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Genomes and Genes | K ClementSummaryCountry: France Publications
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Publications
Cathepsins in human obesity: changes in energy balance predominantly affect cathepsin s in adipose tissue and in circulationNadia Naour
Institut National de la Santé et de la Recherche Méédicale, Unite 872, Universite Pierre et Marie Curie PARIS6, Paris, France
J Clin Endocrinol Metab 95:1861-8. 2010..Recent studies in humans and mice suggest the implication of the cysteine proteases cathepsins S, L, and K in vascular and metabolic complications of obesity...
Genome wide association study identifies KCNMA1 contributing to human obesityHong Jiao
Department of Biosciences and Nutrition, Karolinska Institutet, SE 141 83 Huddinge, Sweden
BMC Med Genomics 4:51. 2011..Thus many genetic variants controlling obesity remain to be identified. The aim of this study was to use GWA followed by multiple stepwise validations to identify additional genes associated with obesity...- Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC geneKarine Clement
Center of Research on Human Nutrition Ile de France, Paris, 75013, France
J Clin Endocrinol Metab 93:4955-62. 2008..Mutations that inactivate the POMC gene have been described in children, causing a pleiotropic syndrome that includes secondary hypocortisolism, severe obesity, and variable changes in skin and hair pigmentation... - Bariatric surgery, adipose tissue and gut microbiotaK Clement
Cardiometabolism Division, Assistance Publique Hopitaux de Paris, Pitie Salpetriere Hospital, Paris, France
Int J Obes (Lond) 35:S7-15. 2011..Roux-en-Y gastric bypass surgery is an increasingly effective model to study in this context because it leads to major improvements in glucose and lipid homeostasis and to the amelioration of some systemic inflammatory markers... - [Inflammation, adipokines and obesity]K Clement
Service de Nutrition, pôle d endocrinologie, Hopital de la Pitie Salpetriere, Assistance Publique Hopitaux de Paris, U872 équipe 7, INSERM, Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie Paris 6, 75006 Paris, France
Rev Med Interne 30:824-32. 2009..A small or even moderate reduction of weight significantly reduces circulating inflammatory markers, modulates adipose tissue profile of inflammatory genes and the risks associated with obesity... - Cathepsin S genotypes are associated with Apo-A1 and HDL-cholesterol in lean and obese French populationsN Spielmann
INSERM, Nutriomique U872, Paris, France Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie Paris 6, UMR S 872, Paris, France
Clin Genet 74:155-63. 2008..03). These results provide the first evidence that CTSS sequence variations are associated with two human metabolic risk factors for cardiovascular diseases: plasma Apo-A1 and HDL-C concentrations... 
Soluble leptin receptor in serum of subjects with complete resistance to leptin: relation to fat massN Lahlou
Unit 342, Institut National de la Sante et de la Recherche Medicale, and the Department of Biochemistry, Hopital Saint Vincent de Paul, Paris, France
Diabetes 49:1347-52. 2000..This finding suggests that the leptin receptor itself may not be specifically involved in the control of leptin secretion, and it supports the concept of relative resistance to leptin in common obesity...- Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese childrenB Dubern
Medicine and Nutrition Department, Hôtel Dieu Teaching Hospital, Paris, France
J Pediatr 139:204-9. 2001..To search for mutations in melanocortin pathway elements, that is, the melanocortin-4 receptor (MC4R ), agouti-related protein (AGRP ), and (alpha-melanocyte-stimulating hormone (alpha MSH ) genes in children with severe obesity... - Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissueR Cancello
Institut National de la Santé et de la Recherche Médicale INSERM U755 Nutriomique, Paris, France
BJOG 113:1141-7. 2006..The interactions of macrophages with adipocytes will certainly be the subject of intense investigations in the future... - The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetesK Clement
Laboratoire de Nutrition et Service de Médecine et Nutrition, Hôtel Dieu place du Parvis Notre Dame, Paris, France
Int J Obes Relat Metab Disord 24:391-3. 2000.... - Using gene expression to predict the secretome of differentiating human preadipocytesD M Mutch
INSERM, UMRS U872 Eq 7 Nutriomique, Centre de Recherche des Cordeliers, Paris, France
Int J Obes (Lond) 33:354-63. 2009..To characterize the secretome of differentiating human preadipocytes using global gene expression profiling... - Regulation of inflammation-related genes in human adipose tissueK Clement
INSERM, U872 Nutriomique, Paris, France
J Intern Med 262:422-30. 2007..e. cathepsins and serum amyloid A) is discussed in the context of weight loss programmes based on calorie restriction and physical exercise. The foreseen clinical and technological challenges are also summarized... - Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjectsS Kipfer-Coudreau
INSERM Avenir and EA 3502, Nutrition Department, Paris VI University, Paris, France
Diabetologia 47:1278-84. 2004..We investigated whether PTP 1B SNPs are associated with obesity and obesity-related traits as well as global metabolic syndrome in morbidly obese subjects... - A mutation in the human leptin receptor gene causes obesity and pituitary dysfunctionK Clement
Laboratoire de Nutrition et Service de Médecine et Nutrition, Hôtel Dieu place du Parvis Notre Dame, Paris, France
Nature 392:398-401. 1998..These results indicate that leptin is an important physiological regulator of several endocrine functions in humans... - Macrophage-secreted factors promote a profibrotic phenotype in human preadipocytesMayoura Keophiphath
Institut National de la Santé et de la Recherche Médicale INSERM Unité 872, Centre de Recherche des Cordeliers, 15 rue de l Ecole de Medecine, 75005 Paris, France
Mol Endocrinol 23:11-24. 2009..This phenomenon might play a role in facilitating the constitution of quiescent preadipocyte pools and eventually in the maintenance and aggravation of increased fat mass in obesity... - Genetics of human obesityDavid M Mutch
INSERM, U755 Nutriomique, 75004 Paris, France
Best Pract Res Clin Endocrinol Metab 20:647-64. 2006..It is now necessary to integrate data of various origins (environment, genotype, expression) to clarify this field... - Relevance of increased serum cystatin C to vascular alterations in obese childrenB Dubern
Institute of Cardiometabolism and Nutrition, Paris, France INSERM, Paris, France
Pediatr Obes 7:374-81. 2012..Epidemiological studies report a positive relationship between serum cystatin C and cardiovascular outcomes in adults. Here, we tested the relevance of cystatin C as a biomarker for early vascular alterations in severely obese children... - [Genetic aspects of obesity]Beatrice Dubern
Service de gastro entérologie et de nutrition pédiatriques, Hopital Armand Trousseau, AP HP, Paris
Presse Med 36:1598-605. 2007..Most human obesity nonetheless results from the interaction of multiple genetic factors and the environment. Molecules acting on the melanocortin pathway are currently under development by the pharmaceutical industry... - [Human obesity: toward functional genomics]Karine Clement
INSERM, Nutriomique U755, 75004 Paris, France
J Soc Biol 200:17-28. 2006..e. environment, phenotype, genotype, gene expression) and thus improve our ability to deal with complexity. Examples of these approaches exist in humans and in animal models... - Serum amyloid A and obstructive sleep apnea syndrome before and after surgically-induced weight loss in morbidly obese subjectsChristine Poitou
INSERM, U755 Nutriomique, Paris, France
Obes Surg 16:1475-81. 2006..To explore the potential role of SAA in the relation between OSA and CVD, we investigated relationships between changes in SAA concentrations and nocturnal respiratory events in obese subjects undergoing bariatric surgery... - Genetics of human obesityKarine Clement
INSERM, U755 and IFR58, Universite Pierre et Marie Curie Paris 6, 75004 Paris, France
C R Biol 329:608-22; discussion 653-5. 2006..The effects are often uncertain and the results not always confirmed. It is now necessary to integrate data of various origins (environment, genotype, expression) to clarify the domain... - Role of serum amyloid a in adipocyte-macrophage cross talk and adipocyte cholesterol effluxChristine Poitou
Institut National de la Sante et de la Recherche Medicale, U872 team7, Nutriomique, Cordelier Research Center, Paris 75006, France
J Clin Endocrinol Metab 94:1810-7. 2009..Acute phase serum amyloid A (A-SAA) is secreted by hepatocytes in response to injury and is regulated by proinflammatory cytokines. In obese humans, adipocytes are also a major contributor to circulating A-SAA levels... - Mutation in the MC4R gene promoter: an elusive or effective role?Karine Clement
U755 Nutriomique, INSERM, Université Pierre and Marie Curie Paris 6, France
Horm Res 66:70-2. 2006 - Adipose angiotensinogen secretion, blood pressure, and AGT M235T polymorphism in obese patientsLydie Prat-Larquemin
Universite Paris VI, Hotel Dieu, Parvis Notre Dame, Paris, France
Obes Res 12:556-61. 2004..To investigate AGT secretion in cultured adipocytes from obese patients and its relationship with obesity-related phenotypes, blood pressure, and the M235T polymorphism in the AGT gene... - Benefits of massive weight loss on symptoms, systemic inflammation and cartilage turnover in obese patients with knee osteoarthritisPascal Richette
Universite Paris 7, UFR médicale, Assistance Publique Hopitaux de Paris, Hopital Lariboisiere, Federation de rhumatologie, Paris Cedex, France
Ann Rheum Dis 70:139-44. 2011..To investigate the effect of massive weight loss on (1) knee pain and disability, (2) low-grade inflammation and metabolic status and (3) joint biomarkers in obese patients with knee osteoarthritis (OA)... - Fibrosis in human adipose tissue: composition, distribution, and link with lipid metabolism and fat mass lossAdeline Divoux
INSERM, U872, Nutriomique, Paris, France
Diabetes 59:2817-25. 2010..We investigated the composition of subcutaneous (scWAT) and omental WAT (oWAT) fibrosis in obesity and its relationship with metabolic alterations and surgery-induced weight loss... - Additive effect of A-->G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesityK Clement
Department de Nutrition, Hotel Dieu, Paris, France
Int J Obes Relat Metab Disord 20:1062-6. 1996.... - Gene expression profiling of human skeletal muscle in response to stabilized weight lossDominique Larrouy
INSERM, U858, Obesity Research Laboratory, Institut de Medecine Moleculaire de Rangueil, Toulouse, France
Am J Clin Nutr 88:125-32. 2008..Whether this reduction remains after stabilized weight loss is still controversial, and the molecular mechanisms are unknown... - Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosisSoraya Taleb
Institut National de la Sante et de la Recherche Medicale, U689, 41 Bd de la Chapelle, Paris, France
Arterioscler Thromb Vasc Biol 27:2691-8. 2007..Obesity is a major risk factor for atherosclerosis and is associated with increased cardiovascular morbidity and mortality. However, the precise molecular pathways responsible for this close association remain poorly understood... - Homozygous null mutation of the melanocortin-4 receptor and severe early-onset obesityBeatrice Dubern
INSERM UMRS U872 Eq 7 Nutriomique, Paris, France
J Pediatr 150:613-7, 617.e1. 2007..To describe the clinical and biological phenotype of a child who is severely obese and is homozygous for a new melanocortin-4 receptor (MC4R) gene mutation leading to a truncated receptor... - The Eating Inventory and body adiposity from leanness to massive obesity: a study of 2509 adultsFrance Bellisle
INRA, Centre de Recherche en Nutrition Humane, Hotel Dieu Hospital, Paris, France
Obes Res 12:2023-30. 2004..Eating Inventory factors were also studied as a function of personal weight history... - Relationship between single nucleotide polymorphisms in leptin, IL6 and adiponectin genes and their circulating product in morbidly obese subjects before and after gastric banding surgeryChristine Poitou
INSERM Avenir EA 3502, Paris 6 University, Nutrition Department, AP HP, Hotel Dieu, Paris, France
Obes Surg 15:11-23. 2005..We hypothesized that polymorphism effects could be better detected in a situation of negative energy balance and that modified concentrations of adiposity signal genes could change the dynamics of weight gain in obese subjects... - Serum amyloid A: a marker of adiposity-induced low-grade inflammation but not of metabolic statusChristine Poitou
INSERM U755, Paris, France
Obesity (Silver Spring) 14:309-18. 2006..05). DISCUSSION: SAA can be considered as a marker of adiposity-induced low-grade inflammation but not of the metabolic status of obese subjects... - 1,2-vinyldithiin from garlic inhibits differentiation and inflammation of human preadipocytesMayoura Keophiphath
Inserm U872, Nutriomique team 7, Paris, France
J Nutr 139:2055-60. 2009..In conclusion, we demonstrated that 1,2-DT, a garlic-derived organosulfur, has antiadipogenic and antiinflammatory actions on human preadipocytes and may be a novel, antiobesity nutraceutical... - Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesityRaffaella Cancello
INSERM, U755 Nutriomique, Service de Nutrition, , 1 place du Parvis Notre-Dame, 75004 Paris, France
Diabetes 55:1554-61. 2006..These data suggest that the presence of macrophages in omental WAT participates in the cellular mechanisms favoring hepatic fibroinflammatory lesions in obese patients... - Architecture and the extracellular matrix: the still unappreciated components of the adipose tissueA Divoux
INSERM, U872, Nutriomique team 7, Paris, France
Obes Rev 12:e494-503. 2011..We conclude this review with possible hypotheses regarding the cellular and molecular contributors of fibrosis initiation... - Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults studyG Dolley
INSERM, U872, Nutriomique team 7, Cordelier Research Center, Paris, France
Int J Obes (Lond) 32:669-75. 2008..Some of these adiponectin polymorphisms have been associated with BMI in cross-sectional studies... - Metabolite profiling identifies candidate markers reflecting the clinical adaptations associated with Roux-en-Y gastric bypass surgeryDavid M Mutch
Nutriomique U872 Team 7, Institut National de la Sante et de la Recherche Medicale, Paris, France
PLoS ONE 4:e7905. 2009..To generate further insight into the numerous metabolic adaptations associated with RYGB surgery, we profiled serum metabolites before and after gastric bypass surgery and integrated metabolite changes with clinical data... - CCL5 promotes macrophage recruitment and survival in human adipose tissueMayoura Keophiphath
Inserm U872, Team 7, Nutriomique, 15, rue de l Ecole de Medecine, 75006, Paris, France
Arterioscler Thromb Vasc Biol 30:39-45. 2010..To examine the role of adipose-produced chemokine, chemokine ligand (CCL) 5, on the recruitment and survival of macrophages in human white adipose tissue (WAT)... - Adipose gene expression prior to weight loss can differentiate and weakly predict dietary respondersDavid M Mutch
INSERM, Nutriomique U872, Paris, France
PLoS ONE 2:e1344. 2007..Therefore, we asked whether it is possible to identify subjects who will lose weight during dietary intervention using only a single gene expression snapshot... - Weight loss regulates inflammation-related genes in white adipose tissue of obese subjectsKarine Clement
INSERM Avenir Paris 6 University, EA 3502, Nutrition Department, AP HP, Hotel Dieu, Paris, France
FASEB J 18:1657-69. 2004..The beneficial effect of weight loss on obesity-related complications may be associated with the modification of the inflammatory profile in adipose tissue... - Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight lossRaffaella Cancello
INSERM Avenir, Paris 6 University EA3502 and Human Research Center on Nutrition CRNH, Hotel Dieu Hospital, AP HP, Paris, France
Diabetes 54:2277-86. 2005..We show that improvement of the inflammatory profile after weight loss is related to a reduced number of macrophages in scWAT. MCP-1, PLAUR, CSF-3, and HIF-1alpha may play roles in the attraction of macrophages in scWAT... - Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitusP Froguel
Centre d Etude du Polymorphisme Humain, Paris, France
Nature 356:162-4. 1992..Because glucokinase is a key enzyme of blood glucose homeostasis, these results are evidence that a gene involved in glucose metabolism could be implicated in the pathogenesis of NIDDM... - Leptin and the genetics of obesityK Clement
Laboratoire de Nutrition, Hotel Dieu de Paris, Paris, France
Acta Paediatr Suppl 88:51-7. 1999..This review focuses on the recent molecular findings that have indicated a putative role for the leptin axis in human obesity... - Serum amyloid A: production by human white adipocyte and regulation by obesity and nutritionC Poitou
Department of Nutrition and Biochemistry, French Institute of Health and Medical Research Avenir, EA 3502, Paris VI University, Hotel Dieu Hospital, Paris, France
Diabetologia 48:519-28. 2005..In the present study a series of histopathological, cellular and gene expression studies was performed to assess the importance of SAA in common obesity and its possible production by mature adipocytes... - Adiponutrin: A new gene regulated by energy balance in human adipose tissueYong Ming Liu
Equipe d Accueil 3502 and Institut National de la Santé et de la Recherche Médicale INSERM Avenir and Department de Nutrition, Paris VI University, Paris, France
J Clin Endocrinol Metab 89:2684-9. 2004..These results indicate that adiponutrin gene expression in humans is highly regulated by changes in energy balance... - SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohortsDelphine Eberle
INSERM Unit 465, University Pierre et Marie Curie, Paris, France
Diabetes 53:2153-7. 2004..03) and increased prevalence of nephropathy (P = 0.028) in a diabetic cohort. Our results indicate a role of the SREBF-1 gene in genetic predisposition of metabolic diseases such as obesity, type 2 diabetes, and dyslipidemia... - Genetics of human obesityKarine Clement
INSERM Avenir, Paris, EA3502 and Paris 6 University, Nutrition Department, Hotel Dieu Hospital, France
Proc Nutr Soc 64:133-42. 2005..Finally, the tremendous progress in biocomputing will allow the integration of these different types of data (relating to environment, phenotype, genotype, gene expression) and will improve the ability to deal with this complex disease... - Adiponutrin gene is regulated by insulin and glucose in human adipose tissueMarthe Moldes
Department of Endocrinology, Cancer and Metabolism, Institut Cochin, Paris F-75014, France, INSERM, U567, Paris F-75014, France
Eur J Endocrinol 155:461-8. 2006..5-fold increased). CONCLUSION: These results suggest a strong relationship between adiponutrin expression, insulin sensitivity, and glucose metabolism in human adipose tissue... - Unraveling the genetics of human obesityDavid M Mutch
French National Institute of Health and Medical Research (INSERM) U755 Nutriomique, Paris, France
PLoS Genet 2:e188. 2006.... - Treatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled studyMorvarid Kabir
INSERM, Nutriomique, U872, Paris, France
Am J Clin Nutr 86:1670-9. 2007..Information is lacking on the potential effect of n-3 polyunsaturated fatty acids (PUFAs) on the adipose tissue of patients with type 2 diabetes... - Needle and surgical biopsy techniques differentially affect adipose tissue gene expression profilesDavid M Mutch
INSERM, Nutriomique U872 Team 7, Paris, France
Am J Clin Nutr 89:51-7. 2009.... - Emerging role of cathepsin S in obesity and its associated diseasesSoraya Taleb
INSERM, U755 Nutriomique, Hotel Dieu Hospital, Paris, France
Clin Chem Lab Med 45:328-32. 2007..We also position this protease as a potential therapeutic target to reduce associated cardiovascular risks in obese patients... - Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markersJean Pierre Furet
French National Institute for Agricultural Research, U910, Unité d Ecologie et de Physiologie du Système Digestif, Jouy en Josas, France
Diabetes 59:3049-57. 2010..We analyzed the impact of RYGB on the modifications of gut microbiota and examined links with adaptations associated with this procedure... - Genetics and the pathophysiology of obesityKarine Clement
INSERM Avenir, EA 3502 Paris 6 University and Service de Nutrition, AP HP, Hotel Dieu, Paris, France
Pediatr Res 53:721-5. 2003..When specific pharmacological treatments based on recent discoveries become available, however, genetic testing could help discriminate between the subtypes of obesity that may respond differentially to treatment... - Potential contribution of adipose tissue to elevated serum cystatin C in human obesityNadia Naour
INSERM, U872, Paris, France
Obesity (Silver Spring) 17:2121-6. 2009.... - In obese and non-obese adults, the cis-regulatory rs361072 promoter variant of PIK3CB is associated with insulin resistance not with type 2 diabetesKarine Clement
Endocrinology and Nutrition Department, Pitie Salpetriere Hospital, Paris, France
Mol Genet Metab 96:129-32. 2009..Allele C of rs361072 is associated with a protection from IR in obese and non-obese adults, but has no significant effect, however, on diabetes risk in obese or non-obese Europeans...