Sylvie Claeysen

Summary

Country: France

Publications

  1. doi request reprint Alzheimer culprits: cellular crossroads and interplay
    Sylvie Claeysen
    CNRS, UMR 5203, Institut de Genomique Fonctionnelle, F 34000 Montpellier, France
    Cell Signal 24:1831-40. 2012
  2. pmc Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling
    Gael Barthet
    Institut de Genomique Fonctionnelle, Universités de Montpellier, CNRS, Montpellier, France
    EMBO J 28:2706-18. 2009
  3. pmc 5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10
    Maud Cochet
    CNRS, UMR 5203, Institut de Genomique Fonctionnelle, F 34000 Montpellier, France
    ACS Chem Neurosci 4:130-40. 2013
  4. doi request reprint Pharmacological profile of engineered 5-HT₄ receptors and identification of 5-HT₄ receptor-biased ligands
    Florence Gaven
    CNRS, UMR 5203, Institut de Genomique Fonctionnelle, F 34000 Montpellier, France
    Brain Res 1511:65-72. 2013
  5. pmc G protein activation by serotonin type 4 receptor dimers: evidence that turning on two protomers is more efficient
    Lucie P Pellissier
    Institut de Genomique Fonctionnelle, Universite de Montpellier, CNRS UMR5203, F 34094 Montpellier, France
    J Biol Chem 286:9985-97. 2011
  6. doi request reprint Serotonin type 4 receptor dimers
    Sylvie Claeysen
    CNRS, UMR 5203, Institut de Genomique Fonctionnelle, Montpellier, France INSERM, U661, Montpellier, France Universités de Montpellier 1 and 2, UMR 5203, Montpellier, France
    Methods Cell Biol 117:123-39. 2013
  7. doi request reprint 5-HT(4) receptors: history, molecular pharmacology and brain functions
    Joel Bockaert
    CNRS UMR 5203, Institut de Genomique Fonctionnelle, Montpellier, France
    Neuropharmacology 55:922-31. 2008
  8. doi request reprint 5-HT(4) receptors, a place in the sun: act two
    Joel Bockaert
    Institut de Genomique Fonctionnelle, Universite de Montpellier, CNRS UMR5203, Montpellier F 34094, France
    Curr Opin Pharmacol 11:87-93. 2011
  9. doi request reprint Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors
    Lucie P Pellissier
    Centre National de Recherche Scientifique Unité Mixte de Recherche 5203, Institut de Genomique Fonctionnelle, Institut National de Sant et de Recherche Médicale U661, Universites Montpellier 1 and 2, Montpellier, France
    Mol Pharmacol 75:982-90. 2009
  10. pmc 5-hydroxytryptamine 4 receptor activation of the extracellular signal-regulated kinase pathway depends on Src activation but not on G protein or beta-arrestin signaling
    Gael Barthet
    Institut de Genomique Fonctionnelle, Montpellier F 34094, France
    Mol Biol Cell 18:1979-91. 2007

Collaborators

Detail Information

Publications11

  1. doi request reprint Alzheimer culprits: cellular crossroads and interplay
    Sylvie Claeysen
    CNRS, UMR 5203, Institut de Genomique Fonctionnelle, F 34000 Montpellier, France
    Cell Signal 24:1831-40. 2012
    ..Being able to reduce the formation of the toxic Aβ peptides is obviously an immediate approach in the trial to prevent AD. The following review summarizes the most relevant discoveries in the field of the last decades...
  2. pmc Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling
    Gael Barthet
    Institut de Genomique Fonctionnelle, Universités de Montpellier, CNRS, Montpellier, France
    EMBO J 28:2706-18. 2009
    ..This is the first demonstration that beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent signalling...
  3. pmc 5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10
    Maud Cochet
    CNRS, UMR 5203, Institut de Genomique Fonctionnelle, F 34000 Montpellier, France
    ACS Chem Neurosci 4:130-40. 2013
    ..These findings describe a new mechanism whereby a GPCR constitutively stimulates the cleavage of APP by α-secretase and promotes the nonamyloidogenic pathway of APP processing...
  4. doi request reprint Pharmacological profile of engineered 5-HT₄ receptors and identification of 5-HT₄ receptor-biased ligands
    Florence Gaven
    CNRS, UMR 5203, Institut de Genomique Fonctionnelle, F 34000 Montpellier, France
    Brain Res 1511:65-72. 2013
    ..This article is part of a Special Issue entitled Optogenetics (7th BRES)...
  5. pmc G protein activation by serotonin type 4 receptor dimers: evidence that turning on two protomers is more efficient
    Lucie P Pellissier
    Institut de Genomique Fonctionnelle, Universite de Montpellier, CNRS UMR5203, F 34094 Montpellier, France
    J Biol Chem 286:9985-97. 2011
    ..These results, together with previous findings, demonstrate that, differently from class C GPCR dimers, class A GPCR dimers have pleiotropic activation mechanisms...
  6. doi request reprint Serotonin type 4 receptor dimers
    Sylvie Claeysen
    CNRS, UMR 5203, Institut de Genomique Fonctionnelle, Montpellier, France INSERM, U661, Montpellier, France Universités de Montpellier 1 and 2, UMR 5203, Montpellier, France
    Methods Cell Biol 117:123-39. 2013
    ..Finally, we adapted the powerful time-resolved FRET technology to assess a relative quantification of dimer formation and affinity. ..
  7. doi request reprint 5-HT(4) receptors: history, molecular pharmacology and brain functions
    Joel Bockaert
    CNRS UMR 5203, Institut de Genomique Fonctionnelle, Montpellier, France
    Neuropharmacology 55:922-31. 2008
    ..However, since 5-HT(4) receptors have recognized effects on memory, depression and feeding in animal models, there is still hope for a therapeutic destiny of this interesting target in brain disorders...
  8. doi request reprint 5-HT(4) receptors, a place in the sun: act two
    Joel Bockaert
    Institut de Genomique Fonctionnelle, Universite de Montpellier, CNRS UMR5203, Montpellier F 34094, France
    Curr Opin Pharmacol 11:87-93. 2011
    ..Several major devastating illnesses could benefit from 5-HT(4) receptors-directed therapy such as Alzheimer's disease, feeding-associated diseases such as anorexia and major depressive disorders...
  9. doi request reprint Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors
    Lucie P Pellissier
    Centre National de Recherche Scientifique Unité Mixte de Recherche 5203, Institut de Genomique Fonctionnelle, Institut National de Sant et de Recherche Médicale U661, Universites Montpellier 1 and 2, Montpellier, France
    Mol Pharmacol 75:982-90. 2009
    ..R(*)-5-HT is probably attained through other routes of activation. Thus, different conformational arrangements occur during stabilization of R(*)basal, R(*)-5-HT, R(*)-benzamides, and R(*)-BIMU8...
  10. pmc 5-hydroxytryptamine 4 receptor activation of the extracellular signal-regulated kinase pathway depends on Src activation but not on G protein or beta-arrestin signaling
    Gael Barthet
    Institut de Genomique Fonctionnelle, Montpellier F 34094, France
    Mol Biol Cell 18:1979-91. 2007
    ..Finally, we confirmed that the main route by which 5-HT(4)Rs activate ERKs in neurons was Src dependent. Thus, in addition to classical cAMP/PKA signaling pathways, 5-HT(4)Rs may use ERK pathways to control memory process...
  11. ncbi request reprint Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation
    Joel Bockaert
    CNRS, UMR5203, Montpellier, F 34094, France
    Cell Tissue Res 326:553-72. 2006
    ..The functions of these proteins are starting to be revealed. These proteins have been implicated in targeting, trafficking to or from the membrane, desensitization, and fine-tuning of signaling...