Faiez Zannad

Summary

Affiliation: CHU de Nancy
Country: France

Publications

  1. ncbi request reprint The challenge of acute decompensated heart failure
    Faiez Zannad
    INSERM, Centre d Investigation Clinique CIC INSERM CHU, Hopital Jeanne d Arc, 54200, Dommartin les Toul, Nancy, France
    Heart Fail Rev 11:135-9. 2006
  2. ncbi request reprint Features of cardiac remodeling, associated with blood pressure and fibrosis biomarkers, are frequent in subjects with abdominal obesity
    Romain Eschalier
    CIC Plurithématique, Institut Lorrain du Cœur et des Vaisseaux, 4 Rue du Morvan, 54500 Vandœuvre lès Nancy, France
    Hypertension 63:740-6. 2014
  3. doi request reprint Is thrombosis a contributor to heart failure pathophysiology? Possible mechanisms, therapeutic opportunities, and clinical investigation challenges
    Faiez Zannad
    INSERM, Centre d Investigation Clinique 9501 and Unité 961, Centre Hospitalier Universitaire, and the Department of Cardiology, Nancy University, Université de Lorraine, Nancy, France
    Int J Cardiol 167:1772-82. 2013
  4. doi request reprint Mineralocorticoid receptor antagonists for heart failure with reduced ejection fraction: integrating evidence into clinical practice
    Faiez Zannad
    INSERM, Centre d Investigation Clinique 9501 and Unité 961, Centre Hospitalier Universitaire, France
    Eur Heart J 33:2782-95. 2012
  5. pmc Prevention of cardiovascular disease guided by total risk estimations--challenges and opportunities for practical implementation: highlights of a CardioVascular Clinical Trialists (CVCT) Workshop of the ESC Working Group on CardioVascular Pharmacology and
    Faiez Zannad
    centre d investigation clinique, Institut Lorrain du Coeuret des Vaisseaux, CHU Brabois, Vandoeuvre, France
    Eur J Prev Cardiol 19:1454-64. 2012
  6. doi request reprint Diabetes clinical trials: helped or hindered by the current shift in regulatory requirements?
    Faiez Zannad
    INSERM, Centre d Investigation Clinique 9501 and Unité 961, Centre Hospitalier Universitaire, and the Department of Cardiology, Nancy University, Hopital Jeanne d Arc, 54200 Toul, Nancy, France
    Eur Heart J 33:1049-57. 2012
  7. doi request reprint Risk stratification in cardiovascular disease primary prevention - scoring systems, novel markers, and imaging techniques
    Faiez Zannad
    Centre for Clinical Investigation, Institut Lorrain du Coeur et des Vaisseaux, CHU Brabois, 54500 Vandoeuvre, France
    Fundam Clin Pharmacol 26:163-74. 2012
  8. pmc Nutrition, environment and cardiovascular health (NESCAV): protocol of an inter-regional cross-sectional study
    Ala a Alkerwi
    Centre de Recherche Public Santé, Centre d Etudes en Santé, Grand Duchy of Luxembourg
    BMC Public Health 10:698. 2010
  9. ncbi request reprint Managing hypertension: a question of STRATHE
    F Zannad
    Department of Cardiovascular Disease, Clinical Investigation Center INSERM CHU, University Henri Poincare, Nancy, France
    J Hum Hypertens 19:S3-7. 2005
  10. doi request reprint Heart failure burden and therapy
    Faiez Zannad
    Departement of cardiology, INSERM, CIC9501 and U961, CHU Nancy, Hypertension and Heart Failure Unit, CHU, Nancy Universite, 54500 Vandoeuvre les Nancy, France
    Europace 11:v1-9. 2009

Detail Information

Publications137 found, 100 shown here

  1. ncbi request reprint The challenge of acute decompensated heart failure
    Faiez Zannad
    INSERM, Centre d Investigation Clinique CIC INSERM CHU, Hopital Jeanne d Arc, 54200, Dommartin les Toul, Nancy, France
    Heart Fail Rev 11:135-9. 2006
    ..A combined endpoint assessing survival and rehospitalisation rates is becoming increasingly popular for acute therapies. Specific trials may also need to be designed according to the time of access to the patient...
  2. ncbi request reprint Features of cardiac remodeling, associated with blood pressure and fibrosis biomarkers, are frequent in subjects with abdominal obesity
    Romain Eschalier
    CIC Plurithématique, Institut Lorrain du Cœur et des Vaisseaux, 4 Rue du Morvan, 54500 Vandœuvre lès Nancy, France
    Hypertension 63:740-6. 2014
    ..It is to be investigated whether in subjects with AO, an early BP reduction, even if normotensive, combined with weight loss may avoid adverse cardiac remodeling and protect against progression to heart failure. ..
  3. doi request reprint Is thrombosis a contributor to heart failure pathophysiology? Possible mechanisms, therapeutic opportunities, and clinical investigation challenges
    Faiez Zannad
    INSERM, Centre d Investigation Clinique 9501 and Unité 961, Centre Hospitalier Universitaire, and the Department of Cardiology, Nancy University, Université de Lorraine, Nancy, France
    Int J Cardiol 167:1772-82. 2013
    ..Critical questions are raised with regard to clinical trial designs that warrant consideration as the field progresses. ..
  4. doi request reprint Mineralocorticoid receptor antagonists for heart failure with reduced ejection fraction: integrating evidence into clinical practice
    Faiez Zannad
    INSERM, Centre d Investigation Clinique 9501 and Unité 961, Centre Hospitalier Universitaire, France
    Eur Heart J 33:2782-95. 2012
    ..When used appropriately, MRAs significantly improve outcomes across the spectrum of patients with HF-REF...
  5. pmc Prevention of cardiovascular disease guided by total risk estimations--challenges and opportunities for practical implementation: highlights of a CardioVascular Clinical Trialists (CVCT) Workshop of the ESC Working Group on CardioVascular Pharmacology and
    Faiez Zannad
    centre d investigation clinique, Institut Lorrain du Coeuret des Vaisseaux, CHU Brabois, Vandoeuvre, France
    Eur J Prev Cardiol 19:1454-64. 2012
    ..In conclusion, opportunities exist to increase guideline implementation in the primary care setting, with potential benefits for both the general population and healthcare resources...
  6. doi request reprint Diabetes clinical trials: helped or hindered by the current shift in regulatory requirements?
    Faiez Zannad
    INSERM, Centre d Investigation Clinique 9501 and Unité 961, Centre Hospitalier Universitaire, and the Department of Cardiology, Nancy University, Hopital Jeanne d Arc, 54200 Toul, Nancy, France
    Eur Heart J 33:1049-57. 2012
    ....
  7. doi request reprint Risk stratification in cardiovascular disease primary prevention - scoring systems, novel markers, and imaging techniques
    Faiez Zannad
    Centre for Clinical Investigation, Institut Lorrain du Coeur et des Vaisseaux, CHU Brabois, 54500 Vandoeuvre, France
    Fundam Clin Pharmacol 26:163-74. 2012
    ..However, their additional value above and beyond classical risk factors has yet to be determined for risk-guided therapy in CVD prevention...
  8. pmc Nutrition, environment and cardiovascular health (NESCAV): protocol of an inter-regional cross-sectional study
    Ala a Alkerwi
    Centre de Recherche Public Santé, Centre d Etudes en Santé, Grand Duchy of Luxembourg
    BMC Public Health 10:698. 2010
    ....
  9. ncbi request reprint Managing hypertension: a question of STRATHE
    F Zannad
    Department of Cardiovascular Disease, Clinical Investigation Center INSERM CHU, University Henri Poincare, Nancy, France
    J Hum Hypertens 19:S3-7. 2005
    ..The results of STRATHE provide further support for an antihypertensive management strategy involving the low-dose combination of perindopril (2 mg) and indapamide (0.625 mg)...
  10. doi request reprint Heart failure burden and therapy
    Faiez Zannad
    Departement of cardiology, INSERM, CIC9501 and U961, CHU Nancy, Hypertension and Heart Failure Unit, CHU, Nancy Universite, 54500 Vandoeuvre les Nancy, France
    Europace 11:v1-9. 2009
    ....
  11. ncbi request reprint Blood pressure-lowering efficacy of olmesartan relative to other angiotensin II receptor antagonists: an overview of randomized controlled studies
    Faiez Zannad
    Division of Hypertension and Preventive Cardiology, Department of Cardiology, Unité INSERM U 684, CIC INSERM CHU de Nancy, Hopital Jeanne d Arc, 54200 Dommartin Les Toul, France
    Fundam Clin Pharmacol 21:181-90. 2007
    ..Olmesartan efficacy was consistently at the highest end of the range of efficacy of ARBs studied...
  12. ncbi request reprint Profile of patients with type 2 diabetes in France and Italy
    Faiez Zannad
    INSERM, CIC 9501 et U684, CHU Nancy, France
    J Hypertens 26:S3-6. 2008
    ..Greater adherence to therapeutic targets recommended in guidelines will ensure that greater proportions of patients attain these treatment goals thereby reducing diabetes-related morbidity and mortality...
  13. ncbi request reprint Rationale and design of the Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure (EMPHASIS-HF)
    Faiez Zannad
    INSERM, Centre d Investigation Cliniques CIC 9501 and U961, CHU and Department of Cardiology, Nancy University, Nancy, France
    Eur J Heart Fail 12:617-22. 2010
    ..Doses are adjusted from 25 mg every other day to 50 mg daily, depending on serum potassium. The primary endpoint is a composite of time to cardiovascular death or first hospital admission for worsening HF, whichever occurs first...
  14. ncbi request reprint Extracellular matrix fibrotic markers in heart failure
    Faiez Zannad
    Hypertension and Heart Failure Unit, Department of Cardiology, Hopital Brabois, CHU de Nancy, Nancy, F 54000, France
    Heart Fail Rev 15:319-29. 2010
    ..Biomarkers may be selectively influenced by pharmacological agents...
  15. doi request reprint Heart failure as an endpoint in heart failure and non-heart failure cardiovascular clinical trials: the need for a consensus definition
    Faiez Zannad
    Hypertension and Preventive Cardiology Division, Department of Cardiovascular Disease, Centre d Investigations Cliniques INSERM CHU, INSERM U684, Hopital Jeanne d Arc, 54200 Dommartin Les Toul, Nancy, France
    Eur Heart J 29:413-21. 2008
    ..This paper examines issues related to defining heart failure events in cardiovascular clinical trials and presents a definition to formally address this issue...
  16. ncbi request reprint Profile of patients with type 2 diabetes in France and Italy
    Faiez Zannad
    INSERM, CIC 9501, INSERM, U684, CHU Nancy and Nancy University, Nancy, France
    J Hypertens Suppl 26:S3-6. 2008
    ..Greater adherence to therapeutic targets recommended in guidelines will ensure that greater proportions of patients attain these treatment goals thereby reducing diabetes-related morbidity and mortality...
  17. ncbi request reprint Clinical profile, contemporary management and one-year mortality in patients with severe acute heart failure syndromes: The EFICA study
    Faiez Zannad
    Department of Cardiology, University Hospital of Nancy, France
    Eur J Heart Fail 8:697-705. 2006
    ..Observational data may improve disease management and guide the design of clinical trials...
  18. ncbi request reprint Implications of the ADVANCE study for clinical practice
    Faiez Zannad
    INSERM, CIC 9501 et U684, CHU Nancy, France
    J Hypertens 26:S31-4. 2008
    ....
  19. ncbi request reprint Left bundle branch block as a risk factor for progression to heart failure
    Faiez Zannad
    CIC INSERM CHU de Nancy, Hopital Jeanne d Arc, Dommartin les Toul, BP 303 54201 Toul Cedex, France
    Eur J Heart Fail 9:7-14. 2007
    ..It also aims to address the potential for future clinical therapies for this conduction disorder...
  20. ncbi request reprint Double-blind, randomized, multicentre comparison of the effects of amlodipine and perindopril on 24 h therapeutic coverage and beyond in patients with mild to moderate hypertension. General Physicians Investigators' Group
    F Zannad
    Centre d Investigation Clinique de Nancy, INSERM Centre Hospitalier Universitaire, Nancy, France
    J Hypertens 17:137-46. 1999
    ..To compare the therapeutic coverage and safety of amlodipine and perindopril in patients with mild to moderate hypertension (diastolic blood pressure > or = 90 mmHg and < or = 109 mmHg)...
  21. ncbi request reprint Prevention of cardiovascular events in end-stage renal disease: results of a randomized trial of fosinopril and implications for future studies
    F Zannad
    Hypertension and Preventive Cardiology Division, Department of Cardiovascular Disease, Centre d Investigations Cliniques INSERM CHU, INSERM U684, Nancy, France
    Kidney Int 70:1318-24. 2006
    ..These trends may have become statistically significant had the sample size been larger, and these findings warrant further study...
  22. pmc Cardiovascular high-risk patients--treat to protect, but whom?
    Faiez Zannad
    Hypertension and Heart Failure Unit, INSERM Clinical Investigation Centre, Nancy, France
    Medscape J Med 10:S2. 2008
    ....
  23. doi request reprint Eplerenone in patients with systolic heart failure and mild symptoms
    Faiez Zannad
    INSERM, Centre d Investigation Clinique 9501 and Unité 961, and the Department of Cardiology, Nancy University, Nancy, France
    N Engl J Med 364:11-21. 2011
    ..We evaluated the effects of eplerenone in patients with chronic systolic heart failure and mild symptoms...
  24. ncbi request reprint [Effects of calcium antagonists on atherosclerosis progression and intima media thickness]
    F Zannad
    Centre d Investigations Cliniques INSERM CHU, Nancy, France
    Drugs 59:39-46. 2000
    ..A larger trial with a longer follow-up period should be performed in order to confirm the promising results of PREVENT...
  25. ncbi request reprint Implications of the ADVANCE study for clinical practice
    Faiez Zannad
    INSERM, CIC 9501 and U684, CHU Nancy, France
    J Hypertens Suppl 26:S29-32. 2008
    ....
  26. ncbi request reprint Incidence, determinants, and prognostic significance of hyperkalemia and worsening renal function in patients with heart failure receiving the mineralocorticoid receptor antagonist eplerenone or placebo in addition to optimal medical therapy: results from
    Patrick Rossignol
    INSERM, Centre d Investigations Cliniques 9501, and Inserm U1116, Nancy, France
    Circ Heart Fail 7:51-8. 2014
    ....
  27. doi request reprint Prognostic value of serum PIIINP, MMP1 and TIMP1 levels in hypertensive patients: a community-based prospective cohort study
    Nelly Agrinier
    INSERM, CIC EC, CIE6, Nancy, F 54 000, France
    Fundam Clin Pharmacol 27:572-80. 2013
    ..06; 95%CI [1.02-1.09]). Adjusting for confounders did not modify this result. Cardiac fibrosis, as assessed with serum ECM biomarkers, might develop early in hypertensive patients and is predictive of cardiovascular events or death...
  28. doi request reprint A role for cardiotrophin-1 in myocardial remodeling induced by aldosterone
    Natalia Lopez-Andres
    U, Faculty of Medicine, Institut National de la Sante et de la Recherche Medicale, Vandoeuvre les Nancy, France
    Am J Physiol Heart Circ Physiol 301:H2372-82. 2011
    ..CT-1-null mice were resistant to Aldo-induced LVH and fibrosis. These data suggest a key role for CT-1 in cardiac remodeling induced by Aldo independent of changes in blood pressure levels...
  29. doi request reprint Timing of eplerenone initiation and outcomes in patients with heart failure after acute myocardial infarction complicated by left ventricular systolic dysfunction: insights from the EPHESUS trial
    Chris Adamopoulos
    INSERM, Centre d Investigations Cliniques CIC Inserm CHU and U961, Hopital Jeanne d Arc, Toul 54200, France
    Eur J Heart Fail 11:1099-105. 2009
    ..To test the hypothesis that an earlier post-acute myocardial infarction (AMI) eplerenone initiation in patients with left ventricular systolic dysfunction (LVSD) and heart failure (HF) is associated with better long-term outcomes...
  30. doi request reprint Extracellular cardiac matrix biomarkers in patients with acute myocardial infarction complicated by left ventricular dysfunction and heart failure: insights from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EP
    Wafae Iraqi
    CHU de Nancy, Hopital Jeanne d Arc, Dommartin les Toul, France
    Circulation 119:2471-9. 2009
    ..Circulating biomarkers of collagen turnover provide a useful tool for the assessment of cardiac remodeling in patients with congestive heart failure and left ventricular systolic dysfunction after acute myocardial infarction...
  31. ncbi request reprint Residual stress ischaemia is associated with blood markers of myocardial structural remodelling
    Anca Radauceanu
    Centre d Investigation Clinique CIC CHU INSERM, Nancy, France
    Eur J Heart Fail 9:370-6. 2007
    ..Long-term prognosis of coronary artery disease (CAD) patients is worsened when stress ischemia persists on treatment, but the relationship with adverse cardiac remodelling had never been investigated...
  32. doi request reprint Safety and efficacy of eplerenone in patients at high risk for hyperkalemia and/or worsening renal function: analyses of the EMPHASIS-HF study subgroups (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure)
    Romain Eschalier
    Centre d Investigation Clinique Inserm CIC P 9501, Centre Hospitalier Universitaire de Nancy, Nancy, France Clermont University, Universite d Auvergne, UMR6284, and the Department of Cardiology, Clermont Ferrand, France
    J Am Coll Cardiol 62:1585-93. 2013
    ..73 m(2) and serum potassium <5.0 mmol/l. Patients were receiving optimal therapy and most had been hospitalized for a cardiovascular reason within 180 days of inclusion...
  33. doi request reprint Association of galectin-3 and fibrosis markers with long-term cardiovascular outcomes in patients with heart failure, left ventricular dysfunction, and dyssynchrony: insights from the CARE-HF (Cardiac Resynchronization in Heart Failure) trial
    Natalia Lopez-Andres
    INSERM U961, CIC Inserm CHU Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu, 4 Rue du Morvan, Vandoeuvre les Nancy, France
    Eur J Heart Fail 14:74-81. 2012
    ..Our aim was to determine, in patients with heart failure (HF) and cardiac dyssynchrony, whether ECCM biomarkers are influenced by CRT and can predict cardiovascular outcomes and response to CRT...
  34. ncbi request reprint Pulse wave velocity assessment by external noninvasive devices and phase-contrast magnetic resonance imaging in the obese
    Laure Joly
    Centre de Geriatrie et Medecine Interne, CHU de Nancy, rue du Morvan, 54511 Vandoeuvre les Nancy, France
    Hypertension 54:421-6. 2009
    ..Our results indicate that, for body mass index values < or =35 kg m(-2), PWV measured externally with Complior or PulsePen validly reflect values obtained directly in the thoracic aorta through MRI...
  35. doi request reprint Association study of gene polymorphisms involved in vascular alterations in elderly hypertensives with subjective memory complaints
    Ghassan Watfa
    Nancy University Hospital and Inserm Clinical Investigation Center, CIC9501, Nancy, France
    Dement Geriatr Cogn Disord 30:440-8. 2010
    ..The aim of the present study was to identify genetic variants associated with the degree of cognitive impairment and the severity of WMH in the same study population, focusing on genes involved in vascular alterations...
  36. ncbi request reprint Early changes in serum markers of cardiac extra-cellular matrix turnover in patients with uncomplicated hypertension and type II diabetes
    Francois Alla
    Epidemiology Department EA 3444, University Hospital, Nancy, France
    Eur J Heart Fail 8:147-53. 2006
    ..Our objective was to compare blood markers of collagen turnover among patients with CHF, patients with hypertension and type II diabetes (HD), and healthy individuals...
  37. doi request reprint Visit-to-visit blood pressure variability is a strong predictor of cardiovascular events in hemodialysis: insights from FOSIDIAL
    Patrick Rossignol
    Institut National de la Sante et de la Recherche Medicale, Centre d Investigations Cliniques 9501, CHU Nancy, Vandoeuvre les Nancy, France
    Hypertension 60:339-46. 2012
    ..Such assessments should be prioritized for testing prevention strategies in end-stage renal disease...
  38. doi request reprint Extracellular matrix turnover and inflammatory markers independently predict functional status and outcome in chronic heart failure
    Anca Radauceanu
    Centre d Investigation Clinique 9501, INSERM, Dommartin les Toul, France
    J Card Fail 14:467-74. 2008
    ..The relationship between markers of inflammation and of ECM remodeling, and their influence on functional status and outcomes has not been examined in a large cohort of CHF patients...
  39. doi request reprint Comprehensive MRI analysis of early cardiac and vascular remodeling in middle-aged patients with abdominal obesity
    Damien Mandry
    CHU Nancy, Department of Radiology, Nancy, France
    J Hypertens 30:567-73. 2012
    ....
  40. ncbi request reprint Differential time effect profiles of amlodipine, as compared to valsartan, revealed by ambulatory blood pressure monitoring, self blood pressure measurements and dose omission protocol
    Anca Radauceanu
    Centre d Investigation Clinique CIC INSERM CHU, Hopital Jeanne d Arc, 54201 Dommartin les Toul, France
    Fundam Clin Pharmacol 18:483-91. 2004
    ..valsartan [DBP (P < 0.04), SBP (n.s.)]. Ankle edema were more often reported in amlodipine group. These results suggest a superior BP lowering and a longer duration of action with amlodipine compared with valsartan...
  41. doi request reprint Statin therapy and clinical outcomes in myocardial infarction patients complicated by acute heart failure: insights from the EPHESUS trial
    Daniela Dobre
    INSERM, Center of Clinical Investigation 9501, Lorraine Institute of Heart and Vessels Louis Mathieu, University Hospital Nancy, France
    Eur J Heart Fail 15:221-7. 2013
    ..We aimed to assess the association between statin therapy and clinical outcomes in the setting of acute HF with systolic dysfunction complicating acute MI...
  42. doi request reprint [Official recommendations and guidelines for the management and reimbursement of severe hypertension as a chronic disease]
    Jean Marc Boivin
    Université Henri Poincaré et CIC Inserm de Nancy, Hopital Jeanne d Arc, F 54200 Dommartin les Toul, France
    Presse Med 38:652-60. 2009
    ..The ALD list should include severe hypertension as well as complicated and treatment-resistant hypertension, with the diagnosis documented by ambulatory or self blood pressure monitoring...
  43. doi request reprint Vascular structure and function is correlated to cognitive performance and white matter hyperintensities in older hypertensive patients with subjective memory complaints
    Anna Kearney-Schwartz
    Nancy University Hospital, Clinical Investigation Centre, J d Arc Hospital, Dommartin les Toul, France
    Stroke 40:1229-36. 2009
    ....
  44. ncbi request reprint Serum aldosterone is associated with mortality and re-hospitalization in patients with reduced ejection fraction hospitalized for acute heart failure: analysis from the EVEREST trial
    Nicolas Girerd
    INSERM, Centre d Investigations Cliniques 9501, Université de Lorraine, CHU de Nancy, Institut Lorrain du Cœur et des Vaisseaux, Nancy, France
    Eur J Heart Fail 15:1228-35. 2013
    ..Although the adverse effects of neurohormonal activation are well known in chronic HF, the prognostic significance of serum aldosterone in patients hospitalized for AHF has not been well studied...
  45. doi request reprint Opposite predictive value of pulse pressure and aortic pulse wave velocity on heart failure with reduced left ventricular ejection fraction: insights from an Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) s
    Veronique Regnault
    Inserm U1116, Faculte de Medecine, 9 ave de la forêt de Haye, 54500 Vandoeuvre les Nancy, France
    Hypertension 63:105-11. 2014
    ..In contrast, increased aortic stiffness, assessed by PWV, contributes significantly to cardiovascular death. ..
  46. doi request reprint Galectin-3 mediates aldosterone-induced vascular fibrosis
    Laurent Calvier
    INSERM, U961, Faculty of Medicine, Université de Lorraine, Vandoeuvre les Nancy, France
    Arterioscler Thromb Vasc Biol 33:67-75. 2013
    ..Galectin-3 (Gal-3), a β-galactoside-binding lectin, plays an important role in inflammation, fibrosis, and heart failure. We investigated here whether Gal-3 is involved in Aldo-induced vascular fibrosis...
  47. doi request reprint Extracellular matrix turnover biomarkers predict long-term left ventricular remodeling after myocardial infarction: insights from the REVE-2 study
    Romain Eschalier
    INSERM, Centre d Investigation Clinique CIC P 9501, Nancy, France
    Circ Heart Fail 6:1199-205. 2013
    ..The aim of the study was to evaluate whether biomarkers of myocardial fibrosis measurements 1 month after MI may predict left ventricular (LV) remodeling...
  48. ncbi request reprint Haemorheological disturbances in hypertensive type 2 diabetic patients--influence of antihypertensive therapy
    Anna Kearney-Schwartz
    Hopital Jeanne d Arc, CHU Nancy, Dommartin les Toul, F 54201, France
    Fundam Clin Pharmacol 21:387-96. 2007
    ..Other factors potentially contributing to rheology and arterial changes may be more critical in HT + DM patients and need further investigation...
  49. doi request reprint Visit-to-visit blood pressure variability and risk for progression of cardiovascular and renal diseases
    Patrick Rossignol
    INSERM, Centre d Investigations Cliniques 9501, France
    Curr Opin Nephrol Hypertens 22:59-64. 2013
    ....
  50. doi request reprint Determinants and consequences of renal function variations with aldosterone blocker therapy in heart failure patients after myocardial infarction: insights from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study
    Patrick Rossignol
    Centre d Investigations Cliniques INSERM CHU de Nancy, France
    Circulation 125:271-9. 2012
    ....
  51. doi request reprint C-reactive protein (CRP) increases VEGF-A expression in monocytic cells via a PI3-kinase and ERK 1/2 signaling dependent pathway
    Gaelle Bello
    INSERM, U684, Vandoeuvre les Nancy, F 54500 France
    Atherosclerosis 200:286-93. 2008
    ..CRP increases VEGF-A expression via a PI3-kinase and an extracellular-signal-regulated kinase (ERK) 1/2 dependent pathway. Our results suggest that CRP could play a role in the angiogenesis process via immune cells such as monocytes...
  52. ncbi request reprint Initial infarct size predicts subsequent cardiac remodeling in the rat infarct model: an in vivo serial pinhole gated SPECT study
    Fatiha Maskali
    UHP INSERM U684, Faculty of Medicine, Nancy, France
    J Nucl Med 47:337-44. 2006
    ..The aim of this study was to assess this new imaging technique for predicting and quantifying variable LV remodeling from the rat infarct model...
  53. ncbi request reprint Serum BNP, hs-C-reactive protein, procollagen to assess the risk of ventricular tachycardia in ICD recipients after myocardial infarction
    Hugues Blangy
    Departement de Cardiologie, CHU de Nancy, Hopital de Brabois, rue du Morvan, 54511, Vandoeuvre les Nancy, France
    Europace 9:724-9. 2007
    ....
  54. doi request reprint Sympathetic-leptin relationship in obesity: effect of weight loss
    Didier Quilliot
    centre d investigation clinique, INSERM CHU, Nancy, France
    Metabolism 57:555-62. 2008
    ..Our results imply therefore that the relationship between leptin and the autonomic nervous system is disturbed in normotensive obese subjects...
  55. ncbi request reprint Predictors of cardiovascular events in patients with end-stage renal disease: an analysis from the Fosinopril in dialysis study
    Michele Kessler
    Department of Nephrology, University Hospital of Nancy, Nancy, France
    Nephrol Dial Transplant 22:3573-9. 2007
    ..A risk prediction model was created from the FOSIDIAL trial to identify factors predictive of CVE and to evaluate the relative strength of known predictors when considered together in a multivariate model...
  56. doi request reprint Left bundle branch block and mortality in patients with acute heart failure syndrome: a substudy of the EFICA cohort
    Etienne Huvelle
    CIC INSEM CHU, Nancy, Hopital Jeanne d Arc, BP 90303, 54201 Toul Cedex, France
    Eur J Heart Fail 12:156-63. 2010
    ..We aimed to investigate the association of LBBB with short- and long-term outcome in patients discharged after a de novo episode of acute heart failure (AHF) or AHF complicating a mild CHF...
  57. doi request reprint Can we prevent or treat renal dysfunction in chronic heart failure?
    Daniela Dobre
    INSERM, Center of Clinical Investigation 9501, University Hospital Nancy, Lorrain Institute of Heart and Vessels Louis Mathieu, 4, rue du Morvan, 54500 Vandoeuvre les Nancy, France
    Heart Fail Rev 17:283-90. 2012
    ..In conclusion, prevention of renal dysfunction is possible in CHF, but treatment is still under investigation. New studies are necessary to establish whether a specific algorithm may be used to prevent renal dysfunction in CHF patients...
  58. ncbi request reprint Epidemiology of acute heart failure syndromes
    Francois Alla
    Epidemiology, INSERM University Hospital, Nancy University, Nancy, France
    Heart Fail Rev 12:91-5. 2007
    ..Further epidemiological and clinical research is needed to improve our understanding of AHFS, thereby enhancing patient care...
  59. ncbi request reprint Effect of MR blockade on collagen formation and cardiovascular disease with a specific emphasis on heart failure
    Faiez Zannad
    Department of Cardiology, Division of Heart Failure, Hypertension and Preventive Cardiolgy, and Centre d Investigation Clinique CIC INSERM CHU, University Henri Poincare, Nancy, France
    Heart Fail Rev 10:71-8. 2005
    ..Understanding various autocrine/paracrine mechanisms involved in extracellular matrix remodeling in heart failure represents a major challenge, essential for developing new cardioreparative and cardioprotective strategies...
  60. ncbi request reprint Treatment of congestive heart failure: interfering the aldosterone-cardiac extracellular matrix relationship
    F Zannad
    Centre d'Investigation Clinique INSERM-CHU, Centre Hospitalier Universitaire, Equipe d'Accueil EA 2403, , Nancy, France
    Hypertension 38:1227-32. 2001
    ....
  61. ncbi request reprint Gene expression profile of blood cells for the prediction of delayed cerebral ischemia after intracranial aneurysm rupture: a pilot study in humans
    Antoine Baumann
    service de réanimation neurochirurgicale, Centre Hospitalier Universitaire de Nancy, Hopital Central, Nancy, France
    Cerebrovasc Dis 36:236-42. 2013
    ..The single gene approach of DCI has demonstrated interest in humans. We hypothesized that whole genome expression profile of blood cells may be useful for better comprehension and prediction of aneurysmal DCI...
  62. ncbi request reprint FOSIDIAL: a randomised placebo controlled trial of the effects of fosinopril on cardiovascular morbidity and mortality in haemodialysis patients. Study design and patients' baseline characteristics
    Faiez Zannad
    Hypertension and Preventive Cardiology Division, Department of Cardiovascular Disease, and Centre d Investigations Cliniques INSERM CHU, Toul, France
    Fundam Clin Pharmacol 16:353-60. 2002
    ..All patients were included by December 2000 and follow-up is ongoing. The last visit for the last patient is scheduled for 30 December 2002. We report here on the study design and the baseline characteristics of the study population...
  63. doi request reprint Influence of the recommendations on the implementation of home blood pressure measurement by French general practitioners: a 2004-2009 longitudinal survey
    Jean Marc Boivin
    Clinical Investigation Center Inserm CIC9501, Lorrain du Coeur et des Vaisseaux Louis Mathieu, Nancy, France
    J Hypertens 29:2105-15. 2011
    ....
  64. ncbi request reprint [Angiotensin-converting enzyme inhibitors in congestive heart failure: clinical practice guidelines]
    Nathalie Thilly
    Service d Epidémiologie et Evaluation Cliniques UPRES EA1124, Hopital Marin, CHU Nancy, Nancy, France
    Therapie 58:341-9. 2003
    ..The drafting of the clinical practice guidelines is the first step in a quality improvement programme, initiated in 1999 in the cardiology wards of the region...
  65. ncbi request reprint Improving ACE inhibitor use in patients hospitalized with systolic heart failure: a cluster randomized controlled trial of clinical practice guideline development and use
    Nathalie Thilly
    Service d épidémiologie et évaluation cliniques UPRES EA3444, CHU Nancy, Nancy, France
    J Eval Clin Pract 9:373-82. 2003
    ..This study aimed to evaluate the effect of developing and implementing Clinical Practice Guidelines (CPGs) on the quality of care given to patients receiving ACE inhibitors for systolic heart failure...
  66. ncbi request reprint Biomarkers of extracellular matrix turnover
    Faiez Zannad
    Hopital Jeanne d Arc, Dommartin les Toul, France
    Heart Fail Clin 5:589-99. 2009
    ..ECCM biomarkers are clinically useful tools, particularly given the potential for cardioprotective and cardioreparative pharmacologic strategies...
  67. ncbi request reprint Heart failure with systolic dysfunction complicating acute myocardial infarction - differential outcomes but similar eplerenone efficacy by ST-segment or non-ST-segment elevation: A post hoc substudy of the EPHESUS trial
    Sylvain Carillo
    INSERM U961, Cardiology, centre d investigations cliniques CIC9501, Institut Lorrain du Cœur et des Vaisseaux, CHU de Nancy, 2, avenue du Morvan, 54500 Vandoeuvre les Nancy, France Electronic address
    Arch Cardiovasc Dis 107:149-57. 2014
    ....
  68. doi request reprint Heart rate: a prognostic factor and therapeutic target in chronic heart failure. The distinct roles of drugs with heart rate-lowering properties
    Daniela Dobre
    INSERM, Center of Clinical Investigation 9501, Institut Lorrain du Coeur et des Vaisseaux, CHU Nancy, Université de Lorraine, Nancy, France
    Eur J Heart Fail 16:76-85. 2014
    ....
  69. ncbi request reprint Changes in first-pass interstitial kinetics of DTPA in myocardium submitted to low-flow ischemia
    Fatiha Maskali
    Department of Nuclear Medicine, Unité mixte UHP Inserm U684, and the Laboratory of Hematology and Physiology, Faculty of Pharmacy, University Henri Poincare, Nancy, France
    Invest Radiol 40:766-72. 2005
    ..This study aimed to determine the changes during ischemia in the myocardial first-pass kinetics of DTPA, an extracellular tracer that is currently used for assessing myocardial perfusion with magnetic resonance imaging (Magnevist)...
  70. doi request reprint Eplerenone survival benefits in heart failure patients post-myocardial infarction are independent from its diuretic and potassium-sparing effects. Insights from an EPHESUS (Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival St
    Patrick Rossignol
    INSERM, Centre d Investigations Cliniques 9501, Nancy, France
    J Am Coll Cardiol 58:1958-66. 2011
    ....
  71. ncbi request reprint Effectiveness of a multidimensional home nurse led heart failure disease management program--a French nationwide time-series comparison
    Nelly Agrinier
    INSERM, CIC EC, CIE6, Nancy F 54 000, France CHU Nancy, Epidémiologie et Evaluation Cliniques, Nancy F 54 000, France Université de Lorraine, Universite Paris Descartes, APEMAC, EA 4360, Nancy F 54 000, France
    Int J Cardiol 168:3652-8. 2013
    ..The purpose of this study was to assess the effectiveness of a disease management program (DMP) in heart failure (HF) on the incidence of HF hospitalizations and related costs in a real-world population-based setting...
  72. ncbi request reprint Self-rating of quality of life provides additional prognostic information in heart failure. Insights into the EPICAL study
    Francois Alla
    Department of Epidemiology, University Hospital, Nancy, France
    Eur J Heart Fail 4:337-43. 2002
    ..The aim of this study was to determine the value of QoL score as a prognostic factor in a prospective cohort of patients with advanced chronic heart failure (CHF)...
  73. ncbi request reprint Effects of sibutramine on ventricular dimensions and heart valves in obese patients during weight reduction
    Faiez Zannad
    Centre d Investigation Clinique INSERM, CHU de Nancy, Hopital Jeanne d Arc, Toul, France
    Am Heart J 144:508-15. 2002
    ..In obese subjects, weight reduction regresses LV mass (LVM), regardless of blood pressure. Sibutramine can increase blood pressure and heart rate, which may attenuate the reductions in LVM associated with weight loss...
  74. ncbi request reprint Exercise release of cardiac natriuretic peptides is markedly enhanced when patients with coronary artery disease are treated medically by beta-blockers
    Pierre Yves Marie
    Department of Nuclear Medicine, UPRES EA 3447, Nancy, France
    J Am Coll Cardiol 43:353-9. 2004
    ..This study sought to identify determinants of the exercise rise in plasma levels of cardiac natriuretic peptides (NPs) in patients with coronary artery disease (CAD)...
  75. ncbi request reprint Time-effect profile of antihypertensive agents assessed with trough/peak ratio, smoothness index and dose omission: an ambulatory blood pressure monitoring study with trandolapril vs. quinapril
    Anca Radauceanu
    Centre d Investigation Clinique CIC, INSERM CHU de Nancy, France
    Fundam Clin Pharmacol 16:545-54. 2002
    ..Nevertheless, residual lowering of blood pressure at 48-h trough suggests that Tra had a longer duration of action than Qui...
  76. ncbi request reprint Aldosterone and telomere length in white blood cells
    Athanase Benetos
    INSERM Unit 684, University of Nancy, 54511 Nancy les Vandoeuvre, France
    J Gerontol A Biol Sci Med Sci 60:1593-6. 2005
    ..The aim of the present study was, therefore, to examine the relationship between plasma aldosterone and telomere length in WBCs...
  77. ncbi request reprint Residual exercise SPECT ischemia on treatment is a main determinant of outcome in patients with coronary artery disease treated medically at long-term with beta-blockers
    Pierre Y Marie
    Department of Nuclear Medicine and Cardiology, UPRES EA 3447, CHU Nancy Brabois, 54511 Vandoeuvre Cedex, France
    J Nucl Cardiol 10:361-8. 2003
    ..However, it is not known whether beta-blockers have the same beneficial prognostic effect when residual ischemia persists on treatment...
  78. ncbi request reprint Incidence, clinical and etiologic features, and outcomes of advanced chronic heart failure: the EPICAL Study. Epidémiologie de l'Insuffisance Cardiaque Avancée en Lorraine
    F Zannad
    Cardiology Department, centre d investigation clinique, INSERM CHU, Nancy, France
    J Am Coll Cardiol 33:734-42. 1999
    ..Characterize the incidence, clinical and etiologic features and outcomes of advanced congestive heart failure...
  79. ncbi request reprint Effects of medical therapy on outcome assessment using exercise thallium-201 single photon emission computed tomography imaging: evidence of a protective effect of beta-blocking antianginal medications
    P Y Marie
    Department of Nuclear Medicine, UPRES EA 2403, CHU Nancy, France
    J Am Coll Cardiol 34:113-21. 1999
    ..The purpose of this study was to determine whether antianginal medications modify the prognostic significance of exercise single photon emission computed tomography (SPECT) ischemia...
  80. ncbi request reprint Differential effects of fosinopril and enalapril in patients with mild to moderate chronic heart failure. Fosinopril in Heart Failure Study Investigators
    F Zannad
    Department of Cardiology, Centre d Investigation Clinique INSERM CHU, University Henri Poincare, Nancy, France
    Am Heart J 136:672-80. 1998
    ....
  81. ncbi request reprint Ambulatory 24-h blood pressure assessment of the felodipine-metoprolol combination versus amlodipine in mild to moderate hypertension. Lorraine General Physician Investigators Group
    F Zannad
    centre d investigation clinique, INSERM CHU, Nancy, France
    J Hypertens 17:1023-32. 1999
    ....
  82. ncbi request reprint Differential clinical prognostic classifications in dilated and ischemic advanced heart failure: the EPICAL study
    F Alla
    Department of Epidemiology and Cardiology, University Hospital, Nancy, France
    Am Heart J 139:895-904. 2000
    ..The clinical management of severe congestive heart failure (CHF) should be graded according to the prognosis of each individual patient. Our objective was to elaborate a prognostic rating system for severe CHF...
  83. ncbi request reprint Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES). Rales Investigators
    F Zannad
    Centre d Investigation Clinique INSERM CHU, Laboratory of Biochemistry, Centre Hospitalier Universitaire, University Henri Poincare, Nancy, France
    Circulation 102:2700-6. 2000
    ..It has been suggested that spironolactone may decrease cardiac fibrosis. We investigated the interactions between serum markers of cardiac fibrosis and the effect of spironolactone on outcome in patients with CHF...
  84. ncbi request reprint Endothelial dysfunction and type 2 diabetes. Part 2: altered endothelial function and the effects of treatments in type 2 diabetes mellitus
    B Guerci
    Service de Diabetologie, Maladies Metaboliques et Maladies de la Nutrition, Hopital Jeanne d Arc, CHU de Nancy, B P 303, 54201 Toul, Cedex
    Diabetes Metab 27:436-47. 2001
    ..Finally, recent reports indicate that an improved metabolic control in diabetic patients, whatever the treatment used, is associated with near normalization or restoration of normal endothelial function...
  85. ncbi request reprint Impaired autonomic control of heart rate and blood pressure in obesity: role of age and of insulin-resistance
    D Quilliot
    centre d investigation clinique, INSERM CHU, Nancy, France
    Clin Auton Res 11:79-86. 2001
    ..Decreased HR and BP variability could partly account for the higher cardiovascular risk and incidence of sudden death in obese persons...
  86. ncbi request reprint Environmental and genetic determinants of intima-media thickness of the carotid artery
    F Zannad
    Centre d Investigation Clinique INSERM CHU de Nancy, France
    Clin Exp Pharmacol Physiol 28:1007-10. 2001
    ..8. In women, none of the studied polymorphisms was associated with CIMT variation. 9. Our study gives new perspectives for understanding CIMT variability in healthy middle-aged subjects...
  87. ncbi request reprint Myocardial collagen turnover in normotensive obese patients: relation to insulin resistance
    D Quilliot
    Service de Diabetologie, Maladies Métaboliques et de Nutrition, Hopital Jeanne d Arc, Centre Hospitalier Universitaire de Nancy, Nancy, France
    Int J Obes (Lond) 29:1321-8. 2005
    ....
  88. ncbi request reprint Endothelial dysfunction and type 2 diabetes. Part 1: physiology and methods for exploring the endothelial function
    B Guerci
    Service de Diabetologie, Maladies Metaboliques et Maladies de la Nutrition, Hopital Jeanne d Arc, CHU de Nancy, B P 303, 54201 Toul Cedex
    Diabetes Metab 27:425-34. 2001
    ..Finally, recent reports indicate that an improved metabolic control in diabetic patients, whatever the treatment used, is associated with near normalization or restoration of normal endothelial function...
  89. doi request reprint C-reactive protein induces pro- and anti-inflammatory effects, including activation of the liver X receptor alpha, on human monocytes
    Didier Hanriot
    INSERM, U684, Nancy, France
    Thromb Haemost 99:558-69. 2008
    ..Among these novel anti-inflammatory effects, we show clearly that CRP activates the LXRalpha pathway...
  90. ncbi request reprint Impaired response of cardiac autonomic nervous system to glucose load in severe obesity
    Didier Quilliot
    centre d investigation clinique, France
    Metabolism 54:966-74. 2005
    ..We hypothesized that, as a consequence of insulin resistance, an inability of insulin to increase the sympathetic modulation of heart rate (HR) and blood pressure (BP) would be observed in normotensive obese patients...
  91. ncbi request reprint Anaphylactic shock: a form of distributive shock without inhibition of oxygen consumption
    Pascale Dewachter
    département d anesthésie réanimation chirurgicale, Centre Hospitalier Universitaire, Nancy, France
    Anesthesiology 103:40-9. 2005
    ..It is described as distributive by analogy with septic shock (anaerobic metabolism, high tissue oxygen pressure [Ptio2] values). The Ptio2 profile and its metabolic consequences during anaphylaxis are not known...
  92. ncbi request reprint [Performance evaluation of a tool for institutional protocol quality assurance]
    Laura Zanetti
    Centre d Investigation Clinique CIC, INSERM CHU, Hopital Jeanne d Arc, Dommartin les Toul, France
    Therapie 60:527-37. 2005
    ..The Clinical Research Centre (CIC) of Nancy developed a checklist-based tool aimed at evaluating the quality of institutional protocols...
  93. ncbi request reprint Antithrombotic therapy is associated with better survival in patients with severe heart failure and left ventricular systolic dysfunction (EPICAL study)
    M Echemann
    Service d Epidémiologie et d Evaluation cliniques, Hopital Marin, CHU Nancy, France
    Eur J Heart Fail 4:647-54. 2002
    ..The aim of this work was to identify the relationship between cardiovascular drug use, especially antithrombotic therapy, and survival of CHF patients in current clinical practice, using an observational, population-based database...
  94. ncbi request reprint Trough/peak ratios of once daily angiotensin converting enzyme inhibitors and calcium antagonists
    F Zannad
    Clinical Pharmacology and Cardiology Department, , Centre Hospitalier Universitaire, Nancy, France
    Am J Hypertens 9:633-43. 1996
    ..This may have important clinical implications...
  95. pmc Association between resting heart rate, chronotropic index, and long-term outcomes in patients with heart failure receiving β-blocker therapy: data from the HF-ACTION trial
    Daniela Dobre
    INSERM, Center of Clinical Investigation 9501, University Hospital Nancy, Lorrain Institute of Heart and Vessels Louis Mathieu, 4, rue du Morvan, 54500 Vandoeuvre les Nancy, France
    Eur Heart J 34:2271-80. 2013
    ..The aim of this study was to assess the association between resting heart rate (HR), chronotropic index (CI), and clinical outcomes in optimally treated chronic heart failure (HF) patients on β-blocker therapy...
  96. ncbi request reprint Genetics of intima-media thickness
    Faiez Zannad
    Department of Cardiovascular Disease, Division of Hypertension and Preventive Cardiology, Equipe d Accueil 3447, Clinical Investigation Center INSERM CHU, University Henri Poincare, Nancy, France
    Curr Opin Lipidol 14:191-200. 2003
    ..The aim of this paper is to review the most recent available data on the genetic determinants of carotid intima-media thickness...
  97. ncbi request reprint Pharmacogenomics in cardiovascular clinical trials
    R Shah
    CIC Inserm CHU, Hopital Jeanne d Arc, 54200 Dommartin Les Toul, France
    Fundam Clin Pharmacol 18:705-8. 2004
    ..Physicians will need to understand the concept of genetic variability, its interactions with the environment (e.g. drug-drug or drug-disease interactions), and its implication for patient care...
  98. ncbi request reprint Effects of blood pressure control on radial artery diameter and compliance in hypertensive patients
    Y Khder
    Department of Clinical Pharmacology, INSERM-CHU, University Henri Poincare, Nancy, France
    Am J Hypertens 10:269-74. 1997
    ..The results of this cross-sectional study suggest that compliance abnormalities of the radial artery, but not internal diameter changes may be reversed by effective therapeutic control of blood pressure in arterial hypertension...
  99. doi request reprint Loop diuretics and ultrafiltration in heart failure
    Patrick Rossignol
    INSERM, Centre d Investigations Cliniques, Université de Lorraine and CHU de Nancy, 9501, UMR 1116, Vandoeuvre les Nancy, France
    Expert Opin Pharmacother 14:1641-8. 2013
    ..Their efficacy and safety compared to venous ultrafiltration are currently under investigation in acute decompensated HF patients...
  100. ncbi request reprint [Proposal of a tool for providing patients with the main results of clinical research studies]
    Camille Ducki
    centre d investigation clinique, Hopital Jeanne d Arc, Dommartin les Toul, France
    Therapie 60:545-51. 2005
    ..However, no precise directives or information are provided to investigators and sponsors on how to implement this...
  101. ncbi request reprint [Management, cost and mortality of a cohort of patients with advanced heart failure (the EPICAL study)]
    F Fagnani
    , , CHU Nancy, France
    Therapie 56:5-10. 2001
    ..These findings confirmed the major clinical and economic interest of any intervention that could lower the rate of readmissions in this group of patients...