Faiez Zannad

..A combined endpoint assessing survival and rehospitalisation rates is becoming increasingly popular for acute therapies. Specific trials may also need to be designed according to the time of access to the patient...

..When used appropriately, MRAs significantly improve outcomes across the spectrum of patients with HF-REF...

..In conclusion, opportunities exist to increase guideline implementation in the primary care setting, with potential benefits for both the general population and healthcare resources...

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..However, their additional value above and beyond classical risk factors has yet to be determined for risk-guided therapy in CVD prevention...

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..The results of STRATHE provide further support for an antihypertensive management strategy involving the low-dose combination of perindopril (2 mg) and indapamide (0.625 mg)...

..Biomarkers may be selectively influenced by pharmacological agents...

..We evaluated the effects of eplerenone in patients with chronic systolic heart failure and mild symptoms...

..Observational data may improve disease management and guide the design of clinical trials...

..CONCLUSION: The study will be complete when approximately 813 subjects experience a primary endpoint. Clinical Trials.gov. NCT00232180...

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..Greater adherence to therapeutic targets recommended in guidelines will ensure that greater proportions of patients attain these treatment goals thereby reducing diabetes-related morbidity and mortality...

..These trends may have become statistically significant had the sample size been larger, and these findings warrant further study...

..A larger trial with a longer follow-up period should be performed in order to confirm the promising results of PREVENT...

..This paper examines issues related to defining heart failure events in cardiovascular clinical trials and presents a definition to formally address this issue...

..Greater adherence to therapeutic targets recommended in guidelines will ensure that greater proportions of patients attain these treatment goals thereby reducing diabetes-related morbidity and mortality...

..Olmesartan efficacy was consistently at the highest end of the range of efficacy of ARBs studied...

..To compare the therapeutic coverage and safety of amlodipine and perindopril in patients with mild to moderate hypertension (diastolic blood pressure > or = 90 mmHg and < or = 109 mmHg)...

..It also aims to address the potential for future clinical therapies for this conduction disorder...

..CT-1-null mice were resistant to Aldo-induced LVH and fibrosis. These data suggest a key role for CT-1 in cardiac remodeling induced by Aldo independent of changes in blood pressure levels...

..To test the hypothesis that an earlier post-acute myocardial infarction (AMI) eplerenone initiation in patients with left ventricular systolic dysfunction (LVSD) and heart failure (HF) is associated with better long-term outcomes...

..Circulating biomarkers of collagen turnover provide a useful tool for the assessment of cardiac remodeling in patients with congestive heart failure and left ventricular systolic dysfunction after acute myocardial infarction...

..Our aim was to determine, in patients with heart failure (HF) and cardiac dyssynchrony, whether ECCM biomarkers are influenced by CRT and can predict cardiovascular outcomes and response to CRT...

..The aim of the present study was to identify genetic variants associated with the degree of cognitive impairment and the severity of WMH in the same study population, focusing on genes involved in vascular alterations...

..Such assessments should be prioritized for testing prevention strategies in end-stage renal disease...

..Our results indicate that, for body mass index values < or =35 kg m(-2), PWV measured externally with Complior or PulsePen validly reflect values obtained directly in the thoracic aorta through MRI...

..The relationship between markers of inflammation and of ECM remodeling, and their influence on functional status and outcomes has not been examined in a large cohort of CHF patients...

..valsartan [DBP (P < 0.04), SBP (n.s.)]. Ankle edema were more often reported in amlodipine group. These results suggest a superior BP lowering and a longer duration of action with amlodipine compared with valsartan...

..The ALD list should include severe hypertension as well as complicated and treatment-resistant hypertension, with the diagnosis documented by ambulatory or self blood pressure monitoring...

..Long-term prognosis of coronary artery disease (CAD) patients is worsened when stress ischemia persists on treatment, but the relationship with adverse cardiac remodelling had never been investigated...

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..CRP increases VEGF-A expression via a PI3-kinase and an extracellular-signal-regulated kinase (ERK) 1/2 dependent pathway. Our results suggest that CRP could play a role in the angiogenesis process via immune cells such as monocytes...

..Our objective was to compare blood markers of collagen turnover among patients with CHF, patients with hypertension and type II diabetes (HD), and healthy individuals...

..Galectin-3 (Gal-3), a β-galactoside-binding lectin, plays an important role in inflammation, fibrosis, and heart failure. We investigated here whether Gal-3 is involved in Aldo-induced vascular fibrosis...

..Our results imply therefore that the relationship between leptin and the autonomic nervous system is disturbed in normotensive obese subjects...

..A risk prediction model was created from the FOSIDIAL trial to identify factors predictive of CVE and to evaluate the relative strength of known predictors when considered together in a multivariate model...

..We aimed to investigate the association of LBBB with short- and long-term outcome in patients discharged after a de novo episode of acute heart failure (AHF) or AHF complicating a mild CHF...

..Other factors potentially contributing to rheology and arterial changes may be more critical in HT + DM patients and need further investigation...

..In conclusion, prevention of renal dysfunction is possible in CHF, but treatment is still under investigation. New studies are necessary to establish whether a specific algorithm may be used to prevent renal dysfunction in CHF patients...

..Further epidemiological and clinical research is needed to improve our understanding of AHFS, thereby enhancing patient care...

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..Understanding various autocrine/paracrine mechanisms involved in extracellular matrix remodeling in heart failure represents a major challenge, essential for developing new cardioreparative and cardioprotective strategies...

..The aim of this study was to assess this new imaging technique for predicting and quantifying variable LV remodeling from the rat infarct model...

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..All patients were included by December 2000 and follow-up is ongoing. The last visit for the last patient is scheduled for 30 December 2002. We report here on the study design and the baseline characteristics of the study population...

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..ECCM biomarkers are clinically useful tools, particularly given the potential for cardioprotective and cardioreparative pharmacologic strategies...

..This study aimed to evaluate the effect of developing and implementing Clinical Practice Guidelines (CPGs) on the quality of care given to patients receiving ACE inhibitors for systolic heart failure...

..The drafting of the clinical practice guidelines is the first step in a quality improvement programme, initiated in 1999 in the cardiology wards of the region...

..We aimed to assess the association between statin therapy and clinical outcomes in the setting of acute HF with systolic dysfunction complicating acute MI...

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..The aim of this study was to determine the value of QoL score as a prognostic factor in a prospective cohort of patients with advanced chronic heart failure (CHF)...

..In obese subjects, weight reduction regresses LV mass (LVM), regardless of blood pressure. Sibutramine can increase blood pressure and heart rate, which may attenuate the reductions in LVM associated with weight loss...

..The aim of the present study was, therefore, to examine the relationship between plasma aldosterone and telomere length in WBCs...

..However, it is not known whether beta-blockers have the same beneficial prognostic effect when residual ischemia persists on treatment...

..This study sought to identify determinants of the exercise rise in plasma levels of cardiac natriuretic peptides (NPs) in patients with coronary artery disease (CAD)...

..Nevertheless, residual lowering of blood pressure at 48-h trough suggests that Tra had a longer duration of action than Qui...

..8. In women, none of the studied polymorphisms was associated with CIMT variation. 9. Our study gives new perspectives for understanding CIMT variability in healthy middle-aged subjects...

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..Characterize the incidence, clinical and etiologic features and outcomes of advanced congestive heart failure...

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..The purpose of this study was to determine whether antianginal medications modify the prognostic significance of exercise single photon emission computed tomography (SPECT) ischemia...

..It has been suggested that spironolactone may decrease cardiac fibrosis. We investigated the interactions between serum markers of cardiac fibrosis and the effect of spironolactone on outcome in patients with CHF...

..The clinical management of severe congestive heart failure (CHF) should be graded according to the prognosis of each individual patient. Our objective was to elaborate a prognostic rating system for severe CHF...

..Finally, recent reports indicate that an improved metabolic control in diabetic patients, whatever the treatment used, is associated with near normalization or restoration of normal endothelial function...

..Finally, recent reports indicate that an improved metabolic control in diabetic patients, whatever the treatment used, is associated with near normalization or restoration of normal endothelial function...

..Decreased HR and BP variability could partly account for the higher cardiovascular risk and incidence of sudden death in obese persons...

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..We hypothesized that, as a consequence of insulin resistance, an inability of insulin to increase the sympathetic modulation of heart rate (HR) and blood pressure (BP) would be observed in normotensive obese patients...

..This could explain rapid organ dysfunction and resuscitation difficulties...

..Initiation of quality assurance tools, such as the one used in this study, was associated with some spontaneous improvement, but did not improve the result significantly...

..This study aimed to determine the changes during ischemia in the myocardial first-pass kinetics of DTPA, an extracellular tracer that is currently used for assessing myocardial perfusion with magnetic resonance imaging (Magnevist)...

..This may have important clinical implications...

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..Among these novel anti-inflammatory effects, we show clearly that CRP activates the LXRalpha pathway...

..The aim of this paper is to review the most recent available data on the genetic determinants of carotid intima-media thickness...

..The results of this cross-sectional study suggest that compliance abnormalities of the radial artery, but not internal diameter changes may be reversed by effective therapeutic control of blood pressure in arterial hypertension...

..Physicians will need to understand the concept of genetic variability, its interactions with the environment (e.g. drug-drug or drug-disease interactions), and its implication for patient care...

..CONCLUSION: After analysis of their answers, we worked out the bases of our tool. This tool is tested in an implementation phase...

..These findings confirmed the major clinical and economic interest of any intervention that could lower the rate of readmissions in this group of patients...

..Those with heart failure or impaired left ventricular left ventricular function after acute myocardial infarction have high complication and mortality rates. Little is known about outcomes with contemporary therapies in these patients...

..The extent of public awareness in Europe is not known...

..Furthermore, evidence in favour of combining an ACE inhibitor and an ARB in certain circumstances is continuously growing...

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..The results of EVEREST will determine whether these effects translate into improved clinical outcomes...

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..Studies in experimental models and preliminary clinical experience suggested a possible therapeutic role for the soluble tumor necrosis factor antagonist etanercept in heart failure...

..The results are expected for 2007...

..This study compared LVH regression during treatment with the selective aldosterone blocker eplerenone, enalapril, and their combination in patients with hypertension...

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..In diabetic hypertensive patients, 20 mg/d quinapril plus 5 mg/d amlodipine besylate was a more effective BP-lowering strategy than monotherapy with 40 mg/d quinapril...