Patrick Collombat

Summary

Country: France

Publications

  1. pmc The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, D 37077 Gottingen, Germany
    Cell 138:449-62. 2009
  2. ncbi request reprint The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas
    Patrick Collombat
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, 37077 Gottingen, Germany
    Development 132:2969-80. 2005
  3. pmc Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage
    Simon Kordowich
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, Gottingen, Germany
    BMC Dev Biol 11:52. 2011
  4. pmc Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany Department of Developmental Biology, Hagedorn Research Institute, Gentofte, Denmark
    J Clin Invest 117:961-70. 2007
  5. ncbi request reprint Specifying pancreatic endocrine cell fates
    Patrick Collombat
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, D 37077 Gottingen, Germany
    Mech Dev 123:501-12. 2006
  6. doi request reprint Reprogramming into pancreatic endocrine cells based on developmental cues
    Simon Kordowich
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, D 37077 Gottingen, Germany
    Mol Cell Endocrinol 323:62-9. 2010
  7. pmc Generation of animals allowing the conditional inactivation of the Pax4 gene
    Simon Kordowich
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, 37077 Gottingen, Germany
    Transgenic Res 21:1215-20. 2012
  8. pmc Reprogramming into pancreatic endocrine cells based on developmental cues
    Simon Kordowich
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, D 37077 Gottingen, Germany
    Mol Cell Endocrinol 315:11-8. 2010
  9. pmc Opposing actions of Arx and Pax4 in endocrine pancreas development
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    Genes Dev 17:2591-603. 2003
  10. ncbi request reprint Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border
    Gundula Griesel
    Max Planck Institute for Biophysical Chemistry, Dept of Molecular Cell Biology, Am Fassberg, 37077 Gottingen, Germany
    Development 133:1779-87. 2006

Collaborators

Detail Information

Publications10

  1. pmc The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, D 37077 Gottingen, Germany
    Cell 138:449-62. 2009
    ....
  2. ncbi request reprint The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas
    Patrick Collombat
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, 37077 Gottingen, Germany
    Development 132:2969-80. 2005
    ..Finally, our data provide evidence that both Arx and Pax4 act as transcriptional repressors that control the expression level of one another, thereby mediating proper endocrine fate allocation...
  3. pmc Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage
    Simon Kordowich
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, Gottingen, Germany
    BMC Dev Biol 11:52. 2011
    ..2-deficient pancreata. Hence in order to precise the functional link between both factors we performed a comparative analysis of Nkx2.2/Arx single- and double-mutants but also of Pax6-deficient animals...
  4. pmc Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany Department of Developmental Biology, Hagedorn Research Institute, Gentofte, Denmark
    J Clin Invest 117:961-70. 2007
    ..These results provide important insights into the complex mechanisms underlying proper pancreatic endocrine cell allocation and cell identity acquisition...
  5. ncbi request reprint Specifying pancreatic endocrine cell fates
    Patrick Collombat
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, D 37077 Gottingen, Germany
    Mech Dev 123:501-12. 2006
    ..This review focuses on the mechanisms regulating the morphogenesis of the pancreas with particular emphasis on recent findings concerning the transcription factor hierarchy orchestrating endocrine cell fate allocation...
  6. doi request reprint Reprogramming into pancreatic endocrine cells based on developmental cues
    Simon Kordowich
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, D 37077 Gottingen, Germany
    Mol Cell Endocrinol 323:62-9. 2010
    ..Furthermore, an emphasize is made on beta-cell regeneration and the determinants implicated...
  7. pmc Generation of animals allowing the conditional inactivation of the Pax4 gene
    Simon Kordowich
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, 37077 Gottingen, Germany
    Transgenic Res 21:1215-20. 2012
    ..Herein, we report the generation of Pax4 conditional knockout mice that will allow the analysis of Pax4 function in mature beta-cells, as well as in the adult central nervous system...
  8. pmc Reprogramming into pancreatic endocrine cells based on developmental cues
    Simon Kordowich
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, D 37077 Gottingen, Germany
    Mol Cell Endocrinol 315:11-8. 2010
    ..Furthermore, an emphasis is made on beta-cell regeneration and the determinants implicated...
  9. pmc Opposing actions of Arx and Pax4 in endocrine pancreas development
    Patrick Collombat
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    Genes Dev 17:2591-603. 2003
    ..We propose that the antagonistic functions of Arx and Pax4 for proper islet cell specification are related to the pancreatic levels of the respective transcripts...
  10. ncbi request reprint Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border
    Gundula Griesel
    Max Planck Institute for Biophysical Chemistry, Dept of Molecular Cell Biology, Am Fassberg, 37077 Gottingen, Germany
    Development 133:1779-87. 2006
    ..Furthermore, we provide evidence that cell proliferation in the mid- and hindbrain is tightly controlled by Sp8 activity. Our observations are consistent with a role for Sp8 in restricting Fgf8 expression at the IsO...