- Bouaziz W, Funck Brentano T, Lin H, Marty C, Ea H, Hay E, et al. Loss of sclerostin promotes osteoarthritis in mice via Î²-catenin-dependent and -independent Wnt pathways. Arthritis Res Ther. 2015;17:24 pubmed publisher..Furthermore, sclerostin treatment inhibited both Wnt canonical and non-canonical JNK pathways in chondrocytes, thus preserving metabolism. Sclerostin may play an important role in maintaining cartilage integrity in OA. ..
- Bouaziz W, Sigaux J, Modrowski D, Devignes C, Funck Brentano T, Richette P, et al. Interaction of HIF1? and ?-catenin inhibits matrix metalloproteinase 13 expression and prevents cartilage damage in mice. Proc Natl Acad Sci U S A. 2016;113:5453-8 pubmed publisher..Our study contributes to the understanding of the role of HIF1? in OA and highlights the HIF1?-?-catenin interaction, thus providing new insights into the impact of hypoxia in articular cartilage. ..
- Al Jazzar A, Javaheri B, Prideaux M, Boyde A, Scudamore C, Cherifi C, et al. Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues. Int J Mol Sci. 2016;18: pubmed publisher..Together, these data lead us to conclude that alternative models for osteocyte ablation should be sought and caution be exercised when drawing conclusions from experiments using these Tg mice alone. ..
- Ah Kioon M, Asensio C, Ea H, Uzan B, Cohen Solal M, Lioté F. Adrenomedullin increases fibroblast-like synoviocyte adhesion to extracellular matrix proteins by upregulating integrin activation. Arthritis Res Ther. 2010;12:R190 pubmed publisher..This effect of adrenomedullin was dependent on adrenomedullin receptors. These results support a new role for adrenomedullin in rheumatoid synovial fibroblast pathobiology. ..