Patrick Collombat

Summary

Country: France

Publications

  1. ncbi The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, D 37077 Gottingen, Germany
    Cell 138:449-62. 2009
  2. ncbi Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage
    Simon Kordowich
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, Gottingen, Germany
    BMC Dev Biol 11:52. 2011
  3. ncbi The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas
    Patrick Collombat
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, 37077 Gottingen, Germany
    Development 132:2969-80. 2005
  4. ncbi Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany Department of Developmental Biology, Hagedorn Research Institute, Gentofte, Denmark
    J Clin Invest 117:961-70. 2007
  5. ncbi Specifying pancreatic endocrine cell fates
    Patrick Collombat
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, D 37077 Gottingen, Germany
    Mech Dev 123:501-12. 2006
  6. ncbi Reprogramming into pancreatic endocrine cells based on developmental cues
    Simon Kordowich
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, D 37077 Gottingen, Germany
    Mol Cell Endocrinol 323:62-9. 2010
  7. ncbi Reprogramming into pancreatic endocrine cells based on developmental cues
    Simon Kordowich
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, D 37077 Gottingen, Germany
    Mol Cell Endocrinol 315:11-8. 2010
  8. ncbi Opposing actions of Arx and Pax4 in endocrine pancreas development
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    Genes Dev 17:2591-603. 2003
  9. ncbi Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border
    Gundula Griesel
    Max-Planck Institute for Biophysical Chemistry, Dept of Molecular Cell Biology, Am Fassberg, , Germany
    Development 133:1779-87. 2006
  10. ncbi Generation of animals allowing the conditional inactivation of the Pax4 gene
    Simon Kordowich
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, 37077 Gottingen, Germany
    Transgenic Res 21:1215-20. 2012

Collaborators

Detail Information

Publications10

  1. ncbi The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, D 37077 Gottingen, Germany
    Cell 138:449-62. 2009
    ....
  2. ncbi Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage
    Simon Kordowich
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, Gottingen, Germany
    BMC Dev Biol 11:52. 2011
    ..2-deficient pancreata. Hence in order to precise the functional link between both factors we performed a comparative analysis of Nkx2.2/Arx single- and double-mutants but also of Pax6-deficient animals...
  3. ncbi The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas
    Patrick Collombat
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, 37077 Gottingen, Germany
    Development 132:2969-80. 2005
    ..Finally, our data provide evidence that both Arx and Pax4 act as transcriptional repressors that control the expression level of one another, thereby mediating proper endocrine fate allocation...
  4. ncbi Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany Department of Developmental Biology, Hagedorn Research Institute, Gentofte, Denmark
    J Clin Invest 117:961-70. 2007
    ..These results provide important insights into the complex mechanisms underlying proper pancreatic endocrine cell allocation and cell identity acquisition...
  5. ncbi Specifying pancreatic endocrine cell fates
    Patrick Collombat
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, D 37077 Gottingen, Germany
    Mech Dev 123:501-12. 2006
    ..This review focuses on the mechanisms regulating the morphogenesis of the pancreas with particular emphasis on recent findings concerning the transcription factor hierarchy orchestrating endocrine cell fate allocation...
  6. ncbi Reprogramming into pancreatic endocrine cells based on developmental cues
    Simon Kordowich
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, D 37077 Gottingen, Germany
    Mol Cell Endocrinol 323:62-9. 2010
    ..Furthermore, an emphasize is made on beta-cell regeneration and the determinants implicated...
  7. ncbi Reprogramming into pancreatic endocrine cells based on developmental cues
    Simon Kordowich
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, D 37077 Gottingen, Germany
    Mol Cell Endocrinol 315:11-8. 2010
    ..Furthermore, an emphasis is made on beta-cell regeneration and the determinants implicated...
  8. ncbi Opposing actions of Arx and Pax4 in endocrine pancreas development
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    Genes Dev 17:2591-603. 2003
    ..We propose that the antagonistic functions of Arx and Pax4 for proper islet cell specification are related to the pancreatic levels of the respective transcripts...
  9. ncbi Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border
    Gundula Griesel
    Max-Planck Institute for Biophysical Chemistry, Dept of Molecular Cell Biology, Am Fassberg, , Germany
    Development 133:1779-87. 2006
    ..Furthermore, we provide evidence that cell proliferation in the mid- and hindbrain is tightly controlled by Sp8 activity. Our observations are consistent with a role for Sp8 in restricting Fgf8 expression at the IsO...
  10. ncbi Generation of animals allowing the conditional inactivation of the Pax4 gene
    Simon Kordowich
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, 37077 Gottingen, Germany
    Transgenic Res 21:1215-20. 2012
    ..Herein, we report the generation of Pax4 conditional knockout mice that will allow the analysis of Pax4 function in mature beta-cells, as well as in the adult central nervous system...