Jean Pierre Claverys

Summary

Country: France

Publications

  1. ncbi request reprint Induction of competence regulons as a general response to stress in gram-positive bacteria
    Jean Pierre Claverys
    Laboratoire de Microbiologie et Genetique Moleculaires, UMR 5100 CNRS Université Paul Sabatier, 31062 Toulouse Cedex 9, France
    Annu Rev Microbiol 60:451-75. 2006
  2. ncbi request reprint Cannibalism and fratricide: mechanisms and raisons d'être
    Jean Pierre Claverys
    Laboratoire de Microbiologie et Genetique Moleculaires, UMR 5100 CNRS Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 9, France
    Nat Rev Microbiol 5:219-29. 2007
  3. ncbi request reprint Adaptation to the environment: Streptococcus pneumoniae, a paradigm for recombination-mediated genetic plasticity?
    J P Claverys
    Laboratoire de Microbiologie et Génétique Moléculaire CNRS UPR 9007, Universite Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex, France
    Mol Microbiol 35:251-9. 2000
  4. ncbi request reprint Competence-induced fratricide in streptococci
    Jean Pierre Claverys
    Laboratoire de Microbiologie et Genetique Moleculaires, UMR5100 CNRS Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 09, France
    Mol Microbiol 64:1423-33. 2007
  5. ncbi request reprint Bacterial "competence" genes: signatures of active transformation, or only remnants?
    Jean Pierre Claverys
    Laboratoire de Microbiologie et Genetique Moleculaires, UMR 5100 CNRS Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex, France
    Trends Microbiol 11:161-5. 2003
  6. ncbi request reprint A new family of high-affinity ABC manganese and zinc permeases
    J P Claverys
    Laboratoire de Microbiologie et Génétique Moléculaire UMR5 100, CNRS Université Paul Sabatier, Toulouse, France
    Res Microbiol 152:231-43. 2001
  7. ncbi request reprint Is the Ami-AliA/B oligopeptide permease of Streptococcus pneumoniae involved in sensing environmental conditions?
    J P Claverys
    Laboratoire de Microbiologie et Genetique Moleculaire, UMR5100, CNRS Université Paul Sabatier, Toulouse, France
    Res Microbiol 151:457-63. 2000
  8. doi request reprint The genetic transformation machinery: composition, localization, and mechanism
    Jean Pierre Claverys
    Centre National de la Recherche Scientifique, LMGM UMR, Toulouse, France
    FEMS Microbiol Rev 33:643-56. 2009
  9. ncbi request reprint Interconnection of competence, stress and CiaR regulons in Streptococcus pneumoniae: competence triggers stationary phase autolysis of ciaR mutant cells
    Adilia Dagkessamanskaia
    Laboratoire de Microbiologie et Genetique Moleculaires, UMR 5100 CNRS Université Paul Sabatier, Toulouse Cedex, France
    Mol Microbiol 51:1071-86. 2004
  10. pmc Homologous recombination at the border: insertion-deletions and the trapping of foreign DNA in Streptococcus pneumoniae
    Marc Prudhomme
    Laboratoire de Microbiologie et Genetique Moleculaire, Unité Mixte de Recherche 5100, Centre National de la Recherche Scientifique Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex, France
    Proc Natl Acad Sci U S A 99:2100-5. 2002

Collaborators

  • Leiv Sigve Havarstein
  • M Prudhomme
  • Dongchang Sun
  • Peter W M Hermans
  • Ola Johnsborg
  • T J Mitchell
  • Francesco Iannelli
  • G Pozzi
  • D E Bessen
  • Gianluca De Bellis
  • Donald A Morrison
  • Susanna Ricci
  • Bernard Martin
  • Chantal Granadel
  • Patrice Polard
  • Isabelle Mortier-Barrière
  • Sebastien Guiral
  • Nicolas Mirouze
  • Anne Lise Soulet
  • Philippe Noirot
  • Laetitia Attaiech
  • Mathieu Berge
  • Marie Francoise Noirot-Gros
  • Vincent Hénard
  • Nathalie Campo
  • Gwennaele Fichant
  • Yves Quentin
  • Miriam Moscoso
  • Calum Johnston
  • Matthieu J Bergé
  • Sophie Quevillon-Cheruel
  • Stéphanie Caymaris
  • Robert A Burne
  • Eivind Knutsen
  • Marco R Oggioni
  • David Halpern
  • Adilia Dagkessamanskaia
  • Mathieu A Bergé
  • Alain Kamgoue
  • Mark A Brooks
  • Herman van Tilbeurgh
  • Dominique Durand
  • Marion Boudes
  • Johnny Lisboa
  • Audrey Olivier
  • Hester J Bootsma
  • Eric Le Cam
  • Marion Velten
  • Pauline Dupaigne
  • Jeffery R Broadbent
  • Olivier Piétrement
  • Stephen McGovern
  • Maria Halima Laaberki
  • Mark Reuter
  • Damiana Chiavolini
  • Claudia Trappetti
  • Alexandra Gruss
  • Karin Overweg
  • Jerry Wells
  • Riccardo Parigi
  • Meriem El-Karoui
  • Hanno Langen

Detail Information

Publications37

  1. ncbi request reprint Induction of competence regulons as a general response to stress in gram-positive bacteria
    Jean Pierre Claverys
    Laboratoire de Microbiologie et Genetique Moleculaires, UMR 5100 CNRS Université Paul Sabatier, 31062 Toulouse Cedex 9, France
    Annu Rev Microbiol 60:451-75. 2006
    ..Whereas B. subtilis combines competence and SOS induction, S. pneumoniae relies only on competence to generate genetic diversity through transformation...
  2. ncbi request reprint Cannibalism and fratricide: mechanisms and raisons d'être
    Jean Pierre Claverys
    Laboratoire de Microbiologie et Genetique Moleculaires, UMR 5100 CNRS Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 9, France
    Nat Rev Microbiol 5:219-29. 2007
    ..pneumoniae during natural genetic transformation. Here, we compare and contrast these two phenomena and discuss whether these processes are fundamentally different from the more traditional 'chemical warfare' among bacteria...
  3. ncbi request reprint Adaptation to the environment: Streptococcus pneumoniae, a paradigm for recombination-mediated genetic plasticity?
    J P Claverys
    Laboratoire de Microbiologie et Génétique Moléculaire CNRS UPR 9007, Universite Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex, France
    Mol Microbiol 35:251-9. 2000
    ..Possible links between transformation and changes in environmental conditions are discussed, and the adaptive 'strategy' deduced for S. pneumoniae is compared with that of Escherichia coli...
  4. ncbi request reprint Competence-induced fratricide in streptococci
    Jean Pierre Claverys
    Laboratoire de Microbiologie et Genetique Moleculaires, UMR5100 CNRS Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 09, France
    Mol Microbiol 64:1423-33. 2007
    ....
  5. ncbi request reprint Bacterial "competence" genes: signatures of active transformation, or only remnants?
    Jean Pierre Claverys
    Laboratoire de Microbiologie et Genetique Moleculaires, UMR 5100 CNRS Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex, France
    Trends Microbiol 11:161-5. 2003
    ....
  6. ncbi request reprint A new family of high-affinity ABC manganese and zinc permeases
    J P Claverys
    Laboratoire de Microbiologie et Génétique Moléculaire UMR5 100, CNRS Université Paul Sabatier, Toulouse, France
    Res Microbiol 152:231-43. 2001
    ..The question of a direct role of MBRs as adhesins of Gram-positive bacteria is then discussed and the importance of metal permeases for cellular processes and host-bacteria interactions is reviewed...
  7. ncbi request reprint Is the Ami-AliA/B oligopeptide permease of Streptococcus pneumoniae involved in sensing environmental conditions?
    J P Claverys
    Laboratoire de Microbiologie et Genetique Moleculaire, UMR5100, CNRS Université Paul Sabatier, Toulouse, France
    Res Microbiol 151:457-63. 2000
    ..The hypothesis that peptide transport plays a pivotal role in sensing environmental conditions and indirectly modulates the expression of several genes is discussed...
  8. doi request reprint The genetic transformation machinery: composition, localization, and mechanism
    Jean Pierre Claverys
    Centre National de la Recherche Scientifique, LMGM UMR, Toulouse, France
    FEMS Microbiol Rev 33:643-56. 2009
    ..This review attempts to summarize these recent observations with special emphasis on the early stages in DNA processing...
  9. ncbi request reprint Interconnection of competence, stress and CiaR regulons in Streptococcus pneumoniae: competence triggers stationary phase autolysis of ciaR mutant cells
    Adilia Dagkessamanskaia
    Laboratoire de Microbiologie et Genetique Moleculaires, UMR 5100 CNRS Université Paul Sabatier, Toulouse Cedex, France
    Mol Microbiol 51:1071-86. 2004
    ..Taken together, these data strongly suggest that differentiation to competence imposes a temporary stress on cells, and that the CiaRH TCS is required for the cells to exit normally from the competent state...
  10. pmc Homologous recombination at the border: insertion-deletions and the trapping of foreign DNA in Streptococcus pneumoniae
    Marc Prudhomme
    Laboratoire de Microbiologie et Genetique Moleculaire, Unité Mixte de Recherche 5100, Centre National de la Recherche Scientifique Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex, France
    Proc Natl Acad Sci U S A 99:2100-5. 2002
    ..The potential of homology- directed illegitimate recombination for genome evolution was illustrated by the trapping of functional heterologous genes...
  11. pmc Direct involvement of DprA, the transformation-dedicated RecA loader, in the shut-off of pneumococcal competence
    Nicolas Mirouze
    Laboratoire de Microbiologie et Génétique Moléculaires Unité Mixte de Recherche 5100, Centre National de la Recherche Scientifique, F 31000 Toulouse, France
    Proc Natl Acad Sci U S A 110:E1035-44. 2013
    ..Finally, phylogenetic analyses revealed that the acquisition of a new function by DprA impacted its evolution in streptococci relying on ComE to regulate comX expression...
  12. ncbi request reprint Antibiotic stress induces genetic transformability in the human pathogen Streptococcus pneumoniae
    Marc Prudhomme
    Laboratoire de Microbiologie et Genetique Moleculaires, UMR 5100 CNRS Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 9, France
    Science 313:89-92. 2006
    ..The design of antibiotherapy should take into consideration this potential of a major human pathogen to increase its rate of genetic exchange in response to antibiotics...
  13. ncbi request reprint Transformation of Streptococcus pneumoniae relies on DprA- and RecA-dependent protection of incoming DNA single strands
    Mathieu Berge
    Laboratoire de Microbiologie et Genetique Moleculaires, UMR 5100 CNRS Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex, France
    Mol Microbiol 50:527-36. 2003
    ..Our results demonstrate that incoming ssDNA requires active protection prior to the RecA-driven search for homology and that both DprA and RecA are needed for this protection...
  14. ncbi request reprint Uptake of transforming DNA in Gram-positive bacteria: a view from Streptococcus pneumoniae
    Mathieu Berge
    Laboratoire de Microbiologie et Genetique Moleculaire, UMR 5100 CNRS Université Paul, Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex, France
    Mol Microbiol 45:411-21. 2002
    ..Finally, inactivation of dprA had no effect on the internalization of DNA, indicating that DprA is required at a later stage in transformation...
  15. doi request reprint ComE/ComE~P interplay dictates activation or extinction status of pneumococcal X-state (competence)
    Bernard Martin
    Centre National de la Recherche Scientifique, LMGM UMR5100, F 31000 Toulouse, France
    Mol Microbiol 87:394-411. 2013
    ....
  16. doi request reprint Expression and maintenance of ComD-ComE, the two-component signal-transduction system that controls competence of Streptococcus pneumoniae
    Bernard Martin
    Centre National de la Recherche Scientifique, LMGM UMR5100, Toulouse, France
    Mol Microbiol 75:1513-28. 2010
    ..Finally, we demonstrate by various means, including single-cell competence analysis with GFP, that readthrough is crucial to avoid the stochastic production of CSP non-responsive cells lacking ComD or ComE...
  17. pmc Competence-programmed predation of noncompetent cells in the human pathogen Streptococcus pneumoniae: genetic requirements
    Sebastien Guiral
    Laboratoire de Microbiologie et Genetique Moleculaires, Unité Mixte de Recherche 5100, Centre National de la Recherche Scientifique, Universite Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex, France
    Proc Natl Acad Sci U S A 102:8710-5. 2005
    ..We propose that allolysis constitutes a competence-programmed mechanism of predation of noncompetent cells, which benefits to the competent cells and contributes to virulence by coordinating the release of virulence factors...
  18. ncbi request reprint Inhibition of competence development in Streptococcus pneumoniae by increased basal-level expression of the ComDE two-component regulatory system
    Sebastien Guiral
    Laboratoire de Microbiologie et Genetique Moleculaires, UMR 5100 CNRS Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 9, France
    Microbiology 152:323-31. 2006
    ..pneumoniae. There is a discussion of how an increased concentration of ComD and/or ComE could affect competence development...
  19. pmc Structure-function analysis of pneumococcal DprA protein reveals that dimerization is crucial for loading RecA recombinase onto DNA during transformation
    Sophie Quevillon-Cheruel
    Institut de Biochimie et de Biophysique Moleculaire et Cellulaire, Universite de Paris Sud, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8619, Bat 430, 91405 Orsay Cedex, France
    Proc Natl Acad Sci U S A 109:E2466-75. 2012
    ..We propose a model in which RecA interaction promotes rearrangement or disruption of the DprA dimer, enabling the subsequent nucleation of RecA and its polymerization onto ssDNA...
  20. ncbi request reprint A key presynaptic role in transformation for a widespread bacterial protein: DprA conveys incoming ssDNA to RecA
    Isabelle Mortier-Barrière
    Laboratoire de Microbiologie et Genetique Moleculaires, UMR 5100 CNRS Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 09, France
    Cell 130:824-36. 2007
    ..We propose that DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation...
  21. ncbi request reprint Independent evolution of competence regulatory cascades in streptococci?
    Bernard Martin
    Laboratoire de Microbiologie et Genetique Moleculaires, UMR 5100 CNRS Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 9, France
    Trends Microbiol 14:339-45. 2006
    ..Comparison of data obtained with two transformable streptococci, Streptococcus pneumoniae and Streptococcus mutans, provides support to this suggestion...
  22. ncbi request reprint New insights into the pneumococcal fratricide: relationship to clumping and identification of a novel immunity factor
    Leiv Sigve Havarstein
    Laboratoire de Microbiologie et Genetique Moleculaires, UMR 5100 CNRS Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex, France
    Mol Microbiol 59:1297-307. 2006
    ..Through such predatory behaviour, pneumococci can get access to transforming DNA and nutrients, promote the release of virulence factors, and at the same time get rid of competitors...
  23. pmc Role of the single-stranded DNA-binding protein SsbB in pneumococcal transformation: maintenance of a reservoir for genetic plasticity
    Laetitia Attaiech
    Centre National de la Recherche Scientifique, LMGM UMR5100, Toulouse, France
    PLoS Genet 7:e1002156. 2011
    ..pneumoniae by increasing the likelihood of multiple transformation events in the same cell...
  24. ncbi request reprint Construction and evaluation of a chromosomal expression platform (CEP) for ectopic, maltose-driven gene expression in Streptococcus pneumoniae
    Sebastien Guiral
    Laboratoire de Microbiologie et Genetique Moleculaires, UMR 5100 CNRS Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 9, France
    Microbiology 152:343-9. 2006
    ..pneumoniae recipient with ligation products between that gene and NcoI/BamHI-digested pCEP DNA, followed by selection for kanamycin-resistant transformants...
  25. ncbi request reprint Extracellular-peptide control of competence for genetic transformation in Streptococcus pneumoniae
    Jean Pierre Claverys
    Laboratoire de Microbiologie et Genetique Moleculaire, UMR 5100 CNRS Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex, France
    Front Biosci 7:d1798-814. 2002
    ..pneumoniae. In this review, we describe the current status of our knowledge of natural competence in this bacterium, with particular emphasis on the early phase of competence induction...
  26. ncbi request reprint Release of DNA into the medium by competent Streptococcus pneumoniae: kinetics, mechanism and stability of the liberated DNA
    Miriam Moscoso
    Laboratoire de Microbiologie et Genetique Moleculaires, UMR 5100 CNRS Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex, France
    Mol Microbiol 54:783-94. 2004
    ..These observations suggest that competence-dependent DNA release is one facet of a more general phenomenon of sensitization to autolysis that reaches its maximum in stationary phase...
  27. pmc Programmed protection of foreign DNA from restriction allows pathogenicity island exchange during pneumococcal transformation
    Calum Johnston
    Centre National de la Recherche Scientifique, LMGM UMR5100, Toulouse, France
    PLoS Pathog 9:e1003178. 2013
    ..Generally, this finding is the first evidence for a mechanism that actively promotes genetic diversity of S. pneumoniae through programmed protection and incorporation of foreign DNA...
  28. pmc RadC, a misleading name?
    Laetitia Attaiech
    Laboratoire de Microbiologie et Genetique Moleculaires, UMR 5100, CNRS, Universite Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 09, France
    J Bacteriol 190:5729-32. 2008
    ..They also display normal sensitivity to DNA-damaging agents, providing no support for the rad epithet...
  29. pmc Identification of a protein that inactivates the competence-stimulating peptide of Streptococcus pneumoniae
    Mathieu Berge
    Laboratoire de Microbiologie et Genetique Moleculaire, UMR 5100 CNRS Université Paul Sabatier, 31062 Toulouse Cedex, France
    J Bacteriol 184:610-3. 2002
    ..To reconcile in vitro and in vivo data, we suggest that LiCl treatment results in the release of intracellular molecules, including PepO...
  30. ncbi request reprint The global nutritional regulator CodY is an essential protein in the human pathogen Streptococcus pneumoniae
    Stéphanie Caymaris
    Centre National de la Recherche Scientifique, LMGM UMR5100, F 31000 Toulouse, France
    Mol Microbiol 78:344-60. 2010
    ..This combination of mutations was confirmed to allow tolerance of codY inactivation. The amiC mutation is in itself sufficient to account for the strong derepression of competence development observed in D39 codY cells...
  31. pmc Midcell Recruitment of the DNA Uptake and Virulence Nuclease, EndA, for Pneumococcal Transformation
    Matthieu J Bergé
    Centre National de la Recherche Scientifique, LMGM UMR5100, Toulouse, France Université de Toulouse, Universite Paul Sabatier, Laboratoire de Microbiologie et Genetique Moleculaires, Toulouse, France
    PLoS Pathog 9:e1003596. 2013
    ..We discuss how midcell uptake could influence homology search, and the likelihood that midcell uptake is characteristic of cocci and/or the growth phase-dependency of competence. ..
  32. pmc Transforming DNA uptake gene orthologs do not mediate spontaneous plasmid transformation in Escherichia coli
    Dongchang Sun
    Centre National de la Recherche Scientifique, LMGM UMR5100, F 31000 Toulouse, France
    J Bacteriol 191:713-9. 2009
    ..Our data together, with previous reports that HofQ is required for the use of dsDNA as a carbon source, suggest the existence of two routes for DNA entry, at least across the outer membrane of E. coli...
  33. pmc Antibacterial activity of a competence-stimulating peptide in experimental sepsis caused by Streptococcus pneumoniae
    Marco R Oggioni
    Laboratorio di Microbiologia Molecolare e Biotecnologia, Dipartimento di Biologia Molecolare, Universita di Siena, Siena, Italy
    Antimicrob Agents Chemother 48:4725-32. 2004
    ..This therapeutic effect is novel, in that the drug-like effect is obtained by stimulation, rather than inhibition, of a bacterial drug target...
  34. pmc BOX elements modulate gene expression in Streptococcus pneumoniae: impact on the fine-tuning of competence development
    Eivind Knutsen
    Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, As, Norway
    J Bacteriol 188:8307-12. 2006
    ..Together, our findings show that BOX elements enhance genetic diversity and genomic plasticity in Streptococcus pneumoniae...
  35. ncbi request reprint rexAB mutants in Streptococcus pneumoniae
    David Halpern
    Unité de Recherches Laitières et Génétique Appliquée, Institut National de la Recherche Agronomique, Domaine de Vilvert, 78352 Jouy en Josas, France
    Microbiology 150:2409-14. 2004
    ..No effect was observed on plasmid and chromosomal transformation efficiencies. These results indicate that in S. pneumoniae, RexAB is required for DNA repair, but not for chromosomal transformation and plasmid establishment...
  36. pmc Identification of the major protein component of the pneumococcal eclipse complex
    Donald A Morrison
    Laboratory for Molecular Biology, Department of Biological Sciences, University of Illinois at Chicago, 900 South Ashland Ave, Chicago, IL 60607, USA
    J Bacteriol 189:6497-500. 2007
    ..Using Western blotting, we identify the principal protein cofractionating with donor DNA in this complex as SsbB...
  37. pmc The Seventh International Conference on the Genetics of Streptococci, Lactococci, and Enterococci
    Robert A Burne
    Department of Oral Biology, Gainesville, FL 32610 0424, USA
    J Bacteriol 189:1209-18. 2007