J P Zarski

Summary

Affiliation: CHU de Grenoble
Country: France

Publications

  1. pmc Contribution of the ELFG test in algorithms of non-invasive markers towards the diagnosis of significant fibrosis in chronic hepatitis C
    Jean Pierre Zarski
    Hepato Gastroenterology Clinic, DIGIDUNE Pole, Grenoble University Hospital, Grenoble, France
    PLoS ONE 8:e59088. 2013
  2. pmc Comparison of accuracy of fibrosis degree classifications by liver biopsy and non-invasive tests in chronic hepatitis C
    Jérôme Boursier
    Liver Gastroenterology department, University Hospital, Angers, France
    BMC Gastroenterol 11:132. 2011
  3. doi request reprint Non-invasive assessment of liver fibrosis progression in hepatitis C patients retreated for 96 weeks with antiviral therapy: a randomized study
    Jean Pierre Zarski
    Department of Hepatology and Gastroenterology, CHU, Grenoble, France
    Liver Int 30:1049-58. 2010
  4. ncbi request reprint Rate of natural disease progression in patients with chronic hepatitis C
    Jean Pierre Zarski
    Département d Hépato Gastroentérologie, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 9, France
    J Hepatol 38:307-14. 2003
  5. doi request reprint [Hepatitis C, cirrhosis and hepatocellular carcinoma]
    J P Zarski
    Clinique universitaire d hepato gastroentérologie, pôle DIGI DUNE, Centre de recherche INSERM UJF U823 IAPC Institut Albert Bonniot, CHU de Grenoble BP 217, 38043 Grenoble Cedex, France
    Gastroenterol Clin Biol 32:S117-20. 2008
  6. doi request reprint [The patient with uncontrolled chronic hepatitis B]
    J P Zarski
    Clinique universitaire d hepato gastroentérologie, pôle DIGI DUNE, Centre de recherche INSERM UJF U823 IAPC, CHU de Grenoble, BP 217, 38043 Grenoble Cedex, France
    Gastroenterol Clin Biol 32:S7-11. 2008
  7. ncbi request reprint [Non invasive markers using for the assessment of fibrosis in hepatitis C]
    Jean Pierre Zarski
    Clinique universitaire d hepato gastroentérologie, pôle DIGI DUNE, Unité INSERM U 548, CHU de Grenoble, Grenoble Cedex 9
    Gastroenterol Clin Biol 31:4S34-9. 2007
  8. ncbi request reprint Characteristics of patients with chronic hepatitis B in France: predominant frequency of HBe antigen negative cases
    Jean Pierre Zarski
    Département d Hépato Gastroentérologie, CHU de Grenoble BP 217 38043 Grenoble CEDEX 9, France
    J Hepatol 45:355-60. 2006
  9. ncbi request reprint [Natural history of viral hepatitis]
    Jean Pierre Zarski
    Clinique universitaire d hepato gastroentérologie, CRI Inserm UJF U823 IAPC, Institut Albert Bonniot, CHU de Grenoble, 38043 Grenoble Cedex
    Rev Prat 61:33-8. 2011
  10. ncbi request reprint [Epidemiology of chronic hepatitis B]
    Jean Pierre Zarski
    Département d Hépato Gastroentérologie, Unité Inserm U548, CHU de Grenoble
    Presse Med 35:304-7. 2006

Collaborators

Detail Information

Publications45

  1. pmc Contribution of the ELFG test in algorithms of non-invasive markers towards the diagnosis of significant fibrosis in chronic hepatitis C
    Jean Pierre Zarski
    Hepato Gastroenterology Clinic, DIGIDUNE Pole, Grenoble University Hospital, Grenoble, France
    PLoS ONE 8:e59088. 2013
    ..We aimed to determine the best algorithms for the diagnosis of significant fibrosis in chronic hepatitis C (CHC) patients using all available parameters and tests...
  2. pmc Comparison of accuracy of fibrosis degree classifications by liver biopsy and non-invasive tests in chronic hepatitis C
    Jérôme Boursier
    Liver Gastroenterology department, University Hospital, Angers, France
    BMC Gastroenterol 11:132. 2011
    ..The secondary aim was to validate these accuracies in independent populations...
  3. doi request reprint Non-invasive assessment of liver fibrosis progression in hepatitis C patients retreated for 96 weeks with antiviral therapy: a randomized study
    Jean Pierre Zarski
    Department of Hepatology and Gastroenterology, CHU, Grenoble, France
    Liver Int 30:1049-58. 2010
    ..The efficacy of a maintenance therapy in non-responder patients with chronic hepatitis C has been essentially evaluated by histological semiquantitative scores...
  4. ncbi request reprint Rate of natural disease progression in patients with chronic hepatitis C
    Jean Pierre Zarski
    Département d Hépato Gastroentérologie, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 9, France
    J Hepatol 38:307-14. 2003
    ..The interval at which liver biopsy should be repeated in untreated patients with chronic hepatitis C is not defined. We examined fibrosis change by METAVIR scoring in these patients in whom two or more liver biopsies were available...
  5. doi request reprint [Hepatitis C, cirrhosis and hepatocellular carcinoma]
    J P Zarski
    Clinique universitaire d hepato gastroentérologie, pôle DIGI DUNE, Centre de recherche INSERM UJF U823 IAPC Institut Albert Bonniot, CHU de Grenoble BP 217, 38043 Grenoble Cedex, France
    Gastroenterol Clin Biol 32:S117-20. 2008
    ..The liver biopsy is also mandatory in the case of a nodule > 2 cm and when the ultrasound sonography is not contributive, especially when the nodule is between 1 and 2 cm in size...
  6. doi request reprint [The patient with uncontrolled chronic hepatitis B]
    J P Zarski
    Clinique universitaire d hepato gastroentérologie, pôle DIGI DUNE, Centre de recherche INSERM UJF U823 IAPC, CHU de Grenoble, BP 217, 38043 Grenoble Cedex, France
    Gastroenterol Clin Biol 32:S7-11. 2008
    ....
  7. ncbi request reprint [Non invasive markers using for the assessment of fibrosis in hepatitis C]
    Jean Pierre Zarski
    Clinique universitaire d hepato gastroentérologie, pôle DIGI DUNE, Unité INSERM U 548, CHU de Grenoble, Grenoble Cedex 9
    Gastroenterol Clin Biol 31:4S34-9. 2007
    ..Diagnostic accuracy is improved by the using of all the markers, especially of Fibrotest. Transient elastography is also a promising method for assessing the severity of cirrhosis...
  8. ncbi request reprint Characteristics of patients with chronic hepatitis B in France: predominant frequency of HBe antigen negative cases
    Jean Pierre Zarski
    Département d Hépato Gastroentérologie, CHU de Grenoble BP 217 38043 Grenoble CEDEX 9, France
    J Hepatol 45:355-60. 2006
    ..The aim of this study was to analyze the frequency and the characteristics of HBeAg-negative as compared with HBeAg-positive chronic hepatitis B in France...
  9. ncbi request reprint [Natural history of viral hepatitis]
    Jean Pierre Zarski
    Clinique universitaire d hepato gastroentérologie, CRI Inserm UJF U823 IAPC, Institut Albert Bonniot, CHU de Grenoble, 38043 Grenoble Cedex
    Rev Prat 61:33-8. 2011
    ..These factors increase the risk of progression of the disease and the evolution to cirrhosis and hepatocellular carcinoma...
  10. ncbi request reprint [Epidemiology of chronic hepatitis B]
    Jean Pierre Zarski
    Département d Hépato Gastroentérologie, Unité Inserm U548, CHU de Grenoble
    Presse Med 35:304-7. 2006
    ..Patients with HBeAg-negative chronic hepatitis B are more likely to be older, male, and have cirrhosis; they also have lower levels of serum transaminase activity and HBV DNA than those with HBeAg-positive chronic hepatitis B...
  11. doi request reprint Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: the ANRS HCEP-23 study
    Jean Pierre Zarski
    Clinique Universitaire d Hépato Gastroentérologie Pôle DIGIDUNE CHU de Grenoble, France
    J Hepatol 56:55-62. 2012
    ..This ANRS HCEP-23 study compared the diagnostic accuracy of nine blood tests and transient elastography (Fibroscan™) to assess liver fibrosis, vs. liver biopsy, in untreated patients with chronic hepatitis C (CHC)...
  12. doi request reprint [Influence of treatment on long-term evolution of chronic hepatitis B]
    J P Zarski
    Clinique universitaire d hepato gastroentérologie, Unité INSERM UJF U823 IAPC Institut Albert Bonniot, CHU de Grenoble, Grenoble, France
    Gastroenterol Clin Biol 34:S109-11. 2010
    ..Finally, negativation and seroconversion of the HBs antigen can be observed in the medium-term. This seroconversion is usually associated with a decreased risk of complications and morbidity-mortality improvement...
  13. ncbi request reprint [Managing resistance to analogue antiviral drugs in a decompensated cirrhosis patient]
    Jean Pierre Zarski
    Département d hépatogastroentérologie, Unité INSERM U 548, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 9, France
    Gastroenterol Clin Biol 30:3S20-1. 2006
  14. ncbi request reprint Dynamics of viral quasispecies during interferon therapy in non responder chronic hepatitis C patients
    M A Thelu
    Département d Hépato Gastroentérologie, Hopital Albert Michallon, 38043, Grenoble, France
    J Clin Virol 22:125-31. 2001
    ..Meanwhile, with the alternative Single-Strand Conformation Polymorphism (SSCP) method, a rough estimation of the quasispecies present in a given sample could be obtained...
  15. pmc Simultaneous evaluation of lymphocyte subpopulations in the liver and in peripheral blood mononuclear cells of HCV-infected patients: relationship with histological lesions
    M Pernollet
    Laboratoire d Immunochimie, CEA DBMS ICH, INSERM U548, Universite Joseph Fourier, Grenoble, France
    Clin Exp Immunol 130:518-25. 2002
    ..Abbreviations:..
  16. ncbi request reprint Influence of three successive antiviral treatments on viral heterogeneity in nonresponder chronic hepatitis C patients
    M A Thelu
    Département d Hépato Gastroentérologie, Hopital Albert Michallon, Grenoble, France
    J Med Virol 65:698-705. 2001
    ..These results reinforce the hypothesis of the presence of preexisting quasispecies best adapted to the host environment, and therefore resistant to any current therapy...
  17. ncbi request reprint IRES complexity before IFN-alpha treatment and evolution of the viral load at the early stage of treatment in peripheral blood mononuclear cells from chronic hepatitis C patients
    M A Thelu
    Département d Hépato Gastroentérologie, Hopital Albert Michallon, Grenoble, France
    J Med Virol 79:242-53. 2007
    ..However, pre-treatment genomic variations observed in the 5'NCR of HCV were not a parameter of a later response to antiviral therapy in chronic hepatitis C patients. (244)..
  18. ncbi request reprint Lack of seroconversion in a health care worker after polymerase chain reaction-documented acute hepatitis C resulting from a needlestick injury
    P Morand
    Laboratoire de Virologie Structurale et Moléculaire, Faculte de Medecine, Centre Hospitalier Universitaire, Grenoble, France
    Clin Infect Dis 33:727-9. 2001
    ....
  19. ncbi request reprint The antibody response to hepatitis B virus vaccination is negatively influenced by the hepatitis C virus viral load in patients with chronic hepatitis C: a case-control study
    Vincent Leroy
    Department of Hepatogastroenterology, Grenoble, France
    Eur J Gastroenterol Hepatol 14:485-9. 2002
    ..65, P < 0.0001), weight < 75 kg (OR = 1.99, P < 0.035), and age < 50 years (OR = 1.58, P < 0.082). Our results suggest that viral load seems to negatively influence the response to HBV vaccine...
  20. ncbi request reprint Effect of ribavirin in genotype 1 patients with hepatitis C responding to pegylated interferon alfa-2a plus ribavirin
    Jean Pierre Bronowicki
    Department of Hepatology and Gastroenterology, INSERM U724, CHU de Nancy, Vandoeuvre les Nancy, France
    Gastroenterology 131:1040-8. 2006
    ..We aimed to investigate the role of ribavirin in HCV clearance during therapy and to evaluate the consequences of ribavirin discontinuation in patients infected with genotype 1 hepatitis C who cleared HCV RNA at week 24...
  21. pmc Complement C4 monitoring in the follow-up of chronic hepatitis C treatment
    C Dumestre-perard
    Laboratoire d Immunologie JE 2236, CHU Grenoble, France
    Clin Exp Immunol 127:131-6. 2002
    ..Specific C4 monitoring appears to be a valuable tool for the follow-up of chronic hepatitis C treatment, together with the other conventional investigations...
  22. ncbi request reprint Biermer's anemia: a new cause of cholestasis and hepatic steatosis?
    Xavier Roblin
    Département d Hépato Gastroentérologie, CHU Grenoble, Grenoble, France
    Dig Dis Sci 52:3366-8. 2007
  23. ncbi request reprint [Steatosis, chronic hepatitis virus C infection and homocysteine]
    Xavier Roblin
    Département d Hépato Gastroentérologie, CHU Michallon, Grenoble, France
    Gastroenterol Clin Biol 31:415-20. 2007
    ..These data should be confirmed to evaluate the importance of homocysteine dosage in the diagnosis of NASH. Finally, treatment of hyperhomocysteinemia could have favourable consequences in steatopathies and HCV infection...
  24. ncbi request reprint Prospective comparison of six non-invasive scores for the diagnosis of liver fibrosis in chronic hepatitis C
    Vincent Leroy
    Département d Hépato Gastroentérologie, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 9, France
    J Hepatol 46:775-82. 2007
    ..The aim of this study was to compare the diagnostic performance of 6 scores (MP3, Fibrotest, Fibrometer, Hepascore, Forns' score and APRI)...
  25. ncbi request reprint [Correction of insulin resistance syndrome does not cause normalisation of hyperferritinaemia]
    Xavier Roblin
    Département d Hépato Gastroentérologie, CHU Michallon 38000 Grenoble
    Gastroenterol Clin Biol 27:1079-83. 2003
    ..Venesection therapy is known to be effective in controlling iron overload parameters although no study has evaluated the impact of the normalization of metabolic dysfunction on iron overload...
  26. ncbi request reprint EBV-B cells as antigen presenting cells in characterization of the self/donor context of allorecognition by T lymphocytes
    C Drouet
    Laboratoire d Immunologie, Hopital Sud, CHU de Grenoble, France
    Transpl Immunol 6:209-15. 1998
    ..These data suggest that EBV-B cells can provide allogeneic determinants recognized by T cells in donor or self-contexts, i.e. through either direct or indirect recognition...
  27. ncbi request reprint Circulating matrix metalloproteinases 1, 2, 9 and their inhibitors TIMP-1 and TIMP-2 as serum markers of liver fibrosis in patients with chronic hepatitis C: comparison with PIIINP and hyaluronic acid
    Vincent Leroy
    Département d Hépato Gastroentérologie, CHU de Grenoble, France
    Am J Gastroenterol 99:271-9. 2004
    ..Histological examination of liver biopsy is currently required in the management of patients with chronic hepatitis C. Our aim was to evaluate the diagnostic utility of a panel of circulating markers in detecting the stage of fibrosis...
  28. ncbi request reprint [Physiopathology of HCV infection]
    Jean Pierre Zarski
    Département d Hépato Gastroentérologie, Hopital Albert Michallon, CHU de Grenoble, Unité Inserm U548, CEA, Grenoble
    Gastroenterol Clin Biol 26:B154-62. 2002
  29. ncbi request reprint Lack of clinical significance of variability in the internal ribosome entry site of hepatitis C virus
    Marie Ange Thelu
    Département d Hépato Gastroentérologie, Hopital Albert Michallon, Grenoble, France
    J Med Virol 72:396-405. 2004
    ..Variations observed in the IRES are not a parameter of response to antiviral therapy, but the integrity of this region is a necessary condition to maintain its activity...
  30. doi request reprint Biological autoimmunity screening in hepatitis C patients by anti-HepG2 lysate and anti-heat shock protein 70.1 autoantibodies
    B F F Chumpitazi
    Laboratoire d Immunologie du Département de Biologie et Pathologie de la Cellule, CHU de Grenoble, Hopital Michalon, BP 217X, 38043, Grenoble, France
    Eur J Clin Microbiol Infect Dis 28:137-46. 2009
    ..1 and anti-HepG2 lysate antigen antibodies, respectively. Therefore, anti-Hsp70.1 autoantibodies may be produced and can partially lead to biological autoimmunity in chronic hepatitis C patients...
  31. ncbi request reprint Features and distribution of CD8 T cells with human leukocyte antigen class I-specific receptor expression in chronic hepatitis C
    Paula Bonorino
    Institut National de la Santé et de la Recherche Médicale Unité 548, Departement Reponse et Dynamique Cellulaires, Commissariat a l Energie Atomique, Universite Joseph Fourier, Grenoble, France
    Hepatology 46:1375-86. 2007
    ..Both NKG2A and KIRs could inhibit the response of HCV-specific CD8(+) T cells ex vivo...
  32. ncbi request reprint [What tests should be prescribed in HBs-positive patients]
    Samira Fafi-Kremer
    Laboratoire de Virologie, CHU de Grenoble, France
    Gastroenterol Clin Biol 29:364-8. 2005
  33. ncbi request reprint [Natural course of chronic viral hepatitis C after 22 years of development]
    Marie Noelle Hilleret
    Department d Hépato Gastroentérologie, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 9, France
    Gastroenterol Clin Biol 26:303-4. 2002
  34. ncbi request reprint Mortality related to chronic hepatitis B and chronic hepatitis C in France: evidence for the role of HIV coinfection and alcohol consumption
    Patrick Marcellin
    Service d hépatologie and INSERM CRB3, University of Paris VII, AP HP, CHU Beaujon, Clichy, France
    J Hepatol 48:200-7. 2008
    ..Mortality related to HCV and HBV infections was estimated in France...
  35. ncbi request reprint Treatment of patients with decompensated post-hepatitis C cirrhosis before liver transplantation: strategy to prevent hepatitis C virus (HCV) recurrence?
    Jean Pierre Zarski
    J Hepatol 39:435-6. 2003
  36. ncbi request reprint Phenotypic and functional characterization of intrahepatic T lymphocytes during chronic hepatitis C
    Vincent Leroy
    Laboratoire d Immunochimie, CEA G DRDC, INSERM U548, Universite Joseph Fourier, Grenoble I, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France
    Hepatology 38:829-41. 2003
    ..In conclusion, these results strongly suggest key roles for CD8+ T cells as effectors of liver damage during chronic HCV infection and for their inability to control viral replication...
  37. ncbi request reprint Predicting efficacy and safety outcomes in patients with hepatitis C virus genotype 1 and persistently 'normal' alanine aminotransferase levels treated with peginterferon alpha-2a (40KD) plus ribavirin
    Eric Snoeck
    Exprimo NV, Mechelen, Belgium
    Liver Int 28:61-71. 2008
    ..Currently, the approved dosage of ribavirin has not been studied in patients with 'normal' alanine aminotransferase (ALT) levels...
  38. ncbi request reprint [Operating tools useful for hepatitis C poles and care networks]
    Marie Noelle Hilleret
    Gastroenterol Clin Biol 27:583-5. 2003
  39. ncbi request reprint T lymphocytes infiltrating the liver during chronic hepatitis C infection express a broad range of T-cell receptor beta chain diversity
    Ines Vigan
    Laboratoire d Immunochimie, CEA Grenoble, DBMS ICH, INSERM U548, UJF Grenoble I, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France
    J Hepatol 38:651-9. 2003
    ....
  40. pmc Ribavirin quantification in combination treatment of chronic hepatitis C
    Sylvie Larrat
    Laboratory of Pharmacology Hepato Gastro Enterology Department, Grenoble University Hospital, BP217, F 38043 Grenoble Cedex 09, France
    Antimicrob Agents Chemother 47:124-9. 2003
    ....
  41. ncbi request reprint Cellular glycosaminoglycans and low density lipoprotein receptor are involved in hepatitis C virus adsorption
    Raphaele Germi
    Laboratoire de Virologie Moléculaire et Structurale EA 2939, Universite Joseph Fourier, Faculté de Médecine Pharmacie de Grenoble, La Tronche, France
    J Med Virol 68:206-15. 2002
    ..These results demonstrate the complexity of the HCV binding step in which LDLr interacts strongly with HCV, whereas the interaction of HCV with GAGs and particularly with CD81 seem to be more moderate...
  42. ncbi request reprint [Candesartan Cilexetil (Atacand) induced prolonged severe cholestasis improved by extracorporeal albumin dialysis]
    Nathalie Sturm
    Gastroenterol Clin Biol 29:1299-301. 2005
  43. ncbi request reprint Lack of evidence of sustained hematopoietic reconstitution after transplantation of unmanipulated adult liver stem cells in monkeys
    Michel Drouet
    Experimental Radiohematology Unit, Centre de Recherches du Service de Sante des Armees, 24 Avenue des Maquis du Gresivaudan, 38702, La Tronche, France
    Haematologica 92:248-51. 2007
    ..In conclusion, adult liver stem cells from a monkey model show a low level of in vivo hematopoietic potential, suggesting ex vivo manipulation will be required before clinical use of such cells...
  44. ncbi request reprint MacDuffie syndrome and primary sclerosing cholangitis: an exceptional association
    Xavier Roblin
    Dig Dis Sci 51:1134-5. 2006