Martine Cohen-Solal


Country: France


  1. Zarka M, Hay E, Ostertag A, Marty C, Chappard C, Oudet F, et al. Microcracks in subchondral bone plate is linked to less cartilage damage. Bone. 2019;123:1-7 pubmed publisher
    ..Microcracks in calcified cartilage may trigger osteocyte density in subchondral bone plate with subsequent regulation of subchondral bone remodeling to prevent cartilage damage. ..
  2. Muller J, Duray E, Lejeune M, Dubois S, Plougonven E, Léonard A, et al. Loss of Stromal Galectin-1 Enhances Multiple Myeloma Development: Emphasis on a Role in Osteoclasts. Cancers (Basel). 2019;11: pubmed publisher
    ..We observed an enhanced tumour development in gal-1-/- mice compared to wild-type mice, suggesting that galectin-1 has a functional role in stromal cells in myeloma microenvironment. ..
  3. Sigaux J, Abdelkefi I, Bardin T, Laredo J, Ea H, UreñaTorres P, et al. Tendon thickening in dialysis-related joint arthritis is due to amyloid deposits at the surface of the tendon. Joint Bone Spine. 2019;86:233-238 pubmed publisher
    ..Special awareness should be drawn by the thickening of the tendon. MRI is required to characterize the pattern of the lesions and to achieve the diagnosis. ..
  4. Garofoli R, Maravic M, Ostertag A, Cohen Solal M. Secular trends of hip fractures in France: impact of changing characteristics of the background population. Osteoporos Int. 2019;30:355-362 pubmed publisher
    ..6% in women and 19.2% in men as a result of a difference in age-structure of the population. The incidence of hip fractures continues to grow despite a reduced incidence rate throughout a 12-year-period. ..
  5. Lin H, Hay E, Latourte A, Funck Brentano T, Bouaziz W, Ea H, et al. Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGF?-dependent manner and limits osteoarthritis in mice. Sci Rep. 2018;8:10488 pubmed publisher
    ..These results support a protective role for furin in OA by maintaining ALK5 receptor levels and reducing MMP-13 expression. Therefore, furin might be a potential target mediating the development of OA. ..
  6. Taillandier A, Domingues C, De Cazanove C, Porquet Bordes V, Monnot S, Kiffer Moreira T, et al. Molecular diagnosis of hypophosphatasia and differential diagnosis by targeted Next Generation Sequencing. Mol Genet Metab. 2015;116:215-20 pubmed publisher
    ..Interestingly, three of these patients were adults with fractures and/or low BMD. Our results indicate that HPP and OI may be easily misdiagnosed in the prenatal stage but also in adults with mild symptoms for these diseases. ..
  7. Maravic M, Ostertag A, Urena P, Cohen Solal M. Dementia is a major risk factor for hip fractures in patients with chronic kidney disease. Osteoporos Int. 2016;27:1665-1669 pubmed publisher
    ..These results highlight dementia as a major risk factor for HF in dialysis and indicate that reduction of fracture risk should include dementia as a risk factor. ..
  8. Funck Brentano T, Ostertag A, Debiais F, Fardellone P, Collet C, Mornet E, et al. Identification of a p.Arg708Gln variant in COL1A2 in atypical femoral fractures. Joint Bone Spine. 2017;84:715-718 pubmed publisher
    ..This finding should encourage clinician to further genotype patients with AFF in a collaborative multicentric project. ..
  9. Pimentel A, Urena Torres P, Zillikens M, Bover J, Cohen Solal M. Fractures in patients with CKD-diagnosis, treatment, and prevention: a review by members of the European Calcified Tissue Society and the European Renal Association of Nephrology Dialysis and Transplantation. Kidney Int. 2017;92:1343-1355 pubmed publisher
    ..The combined expertise of clinicians from various medical disciplines appears crucial for the most successful prevention of fractures in these patients. ..

More Information


  1. Bouaziz W, Funck Brentano T, Lin H, Marty C, Ea H, Hay E, et al. Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways. Arthritis Res Ther. 2015;17:24 pubmed publisher
    ..Furthermore, sclerostin treatment inhibited both Wnt canonical and non-canonical JNK pathways in chondrocytes, thus preserving metabolism. Sclerostin may play an important role in maintaining cartilage integrity in OA. ..
  2. Bouaziz W, Sigaux J, Modrowski D, Devignes C, Funck Brentano T, Richette P, et al. Interaction of HIF1? and ?-catenin inhibits matrix metalloproteinase 13 expression and prevents cartilage damage in mice. Proc Natl Acad Sci U S A. 2016;113:5453-8 pubmed publisher
    ..Our study contributes to the understanding of the role of HIF1? in OA and highlights the HIF1?-?-catenin interaction, thus providing new insights into the impact of hypoxia in articular cartilage. ..
  3. Al Jazzar A, Javaheri B, Prideaux M, Boyde A, Scudamore C, Cherifi C, et al. Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues. Int J Mol Sci. 2016;18: pubmed publisher
    ..Together, these data lead us to conclude that alternative models for osteocyte ablation should be sought and caution be exercised when drawing conclusions from experiments using these Tg mice alone. ..
  4. Ah Kioon M, Asensio C, Ea H, Uzan B, Cohen Solal M, Lioté F. Adrenomedullin increases fibroblast-like synoviocyte adhesion to extracellular matrix proteins by upregulating integrin activation. Arthritis Res Ther. 2010;12:R190 pubmed publisher
    ..This effect of adrenomedullin was dependent on adrenomedullin receptors. These results support a new role for adrenomedullin in rheumatoid synovial fibroblast pathobiology. ..