Jean Francois Timsit

Summary

Affiliation: CHU de Grenoble
Country: France

Publications

  1. doi New challenges in the diagnosis, management, and prevention of central venous catheter-related infections
    Jean Francois Timsit
    University Hospital Albert Michalon, Medical ICU, Grenoble, France
    Semin Respir Crit Care Med 32:139-50. 2011
  2. doi EMPIRICUS micafungin versus placebo during nosocomial sepsis in Candida multi-colonized ICU patients with multiple organ failures: study protocol for a randomized controlled trial
    Jean Francois Timsit
    University Grenoble 1, Intensive Care Unit, Albert Michallon Hospital, BP 217, 38043 Grenoble, Cedex 9, France
    Trials 14:399. 2013
  3. pmc Comparison of four skin preparation strategies to prevent catheter-related infection in intensive care unit (CLEAN trial): a study protocol for a randomized controlled trial
    Véronique Goudet
    Medical Intensive Care Unit, CHU de Poitiers, Poitiers, France
    Trials 14:114. 2013
  4. pmc Investigating hospital heterogeneity with a multi-state frailty model: application to nosocomial pneumonia disease in intensive care units
    Benoit Liquet
    Univ Bordeaux, ISPED, Centre INSERM U 897 Epidemiologie Biostatistique, Bordeaux, F 33000, France
    BMC Med Res Methodol 12:79. 2012
  5. pmc How to deal with dialysis catheters in the ICU setting
    Natacha Mrozek
    Rà animation mà dicale, Hà pital Gabriel Montpied CHU Clermont Ferrand, Clermont Ferrand, 63000, France
    Ann Intensive Care 2:48. 2012
  6. doi Randomized controlled trial of chlorhexidine dressing and highly adhesive dressing for preventing catheter-related infections in critically ill adults
    Jean Francois Timsit
    Université Grenoble 1 Joseph Fourrier U823 Outcome of Cancers and Critical Illness, Albert Bonniot Institute, 38076, La Tronche, France
    Am J Respir Crit Care Med 186:1272-8. 2012
  7. doi Update on bloodstream infections in ICUs
    Jean Francois Timsit
    Integrated Research Center U823, Albert Bonniot Institute, University Grenoble 1, La Tronche, France
    Curr Opin Crit Care 18:479-86. 2012
  8. ncbi A multicentre analysis of catheter-related infection based on a hierarchical model
    J F Timsit
    Medical Polyvalent ICU, University Hospital Albert Michallon, Grenoble 1 University, 38000 Grenoble, France
    Intensive Care Med 38:1662-72. 2012
  9. doi Dressing disruption is a major risk factor for catheter-related infections
    Jean Francois Timsit
    University Joseph Fourrier, Albert Bonniot Institute, La Tronche Cedex, France
    Crit Care Med 40:1707-14. 2012
  10. pmc Acute respiratory failure in kidney transplant recipients: a multicenter study
    Emmanuel Canet
    Medical Intensive Care Unit and Biostatistics Departments, Saint Louis Teaching Hospital, 1 avenue Claude Vellefaux, Paris F 75010, France
    Crit Care 15:R91. 2011

Detail Information

Publications75

  1. doi New challenges in the diagnosis, management, and prevention of central venous catheter-related infections
    Jean Francois Timsit
    University Hospital Albert Michalon, Medical ICU, Grenoble, France
    Semin Respir Crit Care Med 32:139-50. 2011
    ..In the case of persistence of fever or positive blood cultures after 3 days, inadequate antibiotic therapy, endocarditis, or thrombophlebitis should be ruled out...
  2. doi EMPIRICUS micafungin versus placebo during nosocomial sepsis in Candida multi-colonized ICU patients with multiple organ failures: study protocol for a randomized controlled trial
    Jean Francois Timsit
    University Grenoble 1, Intensive Care Unit, Albert Michallon Hospital, BP 217, 38043 Grenoble, Cedex 9, France
    Trials 14:399. 2013
    ..As early diagnostic tests for invasive candidiasis are still considered to be insufficient, the potential interest in this strategy needs to be demonstrated...
  3. pmc Comparison of four skin preparation strategies to prevent catheter-related infection in intensive care unit (CLEAN trial): a study protocol for a randomized controlled trial
    Véronique Goudet
    Medical Intensive Care Unit, CHU de Poitiers, Poitiers, France
    Trials 14:114. 2013
    ..Moreover, the benefits of enhanced cleaning prior to disinfection of skin that is not visibly soiled have yet to be confirmed in a randomized study...
  4. pmc Investigating hospital heterogeneity with a multi-state frailty model: application to nosocomial pneumonia disease in intensive care units
    Benoit Liquet
    Univ Bordeaux, ISPED, Centre INSERM U 897 Epidemiologie Biostatistique, Bordeaux, F 33000, France
    BMC Med Res Methodol 12:79. 2012
    ..Thus a flexible multi-state model with random effects is needed to obtain valid outcome estimates...
  5. pmc How to deal with dialysis catheters in the ICU setting
    Natacha Mrozek
    Rà animation mà dicale, Hà pital Gabriel Montpied CHU Clermont Ferrand, Clermont Ferrand, 63000, France
    Ann Intensive Care 2:48. 2012
    ..The efficacy of ethanol and citrate locks has yet to be demonstrated. Hygiene procedures must be respected during DC insertion and manipulation...
  6. doi Randomized controlled trial of chlorhexidine dressing and highly adhesive dressing for preventing catheter-related infections in critically ill adults
    Jean Francois Timsit
    Université Grenoble 1 Joseph Fourrier U823 Outcome of Cancers and Critical Illness, Albert Bonniot Institute, 38076, La Tronche, France
    Am J Respir Crit Care Med 186:1272-8. 2012
    ..Most vascular catheter-related infections (CRIs) occur extraluminally in patients in the intensive care unit (ICU). Chlorhexidine-impregnated and strongly adherent dressings may decrease catheter colonization and CRI rates...
  7. doi Update on bloodstream infections in ICUs
    Jean Francois Timsit
    Integrated Research Center U823, Albert Bonniot Institute, University Grenoble 1, La Tronche, France
    Curr Opin Crit Care 18:479-86. 2012
    ..To describe new developments in the epidemiology and outcomes associated with bloodstream infections (BSIs) in ICUs...
  8. ncbi A multicentre analysis of catheter-related infection based on a hierarchical model
    J F Timsit
    Medical Polyvalent ICU, University Hospital Albert Michallon, Grenoble 1 University, 38000 Grenoble, France
    Intensive Care Med 38:1662-72. 2012
    ..The aim of our study was to evaluate risk factors for catheter colonisation and infection, focussing specifically on local care bundles...
  9. doi Dressing disruption is a major risk factor for catheter-related infections
    Jean Francois Timsit
    University Joseph Fourrier, Albert Bonniot Institute, La Tronche Cedex, France
    Crit Care Med 40:1707-14. 2012
    ..However, the importance of dressing disruptions in the occurrence of major catheter-related infection has never been studied in a large cohort of patients...
  10. pmc Acute respiratory failure in kidney transplant recipients: a multicenter study
    Emmanuel Canet
    Medical Intensive Care Unit and Biostatistics Departments, Saint Louis Teaching Hospital, 1 avenue Claude Vellefaux, Paris F 75010, France
    Crit Care 15:R91. 2011
    ..Data on pulmonary complications in renal transplant recipients are scarce. The aim of this study was to evaluate acute respiratory failure (ARF) in renal transplant recipients...
  11. pmc Impact of ureido/carboxypenicillin resistance on the prognosis of ventilator-associated pneumonia due to Pseudomonas aeruginosa
    Catherine Kaminski
    Surgical ICU, Hopital Edouard Herriot, 5 Place d Arsonval, Lyon 69437, France
    Crit Care 15:R112. 2011
    ..aeruginosa VAP (PA-VAP), taking into account confounders such as treatment adequacy and prior length of stay in the ICU, has not yet been adequately estimated...
  12. pmc Multiple-center evaluation of mortality associated with acute kidney injury in critically ill patients: a competing risks analysis
    Christophe Clec'h
    Medical Surgical Intensive Care Unit, Avicenne Teaching Hospital, 125 route de Stalingrad, Bobigny Cedex, France
    Crit Care 15:R128. 2011
    ..In this study, we aimed to assess the association between acute kidney injury (AKI) and mortality in critically ill patients using an original competing risks approach...
  13. pmc Quality of life in patients aged 80 or over after ICU discharge
    Alexis Tabah
    Medical Surgical ICU, Saint Joseph Hospital Network, 185 rue Raymond Losserand, 75014 Paris, France
    Crit Care 14:R2. 2010
    ..Our objective was to describe self-sufficiency and quality of life one year after intensive care unit (ICU) discharge of patients aged 80 years or over...
  14. ncbi Diagnosis and prevention of catheter-related infections
    Jean Francois Timsit
    Medical ICU, Hopital Albert Michallon, Grenoble, France
    Curr Opin Crit Care 13:563-71. 2007
    ..To highlight the major advances in diagnosing and preventing catheter-related infections published in research articles published between March 2004 and May 2007...
  15. doi Attributable mortality of ventilator-associated pneumonia
    Jean Francois Timsit
    EA 11, Albert Bonniot Institute U823, Joseph Fourier University, Paris, France
    Curr Opin Crit Care 17:464-71. 2011
    ..To critically discuss the attributable mortality of ventilator-associated pneumonia (VAP) and potential sources of variation...
  16. doi Chlorhexidine-impregnated sponges and less frequent dressing changes for prevention of catheter-related infections in critically ill adults: a randomized controlled trial
    Jean Francois Timsit
    INSERM U823, University Joseph Fourier, Albert Boniot Institute, 38076, Grenoble Cedex, France
    JAMA 301:1231-41. 2009
    ..Use of a chlorhexidine gluconate-impregnated sponge (CHGIS) in intravascular catheter dressings may reduce catheter-related infections (CRIs). Changing catheter dressings every 3 days may be more frequent than necessary...
  17. ncbi Outcome of critically ill HIV infected patients--a huge need for early screening
    Jean Francois Timsit
    Group of Epidemiology of Cancer and Severe Diseases, INSERM U 823 Albert Bonniot Institute Medical ICU, University Hospital Albert Michallon 38000 Grenoble France
    Indian J Med Res 126:97-8. 2007
  18. pmc New materials and devices for preventing catheter-related infections
    Jean Francois Timsit
    Medical Polyvalent Intensive Care Unit, University Joseph Fourier, Albert Michallon Hospital, BP 217, 38043 Grenoble Cedex 9, France
    Ann Intensive Care 1:34. 2011
    ..An antimicrobial or antiseptic lock may prevent bacterial migration from the hub to the bloodstream. This review discusses the available knowledge about these new technologies...
  19. pmc Attributable cost of methicillin resistance: an issue that is difficult to evaluate
    Jean Francois Timsit
    Groupe d Epidémiologie des Cancers et des Affections Graves INSERM U 578, Service de Reanimation Medicale, University Hospital Albert Michallon, 38043 Grenoble Cedex, France
    Crit Care 10:157. 2006
    ..We reviewed some important confounding factors of which the reader should be aware...
  20. ncbi Decisions to forgo life-sustaining therapy in ICU patients independently predict hospital death
    Elie Azoulay
    Saint Louis Teaching Hospital, Medical ICU Department, 1 avenue Claude Vellefaux, 75010, Paris, France
    Intensive Care Med 29:1895-901. 2003
    ..The objectives of this study were to describe the factors and mortality associated with DFLSTs and to evaluate the potential independent impact of DFLSTs on hospital mortality...
  21. doi Outcomes in severe sepsis and patients with septic shock: pathogen species and infection sites are not associated with mortality
    Jean Ralph Zahar
    Infection Control Unit, Necker University Hospital Paris, Assistance Publique Hopitaux de Paris, Paris, France
    Crit Care Med 39:1886-95. 2011
    ..We evaluated the respective influence of the causative pathogen and infection site on hospital mortality from severe sepsis related to community-, hospital-, and intensive care unit-acquired infections...
  22. ncbi Half the family members of intensive care unit patients do not want to share in the decision-making process: a study in 78 French intensive care units
    Elie Azoulay
    Intensive Care Unit of the Saint Louis Teaching Hospital and University of Paris 7, Assistance Publique Hopitaux de Paris, Paris, France
    Crit Care Med 32:1832-8. 2004
    ....
  23. doi Severe hypothermia increases the risk for intensive care unit-acquired infection
    Kevin B Laupland
    Team 11 Outcome of Respiratory Cancers and Mechanically Ventilated Patients, Integrated Research Center U823 Albert Bonniot Institute, Rond Point de la Chantourne, La Tronche, France
    Clin Infect Dis 54:1064-70. 2012
    ..We sought to assess the risk of acquiring intensive care unit (ICU)--acquired infection after hypothermia among medical ICU patients...
  24. doi Safety of intrahospital transport in ventilated critically ill patients: a multicenter cohort study*
    Carole Schwebel
    Medical ICU, Albert Michallon Teaching Hospital, University Joseph Fourier, Grenoble, France
    Crit Care Med 41:1919-28. 2013
    ..To describe intrahospital transport complications in critically ill patients receiving invasive mechanical ventilation...
  25. doi A multifaceted program for improving quality of care in intensive care units: IATROREF study
    Maite Garrouste-Orgeas
    Medical Surgical Intensive Care Unit, Saint Joseph Hospital Network, Paris, France
    Crit Care Med 40:468-76. 2012
    ..Medical errors and adverse events are associated with increased mortality in intensive care patients, indicating an urgent need for prevention programs...
  26. ncbi Calibration and discrimination by daily Logistic Organ Dysfunction scoring comparatively with daily Sequential Organ Failure Assessment scoring for predicting hospital mortality in critically ill patients
    Jean Francois Timsit
    Service de Reanimation Polyvalente, Hopital St Joseph, Paris, France
    Crit Care Med 30:2003-13. 2002
    ..The objective of this study was to evaluate how accurately daily LOD scoring predicts mortality comparatively with daily Sequential Organ Failure Assessment (SOFA) scoring...
  27. doi Attributable mortality of ventilator-associated pneumonia: respective impact of main characteristics at ICU admission and VAP onset using conditional logistic regression and multi-state models
    Molière Nguile-Makao
    INSERM U823, University Grenoble 1, Albert Bonniot Institute, Grenoble, France
    Intensive Care Med 36:781-9. 2010
    ....
  28. doi Determinants of temperature abnormalities and influence on outcome of critical illness
    Kevin B Laupland
    Integrated Research Center U 823, Joseph Fourier University, Albert Bonniot Institute, La Tronche Cedex, France
    Crit Care Med 40:145-51. 2012
    ..To determine the occurrence and determinants of temperature abnormalities among patients presenting (<24 hrs) to an intensive care unit and assess their effect on mortality outcome...
  29. ncbi Platelet count decline: an early prognostic marker in critically ill patients with prolonged ICU stays
    Delphine Moreau
    Medical ICU, Saint Louis Teaching Hospital, 1 Ave Claude Vellefaux, 75010 Paris, France
    Chest 131:1735-41. 2007
    ..Thrombocytopenia is common in ICU patients. The objective of this study was to evaluate possible links between declining platelet counts early in the ICU stay and survival...
  30. doi Increased nonbeneficial care in patients spending their birthday in the ICU
    Elie Azoulay
    Medical ICU, AP HP, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75010, Paris, France
    Intensive Care Med 38:1169-76. 2012
    ..Previous studies identified substantial subjective biases during end-of-life decision-making. We evaluated whether in-ICU patient's birthday influenced management decisions...
  31. doi Jugular versus femoral short-term catheterization and risk of infection in intensive care unit patients. Causal analysis of two randomized trials
    Jean Francois Timsit
    1 Grenoble 1 Joseph Fourier University, U823 Outcome of Cancers and Critical Illness, Albert Bonniot Institute, La Tronche, France
    Am J Respir Crit Care Med 188:1232-9. 2013
    ..When subclavian access is not possible, controversy exists between the internal jugular and femoral sites for the choice of central-venous access in intensive care unit patients...
  32. doi Antifungal use influences Candida species distribution and susceptibility in the intensive care unit
    Pierre Fournier
    Parasitology Mycology Laboratory, Infectious Agent Department, Albert Michallon University Hospital and Joseph Fourier University, Grenoble, France
    J Antimicrob Chemother 66:2880-6. 2011
    ..Our objective here was to evaluate the effect of antifungal drug use on the distribution and drug susceptibility of Candida spp. in a French intensive care unit (ICU)...
  33. pmc Mortality associated with timing of admission to and discharge from ICU: a retrospective cohort study
    Kevin B Laupland
    University of Grenoble 1 Joseph Fourier Integrated Research Center U 823 Albert Bonniot Institute, Rond Point de la Chantourne 38706, La Tronche Cedex, France
    BMC Health Serv Res 11:321. 2011
    ..The objective of this study was to assess effect of timing of admission to and discharge from ICUs and subsequent risk for death...
  34. doi Opinions of families, staff, and patients about family participation in care in intensive care units
    Maite Garrouste-Orgeas
    Medical ICU, Saint Joseph Hospital Network, 75014 Paris, France
    J Crit Care 25:634-40. 2010
    ....
  35. ncbi Impact of unplanned extubation and reintubation after weaning on nosocomial pneumonia risk in the intensive care unit: a prospective multicenter study
    Arnaud de Lassence
    Medical ICU, Avicenne Hospital, Bobigny, France
    Anesthesiology 97:148-56. 2002
    ....
  36. doi Association between hypernatraemia acquired in the ICU and mortality: a cohort study
    Michael Darmon
    Medical Intensive Care Unit, Saint Louis University Hospital, APHP, 1 avenue Claude Vellefaux, Paris, France
    Nephrol Dial Transplant 25:2510-5. 2010
    ..The aim of this study is to describe the prevalence and outcomes of intensive care unit (ICU)-acquired hypernatraemia (IAH)...
  37. doi Impact of adverse events on outcomes in intensive care unit patients
    Maite Garrouste Orgeas
    Medical Surgical ICU, Saint Joseph Hospital Network, Paris, France
    Crit Care Med 36:2041-7. 2008
    ..To examine the association between predefined adverse events (AE) (including nosocomial infections) and intensive care unit (ICU) mortality, controlling for multiple adverse events in the same patient and confounding variables...
  38. ncbi Practices in non-neutropenic ICU patients with Candida-positive airway specimens
    Elie Azoulay
    Intensive Care Unit, Saint Louis Teaching Hospital, 1 avenue Claude Vellefaux, 75010 Paris, France
    Intensive Care Med 30:1384-9. 2004
    ..Design : Closed-item questionnaire with a clinical vignette...
  39. ncbi Predictors of intensive care unit refusal in French intensive care units: a multiple-center study
    Maite Garrouste-Orgeas
    Medical Surgical Intensive Care Unit, Saint Joseph Hospital, Paris, France
    Crit Care Med 33:750-5. 2005
    ..To identify factors associated with granting or refusing intensive care unit (ICU) admission, to analyze ICU characteristics and triage decisions, and to describe mortality in admitted and refused patients...
  40. ncbi Is methicillin resistance associated with a worse prognosis in Staphylococcus aureus ventilator-associated pneumonia?
    Jean Ralph Zahar
    Department of Microbiology, Necker Teaching Hospital, Paris, France
    Clin Infect Dis 41:1224-31. 2005
    ....
  41. doi Pulmonary embolism in mechanically ventilated patients requiring computed tomography: Prevalence, risk factors, and outcome
    Clémence Minet
    Medical Intensive Care Unit, University Hospital Albert Michallon, Grenoble, France
    Crit Care Med 40:3202-8. 2012
    ..To estimate the rate of pulmonary embolism among mechanically ventilated patients and its association with deep venous thrombosis...
  42. doi A model to predict short-term death or readmission after intensive care unit discharge
    Islem Ouanes
    Intensive Care Unit, Saint Joseph Hospital, Paris, France
    J Crit Care 27:422.e1-9. 2012
    ..Our objectives were to identify independent risk factors for early post-ICU readmission or death and to construct a prediction model...
  43. doi Impact of an intensive care unit diary on psychological distress in patients and relatives*
    Maite Garrouste-Orgeas
    Medical ICU, Saint Joseph Hospital Network, Paris, France
    Crit Care Med 40:2033-40. 2012
    ..To assess the impact of an intensive care unit diary on the psychological well-being of patients and relatives 3 and 12 months after intensive care unit discharge...
  44. ncbi Determinants of postintensive care unit mortality: a prospective multicenter study
    Elie Azoulay
    Medical ICU, Hopital Saint Louis, Paris, France
    Crit Care Med 31:428-32. 2003
    ..We investigated determinants of post-ICU mortality, with special attention to this factor...
  45. ncbi Candida colonization of the respiratory tract and subsequent pseudomonas ventilator-associated pneumonia
    Elie Azoulay
    Medical ICU, Saint Louis Teaching Hospital, 1 Ave Claude Vellefaux, 75010 Paris, France
    Chest 129:110-7. 2006
    ..However, interactions between Candida and bacteria, particularly Pseudomonas, have been reported. Thus, Candida colonization of the respiratory tract may predispose to bacterial ventilator-associated pneumonia (VAP)...
  46. ncbi Decision-making process, outcome, and 1-year quality of life of octogenarians referred for intensive care unit admission
    Maite Garrouste-Orgeas
    Medical ICU, Saint Joseph Hospital, 185 rue Raymond Losserand, 75014 Paris, France
    Intensive Care Med 32:1045-51. 2006
    ..To describe triage decisions and subsequent outcomes in octogenarians referred to an ICU...
  47. doi Characteristics and determinants of outcome of hospital-acquired bloodstream infections in intensive care units: the EUROBACT International Cohort Study
    Alexis Tabah
    Albert Michallon University Hospital, Université Grenoble 1, Grenoble, France
    Intensive Care Med 38:1930-45. 2012
    ..We investigated the epidemiology of HA-BSI and evaluated the impact of drug resistance on outcomes of critically ill patients, controlling for patient characteristics and infection management...
  48. doi Systemic antifungal therapy in critically ill patients without invasive fungal infection*
    Elie Azoulay
    Paris 7 University, EA, Saint Louis Hospital, Paris, France
    Crit Care Med 40:813-22. 2012
    ..To determine the number of adult or pediatric intensive care unit patients without documented invasive fungal infection who receive systemic antifungal therapy...
  49. pmc Reliability of diagnostic coding in intensive care patients
    Benoit Misset
    Intensive Care Unit, Fondation Hopital Saint Joseph, Universite Paris Descartes, Faculte de Medecine, 185 rue Losserand, 75014 Paris, France
    Crit Care 12:R95. 2008
    ..We assessed the reliability of coding between different ICU physicians...
  50. doi Minimum inhibitory concentrations of amphotericin B against Candida krusei isolates from a French teaching hospital laboratory: a retrospective study over 8 years
    Jean Benjamin Murat
    Laboratory of Parasitology and Mycology, Grenoble University Hospital, Grenoble, France
    Mycoses 56:56-60. 2013
    ..However, some authors have recently reported much higher MICs. This discrepancy cannot be explained by method biases and could reflect C. krusei epidemiological differences among populations...
  51. ncbi Detrimental role of delayed antibiotic administration and penicillin-nonsusceptible strains in adult intensive care unit patients with pneumococcal meningitis: the PNEUMOREA prospective multicenter study
    Marc Auburtin
    From the Service de Réanimation Médicale et des Maladies Infectieuses, Hopital Bichat Claude Bernard, AP HP, Paris, France
    Crit Care Med 34:2758-65. 2006
    ..To identify factors associated with mortality and morbidity among adults admitted to intensive care units (ICUs) for pneumococcal meningitis, particularly the impact of delayed antibiotic administration...
  52. ncbi Tracheostomy does not improve the outcome of patients requiring prolonged mechanical ventilation: a propensity analysis
    Christophe Clec'h
    Intensive Care Unit, Avicenne Teaching Hospital, 125 route de Stalingrad, 93000 Bobigny, France
    Crit Care Med 35:132-8. 2007
    ..To examine the association between the performance of a tracheostomy and intensive care unit and postintensive care unit mortality, controlling for treatment selection bias and confounding variables...
  53. doi Endovascular treatment of malignant superior vena cava syndrome: results and predictive factors of clinical efficacy
    Dorothée Fagedet
    Clinique Universitaire de Médecine Interne, Pôle Pluridisciplinaire de Médecine, CHU de Grenoble, Grenoble, France
    Cardiovasc Intervent Radiol 36:140-9. 2013
    ..To demonstrate the effectiveness of endovascular treatment (EVT) with self-expandable bare stents for malignant superior vena cava syndrome (SVCS) and to analyze predictive factors of EVT efficacy...
  54. doi Prevalence and factors of intensive care unit conflicts: the conflicus study
    Elie Azoulay
    AP HP, Hopital Saint Louis, Medical ICU, University Paris 7 Paris Diderot, UFR de Medecine, 1 avenue Claude Vellefaux, 75010 Paris, France
    Am J Respir Crit Care Med 180:853-60. 2009
    ..Many sources of conflict exist in intensive care units (ICUs). Few studies recorded the prevalence, characteristics, and risk factors for conflicts in ICUs...
  55. doi Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial
    Lila Bouadma
    Service de Reanimation Medicale, Universite Paris 7 Denis Diderot, Hopital Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Paris, France
    Lancet 375:463-74. 2010
    ..We aimed to establish the effectiveness of an algorithm based on the biomarker procalcitonin to reduce antibiotic exposure in this setting...
  56. pmc Open the intensive care unit doors to HIV-infected patients with sepsis
    Jean Francois Timsit
    Group of Epidemiology of Cancer and Severe Diseases, INSERM U 578, Medical ICU, University Hospital, Albert Michallon, 38000 Grenoble, France
    Crit Care 9:629-30. 2005
    ..This strategy should be used in HIV/AIDS patients with severe sepsis...
  57. doi Important questions asked by family members of intensive care unit patients
    Vincent Peigne
    AP HP, Hopital Saint Louis, Medical ICU, Paris, France
    Crit Care Med 39:1365-71. 2011
    ..We aimed to develop a list of questions important for relatives of patients in the intensive care unit...
  58. doi Use of intensive care in patients with nonresectable lung cancer
    Anne Claire Toffart
    Clinique de Pneumologie, Pôle Médecine Aiguë Communautaire, Centre Hospitalier Universitaire de Grenoble, France
    Chest 139:101-8. 2011
    ..Admission of patients with lung cancer to the ICU has been criticized. We evaluated whether ICU admission improved 3-month survival in patients with nonresectable lung cancer. Factors associated with survival were identified...
  59. doi End-of-life practices in 282 intensive care units: data from the SAPS 3 database
    Elie Azoulay
    Service de Reanimation Medicale, Hôpital Saint Louis et Université Paris 7, Assistance Publique, Hopitaux de Paris, Paris, France
    Intensive Care Med 35:623-30. 2009
    ..To report incidence and characteristics of decisions to forgo life-sustaining therapies (DFLSTs) in the 282 ICUs who contributed to the SAPS3 database...
  60. doi Interventions to decrease tube, line, and drain removals in intensive care units: the FRATER study
    Silvia Calvino Gunther
    Medical ICU, Michallon Teaching Hospital, BP 217, 38043, Grenoble Cedex 9, France
    Intensive Care Med 35:1772-6. 2009
    ..To evaluate the incidence of unintended tube, line, and drain removals (UTRs) in our ICU, to identify system factors associated with UTRs, and to evaluate interventions designed to decrease UTR occurrence...
  61. doi Reporting and handling missing values in clinical studies in intensive care units
    Aurelien Vesin
    Albert Bonniot Institute, U823, University Grenoble 1, Grenoble, France
    Intensive Care Med 39:1396-404. 2013
    ....
  62. doi Transfer of take-home messages in graduate ICU education
    Alexandre Lautrette
    Medical ICU, Pole REUNNIRH, CHU Gabriel Montpied Teaching Hospital of Clermont Ferrand, Université d Auvergne Clermont Ferrand 1, 58 rue Montalembert, 63003 Clermont Ferrand, France
    Intensive Care Med 37:1323-30. 2011
    ..The process involves the transfer of take-home messages. The aim of this study was to assess the number of take-home messages identified by postgraduate critical care junior doctors (juniors) during lectures...
  63. doi Pain assessment is associated with decreased duration of mechanical ventilation in the intensive care unit: a post Hoc analysis of the DOLOREA study
    Jean Francois Payen
    Department of Anesthesiology and Critical Care, Grenoble University Hospital, Grenoble, France
    Anesthesiology 111:1308-16. 2009
    ..Critically ill patients frequently experience pain, but assessment rates remain below 40% in mechanically ventilated patients. Whether pain assessment affects patient outcomes is largely unknown...
  64. doi Economic evaluation of chlorhexidine-impregnated sponges for preventing catheter-related infections in critically ill adults in the Dressing Study
    Carole Schwebel
    Medical Intensive Care Unit, Albert Michallon University Hospital Grenoble, France
    Crit Care Med 40:11-7. 2012
    ..4‰ to 0.6‰ catheter days, and that scheduled dressing changes every 7 days was not inferior to scheduled changes every 3 days. Here, we assessed the cost benefits of chlorhexidine-impregnated sponge use...
  65. doi Immediate prehospital hypothermia protocol in comatose survivors of out-of-hospital cardiac arrest
    Laure Hammer
    Department of Intensive Care Medicine, Grenoble University Hospital, Grenoble, France
    Am J Emerg Med 27:570-3. 2009
    ..Our preliminary observation suggests that in comatose survivors of CA, prehospital TH with infusion of large-volume, ice-cold intravenous saline is feasible and can be used safely by mobile emergency and intensive care units...
  66. doi Diagnosis of toxoplasmosis after allogeneic stem cell transplantation: results of DNA detection and serological techniques
    Hélène Fricker-Hidalgo
    Parasitologie Mycologie, Pôle Biologie, Centre Hospitalier Universitaire, Grenoble, France
    Clin Infect Dis 48:e9-e15. 2009
    ..The aim of our study was to examine the performance of polymerase chain reaction (PCR) and serological techniques in the diagnosis of toxoplasmosis after HSCT...
  67. doi Nosocomial infection after septic shock among intensive care unit patients
    Caroline Landelle
    Service d Hygiène, Epidémiologie et Prévention, Hopital Edouard Herriot, and the Centre d Investigation Clinique de Lyon, CIC201, INSERM, France
    Infect Control Hosp Epidemiol 29:1054-65. 2008
    ..To measure the incidence of nosocomial infection (NI) among patients with septic shock according to the place of septic shock acquisition and to evaluate the increase in the risk of pulmonary infection associated with septic shock...
  68. pmc What is the best site for central venous catheter insertion in critically ill patients?
    Jean Francois Timsit
    Réanimation médicale et infectieuse, Hopital Bichat Claude Bernard, Paris, France
    Crit Care 7:397-9. 2003
  69. pmc Case report: greater meningeal inflammation in lumbar than in ventricular region in human bacterial meningitis
    Walid Naija
    Department of Anesthesiology and Critical Care Medicine, Lariboisiere University Hospital, Paris, France
    Crit Care 8:R491-4. 2004
    ..Our case also showed that the increase in intravenous antibiotics (cefepim from 8 to 12 g/day and ciprofloxacine from 1.2 to 2.4 g/day) led to an increase in concentration in plasma but not in CSF...
  70. doi Epidemiology and outcome of thrombocytopenic patients in the intensive care unit: results of a prospective multicenter study
    Fabrice Thiollière
    Service de Reanimation Medicale, Hopital Gabriel Montpied, CHU de Clermont Ferrand, BP69, 63003, Clermont Ferrand cedex 01, France
    Intensive Care Med 39:1460-8. 2013
    ..To assess the epidemiology of intensive care unit (ICU) patients with thrombocytopenia (TP)...
  71. doi Therapeutic impact and diagnostic performance of multiplex PCR in patients with malignancies and suspected sepsis
    Danièle Maubon
    Infectious Agent Department, Parasitology Mycology Laboratory, Albert Michallon Teaching Hospital, 38043 Grenoble Cedex 9, France
    J Infect 61:335-42. 2010
    ..We evaluated the therapeutic usefulness of multiplex PCR testing in patients with cancer and sepsis...
  72. ncbi Perceptions of a 24-hour visiting policy in the intensive care unit
    Maite Garrouste-Orgeas
    Medical Surgical Intensive Care Unit, Saint Joseph Hospital Network, Paris, France
    Crit Care Med 36:30-5. 2008
    ..To examine perceptions by intensive care unit (ICU) workers of unrestricted visitation, to measure visiting times, and to determine prevalence of symptoms of anxiety and depression in family members...
  73. doi Outcomes in recurrent small-cell lung cancer after one to four chemotherapy lines: a retrospective study of 300 patients
    Hélène Nagy-Mignotte
    Oncology Coordination Centre, Grenoble University Hospital, Grenoble, France
    Lung Cancer 78:112-20. 2012
    ....
  74. ncbi Tumor-specific methylation in saliva: a promising biomarker for early detection of head and neck cancer recurrence
    Christian Adrien Righini
    Institut National de la Sante et de la Recherche Medicale Université Joseph Fourier, La Tronche, France
    Clin Cancer Res 13:1179-85. 2007
    ..Our goal was to define tumor and saliva gene methylation profile of head and neck squamous cell carcinoma and to evaluate its prognostic significance and its biomarker potential for early detection of relapse...
  75. doi Reduced six-minute walking distance, high fat-free-mass index and hypercapnia are associated with endothelial dysfunction in COPD
    Clémence Minet
    Inserm U1042, HP2 Laboratory Hypoxia Pathophysiology, Joseph Fourier University, Grenoble, F 38042, France
    Respir Physiol Neurobiol 183:128-34. 2012
    ..Six-minute walking distance which is a widely available marker of severity and functional capacity in COPD patients is a main predictor of endothelial dysfunction...