Martin Soubrier

Summary

Affiliation: CHU de Clermont-Ferrand
Country: France

Publications

  1. doi request reprint Rheumatoid arthritis in the elderly in the era of tight control
    Martin Soubrier
    Department of Rheumatology, G Montpied Hospital, BP 69, 63003, Clermont Ferrand, France
    Drugs Aging 30:863-9. 2013
  2. doi request reprint Vascular effects of nonsteroidal antiinflammatory drugs
    Martin Soubrier
    Service de Rhumatologie, Hopital G Montpied, BP 69, 63003 Clermont Ferrand, France
    Joint Bone Spine 80:358-62. 2013
  3. doi request reprint Do all lupus patients need statins?
    Martin Soubrier
    Service de Rhumatologie, Hopital G Montpied, Place H Dunant, BP 69, 63003 Clermont Ferrand, France
    Joint Bone Spine 80:244-9. 2013
  4. ncbi request reprint Polymyalgia rheumatica: diagnosis and treatment
    Martin Soubrier
    Service de Rhumatologie, CHU de Clermont Ferrand, Place Henri Dunant, BP 69, 63003 Clermont Ferrand Cedex 1, France
    Joint Bone Spine 73:599-605. 2006
  5. ncbi request reprint [POEMS syndrome]
    Martin Soubrier
    Service de Rhumatologie, Hopital Gabriel Montpied, CHU, Clermont Ferrand
    Presse Med 36:1676-82. 2007
  6. ncbi request reprint Atheroma and systemic lupus erythematosus
    Martin Soubrier
    G Montpied Hospital, Service de Rhumatologie, Place Henri Dunant, BP 69, 63003 Clermont Ferrand, France
    Joint Bone Spine 74:566-70. 2007
  7. ncbi request reprint Effects of anti-tumor necrosis factor therapy on lipid profile in patients with rheumatoid arthritis
    Martin Soubrier
    Service de Rhumatologie, Hopital G Montpied, Place Henri Dunant, BP 69, 63003 Clermont Ferrand Cedex 1, France
    Joint Bone Spine 75:22-4. 2008
  8. doi request reprint Elderly-onset rheumatoid arthritis
    Martin Soubrier
    Service de Rhumatologie, Hopital G Montpied, BP 69, 63003 Clermont Ferrand, France
    Joint Bone Spine 77:290-6. 2010
  9. doi request reprint Schnitzler syndrome
    Martin Soubrier
    Gabriel Montpied Teaching Hospital, Service de Rhumatologie, 58 rue Montalembert, BP 69, 63003 Clermont Ferrand Cedex 1, France
    Joint Bone Spine 75:263-6. 2008
  10. pmc Disease activity score-driven therapy versus routine care in patients with recent-onset active rheumatoid arthritis: data from the GUEPARD trial and ESPOIR cohort
    M Soubrier
    Department of Rheumatology, Hopital G Montpied, 63003 Clermont Ferrand, France
    Ann Rheum Dis 70:611-5. 2011

Detail Information

Publications51

  1. doi request reprint Rheumatoid arthritis in the elderly in the era of tight control
    Martin Soubrier
    Department of Rheumatology, G Montpied Hospital, BP 69, 63003, Clermont Ferrand, France
    Drugs Aging 30:863-9. 2013
    ..The safety of the biotherapies therefore still needs to be confirmed, together with the benefit-risk balance of corticosteroid therapy compared with biological therapy...
  2. doi request reprint Vascular effects of nonsteroidal antiinflammatory drugs
    Martin Soubrier
    Service de Rhumatologie, Hopital G Montpied, BP 69, 63003 Clermont Ferrand, France
    Joint Bone Spine 80:358-62. 2013
    ..Uncertainties persist about aspirin interactions with other NSAIDs and with proton pump inhibitors. An adverse effect of acetaminophen on the risk of cardiovascular disease cannot be completely ruled out. ..
  3. doi request reprint Do all lupus patients need statins?
    Martin Soubrier
    Service de Rhumatologie, Hopital G Montpied, Place H Dunant, BP 69, 63003 Clermont Ferrand, France
    Joint Bone Spine 80:244-9. 2013
    ..Statin therapy requires specific monitoring precautions (transaminase levels) given the high prevalence of comorbidities and use of concomitant medications in SLE patients...
  4. ncbi request reprint Polymyalgia rheumatica: diagnosis and treatment
    Martin Soubrier
    Service de Rhumatologie, CHU de Clermont Ferrand, Place Henri Dunant, BP 69, 63003 Clermont Ferrand Cedex 1, France
    Joint Bone Spine 73:599-605. 2006
    ..Methotrexate is probably useful when glucocorticoid dependency develops. In contrast, TNF-alpha antagonists are probably ineffective...
  5. ncbi request reprint [POEMS syndrome]
    Martin Soubrier
    Service de Rhumatologie, Hopital Gabriel Montpied, CHU, Clermont Ferrand
    Presse Med 36:1676-82. 2007
    ..The usefulness of thalidomide and bevacuzimab in refractory POEMS syndromes remains to be seen...
  6. ncbi request reprint Atheroma and systemic lupus erythematosus
    Martin Soubrier
    G Montpied Hospital, Service de Rhumatologie, Place Henri Dunant, BP 69, 63003 Clermont Ferrand, France
    Joint Bone Spine 74:566-70. 2007
    ..Hypertension and/or dyslipidemia should be treated optimally. The appropriateness of antiplatelet therapy should be assessed...
  7. ncbi request reprint Effects of anti-tumor necrosis factor therapy on lipid profile in patients with rheumatoid arthritis
    Martin Soubrier
    Service de Rhumatologie, Hopital G Montpied, Place Henri Dunant, BP 69, 63003 Clermont Ferrand Cedex 1, France
    Joint Bone Spine 75:22-4. 2008
    ..Analyse the effects of anti-tumor necrosis factor therapy on serum levels of lipid in patients with rheumatoid arthritis (RA)...
  8. doi request reprint Elderly-onset rheumatoid arthritis
    Martin Soubrier
    Service de Rhumatologie, Hopital G Montpied, BP 69, 63003 Clermont Ferrand, France
    Joint Bone Spine 77:290-6. 2010
    ..To combat the 2-fold cardiovascular risk increase associated with RA, disease activity should be stringently controlled and all cardiovascular risk factors managed aggressively...
  9. doi request reprint Schnitzler syndrome
    Martin Soubrier
    Gabriel Montpied Teaching Hospital, Service de Rhumatologie, 58 rue Montalembert, BP 69, 63003 Clermont Ferrand Cedex 1, France
    Joint Bone Spine 75:263-6. 2008
    ..Development of a hematological malignancy is the main complication. Recent reports of remissions induced by IL-1 receptor antagonist therapy shed new light on the pathophysiology of the disease...
  10. pmc Disease activity score-driven therapy versus routine care in patients with recent-onset active rheumatoid arthritis: data from the GUEPARD trial and ESPOIR cohort
    M Soubrier
    Department of Rheumatology, Hopital G Montpied, 63003 Clermont Ferrand, France
    Ann Rheum Dis 70:611-5. 2011
    ....
  11. doi request reprint Oligo-arthritis and type IV hyperlipoproteinemia
    Martin Soubrier
    Hopital Gabriel Montpied, Service de Rhumatologie, Place Henri Dunant, BP 69, Clermont Ferrand, F 63003, France
    Joint Bone Spine 76:95-7. 2009
    ..6 mmol/L; and total cholesterol, 10.7 mmol/L). The clinical and laboratory test abnormalities resolved under fenofibrate therapy...
  12. doi request reprint Evaluation of two strategies (initial methotrexate monotherapy vs its combination with adalimumab) in management of early active rheumatoid arthritis: data from the GUEPARD trial
    Martin Soubrier
    Department of Rheumatology, Hopital G Montpied, 63003 Clermont Ferrand, France
    Rheumatology (Oxford) 48:1429-34. 2009
    ..To compare this strategy with an initial combination of MTX and adalimumab (ADA) given for 3 months and then adjusted based on the disease activity status...
  13. doi request reprint Creutzfeldt-Jakob disease in a patient treated by etanercept for rheumatoid arthritis (RA): just a coincidence?
    Martin Soubrier
    Service de Rhumatologie, Hopital G Montpied, Place Henri Dunant, BP 69, 63003 Clermont Ferrand, France
    Joint Bone Spine 77:174-5. 2010
    ..It may be of interest studying the impact of treatment with TNF-alpha antagonists on prevalence and incidence of those neurodegenerative diseases involving TNF-alpha mediation, such as Alzheimer disease...
  14. ncbi request reprint Which variables best predict change in rheumatoid arthritis therapy in daily clinical practice?
    Martin Soubrier
    Service de Rhumatologie, Hopital G Montpied, Clermont Ferrand, France
    J Rheumatol 33:1243-6. 2006
    ..To determine in clinical practice which clinical status variables for rheumatoid arthritis (RA) are most closely associated with a change in disease modifying antirheumatic drug (DMARD) therapy...
  15. ncbi request reprint Statins in rheumatology
    Martin Soubrier
    Rheumatology Department, G Montpied Hospital, Place H Dunant, BP 69, 63003 Clermont Ferrand, France
    Joint Bone Spine 73:159-68. 2006
    ..When these show dyslipidemia, statin therapy should be started according to current recommendations...
  16. ncbi request reprint Cervical radiculopathy as a manifestation of giant cell arteritis
    Martin Soubrier
    Rheumatology Department, Hopital G Montpied, Clermont Ferrand, France
    Joint Bone Spine 69:316-8. 2002
    ..Preferential involvement of C5 nerve roots may depend on the vascularization of cervical roots but could be due to the inability to diagnose upper cervical involvement (C1-C3). Outcome is favourable in all cases with corticosteroids...
  17. ncbi request reprint Insufficiency fracture. A survey of 60 cases and review of the literature
    Martin Soubrier
    Rheumatology Department, CHU Gabriel Montpied, BP 69, 63003 cedex 1, Clermont Ferrand, France
    Joint Bone Spine 70:209-18. 2003
    ..We report findings on the site, risk factors and imaging of insufficiency fractures (IF) in 60 patients admitted to our department between 1989 and 1997...
  18. ncbi request reprint Restricted use of Vlambda genes in POEMS syndrome
    Soubrier Martin
    Service de Rhumatologie, Hopital G Montpied, Clermont Ferrand, France
    Haematologica 89:ECR02. 2004
  19. doi request reprint Organizing pneumonia after rituximab therapy: Two cases
    Martin Soubrier
    Rheumatology Department, Gabriel Montpied Teaching Hospital, Clermont Ferrand, France
    Joint Bone Spine 75:362-5. 2008
    ..Because organizing pneumonia may be asymptomatic, as illustrated by one of our cases, we recommend obtaining a chest radiograph routinely before rituximab re-treatment...
  20. ncbi request reprint Selecting criteria for monitoring patients with rheumatoid arthritis
    Martin Soubrier
    Service de Rhumatologie, Rheumatology Department, G Montpied Teaching Hospital, Place Henri Dunant, B P 69, 63003 Clermont Ferrand, France
    Joint Bone Spine 72:129-34. 2005
    ..A standardized follow-up protocol is suggested as a means of achieving greater uniformity in clinical practice...
  21. ncbi request reprint [Atherosclerosis and rheumatoid arthritis]
    M Soubrier
    Service de Rhumatologie, Hopital G Montpied, Place H Dunant, Clermont Ferrand, France
    Rev Med Interne 27:125-36. 2006
    ..To identify the different factors that may be involved. To consider what management would decrease the cardiovascular morbidity and mortality of RA...
  22. doi request reprint Effects of 14 weeks of TNF alpha blockade treatment on lipid profile in ankylosing spondylitis
    Sylvain Mathieu
    Rheumatology Department, G Montpied Hospital, 58, rue Montalembert, 63003 Clermont Ferrand, France
    Joint Bone Spine 77:50-2. 2010
    ..This study aims to investigate the impact of TNF alpha-inhibitors, an effective treatment, on lipid profile...
  23. ncbi request reprint Exacerbation of interstitial lung disease during etanercept therapy: Two cases
    Anne Tournadre
    CHU Clermont Ferrand, Rheumatology Department, G Montpied Teaching Hospital, 63 000 Clermont Ferrand, France
    Joint Bone Spine 75:215-8. 2008
    ..The development or exacerbation of interstitial lung disease in a patient on TNF alpha antagonist therapy should lead to investigations for a cause. Should these investigations prove negative, the treatment must be discontinued...
  24. doi request reprint No significant changes in arterial stiffness in patients with ankylosing spondylitis after tumour necrosis factor alpha blockade treatment for 6 and 12 months
    Sylvain Mathieu
    Gabriel Montpied Teaching Hospital, Rheumatology Department, Place H Dunant, Clermont Ferrand, 63000, France
    Rheumatology (Oxford) 52:204-9. 2013
    ..This study aimed to investigate the effects of 24 and 52 weeks of TNF-α inhibitor treatment on arterial stiffness and cardiovascular risk factors...
  25. pmc Construction and utilization of a script concordance test as an assessment tool for dcem3 (5th year) medical students in rheumatology
    Sylvain Mathieu
    Service de Rhumatologie, centre hospitalier Jacques Lacarin, Vichy, France
    BMC Med Educ 13:166. 2013
    ..This study was designed to create a script concordance test in rheumatology and use it for DCEM3 (fifth year) medical students administered via the online platform of the Clermont-Ferrand medical school...
  26. ncbi request reprint Cat scratch disease during etanercept therapy
    Sylvain Mathieu
    Clermont Ferrand Teaching Hospital, Rheumatology Department, G Montpied Hospital, Clermont Ferrand, France
    Joint Bone Spine 74:184-6. 2007
    ..We report a case of granulomatous lymphadenopathy due to Bartonella henselae in a patient taking etanercept to treat ankylosing spondylitis...
  27. ncbi request reprint Recommendations of the French Society for Rheumatology. TNFalpha antagonist therapy in rheumatoid arthritis
    Bruno Fautrel
    Service de Rhumatologie, Groupe Hospitalier Pitie Salpetriere, UFR de Medecine, Universite Pierre et Marie Curie Paris VI, 83, Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Joint Bone Spine 73:433-41. 2006
    ..To develop recommendations for TNFalpha-antagonist therapy in patients with rheumatoid arthritis (RA) seen in everyday practice, under the aegis of the French Society for Rheumatology...
  28. ncbi request reprint Indications for lowering LDL cholesterol in rheumatoid arthritis: an unrecognized problem
    Martin Soubrier
    Service de Rhumatologie, Hopital G Montpied, Clermont Ferrand, France
    J Rheumatol 33:1766-9. 2006
    ..The goal for 0-1 RF is < 160 mg/l, for multiple RF < 130 mg/l, and < 100 mg/l for coronary heart disease (CHD) or CHD risk equivalent (other clinical atherosclerotic diseases and diabetes mellitus)...
  29. ncbi request reprint Streptococcal septic arthritis in adults. A study of 55 cases with a literature review
    Jean Jacques Dubost
    Clinical Immunology Unit, G Montpied Teaching Hospital, 63001 Clermont Ferrand, France
    Joint Bone Spine 71:303-11. 2004
    ..To evaluate the rate of occurrence and characteristics of streptococcal septic arthritis...
  30. doi request reprint TNFα antagonist therapy does not increase the Epstein-Barr virus burden in patients with rheumatoid arthritis or ankylosing spondylitis
    Marion Couderc
    Service de Rhumatologie, CHU de Clermont Ferrand, Clermont Ferrand, France
    Joint Bone Spine 77:414-7. 2010
    ..EBV load monitoring during immunosuppressive treatment may predict the occurrence of EBV-related lymphoma. Here, our objective was to prospectively measure the EBV load in patients receiving TNFα antagonists for RA or AS...
  31. ncbi request reprint Late-onset spondyloarthropathy mimicking reflex sympathetic dystrophy syndrome
    Jean Jacques Dubost
    Clinical Immunology Unit Rheumatology Department, Gabriel Montpied Teaching Hospital, 63001, Clermont Ferrand, France
    Joint Bone Spine 70:226-9. 2003
    ..In older patients, edema of the foot with severe demineralization and the laboratory evidence of inflammation should suggest a spondyloarthropathy...
  32. doi request reprint Polymyositis and pemphigus vulgaris in a patient: successful treatment with rituximab
    Anne Tournadre
    CHU Clermont Ferrand, Rheumatology Department, G Montpied Hospital, Place H Dunant, BP 69, 63003 Clermont Ferrand, France
    Joint Bone Spine 75:728-9. 2008
    ..However, it did not prevent progression to secondary amyloidosis and the fatal infection developed in this patient raises the question of whether a prolonged B cell depletion with rituximab contributes to a greater risk of infection...
  33. ncbi request reprint How to assess early rheumatoid arthritis in daily clinical practice
    Martin Soubrier
    Service de Rhumatologie, Hopital G Montpied, Place H Dunant, B P 69, 63003 Clermont Ferrand, France
    Best Pract Res Clin Rheumatol 19:73-89. 2005
    ..Since increased cardiovascular mortality has been documented even in early RA, other cardiovascular risk factors should be looked for and eventually treated...
  34. doi request reprint Treatment of inflammatory muscle disease in adults
    Anne Tournadre
    Service de Rhumatologie, Hopital G Montpied, CHU Clermont Ferrand, Clermont Ferrand Cedex 1, France
    Joint Bone Spine 77:390-4. 2010
    ..Caution is in order when considering TNFα antagonist therapy, as cases of paradoxical exacerbation of the muscle involvement have been reported...
  35. doi request reprint Rheumatic disease presenting as septic arthritis: a report of 10 cases
    Julie Eberst-Ledoux
    Rheumatology Department, G Montpied Teaching Hospital, Faculty of Medicine, Clermont Ferrand 1 University, Clermont Ferrand, France
    Rheumatol Int 33:2153-8. 2013
    ..These cases of pseudoseptic arthritis were indistinguishable from true septic arthritis. Follow-up is required in septic arthritis with negative culture findings to exclude rheumatic disease...
  36. doi request reprint Efficacy and safety of rituximab in the treatment of refractory inflammatory myopathies in adults: results from the AIR registry
    Marion Couderc
    Rheumatology Department, CHU, Clermont Ferrand, France
    Rheumatology (Oxford) 50:2283-9. 2011
    ..To assess the efficacy and safety of rituximab (RTX) in patients with refractory idiopathic inflammatory myopathies (IIMs)...
  37. doi request reprint No significant change in arterial stiffness in RA after 6 months and 1 year of rituximab treatment
    Sylvain Mathieu
    Rheumatology Department, Gabriel Montpied Teaching Hospital, Place H Dunant, Clermont Ferrand 63000, France
    Rheumatology (Oxford) 51:1107-11. 2012
    ..The aim of this study is to investigate the effects of 24 and 52 weeks of rituximab treatment on arterial stiffness and cardiovascular risk factors...
  38. ncbi request reprint Septic arthritis in patients aged 80 and older: a comparison with younger adults
    Florence Gavet
    Department of Rheumatology, CHU Gabriel Montpied, Clermont Ferrand, France
    J Am Geriatr Soc 53:1210-3. 2005
    ..To compare the frequency and characteristics of septic arthritis in patients younger than 80 and aged 80 and older...
  39. doi request reprint Cardiovascular profile in ankylosing spondylitis: a systematic review and meta-analysis
    Sylvain Mathieu
    Clermont 1 University, centre hospitalier universitaire Gabriel Montpied, Clermont Ferrand, France
    Arthritis Care Res (Hoboken) 63:557-63. 2011
    ..In ankylosing spondylitis (AS), there is a paucity of information concerning this risk. Our objective was to assess the incidence of myocardial infarction (MI) or strokes and the cardiovascular risk profile in AS patients...
  40. doi request reprint Spondyloarthropathies: an independent cardiovascular risk factor?
    Sylvain Mathieu
    Service de Rhumatologie, CHU Gabriel Montpied, 58, rue Montalembert, 63003 Clermont Ferrand, France
    Joint Bone Spine 77:542-5. 2010
    ..Cardiovascular risk management in patients with spondyloarthropathies requires optimal control of disease activity combined with interventions targeting conventional cardiovascular risk factors...
  41. ncbi request reprint [Fractures of the ankylosed spine: MRI features]
    J L Michel
    Service de Radiologie A, Hopital Gabriel Montpied, CHU Clermont Ferrand, 58, rue Montalembert 63003 Clermont Ferrand Cedex 1
    J Radiol 88:1703-6. 2007
    ..MR is advantageous due to its ability to demonstrate signal abnormalities of the posterior elements, which combined with disk and vertebral body abnormalities, play a major role for accurate diagnosis of this type of fracture...
  42. ncbi request reprint Septic arthritis as a late complication of carcinoma of the breast
    V Chanet
    Immunology and Rheumatology Department B SAUVEZIE, Clermont Ferrand, France
    Rheumatology (Oxford) 44:1157-60. 2005
    ..To see if a past history of radiation therapy is a risk factor for septic arthritis...
  43. pmc Is IL-6 an appropriate target to treat spondyloarthritis patients refractory to anti-TNF therapy? A multicentre retrospective observational study
    Fernando Kemta Lekpa
    Rheumatology Department, AP HP, Henri Mondor University Hospital, 51 avenue du Mal de Lattre de Tassigny, 94010 Creteil, France
    Arthritis Res Ther 14:R53. 2012
    ..The aim of this study was to evaluate, under real-life conditions, the safety and efficacy of tocilizumab in patients having failed anti-TNFα therapy for spondyloarthritis...
  44. pmc Infectious sacroiliitis: a retrospective, multicentre study of 39 adults
    Marion Hermet
    Service de Medecine Interne, Hopital G, Montpied, CHU de Clermont Ferrand, 58 rue Montalembert, Cedex 1, Clermont Ferrand 63003, France
    BMC Infect Dis 12:305. 2012
    ..Most observations are based on isolated case reports or small case series. Our aim was to describe the clinical, bacteriological, and radiological characteristics of ISI, as well as the evolution of these arthritis cases under treatment...
  45. doi request reprint Septic arthritis with negative bacteriological findings in adult native joints: a retrospective study of 74 cases
    Julie Eberst-Ledoux
    Rheumatology Department, G Montpied Teaching Hospital, Faculty of Medicine, Clermont Ferrand 1 University, 58, rue Montalembert, 63003 Clermont Ferrand Cedex 1, France
    Joint Bone Spine 79:156-9. 2012
    ..We reviewed our cases of septic arthritis in adult native joints to determine the frequency of negative cultures, disease characteristics and the frequency of misdiagnosis of septic arthritis...
  46. doi request reprint TNF alpha antagonist therapy and safety monitoring
    Thao Pham
    Rheumatology Department, CHU Sainte Marguerite, Marseille, France
    Joint Bone Spine 78:15-185. 2011
    ..To develop and/or update fact sheets about TNFα antagonists treatments, in order to assist physicians in the management of patients with inflammatory joint disease...
  47. doi request reprint Misleading abstract conclusions in randomized controlled trials in rheumatology: comparison of the abstract conclusions and the results section
    Sylvain Mathieu
    INSERM U738, Paris, France
    Joint Bone Spine 79:262-7. 2012
    ..Readers of scientific articles often read only the abstract and its conclusions because of lack of time or of access to the full-length articles...
  48. doi request reprint Trend towards increased arterial stiffness or intima-media thickness in ankylosing spondylitis patients without clinically evident cardiovascular disease
    S Mathieu
    Rheumatology Department, G Montpied Teaching Hospital, France
    Rheumatology (Oxford) 47:1203-7. 2008
    ..e augmentation index AIx), markers of sub-clinical atherosclerosis in AS patients and to examine the effects of TNF-alpha inhibitors on arterial stiffness in active AS patients...
  49. ncbi request reprint Cutaneous lymphoma associated with Epstein-Barr virus infection in 2 patients treated with methotrexate
    A Tournadre
    Department of Rheumatology, Hĵpital Gabriel Montpied, Clermont-Ferrand, France
    Mayo Clin Proc 76:845-8. 2001
    ..Discontinuation of methotrexate is necessary in patients with RA or dermatomyositis who have a lymphoproliferative disorder, and a follow-up period of several weeks should be observed before specific therapy is initiated...
  50. pmc Tolerance and short term efficacy of rituximab in 43 patients with systemic autoimmune diseases
    J E Gottenberg
    Service de Rhumatologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Ann Rheum Dis 64:913-20. 2005
    ..To assess the tolerance and efficacy of rituximab in patients with various autoimmune diseases seen in daily rheumatological practice...
  51. pmc No changes in the distribution of organisms responsible for septic arthritis over a 20 year period
    J J Dubost
    Unit of Clinical Immunology, Hopital Gabriel Montpied, 63000 Clermont Ferrand, France
    Ann Rheum Dis 61:267-9. 2002
    ..To assess changes in the distribution and resistance of the pathogens responsible for septic arthritis over a 20 year period in patients admitted to the same hospital unit...