Port Royal University Hospital, Rene Descartes University, Paris, France
    Lancet 368:379-85. 2006
    ..In this study, we compare the effect of intermittent haemodialysis and continuous venovenous haemodiafiltration on survival rates in critically ill patients with acute renal failure as part of multiple-organ dysfunction syndrome...
  58. ncbi request reprint Acquiring procedural skills in ICUs: a prospective multicenter study*
    Damien Roux
    1AP HP, Hopital Louis Mourier, Service de Réanimation medico chirurgicale, Colombes, France 2UMRS 722, Univ Paris Diderot, Sorbonne Paris Cité, UMRS 722, Paris, France 3Service de réanimation polyvalente, CHD Les Oudaries, La Roche Sur Yon, France 4AP HP, Hopital Saint Louis, Service de Reanimation Medicale, Paris, France 5Service de réanimation médicale, Hopital Pellegrin Tripode, CHU Bordeaux, Bordeaux, France 6Service de Réanimation Polyvalente, CHI Poissy Saint Germain en Laye, site de Saint Germain, Saint Germain en Laye, France 7Service de Réanimation, CHU, Clermont Ferrand, France 8Service de réanimation médicale, Hopital Sainte Marguerite, Marseille, France 9Service de Réanimation Médicale, CHU Angers, Angers, France 10Service de réanimation médicale, CHU Nice, Nice, France 11AP HP, Italy
    Crit Care Med 42:886-95. 2014
    ..We sought to determine how effective and safe procedural skill acquisition is in French ICUs and to identify failure and complication risk factors...
  59. ncbi request reprint [Acute myocarditis]
    Alain Combes
    Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier La Pitié Salpêtrière, AP HP, 75651 Paris Cedex 13, France
    Rev Prat 63:611-6. 2013
    ..For highly unstable patients, a Mobile Cardiac Assistance Unit, that rapidly travels to primary care hospitals with a portable ECMO system and hooks it up before refractory multiorgan failure takes hold, is the preferred option...
  60. ncbi request reprint What is the niche for extracorporeal membrane oxygenation in severe acute respiratory distress syndrome?
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris 6, Paris, France
    Curr Opin Crit Care 18:527-32. 2012
    ..This article reviews the results of case series and trials which evaluated venovenous extracorporeal membrane oxygenation (VV-ECMO) for severe respiratory failure. Potential indications of the technique in this setting are discussed...
  61. doi request reprint Extracorporeal membrane oxygenation for respiratory failure in adults
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Curr Opin Crit Care 18:99-104. 2012
    ..This article reviews case series and trials that evaluated extracorporeal membrane oxygenation (ECMO) for respiratory failure and describes patient and circuit management in the modern era of ECMO support...
  62. doi request reprint Diffusion tensor imaging to predict long-term outcome after cardiac arrest: a bicentric pilot study
    Charles Edouard Luyt
    Service de Reanimation, School of Medicine, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Université Paris Pierre et Marie Curie, Paris, France
    Anesthesiology 117:1311-21. 2012
    ..The authors' objective was to determine whether an assessment with diffusion tensor imaging, a brain magnetic resonance imaging sequence, increases the accuracy of 1 yr functional outcome prediction in cardiac arrest survivors...
  63. doi request reprint Extracorporeal membrane oxygenation for 2009 influenza A (H1N1)-associated acute respiratory distress syndrome
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
    Semin Respir Crit Care Med 32:188-94. 2011
    ..However, whether the 25 to 50% mortality observed in the reported ECMO series was affected by the recourse to this technique could not be established...
  64. pmc The long and difficult road to better evaluation of outcomes of prolonged mechanical ventilation: not yet a highway to heaven
    Alain Combes
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
    Crit Care 11:120. 2007
    ..However, predictors of mortality and long-term functional outcomes that are reliable and accurate at the level of the individual patient remain to be identified...
  65. doi request reprint [Impact of ECMO on drugs pharmacokinetics]
    Nesrine Hasni
    Service Pharmacie, Groupe Hospitalier Pitie Salpetriere, AP HP, Paris, France
    Therapie 66:405-12. 2011
    ..However, more research is needed to identify dosage strategies for this patient population...
  66. pmc Fatal disseminated Acanthamoeba lenticulata infection in a heart transplant patient
    Stephane Barete
    Department of Dermatology and Allergy, Hopital Tenon, Assistance Publique Hopitaux de Paris, France
    Emerg Infect Dis 13:736-8. 2007
    ..The diagnosis was based on skin histopathologic results and confirmed by isolation of the ameba from involved skin and molecular analysis of a partial 18S rRNA gene sequence (DF3)...
  67. ncbi request reprint Circulatory support for fulminant myocarditis: consideration for implantation, weaning and explantation
    Pascal Leprince
    Service de Chirurgie Thoracique et Cardiovasculaire, Groupe Pitié Salpêtrière, Institut de Cardiologie, 47 83 boulevard de l Hopital, 75013 Paris, France
    Eur J Cardiothorac Surg 24:399-403. 2003
    ..Fulminant myocarditis (FM) is an uncommon but life-threatening condition for which a mechanical circulatory support (MCS) device can be life-saving. However, device selection, weaning and explantation procedures remain poorly defined...
  68. ncbi request reprint Reproducibility of protected specimen brush and bronchoalveolar lavage conserved at 4 degrees C for 48 hours
    Xavier Forceville
    Service de Reanimation Polyvalente, Centre Hospitalier de Meaux, Saint Faron, 6 8 rue Saint Fiacre, 77104 Meaux, France
    Intensive Care Med 28:857-63. 2002
    ..Nevertheless, they are only validated for immediate laboratory processing. This study was therefore conducted to determine whether 48 h conservation at a mere 4 degrees C enables good culture reproducibility for both PSB and BAL...
  69. ncbi request reprint Methicillin-resistant Staphylococcus aureus prolongs intensive care unit stay in ventilator-associated pneumonia, despite initially appropriate antibiotic therapy
    Andrew F Shorr
    Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC, USA
    Crit Care Med 34:700-6. 2006
    ....
  70. pmc Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study
    Xavier Forceville
    Service de Reanimation Polyvalente, Centre Hospitalier de Meaux, Hôpital Saint Faron, 6 8 rue Saint Fiacre, 77104 Meaux, France
    Crit Care 11:R73. 2007
    ..We investigated the effects of a continuous administration of high doses of selenium in septic shock patients...
  71. ncbi request reprint Backrest elevation for the prevention of ventilator-associated pneumonia: back to the real world?
    Alain Combes
    Crit Care Med 34:559-61. 2006