Patrick Collombat

Summary

Country: France

Publications

  1. pmc The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, D 37077 Gottingen, Germany
    Cell 138:449-62. 2009
  2. pmc The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells
    Monica Courtney
    Universite de Nice Sophia Antipolis, iBV, UMR 7277, Nice, France INSERM, iBV, U1091, Nice, France CNRS, iBV, UMR 7277, Nice, France
    PLoS Genet 9:e1003934. 2013
  3. ncbi request reprint The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas
    Patrick Collombat
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, 37077 Gottingen, Germany
    Development 132:2969-80. 2005
  4. pmc Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage
    Simon Kordowich
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, Gottingen, Germany
    BMC Dev Biol 11:52. 2011
  5. doi request reprint Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes
    Keith Al-Hasani
    Universite de Nice Sophia Antipolis, FR 06108 Nice, France
    Dev Cell 26:86-100. 2013
  6. doi request reprint [Reprogramming pancreatic cells to β cells]
    Andhira Vieira
    université Nice Sophia Antipolis, Nice, France
    Med Sci (Paris) 29:749-55. 2013
  7. pmc Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany Department of Developmental Biology, Hagedorn Research Institute, Gentofte, Denmark
    J Clin Invest 117:961-70. 2007
  8. doi request reprint From pancreas morphogenesis to β-cell regeneration
    Fabio Avolio
    Univ Nice Sophia Antipolis, iBV, UMR 7277, Nice, France INSERM, iBV, U1091, Nice, France CNRS, iBV, UMR 7277, Nice, France
    Curr Top Dev Biol 106:217-38. 2013
  9. pmc Opposing actions of Arx and Pax4 in endocrine pancreas development
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    Genes Dev 17:2591-603. 2003
  10. ncbi request reprint Specifying pancreatic endocrine cell fates
    Patrick Collombat
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, D 37077 Gottingen, Germany
    Mech Dev 123:501-12. 2006

Collaborators

Detail Information

Publications15

  1. pmc The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, D 37077 Gottingen, Germany
    Cell 138:449-62. 2009
    ....
  2. pmc The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells
    Monica Courtney
    Universite de Nice Sophia Antipolis, iBV, UMR 7277, Nice, France INSERM, iBV, U1091, Nice, France CNRS, iBV, UMR 7277, Nice, France
    PLoS Genet 9:e1003934. 2013
    ..Our data therefore suggest that strategies aiming at inhibiting the expression of Arx, or its molecular targets/co-factors, may pave new avenues for the treatment of diabetes. ..
  3. ncbi request reprint The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas
    Patrick Collombat
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, 37077 Gottingen, Germany
    Development 132:2969-80. 2005
    ..Finally, our data provide evidence that both Arx and Pax4 act as transcriptional repressors that control the expression level of one another, thereby mediating proper endocrine fate allocation...
  4. pmc Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage
    Simon Kordowich
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, Gottingen, Germany
    BMC Dev Biol 11:52. 2011
    ..2-deficient pancreata. Hence in order to precise the functional link between both factors we performed a comparative analysis of Nkx2.2/Arx single- and double-mutants but also of Pax6-deficient animals...
  5. doi request reprint Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes
    Keith Al-Hasani
    Universite de Nice Sophia Antipolis, FR 06108 Nice, France
    Dev Cell 26:86-100. 2013
    ..Importantly, these processes can repeatedly regenerate the whole β cell mass and thereby reverse several rounds of toxin-induced diabetes, providing perspectives to design therapeutic regenerative strategies...
  6. doi request reprint [Reprogramming pancreatic cells to β cells]
    Andhira Vieira
    université Nice Sophia Antipolis, Nice, France
    Med Sci (Paris) 29:749-55. 2013
    ..Clearly, such promising results could open new research avenues in the context of type 1 diabetes research. ..
  7. pmc Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany Department of Developmental Biology, Hagedorn Research Institute, Gentofte, Denmark
    J Clin Invest 117:961-70. 2007
    ..These results provide important insights into the complex mechanisms underlying proper pancreatic endocrine cell allocation and cell identity acquisition...
  8. doi request reprint From pancreas morphogenesis to β-cell regeneration
    Fabio Avolio
    Univ Nice Sophia Antipolis, iBV, UMR 7277, Nice, France INSERM, iBV, U1091, Nice, France CNRS, iBV, UMR 7277, Nice, France
    Curr Top Dev Biol 106:217-38. 2013
    ..Furthermore, a focus is made on new research avenues concerning the conversion of pre-existing pancreatic cells into β-like cells, such approaches holding great promise for the development of type 1 diabetes therapies. ..
  9. pmc Opposing actions of Arx and Pax4 in endocrine pancreas development
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    Genes Dev 17:2591-603. 2003
    ..We propose that the antagonistic functions of Arx and Pax4 for proper islet cell specification are related to the pancreatic levels of the respective transcripts...
  10. ncbi request reprint Specifying pancreatic endocrine cell fates
    Patrick Collombat
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, D 37077 Gottingen, Germany
    Mech Dev 123:501-12. 2006
    ..This review focuses on the mechanisms regulating the morphogenesis of the pancreas with particular emphasis on recent findings concerning the transcription factor hierarchy orchestrating endocrine cell fate allocation...
  11. doi request reprint Reprogramming into pancreatic endocrine cells based on developmental cues
    Simon Kordowich
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, D 37077 Gottingen, Germany
    Mol Cell Endocrinol 323:62-9. 2010
    ..Furthermore, an emphasize is made on beta-cell regeneration and the determinants implicated...
  12. pmc Generation of animals allowing the conditional inactivation of the Pax4 gene
    Simon Kordowich
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, 37077 Gottingen, Germany
    Transgenic Res 21:1215-20. 2012
    ..Herein, we report the generation of Pax4 conditional knockout mice that will allow the analysis of Pax4 function in mature beta-cells, as well as in the adult central nervous system...
  13. pmc Reprogramming into pancreatic endocrine cells based on developmental cues
    Simon Kordowich
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, D 37077 Gottingen, Germany
    Mol Cell Endocrinol 315:11-8. 2010
    ..Furthermore, an emphasis is made on beta-cell regeneration and the determinants implicated...
  14. ncbi request reprint Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border
    Gundula Griesel
    Max Planck Institute for Biophysical Chemistry, Dept of Molecular Cell Biology, Am Fassberg, 37077 Gottingen, Germany
    Development 133:1779-87. 2006
    ..Furthermore, we provide evidence that cell proliferation in the mid- and hindbrain is tightly controlled by Sp8 activity. Our observations are consistent with a role for Sp8 in restricting Fgf8 expression at the IsO...
  15. pmc Pancreatic beta-cells: from generation to regeneration
    Patrick Collombat
    Inserm U636, Diabetes Genetics Team, Nice, France
    Semin Cell Dev Biol 21:838-44. 2010
    ..In this review, we will therefore present new insights into beta-cell development with focus on beta-cell regeneration...