K Clement

Summary

Country: France

Publications

  1. doi request reprint Cathepsins in human obesity: changes in energy balance predominantly affect cathepsin s in adipose tissue and in circulation
    Nadia Naour
    Institut National de la Santé et de la Recherche Méédicale, Unite 872, Universite Pierre et Marie Curie PARIS6, Paris, France
    J Clin Endocrinol Metab 95:1861-8. 2010
  2. pmc Genome wide association study identifies KCNMA1 contributing to human obesity
    Hong Jiao
    Department of Biosciences and Nutrition, Karolinska Institutet, SE 141 83 Huddinge, Sweden
    BMC Med Genomics 4:51. 2011
  3. doi request reprint [Inflammation, adipokines and obesity]
    K Clement
    Service de Nutrition, pôle d endocrinologie, Hopital de la Pitie Salpetriere, Assistance Publique Hopitaux de Paris, U872 équipe 7, INSERM, Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie Paris 6, 75006 Paris, France
    Rev Med Interne 30:824-32. 2009
  4. pmc Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC gene
    Karine Clement
    Center of Research on Human Nutrition Ile de France, Paris, 75013, France
    J Clin Endocrinol Metab 93:4955-62. 2008
  5. doi request reprint Bariatric surgery, adipose tissue and gut microbiota
    K Clement
    Cardiometabolism Division, Assistance Publique Hopitaux de Paris, Pitie Salpetriere Hospital, Paris, France
    Int J Obes (Lond) 35:S7-15. 2011
  6. doi request reprint Cathepsin S genotypes are associated with Apo-A1 and HDL-cholesterol in lean and obese French populations
    N Spielmann
    INSERM, Nutriomique U872, Paris, France Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie Paris 6, UMR S 872, Paris, France
    Clin Genet 74:155-63. 2008
  7. ncbi request reprint Soluble leptin receptor in serum of subjects with complete resistance to leptin: relation to fat mass
    N Lahlou
    Unit 342, Institut National de la Sante et de la Recherche Medicale, and the Department of Biochemistry, Hopital Saint Vincent de Paul, Paris, France
    Diabetes 49:1347-52. 2000
  8. ncbi request reprint Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese children
    B Dubern
    Medicine and Nutrition Department, Hôtel Dieu Teaching Hospital, Paris, France
    J Pediatr 139:204-9. 2001
  9. ncbi request reprint The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes
    K Clement
    Laboratoire de Nutrition et Service de Médecine et Nutrition, Hôtel Dieu place du Parvis Notre Dame, Paris, France
    Int J Obes Relat Metab Disord 24:391-3. 2000
  10. ncbi request reprint Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue
    R Cancello
    Institut National de la Santé et de la Recherche Médicale INSERM U755 Nutriomique, Paris, France
    BJOG 113:1141-7. 2006

Collaborators

Detail Information

Publications59

  1. doi request reprint Cathepsins in human obesity: changes in energy balance predominantly affect cathepsin s in adipose tissue and in circulation
    Nadia Naour
    Institut National de la Santé et de la Recherche Méédicale, Unite 872, Universite Pierre et Marie Curie PARIS6, Paris, France
    J Clin Endocrinol Metab 95:1861-8. 2010
    ..Recent studies in humans and mice suggest the implication of the cysteine proteases cathepsins S, L, and K in vascular and metabolic complications of obesity...
  2. pmc Genome wide association study identifies KCNMA1 contributing to human obesity
    Hong Jiao
    Department of Biosciences and Nutrition, Karolinska Institutet, SE 141 83 Huddinge, Sweden
    BMC Med Genomics 4:51. 2011
    ..Thus many genetic variants controlling obesity remain to be identified. The aim of this study was to use GWA followed by multiple stepwise validations to identify additional genes associated with obesity...
  3. doi request reprint [Inflammation, adipokines and obesity]
    K Clement
    Service de Nutrition, pôle d endocrinologie, Hopital de la Pitie Salpetriere, Assistance Publique Hopitaux de Paris, U872 équipe 7, INSERM, Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie Paris 6, 75006 Paris, France
    Rev Med Interne 30:824-32. 2009
    ..A small or even moderate reduction of weight significantly reduces circulating inflammatory markers, modulates adipose tissue profile of inflammatory genes and the risks associated with obesity...
  4. pmc Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC gene
    Karine Clement
    Center of Research on Human Nutrition Ile de France, Paris, 75013, France
    J Clin Endocrinol Metab 93:4955-62. 2008
    ..Mutations that inactivate the POMC gene have been described in children, causing a pleiotropic syndrome that includes secondary hypocortisolism, severe obesity, and variable changes in skin and hair pigmentation...
  5. doi request reprint Bariatric surgery, adipose tissue and gut microbiota
    K Clement
    Cardiometabolism Division, Assistance Publique Hopitaux de Paris, Pitie Salpetriere Hospital, Paris, France
    Int J Obes (Lond) 35:S7-15. 2011
    ..Roux-en-Y gastric bypass surgery is an increasingly effective model to study in this context because it leads to major improvements in glucose and lipid homeostasis and to the amelioration of some systemic inflammatory markers...
  6. doi request reprint Cathepsin S genotypes are associated with Apo-A1 and HDL-cholesterol in lean and obese French populations
    N Spielmann
    INSERM, Nutriomique U872, Paris, France Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie Paris 6, UMR S 872, Paris, France
    Clin Genet 74:155-63. 2008
    ..03). These results provide the first evidence that CTSS sequence variations are associated with two human metabolic risk factors for cardiovascular diseases: plasma Apo-A1 and HDL-C concentrations...
  7. ncbi request reprint Soluble leptin receptor in serum of subjects with complete resistance to leptin: relation to fat mass
    N Lahlou
    Unit 342, Institut National de la Sante et de la Recherche Medicale, and the Department of Biochemistry, Hopital Saint Vincent de Paul, Paris, France
    Diabetes 49:1347-52. 2000
    ..This finding suggests that the leptin receptor itself may not be specifically involved in the control of leptin secretion, and it supports the concept of relative resistance to leptin in common obesity...
  8. ncbi request reprint Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese children
    B Dubern
    Medicine and Nutrition Department, Hôtel Dieu Teaching Hospital, Paris, France
    J Pediatr 139:204-9. 2001
    ..To search for mutations in melanocortin pathway elements, that is, the melanocortin-4 receptor (MC4R ), agouti-related protein (AGRP ), and (alpha-melanocyte-stimulating hormone (alpha MSH ) genes in children with severe obesity...
  9. ncbi request reprint The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes
    K Clement
    Laboratoire de Nutrition et Service de Médecine et Nutrition, Hôtel Dieu place du Parvis Notre Dame, Paris, France
    Int J Obes Relat Metab Disord 24:391-3. 2000
    ....
  10. ncbi request reprint Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue
    R Cancello
    Institut National de la Santé et de la Recherche Médicale INSERM U755 Nutriomique, Paris, France
    BJOG 113:1141-7. 2006
    ..The interactions of macrophages with adipocytes will certainly be the subject of intense investigations in the future...
  11. ncbi request reprint Regulation of inflammation-related genes in human adipose tissue
    K Clement
    INSERM, U872 Nutriomique, Paris, France
    J Intern Med 262:422-30. 2007
    ..e. cathepsins and serum amyloid A) is discussed in the context of weight loss programmes based on calorie restriction and physical exercise. The foreseen clinical and technological challenges are also summarized...
  12. ncbi request reprint Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects
    S Kipfer-Coudreau
    INSERM Avenir and EA 3502, Nutrition Department, Paris VI University, Paris, France
    Diabetologia 47:1278-84. 2004
    ..We investigated whether PTP 1B SNPs are associated with obesity and obesity-related traits as well as global metabolic syndrome in morbidly obese subjects...
  13. doi request reprint Using gene expression to predict the secretome of differentiating human preadipocytes
    D M Mutch
    INSERM, UMRS U872 Eq 7 Nutriomique, Centre de Recherche des Cordeliers, Paris, France
    Int J Obes (Lond) 33:354-63. 2009
    ..To characterize the secretome of differentiating human preadipocytes using global gene expression profiling...
  14. ncbi request reprint A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
    K Clement
    Laboratoire de Nutrition et Service de Médecine et Nutrition, Hôtel Dieu place du Parvis Notre Dame, Paris, France
    Nature 392:398-401. 1998
    ..These results indicate that leptin is an important physiological regulator of several endocrine functions in humans...
  15. ncbi request reprint Genetics of human obesity
    David M Mutch
    INSERM, U755 Nutriomique, 75004 Paris, France
    Best Pract Res Clin Endocrinol Metab 20:647-64. 2006
    ..It is now necessary to integrate data of various origins (environment, genotype, expression) to clarify this field...
  16. doi request reprint Macrophage-secreted factors promote a profibrotic phenotype in human preadipocytes
    Mayoura Keophiphath
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 872, Centre de Recherche des Cordeliers, 15 rue de l Ecole de Medecine, 75005 Paris, France
    Mol Endocrinol 23:11-24. 2009
    ..This phenomenon might play a role in facilitating the constitution of quiescent preadipocyte pools and eventually in the maintenance and aggravation of increased fat mass in obesity...
  17. doi request reprint Relevance of increased serum cystatin C to vascular alterations in obese children
    B Dubern
    Institute of Cardiometabolism and Nutrition, Paris, France INSERM, Paris, France
    Pediatr Obes 7:374-81. 2012
    ..Epidemiological studies report a positive relationship between serum cystatin C and cardiovascular outcomes in adults. Here, we tested the relevance of cystatin C as a biomarker for early vascular alterations in severely obese children...
  18. ncbi request reprint [Genetic aspects of obesity]
    Beatrice Dubern
    Service de gastro entérologie et de nutrition pédiatriques, Hopital Armand Trousseau, AP HP, Paris
    Presse Med 36:1598-605. 2007
    ..Most human obesity nonetheless results from the interaction of multiple genetic factors and the environment. Molecules acting on the melanocortin pathway are currently under development by the pharmaceutical industry...
  19. ncbi request reprint [Human obesity: toward functional genomics]
    Karine Clement
    INSERM, Nutriomique U755, 75004 Paris, France
    J Soc Biol 200:17-28. 2006
    ..e. environment, phenotype, genotype, gene expression) and thus improve our ability to deal with complexity. Examples of these approaches exist in humans and in animal models...
  20. ncbi request reprint Serum amyloid A and obstructive sleep apnea syndrome before and after surgically-induced weight loss in morbidly obese subjects
    Christine Poitou
    INSERM, U755 Nutriomique, Paris, France
    Obes Surg 16:1475-81. 2006
    ..To explore the potential role of SAA in the relation between OSA and CVD, we investigated relationships between changes in SAA concentrations and nocturnal respiratory events in obese subjects undergoing bariatric surgery...
  21. pmc Fibrosis in human adipose tissue: composition, distribution, and link with lipid metabolism and fat mass loss
    Adeline Divoux
    INSERM, U872, Nutriomique, Paris, France
    Diabetes 59:2817-25. 2010
    ..We investigated the composition of subcutaneous (scWAT) and omental WAT (oWAT) fibrosis in obesity and its relationship with metabolic alterations and surgery-induced weight loss...
  22. ncbi request reprint Genetics of human obesity
    Karine Clement
    INSERM, U755 and IFR58, Universite Pierre et Marie Curie Paris 6, 75004 Paris, France
    C R Biol 329:608-22; discussion 653-5. 2006
    ..The effects are often uncertain and the results not always confirmed. It is now necessary to integrate data of various origins (environment, genotype, expression) to clarify the domain...
  23. ncbi request reprint Adipose angiotensinogen secretion, blood pressure, and AGT M235T polymorphism in obese patients
    Lydie Prat-Larquemin
    Universite Paris VI, Hotel Dieu, Parvis Notre Dame, Paris, France
    Obes Res 12:556-61. 2004
    ..To investigate AGT secretion in cultured adipocytes from obese patients and its relationship with obesity-related phenotypes, blood pressure, and the M235T polymorphism in the AGT gene...
  24. ncbi request reprint Mutation in the MC4R gene promoter: an elusive or effective role?
    Karine Clement
    U755 Nutriomique, INSERM, Université Pierre and Marie Curie Paris 6, France
    Horm Res 66:70-2. 2006
  25. doi request reprint Benefits of massive weight loss on symptoms, systemic inflammation and cartilage turnover in obese patients with knee osteoarthritis
    Pascal Richette
    Universite Paris 7, UFR médicale, Assistance Publique Hopitaux de Paris, Hopital Lariboisiere, Federation de rhumatologie, Paris Cedex, France
    Ann Rheum Dis 70:139-44. 2011
    ..To investigate the effect of massive weight loss on (1) knee pain and disability, (2) low-grade inflammation and metabolic status and (3) joint biomarkers in obese patients with knee osteoarthritis (OA)...
  26. doi request reprint Role of serum amyloid a in adipocyte-macrophage cross talk and adipocyte cholesterol efflux
    Christine Poitou
    Institut National de la Sante et de la Recherche Medicale, U872 team7, Nutriomique, Cordelier Research Center, Paris 75006, France
    J Clin Endocrinol Metab 94:1810-7. 2009
    ..Acute phase serum amyloid A (A-SAA) is secreted by hepatocytes in response to injury and is regulated by proinflammatory cytokines. In obese humans, adipocytes are also a major contributor to circulating A-SAA levels...
  27. ncbi request reprint Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study
    G Dolley
    INSERM, U872, Nutriomique team 7, Cordelier Research Center, Paris, France
    Int J Obes (Lond) 32:669-75. 2008
    ..Some of these adiponectin polymorphisms have been associated with BMI in cross-sectional studies...
  28. ncbi request reprint Additive effect of A-->G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity
    K Clement
    Department de Nutrition, Hotel Dieu, Paris, France
    Int J Obes Relat Metab Disord 20:1062-6. 1996
    ....
  29. ncbi request reprint The Eating Inventory and body adiposity from leanness to massive obesity: a study of 2509 adults
    France Bellisle
    INRA, Centre de Recherche en Nutrition Humane, Hotel Dieu Hospital, Paris, France
    Obes Res 12:2023-30. 2004
    ..Eating Inventory factors were also studied as a function of personal weight history...
  30. ncbi request reprint Gene expression profiling of human skeletal muscle in response to stabilized weight loss
    Dominique Larrouy
    INSERM, U858, Obesity Research Laboratory, Institut de Medecine Moleculaire de Rangueil, Toulouse, France
    Am J Clin Nutr 88:125-32. 2008
    ..Whether this reduction remains after stabilized weight loss is still controversial, and the molecular mechanisms are unknown...
  31. ncbi request reprint Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis
    Soraya Taleb
    Institut National de la Sante et de la Recherche Medicale, U689, 41 Bd de la Chapelle, Paris, France
    Arterioscler Thromb Vasc Biol 27:2691-8. 2007
    ..Obesity is a major risk factor for atherosclerosis and is associated with increased cardiovascular morbidity and mortality. However, the precise molecular pathways responsible for this close association remain poorly understood...
  32. ncbi request reprint Homozygous null mutation of the melanocortin-4 receptor and severe early-onset obesity
    Beatrice Dubern
    INSERM UMRS U872 Eq 7 Nutriomique, Paris, France
    J Pediatr 150:613-7, 617.e1. 2007
    ..To describe the clinical and biological phenotype of a child who is severely obese and is homozygous for a new melanocortin-4 receptor (MC4R) gene mutation leading to a truncated receptor...
  33. ncbi request reprint Relationship between single nucleotide polymorphisms in leptin, IL6 and adiponectin genes and their circulating product in morbidly obese subjects before and after gastric banding surgery
    Christine Poitou
    INSERM Avenir EA 3502, Paris 6 University, Nutrition Department, AP HP, Hotel Dieu, Paris, France
    Obes Surg 15:11-23. 2005
    ..We hypothesized that polymorphism effects could be better detected in a situation of negative energy balance and that modified concentrations of adiposity signal genes could change the dynamics of weight gain in obese subjects...
  34. ncbi request reprint Serum amyloid A: a marker of adiposity-induced low-grade inflammation but not of metabolic status
    Christine Poitou
    INSERM U755, Paris, France
    Obesity (Silver Spring) 14:309-18. 2006
    ..We studied the variations of expression of the SAA gene in adipose and liver tissues and of SAA serum levels, as well as their relationships with metabolic features during weight loss...
  35. ncbi request reprint Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity
    Raffaella Cancello
    INSERM, U755 Nutriomique, Service de Nutrition, Hotel Dieu, 1 Place du Parvis Notre Dame, 75004 Paris, France
    Diabetes 55:1554-61. 2006
    ..These data suggest that the presence of macrophages in omental WAT participates in the cellular mechanisms favoring hepatic fibroinflammatory lesions in obese patients...
  36. doi request reprint 1,2-vinyldithiin from garlic inhibits differentiation and inflammation of human preadipocytes
    Mayoura Keophiphath
    Inserm U872, Nutriomique team 7, Paris, France
    J Nutr 139:2055-60. 2009
    ..In conclusion, we demonstrated that 1,2-DT, a garlic-derived organosulfur, has antiadipogenic and antiinflammatory actions on human preadipocytes and may be a novel, antiobesity nutraceutical...
  37. doi request reprint Comparison of body composition, basal metabolic rate and metabolic outcomes of adults with Prader Willi syndrome or lesional hypothalamic disease, with primary obesity
    C Lloret-Linares
    1 Assistance Publique Hôpitaux de Paris, Hopital Lariboisiere, Unit of Therapeutic Research, Department of Internal Medicine, Paris, France 2 INSERM U705, CNRS UMR 8206, Neuropsychopharmacology of Drug Addiction, Faculty of Pharmacy, University Paris Descartes, Paris, France
    Int J Obes (Lond) 37:1198-203. 2013
    ..The mechanisms of adipose tissue development and metabolic complications may be different between genetic and lesional obesities. ..
  38. doi request reprint Gut microbiota and non-alcoholic fatty liver disease: new insights
    J Aron-Wisnewsky
    Institute of Cardio metabolism and Nutrition APHP, Pitié Salpétrière Hospital and Centre de Recherche en Nutrition Humaine Ile de France, Universite Pierre et Marie Curie, Paris, France
    Clin Microbiol Infect 19:338-48. 2013
    ..All of these factors are molecular mechanisms by which the microbiota can induce NAFLD or its progression toward overt non-alcoholic steatohepatitis...
  39. doi request reprint Architecture and the extracellular matrix: the still unappreciated components of the adipose tissue
    A Divoux
    INSERM, U872, Nutriomique team 7, Paris, France
    Obes Rev 12:e494-503. 2011
    ..We conclude this review with possible hypotheses regarding the cellular and molecular contributors of fibrosis initiation...
  40. pmc Adipose gene expression prior to weight loss can differentiate and weakly predict dietary responders
    David M Mutch
    INSERM, Nutriomique U872, Paris, France
    PLoS ONE 2:e1344. 2007
    ..Therefore, we asked whether it is possible to identify subjects who will lose weight during dietary intervention using only a single gene expression snapshot...
  41. ncbi request reprint Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss
    Raffaella Cancello
    INSERM Avenir, Paris 6 University EA3502 and Human Research Center on Nutrition CRNH, Hotel Dieu Hospital, AP HP, Paris, France
    Diabetes 54:2277-86. 2005
    ..We show that improvement of the inflammatory profile after weight loss is related to a reduced number of macrophages in scWAT. MCP-1, PLAUR, CSF-3, and HIF-1alpha may play roles in the attraction of macrophages in scWAT...
  42. ncbi request reprint Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects
    Karine Clement
    INSERM Avenir Paris 6 University, EA 3502, Nutrition Department, AP HP, Hotel Dieu, Paris, France
    FASEB J 18:1657-69. 2004
    ..The beneficial effect of weight loss on obesity-related complications may be associated with the modification of the inflammatory profile in adipose tissue...
  43. doi request reprint CCL5 promotes macrophage recruitment and survival in human adipose tissue
    Mayoura Keophiphath
    Inserm U872, Team 7, Nutriomique, 15, rue de l Ecole de Medecine, 75006, Paris, France
    Arterioscler Thromb Vasc Biol 30:39-45. 2010
    ..To examine the role of adipose-produced chemokine, chemokine ligand (CCL) 5, on the recruitment and survival of macrophages in human white adipose tissue (WAT)...
  44. pmc Metabolite profiling identifies candidate markers reflecting the clinical adaptations associated with Roux-en-Y gastric bypass surgery
    David M Mutch
    Nutriomique U872 Team 7, Institut National de la Sante et de la Recherche Medicale, Paris, France
    PLoS ONE 4:e7905. 2009
    ..To generate further insight into the numerous metabolic adaptations associated with RYGB surgery, we profiled serum metabolites before and after gastric bypass surgery and integrated metabolite changes with clinical data...
  45. ncbi request reprint Leptin and the genetics of obesity
    K Clement
    Laboratoire de Nutrition, Hotel Dieu de Paris, Paris, France
    Acta Paediatr Suppl 88:51-7. 1999
    ..This review focuses on the recent molecular findings that have indicated a putative role for the leptin axis in human obesity...
  46. ncbi request reprint Serum amyloid A: production by human white adipocyte and regulation by obesity and nutrition
    C Poitou
    Department of Nutrition and Biochemistry, French Institute of Health and Medical Research Avenir, EA 3502, Paris VI University, Hotel Dieu Hospital, Paris, France
    Diabetologia 48:519-28. 2005
    ..In the present study a series of histopathological, cellular and gene expression studies was performed to assess the importance of SAA in common obesity and its possible production by mature adipocytes...
  47. ncbi request reprint Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus
    P Froguel
    Centre d Etude du Polymorphisme Humain, Paris, France
    Nature 356:162-4. 1992
    ..Because glucokinase is a key enzyme of blood glucose homeostasis, these results are evidence that a gene involved in glucose metabolism could be implicated in the pathogenesis of NIDDM...
  48. ncbi request reprint Adiponutrin: A new gene regulated by energy balance in human adipose tissue
    Yong Ming Liu
    Equipe d Accueil 3502 and Institut National de la Santé et de la Recherche Médicale INSERM Avenir and Department de Nutrition, Paris VI University, Paris, France
    J Clin Endocrinol Metab 89:2684-9. 2004
    ..These results indicate that adiponutrin gene expression in humans is highly regulated by changes in energy balance...
  49. ncbi request reprint SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts
    Delphine Eberle
    INSERM Unit 465, University Pierre et Marie Curie, Paris, France
    Diabetes 53:2153-7. 2004
    ..03) and increased prevalence of nephropathy (P = 0.028) in a diabetic cohort. Our results indicate a role of the SREBF-1 gene in genetic predisposition of metabolic diseases such as obesity, type 2 diabetes, and dyslipidemia...
  50. ncbi request reprint Genetics of human obesity
    Karine Clement
    INSERM Avenir, Paris, EA3502 and Paris 6 University, Nutrition Department, Hotel Dieu Hospital, France
    Proc Nutr Soc 64:133-42. 2005
    ..Finally, the tremendous progress in biocomputing will allow the integration of these different types of data (relating to environment, phenotype, genotype, gene expression) and will improve the ability to deal with this complex disease...
  51. ncbi request reprint Adiponutrin gene is regulated by insulin and glucose in human adipose tissue
    Marthe Moldes
    Department of Endocrinology, Cancer and Metabolism, Institut Cochin, Paris F 75014, France, INSERM, U567, Paris F 75014, France
    Eur J Endocrinol 155:461-8. 2006
    ....
  52. pmc Unraveling the genetics of human obesity
    David M Mutch
    French National Institute of Health and Medical Research INSERM U755 Nutriomique, Paris, France
    PLoS Genet 2:e188. 2006
    ....
  53. ncbi request reprint Emerging role of cathepsin S in obesity and its associated diseases
    Soraya Taleb
    INSERM, U755 Nutriomique, Hotel Dieu Hospital, Paris, France
    Clin Chem Lab Med 45:328-32. 2007
    ..We also position this protease as a potential therapeutic target to reduce associated cardiovascular risks in obese patients...
  54. ncbi request reprint Treatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled study
    Morvarid Kabir
    INSERM, Nutriomique, U872, Paris, France
    Am J Clin Nutr 86:1670-9. 2007
    ..Information is lacking on the potential effect of n-3 polyunsaturated fatty acids (PUFAs) on the adipose tissue of patients with type 2 diabetes...
  55. doi request reprint Needle and surgical biopsy techniques differentially affect adipose tissue gene expression profiles
    David M Mutch
    INSERM, Nutriomique U872 Team 7, Paris, France
    Am J Clin Nutr 89:51-7. 2009
    ....
  56. pmc Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers
    Jean Pierre Furet
    French National Institute for Agricultural Research, U910, Unité d Ecologie et de Physiologie du Système Digestif, Jouy en Josas, France
    Diabetes 59:3049-57. 2010
    ..We analyzed the impact of RYGB on the modifications of gut microbiota and examined links with adaptations associated with this procedure...
  57. ncbi request reprint Genetics and the pathophysiology of obesity
    Karine Clement
    INSERM Avenir, EA 3502 Paris 6 University and Service de Nutrition, AP HP, Hotel Dieu, Paris, France
    Pediatr Res 53:721-5. 2003
    ..When specific pharmacological treatments based on recent discoveries become available, however, genetic testing could help discriminate between the subtypes of obesity that may respond differentially to treatment...
  58. doi request reprint In obese and non-obese adults, the cis-regulatory rs361072 promoter variant of PIK3CB is associated with insulin resistance not with type 2 diabetes
    Karine Clement
    Endocrinology and Nutrition Department, Pitie Salpetriere Hospital, Paris, France
    Mol Genet Metab 96:129-32. 2009
    ..Allele C of rs361072 is associated with a protection from IR in obese and non-obese adults, but has no significant effect, however, on diabetes risk in obese or non-obese Europeans...
  59. doi request reprint Potential contribution of adipose tissue to elevated serum cystatin C in human obesity
    Nadia Naour
    INSERM, U872, Paris, France
    Obesity (Silver Spring) 17:2121-6. 2009
    ....